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How the Cardiac High Acuity Monitoring Program (CHAMP) is Helping Change Lives

CHAMP (Cardiac High Acuity Monitoring Program) is a multi-disciplinary based team that has been designed to meet the needs of the most complex cardiac population with single ventricle heart disease. The program closely monitors patients with single ventricle heart disease between the critical first and second stages (before stage II Glenn surgery). The team at the Ward Family Heart Center at Children's Mercy has also developed a tool that makes it easier for families to report their single...


Pediatric Dialysis Case Studies: What We’ve Learned and Where We Are Heading

Bradley Warady, MD, Division Chief of Pediatric Nephrology at Children's Mercy Kansas City is an international leader in pediatric dialysis. In addition to being one of the principal investigators for CKiD, the largest study of pediatric chronic kidney disease ever conducted in North America, Dr. Warady is the lead editor of two authoritative textbooks: Pediatric Dialysis Case Studies and Pediatric Dialysis. He is also on the international committee developing new pediatric dialysis...

Pediatrics in Practice: Influenza, Test or Treat?

Every year, influenza causes many people to become ill. All children 6 months and age and older should receive a yearly flu vaccine. Vaccination remains the best way to prevent influenza. Symptoms of influenza include abrupt onset of fever, myalgias, headache, nonproductive cough, sore throat and runny nose. Fever and cough are the two most common symptoms. When presented with these symptoms, providers are faced with the question to test and confirm the diagnosis of influenza or to...


Transformational Pediatrics: Targeted Therapy to Reduce Relapse of Pediatric Leukemia

Patients that have residual leukemia stem cells after chemotherapy and other treatments have substantially higher risk for relapse. Survival rates for relapsed leukemia are very poor. Even when patients survive long-term, the very toxic anti-cancer treatments are escalated in treating relapsed leukemia. This particularly risks long-term health and substantially increases the risk of early death due to side-effects of the treatment itself. John Perry, PhD, faculty member of the Children's...


Identifying Novel Drug Treatment Options for Pediatric Osteosarcoma

Osteosarcoma is a highly metastatic and drug resistant cancer. Survival rate for metastatic osteosarcoma remains less than 20 percent for the last 40 years. Tomoo Iwakuma, MD, PhD, is leading research focused on elucidation of mechanisms underlying osteosarcoma progression and discovery of novel drugs against this osteosarcoma. His laboratory has identified a lead compound that specifically killed canine and human osteosarcoma cells lacking the activity of the tumor suppressor p53, with...


Developmental Screening: Navigating the Pediatrician Visits

The AAP recommends conducting general developmental screening at 9, 18, and 30 months, or whenever a concern is expressed. In addition, autism-specific screening is recommended at ages 18 and 24 months of age. When families arrive for their child's well-visits, how can each pediatrician be sure the right screening is taking place to identify any developmental delays quickly and effectively? Hear from Cy Nadler, Phd, and Sarah Nyp, MD, as they discuss the screening process and how to...


Management and Treatment for Peutz-Jeghers Syndrome

Peutz-jeghers syndrome (PJS) is an inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. Individuals that present with PJS tend to have polyps often in their small intestine as well as their stomach and large intestine. Recently the European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) group published the first set of guidelines in treating PJS in pediatric patients. Hear from Thomas Attard...


Pediatrics in Practice: Common Kidney Conundrums

Enuresis, hematuria and proteinuria are common pediatric kidney disorders, but the when do these problems warrant a referral to a pediatric nephrologist? What red flag symptoms require more urgent consultation and evaluation? New specialty-specific guidelines from the "Choosing Wisely" campaign were just released for pediatric nephrology in an effort to educate about unnecessary medical tests, treatments and procedures. In this podcast, Darcy Weidemann, MD, pediatric nephrologist at...


Pediatrics in Practice: Positive Antinuclear Antibody: What Now?

“Positive ANA” is one of the most common reasons for referral to the pediatric rheumatology clinic. The antinuclear antibody (ANA) is often mistakenly considered a good screening test for rheumatic disease. Dr. Ashley Cooper, Interim Division Director of Pediatric Rheumatology, discusses what it means when a child has a positive anti-nuclear antibody test, when ANA should be checked, and how to talk about the test results with the family.


Common Orthopedic Conditions and How to Treat Them

Orthopedic conditions can cause pain and dysfunction, causing aches and pains in bones and joints. Mobility and activity may be limited by these conditions. Polly Wimer, CPNP, APRN discusses common orthopedic conditions and their treatment.


