MS-Perspektive - The Multiple Sclerosis Podcast

The EMSP 2026 Conference in Berlin highlighted how much is currently evolving in multiple sclerosis (MS) – from improved diagnostics and emerging therapies to long-overdue topics like fatigue, PIRA, and menopause. In this episode, I share my personal insights from Day 1 on site and summarize the key developments from Day 2. We explore why the "MS iceberg" is still widely misunderstood, how new approaches like CAR-T and stem cell therapy are shaping the future, and why access to care across Europe remains a major challenge. 👉 Read the full blog article: https://ms-perspektive.de/en/164-emsp 🔎 What we cover in this episode 🔗 Mentioned resources & episodes 👉 Barbara Willekens on CAR-T cell therapy 👉 Christoph Heesen on stem cell therapy 👉 Roland Martin on aHSCT 👉 Riley Bove on menopause & MS 👉 Gavin Giovannoni on PIRA 👉 Fatigue article 👉 Article: From Fatigue to Focus (ECTRIMS insights) 👉 MS Selfie Microsite: https://msselfie.co.uk/ 👉 McDonald Criterie 2024 👉 Full blog article: https://ms-perspektive.de/en/164-emsp --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode, I speak with neurologist and researcher Professor Barbara Willekens about one of the most exciting and complex developments in MS research: CAR-T cell therapy. Originally developed for blood cancers, this innovative treatment is now being explored for autoimmune diseases like multiple sclerosis. We discuss how CAR-T therapy works, how it differs from existing MS treatments, and why it may have the potential to "reset" the immune system. At the same time, we take a close look at the current scientific evidence, including early clinical data, safety concerns, and why this therapy is still far from routine clinical use. You'll also learn who might be eligible for current trials and what the future of CAR-T in MS care could look like. You can read the full blog article here: https://ms-perspektive.de/EN/163-car-t-cell-therapy 🧠 What you'll learn in this episode 🔬 Resources & Links MS Brain Health Strategy (Episode 125)https://clinicaltrials.govMackensen et al., Nature Medicine (2022) – CAR-T in lupusDiLillo et al., Blood Advances (2021) Note: This episode is for informational purposes only and does not replace medical advice. Please consult your healthcare provider before making any treatment decisions. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

Pain is one of the most common and challenging symptoms of multiple sclerosis (MS). In this episode, neurologist and pain specialist Dr. Camelia Ionescu explains how pain in MS develops—and how a multimodal approach can help manage it effectively. 👉 This episode is based on an interview originally recorded in German (January 2025) and has been translated to make these important insights accessible to an international audience. You'll learn how different types of pain arise, why treatment must be individualized, and how combining medication, physiotherapy, psychological support, and self-management strategies can improve quality of life. 🔎 What you'll learn in this episode 🌐 Read the full blog article 👉 You can find the full article with all questions and detailed answers here: https://ms-perspektive.de/en/162-pain-relief 🌍 International resources on MS & pain For further information and support, these organizations provide reliable, up-to-date resources: National Multiple Sclerosis SocietyMS International FederationInternational Association for the Study of Pain Note: This content is for informational purposes only and does not replace professional medical advice, diagnosis, or treatment. Would you like to give listeners something to take away? Dr. Camelia Ionescu: I would like to tell everyone affected: Do not give up! There are always ways to relieve pain and improve quality of life. It can take time, but together we will find the right solution. Nele von Horsten: Thank you very much, Dr. Ionescu, for the insights and valuable tips. Your work is so important. Thank you! --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode, we talk about progressive multiple sclerosis (PMS), including primary progressive MS (PPMS) and secondary progressive MS (SPMS). Neurologist Dr. Thomas Knoll shares insights from over 30 years of clinical experience, focusing on disease mechanisms, current treatment options, and what people living with progressive MS can actively do to maintain their quality of life. 💡 Note: This episode is based on an interview originally recorded in November 2023 and has been translated and adapted for an international audience. A key takeaway: While neurodegeneration is still difficult to treat, an active lifestyle, symptom management, and strong support systems can make a meaningful difference. 👉 Read the full interview (English): https://ms-perspektive.com/161-pms 🧠 Topics covered 🔗 Resources & Links Organizations & Support: https://www.dmsg.dehttps://www.amsel.dehttps://www.msif.orghttps://www.emsp.org Recommended by Dr. Knoll: https://msselfie.co.uk/ Further information & networks: https://www.neurotransdata.comhttps://www.neurotransconcept.comhttps://www.neuromuenchen.de Would you like to share a final message with the listeners? I see what a difference it makes whether patients engage with their condition or not. This helps to develop a realistic understanding, reduces fear, and creates perspective. --- Thank you to Dr. Thomas Knoll for his insights into progressive MS and for repeatedly emphasizing how important it is to actively engage with the disease in order to shape everyday life—even with progressive MS. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

