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A New Questionnaire To Measure Quality Of Life In Inflammatory Neuropathies

Quality of life (QoL) is one of the most important outcomes for chronic diseases, although it remains remarkably difficult to quantify. Dr. Thomas Draak (Maastricht University, The Netherlands) discusses his new questionnaire, and how it aims to capture the patient’s perspective. Read the full paper here:


Marriage and a reduced risk of dementia

Recent research has indicated that being married is associated with a reduced risk of dementia. What is it about marriage? Dr Andrew Sommerlad (University College London) discusses this question and more. Read the full paper here:


Anti-inflammatory approaches to stroke prevention; monitoring disease progression in ALS

Atherosclerosis is a major contributor to increased risk of stroke. Our patient’s choice, Professor Peter Kelly (University College Dublin, Dublin, Ireland) discusses the evidence base implicating inflammation as a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. Read the full paper here: How do you measure disease progression in a highly variable and heterogeneous clinical population, such as amyotrophic...


Nodes and paranodes; alternative treatments in MS

People with multiple sclerosis (MS) use complementary and alternative treatments (CAM), but what does the evidence say? Patient’s Choice, Professor Bruce Taylor (University of Tasmania) discusses the modern evidence for CAM use. Read the paper here: What roles do nodes and paranodes play in complex neuropathies? Dr Simon Rinaldi (University of Oxford) summarises the involvement of these specialised domains as this month’s Editor’s Choice. Read the full...


Pathophysiology of functional neurological disorder

Despite the prevalence of the disease, neurologists and psychiatrists can be wary of treating patients with functional neurological disorder (FND). Associate Professor David Perez (Massachusetts General Hospital, USA) discusses how FND sits between neurological and psychiatric disciplines, the relationship between poor health status and affective symptoms, and associations with grey matter volumetric profiles. Read more here:...


Is methamphetamine use linked to stroke in young adults?

Is methamphetamine use linked to strokes in young adults? Important clinical implications discussed by Dr. Julia Lappin (University of New South Wales) in this month’s JNNP podcast.


Cerebral Amyloid Angiopathy: New Insights For Clinical Practice

Cerebral amyloid angiopathy (CAA) has been gaining attention over the past few years, thanks to increased research in the field. Professor David Werring (UCL Institute of Neurology, Queens Square, London) discusses the recent advances in biomarkers analysis, as well as providing an overview of the clinical spectrum of CAA. Read the full paper here:


Cortical Influences in ALS

Professor Emeritus Andrew Eisen (University of British Columbia, Canada) discusses the theory of corticofugal primary in amyotrophic lateral sclerosis. ALS can be viewed as a primarily human disorder mediated by corticomotorneuronal pathways, originating in the cerebral cortex. Read the full paper here:


Intravenous immunoglobulin in CIDP

Can IViG be used as a longer term maintenance therapy for CIDP patients? JNNP Associate Editor, Professor Satoshi Kuwabara (Chiba University Hospital, Japan) joins us for this podcast, discussing recent trial results and their implications for patient care. Read the full paper here:


Complex inherited neuropathies: a new approach to diagnosis?

Professor Mary Reilly (Institute of Neurology, Queens Square, London) discusses how complex inherited neuropathies can be a daunting diagnosis for clinicians. However, through exciting advances in next generation sequencing and knowledge of distinct syndromic categories, a new diagnostic approach emerges. Her review and her interview provide excellent over of this new approach, and how it may serve as a resource for clinicians. Link to paper here:


Cerebellum and neurodegeneration; autoantibodies and psychological development in children

The September 2017's JNNP podcast is a double episode. The first conversation is with Professor Michael Hornberger from the Norwich Medical School, University of East Anglia, UK. The cerebellum is often overlooked when looking at neurodegenerative diseases, a practice which Professor Hornberger and his team are challenging. Their recent JNNP paper looks at patterns of grey matter atrophy in the cerebellum across neurodegenerative diseases. What they found may surprise some listeners. Read...