Pediatrics in Practice: The Opioid-Pain Nexus: Current Opioid Use and Safety

Although there has been less emphasis on responsible prescribing of opioids in children, with newly developed legal and regulatory efforts focused almost exclusively on adults, it remains important for pediatric providers to be aware of the heightened risk for substance misuse in adolescents, and the appropriate use of opioids in a pediatric population. In this podcast, Daniel Millspaugh, MD, anesthesiologist and Director of the Comprehensive Pain Management and Opioid Stewardship...


Pediatrics in Practice: Primary Care for Pediatric Cancer Survivors

As pediatric cancer survival rates continue to improve, we are faced with a new set of health challenges in caring for these survivors. Joy Fulbright, MD, Director of the Survive and Thrive program at Children’s Mercy Kansas City, discusses health concerns after cancer treatment, what primary care providers need to know, and the need for yearly screenings addressing medical and psychosocial issue.


Previously Untreated Patients with Hemophilia Matter

As regional hemophilia treatment center, Children's Mercy follows more than 900 patients with bleeding disorders. Listen as Shannon Carpenter, MD, pediatric hematologist/oncologist and director of the Hemophilia Treatment Center at Children's Mercy Kansas City, discusses hemophilia A and B in children, current treatments and promising new research studies and options on the horizon, such as the PUPS Matter cohort study.


Getting in Front of Type 2 Diabetes

Type 2 diabetes was commonly associated with the adult population. This diagnosis was even referenced as adult-onset diabetes but in recent years type 2 diabetes in children is on the rise. Although researchers aren’t clear as to why some children develop type 2 diabetes there are some causes that can increase the risk. When children present with these risks the Children Mercy Diabetes Center can evaluate these patients and create a care plan to possibly alter the path to such a...


Kids and Kidney Stones

Kidney stones in children have been on the rise for more than a decade, mostly due to hypercalciuria and hypocitraturia. Join us as Uri Alon, MD, Director of the Bone and Mineral Disorders Clinic at Children’s Mercy Kansas City, discusses what is behind the increasing incidence of kidney stones, and medical and non-pharmacological interventions to prevent new stones and inhibit the growth of existing ones.


Is There a Role for Fecal Transplant in IBD?

Can an effective treatment for medically refractive Crohn’s disease be found in the gastrointestinal tract itself? Dr. Alka Goyal with Children’s Mercy Kansas City is exploring the role of fecal transplant as a rescue therapy for patients whose inflammatory bowel disease has not responded to traditional treatment. Early research showed that a single transplant is relatively safe and can result in a short-term response in young patients with active IBD but doesn’t provide long-term relief....


Tourette Syndrome: Using an Evidence-based Algorithm to Guide Treatment

As an expert in the treatment of Tourette Syndrome (TS), recently, Dr. Coffman was asked to author an article on the pharmacological treatment of Tourette Syndrome. In collaboration with Dr. Quezada, the paper was published in CNS Drugs Journal, focusing on current approaches and new developments regarding treatment of Tourette Syndrome. The team developed a visual algorithm to help guide the treatment of TS using medication based on the level-of-evidence and side-effects. It has been...


Precision Therapeutics in the NICU

Neonatal pharmacotherapy is a field ripe with opportunity. Efficacy and toxicity is unpredictable and varies greatly for many drug classes commonly used. Weight-based dosing continues to be the standard of care as individualized drug markers are lacking. To better understand variability in drug response, the focus must shift from drug dosing to drug exposure. Tamorah Lewis, MD, neonatologist and clinical pharmacologist, joins us to discuss how pharmacotherapy and individualized medicine can...


Cancer Genomics: Finding Answers Through Data and DNA

Approximately 10 to 15 percent of childhood cancer cases are due to a genetic predisposition. Children’s Mercy Kansas City is searching within the genetic code to not only identify genes that may lead to cancer, but to find answers in how to better treat or cure pediatric cancer. Erin Guest, MD, Director of Cancer Genomics at Children’s Mercy, discusses the growing role of cancer genomics and how big data, new tests, and personalized treatments could change the future of pediatric cancer...


Mitigating Hyperfiltration-Mediated Kidney Injury

Thanks to the research being done in CKid, we know that children diagnosed with chronic kidney disease progress over time to dialysis and transplantation. That makes it very important to address therapies which can mitigate the progression of chronic kidney disease. Joining the show today is Tarak Srivastava, MD, he has been awarded R01 funding from the National Institutes of Health to work on targeting EP2, one of the four PGE2 receptors to mitigate hyperfiltration–mediated kidney injury...