The EMSP Conference 2026 is one of Europe's most important events for people living with MS, NMOSD, and MOGAD—and you can join online for free. Even though the conference takes place in Berlin this year, onsite participation is already fully booked. But the good news is: you don't have to miss out. From April 24–25, 2026, you can follow all sessions virtually and gain access to the latest insights in diagnosis, treatment, and patient care. This year's focus: 👉 From Diagnosis to Access: Data-Driven Solutions for MS, NMOSD, and MOGAD You'll hear from leading experts, researchers, and patient advocates—including familiar voices from the MS-Perspektive podcast like: https://ms-perspektive.de/en/125-barbara-willekens/https://ms-perspektive.de/en/82-leda/ A unique opportunity to learn, connect, and feel empowered—no matter where you are. 🧠 Topics Covered in This Episode 🔗 Useful Links & Resources https://eu.eventscloud.com/website/19094/registration/ https://ms-perspektive.de/en/125-barbara-willekens/ https://ms-perspektive.de/en/82-leda/ https://ms-perspektive.de/en/160-emsp 🎯 Who This Episode Is For --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode, we explore multiple sclerosis in Saudi Arabia with neurologist Dr. Yasser Alamri. He shares insights into MS care, treatment access, research developments, and the growing awareness of the disease. You'll learn how early diagnosis and high-efficacy therapies can improve long-term outcomes, why multidisciplinary care is essential, and how stigma is being reduced through education and support programs. This episode offers valuable perspectives for people living with MS, caregivers, and healthcare professionals alike. 🧠 Topics covered in this episode 🔗 Resources & Links https://ms-perspektive.de/en/159-saudi-arabia https://x.com/dryasseralamri?s=21 https://www.tiktok.com/@dryasseralamri?_r=1&_t=ZS-94xQT3NpgmH Dr. Alamri: MS today is very different from the past. We now have effective treatments, better understanding, and improved long-term outcomes. Do not delay evaluation. Do not fear treatment. Early care truly makes a difference. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

This episode explores shared decision making in multiple sclerosis (MS) and why it is essential for patient-centered care. 👉 Note: This is the English version of an interview originally recorded in German in November 2024. You can find the original German episode here: 🔗 https://ms-perspektive.de/278-uli-rueffer/ You can also read the full English article with all insights and resources on my website: 🔗 https://ms-perspektive.de/en/158-rueffer Together with Dr. Jens Ulrich Rüffer, we discuss how patients and doctors can make treatment decisions together on equal footing—and why this leads to better outcomes, higher satisfaction, and more sustainable care. 🧠 What you will learn in this episode What shared decision making (SDM) really means in MS care Why patient empowerment improves treatment outcomes How doctors and patients can communicate more effectively Which tools (e.g. decision aids, coaching) support SDM Why SDM is still not widely implemented How artificial intelligence may support future decision-making Whether patients can (and should) delegate decisions 🌍 Resources & Further Reading Multiple Sclerosis International Federation (MSIF) – global resources on MS, patient empowerment, and access to care European Multiple Sclerosis Platform (EMSP) – European initiatives on patient rights and healthcare quality International Shared Decision Making Society – research and best practices on shared decision making 🔎 About this episode Shared decision making in multiple sclerosis is a key element of modern, patient-centered healthcare. When patients are fully informed and actively involved, they can choose treatments that truly fit their lives. This episode highlights how collaboration between patients and healthcare professionals improves adherence, outcomes, and quality of life—and why this approach is the future of MS care. