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Running Through Walls

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Pivoting to Success

Brian O’Kelley, CEO and co-founder of AppNexus, started his entrepreneurial endeavors early, first in high school refurbishing old Apple II computers and later in college creating websites in the nascent days of the internet. Venrock partner Mike Tyrrell talks to O’Kelley about his path from odd jobs to CEO of a $1 billion company. He discusses the tough times at Right Media that led to his firing, and how he turned that experience into a positive one with the founding of AppNexus. And in...

Duration: 00:26:16

Tales from a Turnaround

As the CEO of medical technology company ZELTIQ, Mark Foley was on the front lines of a major business transformation. Venrock’s Bryan Roberts talks to Foley about turning the company around by changing the business model and swapping out the majority of leadership, culminating in the successful acquisition by Allergan for $2.4 billion in April 2017. But the exit wasn’t all smooth sailing. Foley shares details on the initial failed bids that rocked the company’s culture, how he managed...

Duration: 00:25:09

How To Build A Sales Team

Steve Walske founded Parametric Technology Corporation in 1985 and is now on the board of several prominent Silicon Valley companies including Synopsys and 6sense. Venrock partner Brian Ascher talks to Walske about his unique formula for building a strong sales team and striking a balance between managing and empowering salespeople. Walske believes in efficiency above all else, and that means turning down opportunities until the company establishes a real sales presence in the area. They...

Duration: 00:18:55

I Don’t Like Hype

Steve Papa, founder and CEO of Endeca through its acquisition by Oracle in 2011, has thrived in many roles throughout his career: neighborhood Mr. Fix-it, entrepreneur, founder, CEO, mentor and angel investor. In this week’s podcast, Venrock’s Bryan Roberts talks to Papa — now founder and CEO of Parallel Wireless — about his early aspirations and founding Endeca during the rapid expansion of the Internet in 1999. The company survived through two major economic downturns and went through a...

Duration: 00:19:28

Entrepreneur on a Mission

Venrock partner Nick Beim talks to Mark Gerson, co-founder and Chairman of Gerson-Lehrman Group, about his early entrepreneurial pursuits, why society should promote entrepreneurism and why it’s a bad idea to keep all of your ideas to yourself when first starting out. When Gerson’s innovations stretched to providing first-response services and healthcare for underserved populations, he came to the realization that philanthropy, like any other venture, focuses on the amount of return —...

Duration: 00:16:12

From Genentech to Facebook to Startup: Part Two

Part two of the discussion between former Genentech and Facebook CFO David Ebersman and Venrock’s Bryan Roberts centers on Ebersman’s time at Genentech, where he started working in his 20s and worked up his way up, eventually becoming CFO. He shares anecdotes about working with another executive dynamic duo, Art Levinson and Sue Desmond-Hellmann, and what he learned about problem-solving after working closely with them for several years. Ebersman also discusses Roche’s hostile takeover of...

Duration: 00:23:15

From Genentech to Facebook to Startup: Part One

In the first part of his discussion with Bryan Roberts of Venrock, former Genentech and Facebook CFO David Ebersman shares what he learned about leadership from the dynamic duo of Mark Zuckerberg and Sheryl Sandberg at Facebook, and discusses his experience taking the company public in 2012. Now CEO and founder of Lyra Health, Ebersman discusses how Lyra solves the problem of finding quality care for mental health conditions, and talks about the most surprising aspects of being a startup...

Duration: 00:12:56

Culture Conscious

When Matthew Prince and Michelle Zatlyn met in business school, they didn’t envision a class project turning into a billion-dollar company, but that’s exactly what happened. Bryan Roberts, partner at Venrock and Cloudflare board member, talks with the co-founders about the early days of company building and how their initial mission statement has remained the same years later, a rarity among Silicon Valley startups. Prince and Zatlyn discuss their measured and thoughtful approach to...

Duration: 00:22:46

Surviving a Slump

Bruce Cozadd was a musician in his early years, but a passion for science and business led him to enter the biopharma industry. Venrock partner Camille Samuels talks to Cozadd, now CEO of Jazz Pharmaceuticals, about his journey to co-founding Jazz and the people who helped him along the way. He shares the joys of starting Jazz with a team that had worked together in the past, but also highlights the downside: that his team lacked diverse prior experiences to rely upon while building a...

Duration: 00:21:39

The Doctor is Online

Hill Ferguson joined Doctor on Demand as CEO in 2016. Venrock’s Bob Kocher talks to Ferguson about his first day on the job and hallmarks of a successful founder to CEO transition, including the delicate balance of fixing problems while preserving what’s already great with the company. Ferguson was on the employee side of this transition in previous roles, and learned the importance of creating an environment where all employees, regardless of position, feel comfortable asking questions....

