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Empowered Patient Podcast

Health, Home & Life

Empowered Patient Podcast with Karen Jagoda is a window into the latest innovations in digital health, the changing dynamic between doctors and patients, and the emergence of precision medicine. The show covers such topics as aging in place, innovative uses for wearables and sensors, advances in clinical research, applied genetics, drug development, and challenges for connected health entrepreneurs.

Empowered Patient Podcast with Karen Jagoda is a window into the latest innovations in digital health, the changing dynamic between doctors and patients, and the emergence of precision medicine. The show covers such topics as aging in place, innovative uses for wearables and sensors, advances in clinical research, applied genetics, drug development, and challenges for connected health entrepreneurs.


San Diego, CA


Empowered Patient Podcast with Karen Jagoda is a window into the latest innovations in digital health, the changing dynamic between doctors and patients, and the emergence of precision medicine. The show covers such topics as aging in place, innovative uses for wearables and sensors, advances in clinical research, applied genetics, drug development, and challenges for connected health entrepreneurs.






Healing Chronic Complex Wounds with Perinatal Tissue Allografts with Jason Matuszewski and Andrew Van Vurst BioStem Technologies

Jason Matuszewski, Chief Executive Officer and Chairman of the Board, and Andrew Van Vurst, Chief Operating Officer of BioStem Technologies have a vision to change the paradigm on the use of perinatal tissue for advanced wound care. Their initial target is complex wounds in the lower extremity region, specifically focusing on diabetic foot ulcers, venous ulcers, and pressure ulcers using a perinatal tissue allograft to promote healing. Jason explains, "In general, non-healing and complex...


Improving Cognitive and Independent Function of Alzheimer’s Patients with Sharon L. Rogers AmyriAD Therapeutics

Sharon L. Rogers Ph.D. is the CEO of AmyriAD Therapeutics and has a deep understanding of the development of drugs to address the impact of Alzheimer's disease. Currently, the most common treatment is Aricept which Sharon developed and brought to market in 1996. Based on recent research, it does not appear that disease modification leads to clinical benefit or reduction in the progression of the disease. Sharon explains, "We're not doing anything that's going to modify the underlying...


Targeting and Deploying Optimum Radiopharmaceuticals to Treat Cancer with Jack Hoppin and John Babich Ratio Therapeutics

Jack Hoppin Ph.D. Chief Executive Officer and John Babich Ph.D., President and Chief Scientific Officer, and Co-Founders of Ratio Therapeutics aim to develop and produce best-in-class radiopharmaceuticals. Harnessing the power of radiation by making it into an injectable drug, Ratio is creating a way to find tumor cells anywhere in the body. John explains, "And what we are doing, which is quite unique, is creating a platform of small molecules that can be radiolabeled with a variety of...


Targeting the Adenosine Pathway to Stimulate the Immune System to Destroy Tumors with Dr. Robert Ross Surface Oncology

Dr. Robert Ross is the CEO of Surface Oncology, which is focused on immune modulation in the treatment of cancers. Their hypothesis is that IL-27, a cytokine, is telling the immune system to ignore the cancer and providing a hiding place for the cancer cells. By administering their drug SRF 388 to bind up all the IL-27, the immune system can properly identify and fight the cancer. Robert explains, "SRF 388, all of these drugs, have such needlessly complicated names when they get started,...


Administering Cellular Therapy for Solid Tumors and Blood Cancers Without Lymphodepleting Chemotherapy with Greg Frost EXUMA Biotech

Greg Frost is the Chairman and CEO of EXUMA Biotech, which is working on a cancer cellular therapy that can be administered in a patient without lymphodepletion from chemotherapy. Traditionally, it was thought that some cells needed to be eliminated before new cells could be introduced. EXUMA is working on a rapid point of care, rPOC, technology that will allow this approach to be expanded to various cancers and readily available to patients. Greg explains, "What we came to realize was that...