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode of the MS-Perspektive Podcast, neurologist Dr. Joachim Havla explains the potential of Optical Coherence Tomography (OCT) for monitoring and understanding multiple sclerosis. OCT is a quick, non-invasive eye scan that measures the tiny layers of the retina with micrometer precision. Because the retina is part of the central nervous system, researchers are investigating whether OCT measurements could help detect neurodegeneration and disease activity in MS. In this interview we also discuss the role of optic neuritis and why it is important to distinguish between Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder (NMOSD) and MOG Antibody Disease (MOGAD). 🎧 Note: This episode is the English adaptation of a German interview. Read the original German article: https://ms-perspektive.de/EN/157-oct Learn more about the research of Dr. Havla's team at the: Havla Lab – Neuro\Vision Topics in this episode Why the eye can reveal changes in the brain How OCT works and what it measures Optic neuritis in MS, NMOSD and MOGAD What retinal thinning may tell us about neurodegeneration Current OCT research and future perspectives for MS care --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

Sexuality is still a taboo topic for many people with multiple sclerosis (MS), even though sexual dysfunction is a common symptom of the disease. In this episode, I speak with neurologist Dr. Markus Heibel, medical director of a specialized MS clinic in Germany, about why sexual problems occur in MS—and what can help. We discuss the difference between primary, secondary, and tertiary sexual dysfunction, how symptoms like spasticity, pain, medication side effects, or psychological stress can affect intimacy, and which treatment options exist. Dr. Heibel also shares practical strategies from clinical practice—from physiotherapy and psychotherapy to communication within relationships and creative solutions that couples have found helpful. The conversation shows that fulfilling intimacy is still possible with MS—and that talking openly about the topic is often the first and most important step. 👉 Read the full interview and resources on the blog: https://ms-perspektive.com/156-dr-heibel Topics in this episode Why sexual dysfunction in MS is still a taboo topic Primary, secondary, and tertiary sexual dysfunction explained The role of medication, hormones, physiotherapy, and psychotherapy Practical strategies for couples living with MS Why communication and openness are key What people with MS can do themselves to improve intimacy Further resources on sexuality and multiple sclerosis Sexual health is an important part of overall wellbeing, but many people with multiple sclerosis (MS) still find it difficult to talk about intimacy, desire, and sexual dysfunction. Fortunately, several international MS organizations provide reliable information, practical advice, and educational materials about sexuality, relationships, and intimacy with MS. The following resources are good starting points if you would like to learn more or look for further support. Global resources MS International Federation (MSIF) – Relationships and intimacy Overview article on intimacy, relationships, and communication when living with MS. https://www.msif.org/living-with-ms/relationships-and-intimacy/ MS International Federation (MSIF) – Sexual problems Explains the different types of sexual dysfunction in MS (primary, secondary, tertiary) and common symptoms. https://www.msif.org/about-ms/symptoms-of-ms/sexual-problems/ MS International Federation (MSIF) – Sexuality and MS (resource guide) Educational resource covering topics such as body image, desire, intimacy, and coping strategies. https://www.msif.org/resource/sexuality-ms/ MS International Federation (MSIF) – Intimacy and Sexuality in MS (MS in Focus issue) A thematic publication with expert articles and patient perspectives on sexuality and MS. https://www.msif.org/resource/intimacy-and-sexuality-ms/ United States National Multiple Sclerosis Society – Sexual problems in MS Overview of sexual dysfunction in MS, including causes, treatment options, and communication tips for couples. https://www.nationalmssociety.org/understanding-ms/what-is-ms/ms-symptoms/sexual-problems National Multiple Sclerosis Society – Intimacy and MS Guidance on maintaining intimacy, emotional closeness, and communication in relationships affected by MS. https://www.nationalmssociety.org/managing-ms/living-with-ms/relationships/intimacy Multiple Sclerosis Association of America (MSAA) – Sexual dysfunction Practical information about sexual symptoms, contributing factors, and possible treatment approaches. https://mymsaa.org/ms-information/symptoms/sexual-dysfunction/ United Kingdom MS Society (UK) – Sex and relationships Comprehensive information on intimacy, sexual health, and relationship challenges for people living with MS. https://www.mssociety.org.uk/living-with-ms/physical-and-mental-health/sex-and-relationships MS Society (UK) – Sex and relationship problems Focused guidance on common sexual difficulties and possible ways to address...