Duration: 00:19:13

Talk About (Your) Mistakes

Steven Aldrich, Chief Product Officer at GoDaddy, has thrived professionally at both large companies and startups, something Brian Ascher of Venrock notes is unusual during this interview. Aldrich shares lessons startups can learn from more established companies and vice versa, noting that startups often try to be scrappy and do things internally regardless of expertise, while hiring someone with expertise would save them time and money. Conversely, big companies need to encourage...

Duration: 00:20:56

Apple Intern to Entrepreneur

Matt Rogers, co-founder of Nest, started his career as an intern at Apple and it was during that first week on the job when he met his co-founder Tony Fadell. While speaking with David Pakman of Venrock, Rogers talks about stretching people to help them grow, why he and Fadell chose to reinvent the thermostat, and why Apple is a breeding ground for entrepreneurs. Nest was going after a market dominated by well-entrenched players, but Rogers says they were prepared for a fight and...

Duration: 00:19:32

Fail Quickly

Founded as Microbia to explore and develop antifungal and antibacterial drugs, Ironwood Pharmaceuticals now has two drugs on the market helping patients with IBS and Gout. After nearly 20 years and many different approaches and targets, founder and CEO Peter Hecht tells Venrock’s Bryan Roberts that he is proud of the failures along the way as the end goal was always to build an enduring pharmaceutical company. The key is to kill programs that aren’t working early and not let them go too...

Duration: 00:12:34

Priority One: People Matters

Gio Colella, co-founder of RelayHealth and Castlight Health, speaks with Bryan Roberts at Venrock about starting companies and the importance of surrounding yourself with amazing people. Colella advises other entrepreneurs to find partners you can trust, who are very different from you, and who are aligned with the vision for the company. Colella and Roberts also talk about the early days of Castlight and the iterative process that revealed the foundation of the company, as well as the...

Duration: 00:19:20

Data Driven Healthcare

Farzad Mostashari, founder and CEO of Aledade, speaks with Bob Kocher at Venrock about bringing a data-driven approach to solving problems and the importance of knowing the question you want to answer, so you can apply the appropriate analysis. Mostashari, who went to medical school, knew quickly that he would not pursue a traditional career as a physician. In medical school he was an outlier, asking questions about population/public health, and then during his residency was mostly curious...

Duration: 00:24:45

Building A Cancer Killer

Sam Mazin, Founder and CEO of RefleXion Medical, speaks with Colin Cahill at Venrock about managing a big project with a lean budget, raising money, and communicating an evolving and complex vision. They explore the evolution of RefleXion’s addressable market as clinical data showed better results than the standard of care, and what that means for some cancer patients. Sam and Colin also talked about learning to manage “on the job” and how you manage people who have more experience. Sam’s...

Duration: 00:18:59

No Straight Shots in FinTech

Ryan Gilbert, co-founder of SmartBiz Loans, speaks with Brian Ascher of Venrock about building a fintech company and what went wrong along the way. The company mastered the art of pivoting and ultimately found its niche in small business loans. Gilbert advises new fintech entrepreneurs to partner with large banks rather than focusing on disruption, as banks have started to embrace new technology. A catch-phrase master, Gilbert wonders where truly novel technology can be found in the...

Duration: 00:18:45

Genetic Truths, No Veneers

Anne Wojcicki, founder of 23andMe, speaks with Bob Kocher of Venrock about her path to entrepreneurship, the importance of authenticity and health as the ultimate equalizer of humanity. Wojcicki was dismayed by the lack of transparency in healthcare, which led the company to sell direct to consumers and empower them with information to get the care they want. In addition to understanding how their genetic information impacts their health, 23andMe has allowed people to engage with their...

Duration: 00:19:30

The Serial Entrepreneur

Kevin Ryan, co-founder of DoubleClick, MondoDB, Business Insider, and Gilt Groupe (among others), speaks with Nick Beim at Venrock about building teams and what to look for in a VC. Ryan advocates taking risks as an entrepreneur, even if it leads to a failure or two. You can learn a lot from unsuccessful ventures and it prepares you for the next thing. They also discuss how entrepreneurial optimism is essential as there will always be rejection and bumps along the way, but it can also...

Duration: 00:16:21

Healthcare. It’s Complicated.

Blue Shield of California (BSCA) CEO Paul Markovich speaks with Bob Kocher at Venrock about bringing the healthcare system out of the stone age and the opportunities for entrepreneurs to bring much needed change to the industry. They talk about how Paul’s career path led him to healthcare, how he fosters an open environment that welcomes feedback and what BSCA is doing to create new efficiencies through a collaboration with Anthem Blue Cross, called Cal INDEX. They also discuss “what...

Duration: 00:20:41

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