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MoneyBall Medicine

Health & Wellness Podcasts

The power of data is remaking everything in healthcare—not just the way doctors diagnose patients, but the way pharma companies develop drugs and the way hospitals and insurers control costs and create value. Here at MoneyBall Medicine, host Harry Glorikian talks with the executives, entrepreneurs, physicians, and scientists who are pushing that high-tech revolution forward. Harry's 2017 book "MoneyBall Medicine" offered an inside look at the ways genomics, machine learning, and other trends are improving healthcare delivery and efficiency. And now he brings you intimate conversations with industry pioneers—like Mount Sinai's Joel Dudley, N-of-One's Jennifer Carter, Semeion's Massimo Buscema, Genetic Alliance's Sharon Terry, and many more—who share their hard-won experience in the surprising, exciting, untamed world of data-driven healthcare.

The power of data is remaking everything in healthcare—not just the way doctors diagnose patients, but the way pharma companies develop drugs and the way hospitals and insurers control costs and create value. Here at MoneyBall Medicine, host Harry Glorikian talks with the executives, entrepreneurs, physicians, and scientists who are pushing that high-tech revolution forward. Harry's 2017 book "MoneyBall Medicine" offered an inside look at the ways genomics, machine learning, and other trends are improving healthcare delivery and efficiency. And now he brings you intimate conversations with industry pioneers—like Mount Sinai's Joel Dudley, N-of-One's Jennifer Carter, Semeion's Massimo Buscema, Genetic Alliance's Sharon Terry, and many more—who share their hard-won experience in the surprising, exciting, untamed world of data-driven healthcare.

Location:

United States

Description:

The power of data is remaking everything in healthcare—not just the way doctors diagnose patients, but the way pharma companies develop drugs and the way hospitals and insurers control costs and create value. Here at MoneyBall Medicine, host Harry Glorikian talks with the executives, entrepreneurs, physicians, and scientists who are pushing that high-tech revolution forward. Harry's 2017 book "MoneyBall Medicine" offered an inside look at the ways genomics, machine learning, and other trends are improving healthcare delivery and efficiency. And now he brings you intimate conversations with industry pioneers—like Mount Sinai's Joel Dudley, N-of-One's Jennifer Carter, Semeion's Massimo Buscema, Genetic Alliance's Sharon Terry, and many more—who share their hard-won experience in the surprising, exciting, untamed world of data-driven healthcare.

Twitter:

@hglorikian

Language:

English

Contact:

617-407-5093

Episodes

Rana el Kaliouby: When Will Machines Understand Human Emotions

4/12/2021
Computers can interpret the text we type, and they’re getting better at understanding the words we speak. But they’re only starting to understanding the emotions we feel—whether that means anger, amusement, boredom, distraction, or anything else. This week Harry talks with Rana El Kaliouby, the CEO of a Boston-based company called Affectiva that’s working to close that gap. El Kaliouby and her former MIT colleague Rosalind Picard are the inventors of the field of emotion AI, also called...

Duration:00:33:04

Jason Gammack on the Promise of Spatial Biology

3/29/2021
Rapid and cheap DNA sequencing technology can tell us a lot about which genes a patient is carrying around, but it can't tell us when and where the instructions in those genes get carried out inside cells. Resolve Biosciences—headed by this week's guest, Jason Gammack—aims to solve that problem by scaling up a form of intracellular imaging it calls molecular cartography. Gammack says the technology offers a high-resolution way to see the geography of gene transcription in single cells, that...

Duration:00:54:36

Auransa's Pek Lum on Using Machine Learning to Match New Drugs with the Right Patients

3/15/2021
Pek Lum, co-founder, and CEO of Auransa believes that a lot fewer drugs would fail in Phase 2 clinical trials if they were tested on patients predisposed to respond. The problem is finding the sub-populations of likely high-responders in advance and matching them up with promising drug compounds. That’s Auransa's specialty. The Palo Alto, CA-based drug discovery startup, formerly known as Capella Biosciences, has a pipeline of novel compounds for treating cancer and other conditions...