Why does multiple sclerosis progress very differently from person to person? And could your genes help predict your individual MS pathway in the future? In this episode of the MS Perspektive Podcast, I speak with neurologist and researcher Dr. Karim Kreft from the University of Nottingham about his groundbreaking work on genetic subtypes in MS. His research explores whether known MS risk genes may also influence long-term disease progression and response to treatment. Using genetic clustering methods, his team identified three distinct genetic groups of MS patients – with interesting differences in progression and treatment benefit. While this research is not yet ready for clinical use, it offers an exciting glimpse into the future of personalized medicine in MS. What You'll Learn in This Episode How much genetics actually contributes to MS risk What "genetic clustering" means in simple terms Why MS is such a heterogeneous disease The three identified genetic subtypes in MS Why one group benefited significantly more from treatment Whether mild MS patients benefit differently from medication The limitations of real-world data in MS research Why future MS care may move beyond clinical labels When genetic testing might become part of routine care About My Guest Dr. Karim Kreft is a consultant neurologist and Associate Professor in Neurology at the University of Nottingham, UK. His research focuses on understanding the biological mechanisms behind MS progression and improving personalized treatment strategies. A Hopeful Outlook Genetic testing has become dramatically more affordable in recent years. Although validation studies are still needed, this research may one day help predict prognosis and guide treatment decisions more precisely – potentially within the next decade. As always: this episode provides scientific insights but does not replace individual medical advice. Connect & Follow You can follow Dr. Kreft's research updates via LinkedIn and through the University of Nottingham. Read the full interview on genetic subtypes in MS and their impact on progression and treatment on my blog at: https://ms-perspektive.de/en/155-genetic-subtypes --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

How safe are MS therapies? And how do we actually know? In this episode, neurologist Dr. Nora Möhn explains the concept of pharmacovigilance — the continuous monitoring of drug safety from early development through approval and real-world use. This conversation was originally published in September 2023 on the German MS-Perspektive podcast. For this English edition, regulatory references and country-specific details have been carefully adapted to reflect internationally relevant systems and resources. The medical content remains fully up to date. You will learn: What pharmacovigilance means and why it is essential for people with MS How safety data is collected in Phase I–IV clinical trials How rare side effects are detected after market approval How neurologists assess the benefit-risk profile of MS therapies What special considerations apply during pregnancy, in children/adolescents, and in older patients How patients can report suspected side effects in different countries Why ongoing monitoring builds trust and treatment confidence A well-monitored therapy not only slows down MS — it enables long-term safety, confidence, and self-determined living. 🔗 Read the full article here: https://ms-perspektive.de//en/154-pharmacovigilance 🌍 International Pharmacovigilance Reporting Systems If you would like to report suspected side effects, you can contact your national medicines authority. Here are official resources: European Union European Medicines Agency (EMA) – EudraVigilance https://www.adrreports.eu https://www.ema.europa.eu United States FDA MedWatch Program https://www.fda.gov/medwatch https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program United Kingdom MHRA Yellow Card Scheme https://yellowcard.mhra.gov.uk Canada Health Canada – Canada Vigilance Program https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html Is there anything else you would like to say to our listeners? Dr. Nora Möhn: I would like to express my sincere thanks for listening and for your interest in this exciting topic. I would also like to encourage all those affected to openly express any concerns or worries they may have regarding drug safety/potential side effects to their healthcare providers so that an informed treatment decision can be made in consultation with them. The field of MS therapeutics can sometimes be very confusing and overwhelming, so it is essential to address any uncertainties and fears. Where can you find her and her scientific work on the Internet? Dr. Nora Möhn: My scientific publications can be found via PubMed by searching for "Nora Möhn" on the website of the U.S. National Library of Medicine (NIH): https://pubmed.ncbi.nlm.nih.gov Further professional information and updates can be found on my LinkedIn profile. --- I hope you now know more about pharmacovigilance and feel confident enough to discuss any concerns or fears you may have about the treatments suggested to you with your doctor. And remember, even though MS has become much less frightening, it is still a serious disease that should be slowed down as much as possible with medication and a healthy lifestyle. This will ensure that you can still lead a fulfilling life in several decades' time and won't have to regret missed opportunities. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far. ⚠️ Medical Disclaimer This podcast provides medical background information but does not replace individual medical advice. Please discuss all therapy decisions and concerns with your treating neurologist.

