In the wake of disaster, the surviving members of the Ballou family sought a new beginning on the Texas Frontier. A minister and his family become their traveling companions. Tragedy strikes when the minister and his young daughter are attacked by rattlesnakes and severely bitten. Their lives depend on the only medical attention available, that of a Comanche medicine man. And it is up to Ruff to persuade the reluctant Comanches to give them aid.