Duration:00:48:33

Eight Sleep Matteo Franceschetti Says it's time for a Smarter Mattress to improve your health

3/1/2021
This week Harry talks with Matteo Franceschetti, founder and CEO of the Khosla Ventures-backed startup Eight Sleep. The company' smart mattress, called the Pod, is one of the latest (and largest) entries in the burgeoning market for home digital-health devices. The Pod is designed to counteract body heat and provide a surface that stays cool all night, on the theory that people sleep better when it’s cool or cold. It includes four layers of foam topped by an “Active Tech Grid Cover” that...

Duration:00:33:42

What's more important? Lifespan or Health Span? - Michael Geer

2/15/2021
Michael Geer is co-founder and CSO (Chief Strategy Officer) of Humanity Health, a London-based startup that's building an iPhone app and subscription service designed to help users slow or reverse their rate of aging. Geer's co-founder Pete Ward has described the app as like “Waze for maximizing health span," or years of healthy functioning. The Humanity iPhone app, which is currently being beta-tested by users in the UK, is designed to track various types of health-related data for free,...

Duration:00:49:17

IntelinAir's AI-Driven Image Analysis is Saving Crops - Down on the Farm today but tomorrow.....

2/1/2021
This week on MoneyBall Medicine, Harry takes a field trip (literally!) into farming and agriculture. His guests are Al Eisaian co-founder and CEO of crop intelligence IntelinAir, and the company’s director of machine learning, Jennifer Hobbs. Intelinair’s AGMRI platform uses customized computer vision and deep learning algorithms to sift through terabytes of aerial image data, to help farmers identify problems like weeds or pests that can go undetected from the ground. The parallels to the...

Duration:00:55:28

Tempus's Joel Dudley on Building a New Infrastructure for Precision Medicine

1/18/2021
What if there were a single company that could connect hospital electronic health record systems to a massive genomic testing and analytics platform? It would be a little like Amazon Web Services (AWS) for healthcare—an enabling platform for anyone who wants to deploy precision medicine at scale. That's exactly what Joel Dudley says he's now helping to build at Tempus. When Harry last spoke with Dudley in January 2019, he was a tenured professor of genetics and genomics at the Icahn School...

Duration:00:52:09

Christine Lemke on Evidation's Push to Use Wearables in Healthcare

1/4/2021
This week Harry catches up with Christine Lemke from Evidation Health, a startup in San Mateo, CA, that helps drug developers and other organizations analyze the effectiveness of smart devices and wearables in new types of therapies. Lemke is Evidation's co-CEO. Our Fitbits and Apple Watches are with us so much of the time that the data they collect can go way beyond telling us whether we’ve completed our 10,000 steps for the day. They can also help doctors diagnose cardiovascular problems,...

Duration:00:38:55

Genuity's Thomas Chittenden on Using Genomics and Statistics to Eradicate Disease

11/23/2020
Thomas Chittenden, chief data science officer at Genuity Science, says what's keeping the genomics revolution from turning into an equivalent revolution in drug discovery is that most of our domain knowledge about the molecular biology of disease has come from a hunt-and-peck approach, focused on one gene at a time. Find some gene relevant to a disease, knock it out, and you see what happens. Such experiments are always revealing, but the reality is that human biology is the product of the...

Duration:00:54:08

Shane Cooke Explains Why Intensive Care Unit Docs Need a Dashboard

11/13/2020
This week Harry interviews the head of Etiometry, a Boston-based startup building visualization systems and decision support software for hospital intensive care units. Shane Cooke says critical care "is an incredibly complex environment where speed matters and information matters." By aggregating real-time data, lab results, and historical patient records on a single screen, Cooke says, Etiometry hopes to show caregivers that they can glean more value from the data that's already collected...

Duration:00:30:55

Charles Fisher on Using Digital Twins to Speed Clinical Trials

10/29/2020
Charles Fisher is the founder and CEO at Unlearn, a San Francisco company using purpose-built machine learning algorithms that use historical clinical trial data to create "digital twins" of actual participants in controlled drug trials to help predict how each participant would have fared if they'd been given a placebo. By comparing a patient's actual record to their digital twin, Fisher says, the company can pinpoint the treatment effect at the patient level and conduct trials with fewer...