In this episode of MS-Perspektive International, host Nele von Horsten speaks with David Walzik, PhD student in exercise science at TU Dortmund University and medical student at the University of Cologne, about exercise immunology and what current research can tell us about immune adaptation through movement. David explains the difference between epidemiological findings and underlying biological mechanisms, and shares results from a recent study comparing high-intensity interval training (HIIT) with moderate-intensity continuous exercise. While both types of exercise mobilized immune cells, high-intensity exercise led to much stronger changes inside the immune cells — with over 1,000 proteins reorganized after just one session. Photo of David Walzik (Copyright: Niklas Joisten, TU Dortmund, Germany) They also discuss what this could mean for people living with multiple sclerosis, why flexibility matters when symptoms fluctuate, and why community and support are key to building sustainable exercise habits. 👉 You can read the full interview on the blog, where all questions and answers are available in detail and easy to follow: https://ms-perspektive.de/en/153-exercise 🧩 Topics covered in this episode What exercise immunology is and why it matters How exercise affects immune cells HIIT vs moderate exercise: what's the difference? Can the immune system be "trained" like a muscle? What we still need to learn specifically for people with MS Why regular movement matters more than perfect training 💛 A gentle reminder You don't have to exercise perfectly or intensely to benefit. The most important thing is to stay active regularly. Whether it's walking, cycling, strength training, or something else you enjoy — consistency matters more than intensity, especially when living with MS. 🔎 Read more 📖 Full interview & background: All questions and answers from this episode are available on the MS-Perspektive blog, including detailed explanations and practical insights: https://ms-perspektive.de/en/153-exercise --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

This time I speak with Dr. Ingrid Klingmann about empowering patient voices in medical research and innovation. Dr. Klingmann is one of the initiators of EUPATI, a European initiative dedicated to educating patients about the medicines development process. Drawing on her experience as a physician, researcher, and former cancer patient, she explains why informed patients are essential partners in clinical research. The conversation explores how patient education improves clinical trials, why lay summaries matter, and how digital tools can help patients move from passive recipients to active contributors in healthcare and research. Topics covered in this episode: Dr. Ingrid Klingmann's journey from family physician to medical research Why EUPATI was founded and which gap it fills The benefits of patient involvement for research and industry How patients can influence clinical trial design Why health literacy and education are key to empowerment The future of patient involvement in medical research Resources & Links: EUPATI – European Patients' Academy on Therapeutic Innovation: Home | EUPATI Open Classroom More episodes and blog articles: https://ms-perspektive.de/en/152-eupati Finally, what message would you like to leave with our listeners, especially patients? Dr. Ingrid Klingmann: Please explore EUPATI and use the resources available. Move away from complaining and toward action. Knowledge builds confidence, and confidence empowers patients to shape their own healthcare journey. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode of the MS Perspektive Podcast, Nele von Horsten speaks with Paola Escamilla Greenham, MS patient advocate and patient experience designer living in Grenoble, France. Paola shares how her life with multiple sclerosis reshaped her priorities and led her toward patient advocacy across Europe. She talks openly about her diagnosis, the emotional shock that followed, and why joy has become her guiding principle in daily life. The conversation explores the importance of community, lived experience in healthcare design, and Paola's vision for involving patients more meaningfully in MedTech and Biotech innovation. We also discuss Paola's journey through the EUPATI program, her work as a business angel, and what empowerment truly means when living with a chronic illness. This episode offers inspiration, honesty, and a strong reminder: living well with MS starts with listening to your body and choosing what brings you joy. 📝 Topics covered in this episode Living with MS between Mexico, France, and Europe Diagnosis, shock, and patient experience Joy, energy, and improvisational theatre Patient advocacy and community support Lived experience in healthcare design Empowerment and future perspectives in MS care 🔗 Links & Resources 🌍 Learn more about EUPATI: https://eupati.eu 💼 Connect with Paola on LinkedIn: Paola Escamilla Greenham | LinkedIn 📖 Read the full blog article: 👉 https://ms-perspektive.de/en/151-paola ... See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

