MedEvidence! Truth Behind the Data

Send us a text Dr. Michael Koren hosts Brian Achille, the Chief Operating Officer of the Certified Clinical Research Professionals Society (CCRPS). Brian draws a distinction between doing clinical research casually and doing it professionally. The distinction highlights how professional training and attitudes prove to be a benefit to research and the community at large. The duo discuss how CCRPS offers training for many different clinical research roles, from "entry level" to physicians. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Cardiologist Michael Koren joins Kevin Geddings to discuss how kidney disease can offect other body systems, including the heart. The doctor explains that people with kidney dysfunction have significantly higher risks for cardiovascular problems including heart attacks, heart failure, and strokes. Dr. Koren differentiates between typical, insurance-driven care and the attentive clinical research experience, noting that the clnical research model may be better for many kidney disease patients. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Surveys show that 97-99% of participants who participate in one clinical research study would sign up for another. We wind out why in this episode, recorded in front of a live audience. Dr. Michael Koren and Nalini Jones, CCRC are joined by three clinical research patients to review the good, the bad, and the ugly in the history of clinical research. They also discuss the ins and outs of how the clinical research process works and share patient stories of their experiences as research participants. Step into a behind-the-scenes look at how we get from medical ideas to medical treatments and how the process leaves a lasting impact on patients and the legacy of knowledge. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Mitchell Rothstein joins Dr. Michael Koren to wake us up to the dangers of insomnia. Insomnia is a common sleep disorder affecting approximately 30% of adults and is characterized by poor sleep on at least three nights a week for three months or more. Dr. Rothstein reviews what insomnia is, what is happening in the brain, and what sufferers can do about it. He explains how lifestyle changes can make a big difference, especially in our digital world. Dr. Rothstein then reviews the effectiveness of cognitive behavior therapy, common over-the-counter treatments, prescription medicines, and when it's time to see a sleep specialist. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren joins Kevin Geddings to explain biomarkers, which he describes as biological indicators that may mark the presence of disease. Researchers are increasingly looking at biomarkers for their potential in early detection of disease before symptoms appear. Dr. Koren brings it home with a personal story of how current research studies looking into lung cancer biomarkers may have real-world effects for participants. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Steve Satek shares his journey from bench researcher to founding Great Lakes Clinical Trials, where he pioneered bringing clinical research directly to Chicago neighborhoods, rather than expecting patients to travel downtown to academic centers. His community-centered approach focused on education and relationship-building, breaking down barriers to participation through transparency and engagement. • Started career with a biochemistry degree before realizing he needed more human interaction than lab work provided • Mentored by industry legends Dr. Michael Davidson and Kathleen Drennan, who shaped his leadership philosophy • Founded Great Lakes Clinical Trials in Andersonville after identifying a lack of accessible research in Chicago communities • Secured funding through angel investors who believed in community-based research model • Built trust through educational sessions at libraries, senior centers, and community venues • Invited community members to tour the research facility to demystify the clinical trial process • Only 8% of people have ever been approached about clinical trials, yet 97-99% of participants would join another study • Research participation often involves entire family and community support, not just individual patients • Shared story of patient with complex regional pain syndrome who progressed from needing crutches to walking independently during trial • Recently retired but continues mentoring and supporting industry through volunteer work Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Koren reflects on conversations with Harvard Medical School classmates who shared stories about struggling to navigate the healthcare system despite their medical training. Clinical trials provide valuable structure and support to help patients navigate healthcare complexities, offering personalized attention often unavailable in traditional medical settings. • Harvard Medical School graduates find healthcare navigation difficult, highlighting challenges for average patients • Case study of 78-year-old with heart failure who was accidentally overdosed on medications after discharge • Clinical trials break down complex health information into clear protocols • Research coordinators help patients understand treatments and communicate with other providers • Studies available for congestive heart failure patients, including both types of heart failure • Harvard classmates will be featured on upcoming MedEvidence episodes Visit EncoreDocs.com to learn more about participating in clinical trials, or call 904-730-0166. For reliable medical information, check out MedEvidence.com - the truth behind the data, a better alternative to "Dr. Google." Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren interviews Laverne Dowell, an advanced registered nurse practitioner who specializes in diabetes care. They discuss her approach to treating the whole person and how mental health can impact everything from diet and excercise to the ability to go see a physician. They also explain the need to increase diversity in medical research and the importance of delivering diagnoses with sensitivity to avoid shaming patients. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dermatologist Dr. Michael Bernhardt joins Dr. Eric Schramm to discuss hidradenitis suppurativa (HS), a debilitating skin condition that affects skin creases such as the armpits and groin. HS is an inflammatory condition that can be misdiagnosed for years. New medications target the underlying inflammation. Treatments are currently in clinical trials as part of an effort to tackle the last of the "three-headed monsters" in dermatology. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren joins Kevin Geddings to discuss the motivations of clinical trial veterans who repeatedly participate in medical research studies. Dr. Koren shares that these participants consistently cite the desire to "Make a Difference" as their primary motivation, helping to push science and medicine forward for generations to come. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Nikhil Kapila joins Dr. Michael Koren on this rebroadcast from a live MedEvidence! presentation. Dr. Kapila, a liver disease specialist, explains why we can't live without our liver. The doctors review what the liver does, what can cause damage to the liver, and what can go wrong when the liver suffers damage. They also discuss the importance of early testing, treatment options for some conditions, and the importance of clinical research in pushing liver health forward. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren joins Kevin Geddings to discuss how Knowledge is POwer - especially when it comes to medicine. The doctor explains how diagnostic tests like high sensitivity C-reactive protein (HSCRP) empowers physicians and patients by giving insight into heart attack and stroke risk. Dr. Koren aso tells us that even simple things like knowing you are in a research study can improve patient outcomes and that knowledge is the guiding principle in medicine. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren joins Kevin Geddings to reveal why atrial fibrillation (AFib) receives so much advertising attention when compared with other services hospitals provide. The cardiologist explains the financial incentives for hospitals and device manufacturers behind these marketing campaigns., and contrasts that with clinical research, which has the financial and legal incentive to measure accurate data when lookingfor the success rate of a particular medication or device. Dr. Koren also discusses a current research study for a new AFib monitoring patch to highlights the difference between objective medical research and profit-driven medical marketing. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Bernhardt, a dermatologist and clinical researcher, joins Dr. Erich Schramm to discuss the revolutionary advancements in psoriasis treatment over the past two decades. The doctors discuss how psoriasis is an inflammatory disease more than an autoimmune disease. They discuss what inflammation is, the inflammation pathway in the body, and how different medications can help suppress the body's out-of-control inflammatory response. They go over the history of psoriasis medicaitons, which ones may appropriate for different severities of the disease, and what's on the cutting edge of psoriasis treatment. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Migraine is a complex brain disease affecting one in five women and one in ten men, with treatments ranging from traditional medications to cutting-edge therapies targeting specific pathways in the brain. • Migraine is not just a severe headache but a primary headache disorder with genetic origins involving 30-35 genes • Less than 50% of migraine sufferers seek medical help, and only 12% of those needing prevention receive adequate treatment • 85% of what doctors diagnose as "sinus headaches" are actually migraines • Migraine exists in distinct phases: prodrome, aura (in 25% of patients), headache, and postdrome • The newer CGRP antagonist medications and Botox injections provide effective options with success rates higher than traditional preventives • Preventive treatment should be considered when headaches occur four or more times monthly or cause significant disability • Beyond medications, behavioral modifications like hydration, regular sleep patterns, and yoga can significantly reduce migraine frequency • The stigma surrounding migraine continues to be a barrier to proper diagnosis and treatment For more information about migraine treatments or the clinical trial for menstrual migraine currently being conducted at Jacksonville Center for Clinical Research, please contact us. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text The FDA has granted full approval to Novavax's COVID-19 vaccine, providing an alternative to mRNA vaccines that works through a different mechanism using proteins and adjuvants. Despite being four years into the pandemic, COVID-19 remains a significant health concern, causing approximately 1 in 200 deaths in the US in 2025. • Novavax uses bioengineered spike proteins combined with an adjuvant rather than mRNA technology • FDA approved Novavax for all Americans over 65 and those 12-64 with at least one risk factor • Risk factors include conditions like asthma, diabetes, and obesity • Northeast Florida contributed 500 patients to the original Novavax clinical trials • Encore Research Group is currently enrolling participants for an oral COVID vaccine clinical trial • Participants in the oral vaccine trial will receive compensation for their time For more information about participating in the oral COVID vaccine study, visit EncoreDocs.com or call 904-730-0101. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren shares exciting news about the revival of an oral COVID vaccine study previously halted by government spending cuts. The non-mRNA vaccine trial represents an important alternative approach that apparently received priority status even under strict budget reviews. • Oral COVID vaccine study in Jacksonville now actively enrolling participants after being temporarily halted by DOGE initiative • Study offers a non-mRNA alternative that might appeal to those concerned about messenger RNA technology • Summer months in Florida paradoxically see increases in respiratory infections as people spend more time indoors with air conditioning • Dr. Koren explains why most vaccines require injection rather than oral delivery • Discussion of pharmaceutical pricing disparities between US and other countries • The "innovation premium" Americans pay funds research that benefits the global population • Finding balance between incentivizing medical breakthroughs and ensuring fair cost distribution remains challenging For reliable, unbiased medical information, visit MedEvidence.com. To learn more about participating in the oral COVID vaccine study or other clinical trials, visit EncoreDocs.com. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Urologist and president of the Duval County Medical Society Dr. Ali Kasraeian joins Dr. Michael Koren to update us on recent advances in Urology. In Part 3 of this series, Dr. Koren and Dr. Kasraeian dive deep into the latest advancements in prostate cancer detection and treatment options. They explore the evolution from basic PSA screening to personalized approaches . Dr. Kasraeian focuses on the modern shift to patient-focused, individualized approaches that meet patients where they are by balancing early detection with quality of life considerations. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Dr. Michael Koren shares insights from his recent speaking tour across Saudi Arabia where he delivered 14 lectures in 6 days to sophisticated healthcare providers eager for American medical research. His observations reveal surprising aspects of Saudi healthcare including English as the professional language, universal insurance coverage, and the powerful roles women play despite traditional cultural restrictions. • Saudi Arabia offers universal healthcare coverage with additional private insurance options • English serves as the professional language in Saudi healthcare settings • Women in healthcare occupy positions of authority despite only gaining driving rights in 2019 • Female healthcare professionals maintain strong professional presence while following traditional covering practices • Dr. Koren shared research on improving cholesterol management published in JACC • Saudi physicians highly value clinical research conducted in Northeast Florida • The rivalry between Saudi Arabia and Iran remains strong despite geographic proximity • MedEvidence platform received enthusiastic response from Saudi healthcare professionals Visit MedEvidence.com to learn how we break down complex medical issues, identify knowledge gaps, and explain the research process for both healthcare professionals and patients. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!

Send us a text Urologist and president of the Duval County Medical Society Dr. Ali Kasraeian joins Dr. Michael Koren to update us on recent advances in Urology. In Part 2 of this series, Dr. Koren and Dr. Kasraeian explore into the controversial history of PSA testing. Dr. Kasraeian explains how this simple blood test revolutionized prostate cancer detection while creating challenges around overdiagnosis and overtreatment. The doctors also talk about how modern approaches to prostate screening have evolved to balance finding dangerous cancers while avoiding unnecessary interventions. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!