AJT Highlights

Host Roz is joined by AJT Editor-in-Chief Emeritus Allan Kirk, MD, PhD, (Duke University) and AJT Editorial Fellow Laura Binari, MD (Vanderbilt University). [2:34] Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates [14:09] A2/A2B to B deceased donor kidney transplantation in the Kidney Allocation System era [24:01] Xenotransplantation Papers [25:07] Xenotransplantation experiments in brain-dead human subjects–A critical appraisal [28:11] The decedent model: A new paradigm for de-risking high stakes clinical trials like xenotransplantation [32:45] Exploring the single-cell immune landscape of kidney allograft inflammation using imaging mass cytometry

Host Roz is joined by AJT Editorial Board Member Alexandre Loupy, MD, PhD (Necker Hospital) and AJT Editorial Fellow Thiago J Borges, PhD (Massachusetts General Hospital). [2:39] Transplanting old organs promotes senescence in young recipients [11:33] The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics [15:45] The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts (Editorial) [18:12] The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation [20:25] Antiobesity pharmacotherapy to facilitate living kidney donation [27:04] Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients

Host Roz is joined by AJT Editorial Board Member John Greenland, MD, PhD (University of California, San Francisco) and AJT Editorial Fellow David Cron, MD, MS (Massachusetts General Hospital). [2:53] Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National University Hospital [11:26] Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation & Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response [20:28] Augmenting the Unites States transplant registry with external mortality data: A moving target ripe for further improvement (Editorial) How hard are the hard outcomes reported in national transplant registries? [32:25] Maintaining the permanence principle of death during normothermic regional perfusion in controlled donation after the circulatory determination of death: Results of a prospective clinical study

The podcast discusses the impact and implications the kidney allocation system (KAS 250) has had over kidney allocation in the United States, focusing on the effect on operational challenges, cold ischemic times, delayed graft function, and organ discard rates. Guest speakers include Joel Adler (Dell Medical School, University of Texas in Austin) and John Friedewald (Northwestern Memorial Hospital).

Host Roz is joined by AJT Editorial Board Member Michael Mengel, MD (University of Alberta) and AJT Editorial Fellow Kazem Fallahzadeh, MD (Emory University). [2:43] Recurrent atypical antiglomerular basement membrane nephritis in the kidney transplant [14:26] Pretransplantation coronavirus disease 2019 vaccination requirements: A matched case-control study of factors associated with waitlist inactivation (Editorial) Coronavirus disease 2019 vaccine mandates and the Owl of Minerva [21:45] Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak [29:48] Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy [37:07] De novo membranous nephropathy in a pig-to-baboon kidney xenograft: A new xenograft glomerulopathy

Host Roz is joined by AJT Editorial Board Member Emily Blumberg, MD (University of Pennsylvania) and AJT Editorial Fellow Dempsey Hughes, MD (Northwestern Medicine). [03:03] Predicting post–liver transplant outcomes in patients with acute-on-chronic liver failure using Expert-Augmented Machine Learning [10:34] Clinical features, treatment, and outcomes of mpox in solid organ transplant recipients: A multicenter case series and literature review [14:05] First case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient [15:28] A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study [22:55] A rational approach to guide cost-effective de novo donor-specific antibody surveillance with tacrolimus immunosuppression [30:04] (Editorial) Personalizing kidney transplant donor-specific antibody surveillance: The devil is in the details [33:20] Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial

In this specialty podcast, Arielle Cimeno, hosts Raymond Lynch and Amit Mathur to discuss recent trends and new initiatives to assess kidney utilization and organ procurement organization performance.

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center) [03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient [06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis [10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk [14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization [19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience [23:00] (Editorial) What is a Clinically Significant Donor-Specific Antibody Before Lung Transplantation? [25:38] Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation [35:11] (Editorial) Understanding the mechanisms and implications of the association between community distress and organ non-utilization [37:18] Sex as a Biological Variable: Mechanistic Insights and Clinical Relevance in Solid Organ Transplantation

Host Roz is joined by AJT Editorial Fellow Salil Kumar, MD (incoming Assistant Professor at MD Anderson Medical Center) [2:24] Importance of social vulnerability on long-term outcomes after heart transplantation [12:51] Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia [21:26] Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation [28:52] Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study [36:44] Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes

Host Roz is joined by AJT Editorial Board Member Kenneth Newell, MD, PhD (Emory University) and AJT Editorial Fellow Kyle Jackson, MD, PhD (Emory University) [2:45] Identifying and understanding variation in population-based access to liver transplantation in the United States [12:44] Intra-graft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics [18:21] Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient [22:20] Impact of allele-specific anti-HLA class I antibodies on organ allocation [28:12] Autoantibodies against DNA-topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses

In this specialty podcast, Carrie Thiessen, MD, PhD (University of Wisconsin-Madison) hosts Robert Montgomery, MD, PhD, (NYU Langone) and Muhammad Mohiuddin, MBBS, (University of Maryland) to discuss ethical issues related to informed authorization and informed consent for decedent kidney and human cardiac xenotransplants.