Research News with Dr. Boris Kallmann In this episode of the MS Perspective Podcast, we focus on chronic smoldering inflammation in multiple sclerosis (MS) – a process that can drive slow disease progression, even when relapses no longer occur. I speak with Dr. Boris Kallmann, neurologist and MS specialist, about how these subtle changes develop, how they can be recognized in everyday clinical practice, and which treatment options are available today – and may become available in the near future. 👉 You can also read the full interview on my blog, where this episode is available as a written article. ℹ️ Important notes This episode is the English translation of the original German interview. The conversation was translated carefully to preserve medical accuracy and meaning. This episode was supported by Sanofi S.A. The content reflects independent editorial work. 🧠 Topics covered in this episode What chronic smoldering inflammation means in MS Why MS can progress slowly without relapses How neurologists recognize subtle, long-term changes The importance of listening closely to patients' experiences Using digital tools and smartphones to monitor disease progression Realistic therapy goals when progression is present The three key pillars of MS management: lifestyle and physical activity symptom management immunomodulatory therapies New therapeutic approaches and insights from clinical trials BTK inhibitors: how they work, what makes them different, and why they are promising What "non-inferiority" in clinical studies really means Possible side effects and the need for careful monitoring Why new therapies may initially be used in specialized MS centers Challenges in rural healthcare and the importance of collaboration What the future of MS treatment may look like in the next five years 📖 You can also read the full interview on my blog for a detailed, structured version of the conversation: https://ms-perspektive.de/en/150-boris-kallmann 💬 Takeaway MS is highly individual – and so are the ways people experience progression. Staying informed, observing changes over time, and working closely with experienced healthcare providers can make a meaningful difference.

What can your mouth tell us about multiple sclerosis? In this episode of the MS-Perspektive Podcast, Professor Dr. Ashutosh Mangalam, immunologist and microbiome researcher at the University of Iowa, shares fascinating insights into the oral microbiome and multiple sclerosis. While most MS research focuses on the gut, this conversation highlights why oral bacteria and their metabolites may also play an important role in inflammation, immune regulation, and disease activity. We talk about what the microbiome is, how the oral microbiome differs in people with MS, and why beneficial bacteria are reduced while potentially harmful ones increase. Professor Mangalam explains the relevance of microbial metabolites such as hypotaurine, discusses whether saliva could become a future biomarker for MS monitoring, and why oral health and regular dental care matter for people living with MS. The episode also explores how combining oral, gut, and blood-based markers could support more personalized MS care in the future. you can read the interview here: https://ms-perspektive.de/EN/149-ashu-mangalam 📌 Topics covered in this episode What the microbiome is and why it matters in MS The role of the oral microbiome in relapsing-remitting MS Dysbiosis: loss of beneficial bacteria and rise of pathogenic species Microbial metabolites and inflammation Saliva as a potential biomarker for MS monitoring Oral health, dental care, and lifestyle factors Personalized MS treatment using microbiome-based markers Future directions in MS and microbiome research Final message to people living with MS Prof. Dr. Ashutosh Mangalam: MS should not define you. A healthy lifestyle, social support, and staying positive truly matter. I have great respect for what people with MS go through every day. From a researcher's perspective, it is incredibly important for us to listen to patients, understand their real challenges, and work on questions that can truly improve quality of life. That is what motivates my work. Nele von Horsten: Thank you so much, Ashu, for this insightful and hopeful conversation. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this episode, Prof. Dr. Heinz Wiendl discusses why disease progression can occur even when relapses are well controlled and MRI scans appear stable. The conversation focuses on how subtle changes can develop over time, how they can be recognized earlier, and what this means for people living with MS. This episode was supported by Sanofi S.A. and is an English translation of the original German interview. You can find the full blog article with all questions, answers, and additional context here: 👉 https://ms-perspektive.de/en/148-heinz-wiendl/ Topics discussed in this episode why disease progression can occur even when relapses are well controlled how often this affects people and why most patients remain stable what progression independent of relapse activity (PIRA) means in everyday practice the importance of invisible symptoms such as fatigue, cognitive changes, bladder dysfunction, and spasticity why commonly used scales often fail to capture subtle but relevant changes what MRI can reveal, where its limits lie, and why it should not be interpreted in isolation why long-term observation over months matters more than day-to-day fluctuations how patients can actively contribute by observing and documenting changes what current research tells us about silent inflammatory processes