Crippled by a high-altitude collision with another airplane, Wayfarer 880, half the roof ripped away, flies on in the evening sky. Seated in the back, amid dead and dying passengers, pilot Donovan Nash fights decompression and oxygen deprivation to make it to the shattered cockpit. With help from a woman from his carefully concealed past, and a handful of survivors, Donovan must try to fly the heavily damaged plane with no electrical power or functioning instruments. On the ground, Dr. Lauren McKenna waits for Donovan, her fiancée, to arrive in Chicago, only to hear firsthand of the midair collision. Faced with a hostile airline executive who secretly wants the stricken airliner to vanish into the icy waters of Lake Michigan, Lauren must convince Henry Parrish, an unlikely ally, to help save the man she loves. Lauren and Henry find themselves involved in a deadly game of deception to try and stay one step ahead of the Airline as well as heightened security forces. As Flight 880 burns the last of its fuel, and not knowing who they can trust, Henry and Lauren rush to execute a daring midair solution to save Donovan and the others circling helplessly above.