Early Detection of Liver Cancer with New Blood Tests and Increased Cirrhosis and Hep B Education with Dr. Robert Gish Helio Genomics and Hepatitis B Foundation

Dr. Robert Gish is the Medical Advisor to Helio Genomics and the Medical Director of the Hepatitis B Foundation and is looking for answers to questions related to who is most at risk for liver cancer. He is also working to improve blood testing to diagnose liver cancer earlier by looking for tumor material that shows methylated DNA changes. Robert explains, "So, one of the biggest messages I would have is the deficiency in surveillance for liver cancer. Screening is the first test, and...


Using Oncolytic Viral Immunotherapy to Kill Solid Tumors with Dr. Paul Peter Tak Candel Therapeutics

Dr. Paul Peter Tak is the CEO and President of Candel Therapeutics, developing innovative immunotherapies for patients with solid tumors that are difficult to treat, like brain cancer, pancreatic cancer, prostate cancer, and non-small cell lung cancer. This approach induces cell death in cancer cells at the site of injection, and it also trains cells to look for tumor cells migrating throughout the body. Paul Peter explains, "The approach we call oncolytic viral immunotherapy. The name...


Transomic Data Analysis Driving New Understanding of Diseases and Actionable Insights for Drug Development and Treatments with Dr. Samantha Dale Strasser Pepper Bio

Dr. Samantha Dale Strasser Chief Scientific Officer and Co-Founder at Pepper Bio, uses a transomic perspective with a global functional causal lens on genomic data to drive insights throughout the drug discovery process and identify the best treatments for patients. The goal is to go beyond the traditional understanding of diseases to unlock opportunities and solutions not considered in the past. Samantha explains, "So, I mentioned the genome is fantastic because it looks at instructions,...


Advanced Options for Reconstruction of the Mouth with Dr. Miguel Grillo Prosthodontic Specialists of San Diego

Dr. Miguel Grillo, Prosthodontic Specialists of San Diego raises awareness about the importance of proper chewing and the role teeth play in overall health. Finding periodontal disease at an early stage means measures can be taken to save teeth. Patients with the late-stage disease and those with cosmetic concerns now have more options for permanent solutions to restore their smiles. Miguel explains, "So prosthodontist is a specialty within dentistry. What we specialize in is the...


Alternative Non-Pharmacologic Solutions for Pain Management with Chuck Sawyer Northwestern Health Sciences University

Chuck Sawyer is the Special Assistant to the President at Northwestern Health Sciences University, NWHSU, located in Bloomington, Minnesota. Chuck argues for a different approach to pain management given the opioid epidemic and the overuse of opioid narcotics to treat acute pain and chronic pain. Of particular concern is extending the use of chiropractic treatments and acupuncture for Medicaid and Medicare patients. Chuck explains, "And fast forward to the present day, we now have ten...


How Dynamic Synthetic Data is Changing Healthcare with Dr. Jon Morrow and Daniel Blumenthal MDClone

Dr. Jon Morrow, Senior VP of Medical Affairs and Informatics, and Daniel Blumenthal, Vice President of Strategy at MDClone, shed light on the meaning of synthetic data for drug discovery and patient care. Using both original data and statistical models of the data, researchers and clinicians can quickly gain insights that can impact patient care, facilitate collaborations and partnerships, and dramatically shorten the time required for product development. Daniel explains, "Actually, the...


Platform Breaks Down Health Data Silos Allowing Interoperability and Access to Real-Time Real-World Information with Ardy Arianpour SEQSTER

Ardy Arianpour, CEO and Co-Founder of SEQSTER, is breaking down health data silos using their enterprise operating system, which aggregates disparate health data sources, including real-world data, into a single 360-degree view of a patient in real-time. This integrated approach with a Digital Front Door solves many challenges for life sciences, patient engagement, and data interoperability. Ardy elaborates, "We have achieved nationwide coverage of electronic health records from hospitals...