and endophenotypes why reliable biomarkers are still missing and what research is focusing on the therapeutic idea behind BTK inhibitors and which patient groups may benefit a realistic and hopeful outlook on future developments in MS care Is there anything you would like to share with our listeners as a final message? Prof. Dr. Heinz Wiendl: I believe my most important message is this: we can be hopeful. The developments of recent years show that we are far from reaching the end of the road. On the contrary, we have learned that progress continues — new therapies are being developed, and our understanding of the disease is steadily improving. At the same time, there are still cases that are frustrating, because patients are not treated early or effectively enough, or because the disease course is particularly challenging. That is precisely why we must continue to do research, continue to improve, and continue to refine our approaches. My hope is that in five years' time, we will be able to say: now everyone truly benefits from these advances. And I hope this sends a positive signal — one of courage and optimism for the future. --- I would like to thank Prof. Heinz Wiendl for this insightful interview and for his encouraging outlook on current developments and future perspectives. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

In this very personal episode, I open the doors behind the microphone and share what truly shaped 2025 – a year of endurance, motherhood, advocacy work, sleep deprivation, and two weekly podcast shows in German and English. I also share what will change in 2026 – with a focus on sleep, gentle growth, an English talk format, books, and fast-track MS knowledge for the community. https://ms-perspektive.de/EN/147-review-2025 🔍 In this episode You will hear about: why I do a yearly review and why reflection matters 2025 in one word: endurance family milestones – daycare and school beginnings building a home instead of moving again work highlights: Patient Council & AI Whitepaper on Shared Decision Making what AI can and cannot replace 57 German & 54 English episodes in 2025 – and the price I paid the joy of the German "Kamingespräch" format – and plans to launch an English version lessons learned about boundaries, friendships, and MS what I will prioritise in 2026 (sleep, health, books, course, newsletter) 🌍 Global audience MS-Perspective is now listened to in 80+ countries. Guests so far came from: 🌎 North America 🌍 South America 🌍 Europe 🌍 Africa 🌏 Australia …plus expats from the Middle East ➡️ In 2026 I hope to welcome first interview guests from Asia as well. 🧩 Links & resources mentioned AI Whitepaper on Shared Decision Making → 250822_AI_SDM_Whitepaper_english.pdf German podcast archive → Alle Folgen vom Podcast sortiert nach Themenbereichen English podcast episodes → Alle Folgen vom Podcast sortiert nach Themenbereichen Episode on sleep / fatigue → The Power of Sleep and Exercise in Managing MS Episode on pregnancy & MS → Pregnancy, childbirth, and breastfeeding with multiple sclerosis Newsletter sign-up → Newsletter mit positiven Impulsen zur Multiplen Sklerose (MS) MS course waiting list (coming soon) About the host → Wer ist Nele Handwerker von MS-Perspektive? Mehr über mich... ✉️ Connect with me I would love to hear what you wish for the English podcast in 2026. Send me a message anytime: Instagram: → Nele von Horsten (geb. Handwerker) (@ms.perspektive) • Instagram photos and videos Email: → nele@ms-perspektive.com ⭐ If this episode supported you… Please consider leaving a rating or review – it helps others with MS find this podcast more easily. --- See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

This episode was supported by Sanofi S.A. In this episode, I speak with Dr. Klarissa Hanja Stürner about chronic smoldering inflammation in multiple sclerosis (MS)—a slow, often hidden process that may drive disease progression even when relapses and MRI activity appear stable. Dr. Stürner explains how chronic inflammation behind the blood–brain barrier differs from acute relapse-related inflammation, why it is so difficult to detect with current imaging, and which warning signs people with MS should take seriously. We also discuss PIRA (Progression Independent of Relapse Activity), the role of microglia and macrophages, and why new treatment approaches such as BTK inhibitors are considered a promising step forward in MS research. This episode offers a clear, evidence-based, and hopeful perspective for anyone who wants to better understand MS progression beyond relapses. 📝 Read the full article on the MS-Perspective blog for a detailed written summary of the conversation: https://ms-perspektive.de/EN/146-dr-stuerner Topics covered in this episode What chronic smoldering inflammation in MS means Differences between acute relapses and smoldering inflammation Inflammation behind the blood–brain barrier Why MRI often fails to detect these processes Clinical red flags for progression without relapses PIRA explained in simple terms The role of microglia and macrophages in MS BTK inhibitors as a new therapeutic approach Current challenges and future directions in MS research --- Many thanks to Dr. Stürner for the insightful interview and this positive outlook on the present and the future. See you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.