Host Roz is joined by AJT Editorial Board Member Sanjay Kulkarni, MD, (Yale School of Medicine) and AJT Editorial Fellow Luise Holzhauser, MD (University of Pennsylvania) [2:40] In a real-life setting, risk factors, Coronary artery calcium score and coronary stenosis at Computed Tomography Angiography are associated with MACE and all-cause mortality among kidney transplant candidates [16:00] The minimum weight and age of kidney donors: En bloc kidney transplantation from preterm neonatal donors weighing less than 1.2kg to adult recipients [24:35] Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation [31:07] Recipient Race Modifies the Association between Obesity and Long-term Graft Outcomes After Kidney Transplantation

In this AJT specialty podcast, Aly Strauss, hosts Allison Kwong and Manuel Rodriguez-Peralvarez to discuss MELD 3.0, Gender-Equity Model for Liver Allocation (GEMA), and international efforts to eliminate gender disparities in allocation of liver transplants. Bernards et al. AJT: https://pubmed.ncbi.nlm.nih.gov/35871752/ Kim et al. Meld 3.0: https://pubmed.ncbi.nlm.nih.gov/34481845/ Meld 3.0 calculator: https://medcalculators.stanford.edu/meld Rodriguez-Peralvarez et al. GEMA: https://pubmed.ncbi.nlm.nih.gov/36528041/ GEMA calculator: http://gema-transplant.com/

Host Roz is joined by AJT Editorial Board Member Seth Karp, MD (Vanderbilt University Medical Center) and AJT Editorial Fellow Thiago Borges, PhD (Massachusetts General Hospital) [2:33] Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses [11:28] The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine [21:18] The 20-year paradigm shift toward organ recovery centers: 2500 donors at Mid-America Transplant and broader adoption across the United States [33:13] Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death [42:17] Stakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference

Host Roz is joined by AJT Editorial Board Member Seth Karp, MD (Vanderbilt University Medical Center) and AJT Editorial Fellow Thiago Borges, PhD (Massachusetts General Hospital) [2:33] Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses [11:28] The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine [21:18] The 20-year paradigm shift toward organ recovery centers: 2500 donors at Mid-America Transplant and broader adoption across the United States [33:13] Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional perfusion in donors after the circulatory determination of death versus donors after brain death [42:17] Stakeholders’ perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients’ consensus conference

Hosts Roz and Josh discuss the key articles of the June issue of American Journal of Transplantation. [1:30] The evolving use of biomarkers in heart transplantation: Consensus of an expert panel [9:49] Effects of in vivo CXCR4 Blockade and Proteasome Inhibition on Bone Marrow Plasma Cells in HLA Sensitized Kidney Transplant Candidates [16:50] An ethical analysis of obesity as a contraindication to pediatric liver transplant candidacy [23:53] Racial and ethnic disparities in psychosocial evaluation and liver transplant waitlisting

Host Roz and Josh are joined by AJT Editorial Fellow Scott Krummey, MD, PhD, to discuss the key articles of the May issue of American Journal of Transplantation. [01:59] Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices [11:36] Mutations In Latent Membrane Protein 1 of Epstein-Barr Virus are Associated with Increased Risk for Post-Transplant Lymphoproliferative Disorder in Children [23:13] Impacts of removing race from the calculation of the Kidney Donor Profile Index [31:49] The Association of Donor Hepatitis C Virus Infection with Three-Year Kidney Transplant Outcomes in the Era of Direct-Acting Antiviral Medications [41:40] Time to discard the term “discard”

Host Roz and Josh are joined by AJT Editorial Fellow Daniel Galvez Lima, MD, to discuss the key articles of the April issue of American Journal of Transplantation. [02:01] Successful pathways to liver transplant for undocumented immigrants, Kerznerman et al [10:30] Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial, Eelderink et al [18:07] ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping, Joseph et al [29:15] Oxidative stress and related metabolic alterations are induced in ex situ perfusion of donated hearts regardless of the ventricular load or leukocyte depletion, Hatami et al

Host Roz is joined by AJT Editorial Fellow Aly Strauss, MD, to discuss the key articles of the March issue of American Journal of Transplantation. [2:57] Milestones on the path to clinical pig organ xenotransplantation, Cooper & Pierson. [12:45] Infection and clinical xenotransplantation: Guidance from the Infectious Disease Community of Practice of the American Society of Transplantation, Mehta et al. [20:30] Addressing sex-based disparities in solid organ transplantation in the United States – a conference report, Sawinski et al. [33:45] A comparison of deprivation indices and application to transplant populations, Park et al.

In this specialty podcast, Katie Ross-Driscoll, PhD, MPH (Emory University) hosts Jon Snyder, PhD, MS (Scientific Registry of Transplant Recipients) to discuss the utility of registries in transplantation research, considerations for study design and analysis, and common errors when using registry data.