Providing Larger Stent Sizes to Interventional Cardiologists Means More Personalized Heart Health Therapies with Alex Nepogodiev Abbott Vascular

Alex Nepogodiev is a Divisional Vice President of Abbott Vascular Business and shares insights about the need for stents with larger diameters. In the past, physicians would have to take a smaller diameter stent and follow up with another catheter to expand that stent to a larger size and to match the vessel. This procedure added an additional step and risk. Alex explains, "Some of the bigger challenges today are, of course, the variation in anatomy and the complexity of some of those...


Bringing Behavioral Health and Telepsychiatry to Underserved People with Dr. Tom Milam Iris Telehealth

Dr. Tom Milam is the Chief Medical Officer at Iris Telehealth, which focuses on providing in-person and digital support to community mental health centers, Federally Qualified Health Centers, and rural health clinics that don't have enough access to behavioral health providers. The populations they treat are often underserved and have social determinants of health that are barriers to accessing timely care. Tom elaborates, "We're also working a lot in emergency rooms and hospitals around...


Improving Recruitment Retention and Outcomes of Clinical Trials with Scott Gray Clincierge

Scott Gray is the President and CEO of Clincierge and is focused on streamlining clinical trial recruitment, retention, and completion and improving the results of trials to speed time to approval. Clincierge is most concerned about the challenges presented by travel needs and logistics for patients, caregivers, and family members. Scott explains, "Our mission is to lead the global clinical trial performance improvement market. So a lot of my experience has been in leadership development...


Accurately Determining Behavioral Health Status and Treatment Options with Dr. Thomas Young nView Health

Dr. Thomas Young is the Founder and Chief Medical Officer of nView Health, a behavioral health technology company providing tools for physicians and researchers to help diagnose psychiatric disorders accurately and efficiently determine treatment options. In addition, the nView Health tools allow tracking and following outcomes to determine if the right drugs have been prescribed and if the cognitive behavioral therapy intervention is working. Thomas elaborates, "Mental health is a large...


Cardiovascular Rehab Transformed by Digital Health Solutions with Shuo Qiao Moving Analytics

Shuo Qiao is the Co-Founder and CTO of Moving Analytics, a digital health company focusing on cardiovascular health and providing alternatives to traditional cardiac services. While many devices measure blood pressure and monitor activity, using them can be time-consuming and provide inaccurate readings. Shou points to clinical evidence that home-based cardiac rehabilitation with remote sensing support is as safe and effective as in-person care. The challenge is getting providers and payers...


Inducing Local Immune Tolerance to Cure Type 1 Diabetes with Dr. Anthony Japour iTolerance

Dr. Anthony Japour is the Chief Executive Officer and President at iTolerance, an early-stage privately-held regenerative medicine company. Currently, if a patient receives a pancreatic islet transplant to treat type 1 diabetes, there is a need for lifelong immune suppression. The technology that iTolerance is developing leverages the protein Fas Ligand to enable implantation without the need to be immune suppressed to suppress the body from rejecting the foreign tissue. Anthony explains,...


Streamlining Clinical Trials for Fadra in Solid Tumors and Blood Cancers with Spiro Rombotis Cyclacel

Spiro Rombotis is the CEO of Cyclacel, which is identifying biomarkers relevant to their drug fadraciclib's mechanism to increase the chance for success in trials for a wide range of cancers. Cyclacel has seen activity of fadra as a single agent in phase one patients with women's cancers like endometrial, ovarian, and breast cancers, and lymphomas, liver cancer, and colorectal cancer. Spiro explains, "Before the pandemic, we had an intravenous version of fadra administered to patients in a...


Patient-Centered Digital Musculoskeletal Clinic Aims to Relieve Pain of Millions with Jim Pursley Hinge Health

Jim Pursley is the President of Hinge Health, the leading digital health musculoskeletal (MSK) clinic that aims to reduce joint and surgical pain by deploying wearable sensors and computer-vision technology and clinical care teams. Hinge is addressing chronic and acute MSK pain with a mission to reduce the use of opioids and bring lasting relief to patients. Jim explains, "We have the goal of alleviating pain for millions of people, not just here in the United States but around the globe....