Living with multiple sclerosis means making daily decisions that go far beyond medication. Mental health, lifestyle, rehabilitation, empowerment, and access to care all play a crucial role in how well people live with MS. In this special episode from ECTRIMS 2025, I bring together insights from six international experts who presented new research on well-being, mental health, lifestyle interventions, and patient empowerment in MS. You'll hear what is already evidence-based, what looks promising but needs more research, and—most importantly—what you can realistically take from this research into your everyday life with MS. 👉 You can also read the full blog article with all details and references here: https://ms-perspektive.de/EN/145-mental-health 🧠 Presentations & Key Topics 1️⃣ Types of Mental Health and Psychological Well-Being Rehabilitation in MS Christoph Heesen (Germany) What actually works when it comes to mental health support in MS? This presentation reviews psychotherapy, mindfulness, self-management, and multidisciplinary rehabilitation—and why mental health care should be a standard part of MS treatment. 2️⃣ Designing Well-Being Rehabilitation Trials With Implementation in Mind Marcia Finlayson (Canada) Why promising interventions often never reach everyday care—and how research design must change so that well-being programs become accessible, affordable, and sustainable for people with MS. 3️⃣ Concealment of MS Diagnosis and Symptoms Rebecca Maguire (Ireland) Many people with MS hide their diagnosis or symptoms. This talk explores how concealment affects mental health, help-seeking behavior, and long-term well-being—and what support is needed. 4️⃣ A Goal-Oriented, Personalized Well-Being Intervention for Progressive MS Silvia Poli (Italy) Insights from the Living Well Program show how personalized, goal-based approaches can restore meaning, motivation, and a sense of control—especially for people with progressive MS. 5️⃣ Nurse-Led Expert Patient Programmes in MS Care Miguel Angel Robles Sanchez (Spain) How nurse-led, empowerment-focused programs improve knowledge, confidence, and engagement with care—and why peer learning matters in long-term MS management. 6️⃣ Sustained Benefits of a Multi-Domain Lifestyle Intervention: The LIMS Study Arianne Gravesteijn (Netherlands) Long-term results from a lifestyle intervention targeting diet, physical activity, sleep, and stress show sustained improvements in anxiety, fatigue, psychological impact, and general health over 24 months. 🌱 What This Means for You Across all six presentations, one message stands out: Living well with MS is multifaceted, modifiable, and supported by growing evidence. Mental health, lifestyle habits, empowerment, and personalized goals are not "extras"—they are essential parts of MS care today and in the future. 📌 Further Reading 👉 Read the full accompanying blog article with detailed explanations and practical takeaways: https://ms-perspektive.de/EN/145-mental-health 🔔 Subscribe & Share If you found this episode helpful, please subscribe, share it with others living with MS, and help spread evidence-based information that empowers. This podcast shares research insights and lived perspectives. It does not replace individual medical advice. --- Hear you soon and try to make the best out of your life, Nele For more information and positive thoughts, subscribe to my newsletter for free. Click here for an overview of all podcast episodes published so far.