How the real costs of MS are being concealed

“Take a comprehensive economic approach to evaluating treatment cost-effectiveness in MS”. Jacqueline Palace (Consultant Neurologist, Nuffield Department of Clinical Neurosciences, University of Oxford) and Ruth Geraldes (Neurologist, Department of Clinical Neurosciences, University of Oxford) examine the economic burden of multiple sclerosis, which was debated at the international roundtable “Time Matters in MS”, organised by the BMJ and the JNNP on World MS Day 2017, in Lisbon. Read...


Survival and cause of death in Multiple Sclerosis

There has been an increase in life expectancies for the general population over the last few decades. A similar trend has also been identified in patients with Multiple Sclerosis (MS). To investigate this trend further, Dr Lunde and colleagues, from the Norwegian Multiple Sclerosis Competence Centre, investigated survival and cause of death in an MS cohort. Dr Lunde discusses the findings with Elizabeth Highton in the August 2017's JNNP podcast. Download the paper here:...


Time Matters - part 1: delay is “expensive” in all aspects of multiple sclerosis

Professor Emeritus Alastair Compston (University of Cambridge) discusses with JNNP’s Publisher Janet O'Flaherty the issues raised by the discussion “Brain health matters in multiple sclerosis” (MS), which was part of the international roundtable “Time Matters in MS”, organised by the BMJ and the JNNP on World MS Day 2017, in Lisbon. Read more, watch the videos and access all the information about the event on the JNNP's website special page:


Seven tesla MRI In Neurodegenerative Dementias

MRI is an important clinical tool to study dementia symptoms in vivo. However, certain pathologies (microbleeds, plaques, tangles) can evade current imaging techniques. Seven tesla (7T) MRI provides a potentially exciting new opportunity to visualise these pathologies in vivo. Dr. Elizabeth McKiernan (University of Cambridge) discusses the literature around 7T MRI, and its scope in neurodegenerative dementias. Read the review in the JNNP website:...


Conversational Laughter In Dementia

Laughter serves a fundamental social purpose, the appropriate use of which requires recognition of social norms. So what happens when these interpersonal abilities are affected, such as in the frontotemporal dementias? Does use of laughter change too? Dr Peter Pressman (Rocky Mountain Alzheimer’s Disease Center, University of Colorado, USA) talks to Elizabeth Highton about observing conversational laughter in frontotemporal dementia. This paper was chosen for this month’s Editor’s Choice...


Narrative and Neurology: The Andrew Lees Experiment

Professor Andrew Lees discusses his book "Mentored by a Madman: The William Burroughs Experiment" with Dr Sean O’Sullivan and Elizabeth Highton. Andrew speaks to the importance of looking beyond one’s area of expertise for mentorship, the relationship between art and science in neurology, Parkinson's disease and how William Burroughs played an unlikely role in his own medical career. You can read Sean O’Sullivan’s review of the book on the JNNP website:


April 2017: deconstructing dilemmas in Amyotrophic Lateral Sclerosis and Guillain-Barré Syndrome

Both patient and editor's choices are discussed in this monthly episode of the JNNP podcast. The clinical care of patients with Guillain-Barré syndrome (GBS) can often be complex; a disease with a highly variable clinical course. Professor Bart Jacobs, from the Department of Neurology at Erasmus Medical Centre (Rotterdam) provides an overview of some of the dilemmas that may arise when treating patients with GBS. The full article: In the second part of...


Zika virus and Guillain-Barré Syndrome: what do we know?

There is concern that, despite being a rare complication of the Zika virus, we could see a steady rise in the number of cases of Guillain-Barré Syndrome (GBS). In preparation for this, it is important that clinicians are able to appropriately identify and differentiate between Zika-associated GBS and other neurological disorders. In this podcast, Professor Antonino Uncini (University ‘G’ d’Annunzio’, Chieti, Italy) discusses Guillain-Barré Syndrome (GBS) and it’s associations with Zika...


Immunomodulatory therapy in advanced multiple sclerosis

Could currently available immunomodulatory therapies modify disability trajectories in patients with moderately advanced and advanced multiple sclerosis (MS)? Tomas Kalincik, Department of Medicine, University of Melbourne, Australia, discusses the findings from the MSbase cohort study with Elizabeth Highton. Read the full article here:


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