Duration:00:38:54

Jeff Booth on the Power of Falling Prices in Technology and Healthcare

9/30/2020
What if all our everyday assumptions about economics are wrong? This week Harry speaks with author and entrepreneur Jeff Booth, who says the most powerful force for change in the future will be deflation: getting more for less. Even the healthcare industry will feel the effects, he says. Listen to find out how. Booth is the author of The Price of Tomorrow: Why Deflation is the Key to an Abundant Future. The book argues that the most powerful force for innovation and change is not endless...

Duration:00:57:16

How Drug Development Guru Mark Eller Went from AI Skeptic to AI Supporter

9/14/2020
How does an expert in pharmacokinetics, whose only exposure to computers was taking one semester of programming in college to meet a language requirement, become an advocate for the new AI-driven style of drug discovery? This week Harry finds out from Mark Eller, who helped to invent Allegra at Hoechst Marion Roussel (now Sanofi), spent 12 years at Jazz Pharmaceuticals, and is now senior vice president of research and development at twoXAR, an AI-driven drug discovery startup. In our...

Duration:00:41:58

Andrew A. Radin Returns with a Progress Report on twoXAR

8/31/2020
Harry welcomes back Andrew A. Radin, CEO of the drug discovery startup twoXAR, where scientists model pathogenesis computationally to identify potential drug molecules, ideally shaving years off the drug development process. Harry first spoke with Radin two years ago at the AI Applications Summit—Biopharma. (Listen back to MoneyBall Medicine Episode 9 from November 2018 for more details about the company's innovations.) Since then, the company has begun to use what Radin calls twoXAR's...

Duration:00:56:58

Rayid Ghani Explains How AI Can Both Predict and Shape Patient Behavior

8/20/2020
In this week's show Harry interviews Rayid Ghani, a computer scientist at Carnegie Mellon University who studies how to use AI and data science to model and influence people's behavior in realms like politics, healthcare, education, and criminal justice. Ghani tell Harry he grew up hating coding, since the very need for it showed that "computers are really stupid and dumb." But Ghani says he eventually realized that machine learning can change that by allowing programmers to teach computers...

Duration:00:44:19

Oura's Harpreet Rai on a Ring That May Change Covid-19 Detection

8/3/2020
This week Harry speaks with Oura Health CEO Harpreet Rai, who's leading an effort to explore how a wearable sleep-monitoring device—the Oura Ring—can pick up patterns that may help diagnose covid-19 infections and other problems. The ring is equipped with sensors that measure heart rate and body temperature, as well as a tiny Bluetooth radio that syncs the data it collects with a smartphone app. The Finland-based company designed the ring primarily to measure sleep quality, but it also...

Duration:00:46:13

David Sable on the Genetic Revolution in Fertility Treatment

7/20/2020
David Sable got his start in reproductive medicine in the late 1980s, a time when he says fertility treatments were "very primitive." But by the mid-2000s, he says, new procedures and new insights into the genetics of development had changed everything. His subsequent time observing (and investing in) the field has convinced him that reproductive medicine is "the most interesting area of medicine this century." Sable is a medical and entrepreneurial chameleon who trained in obstetrics and...

Duration:00:48:58

Elli Papaemmanuil Explains How Genomics Will Transform Cancer Care

6/29/2020
This week Harry speaks with molecular geneticist Elli Papaemmanuil about how newly available genomic data could lead to major improvements in the standard of care for cancer patients, leading to an age of true precision medicine. Papaemmanuil is an assistant professor of computational oncology at Memorial Sloan Kettering Cancer Center in New York. Her lab's research is built around the idea that the genetic sequences of tumor cells reveal distinctive acquired mutations that can allow...

Duration:00:51:51

Gregory Bowman Explains How You Can Help Cure the Coronavirus from Home

6/17/2020
This week Harry interviews Gregory Bowman, an associate professor in the department of biochemistry and molecular biophysics in the School of Medicine at Washington University in St. Louis. Bowman is the current director of Folding@home, a distributed computing project currently focused on analyzing the structures of coronavirus proteins to find targets for new drug therapies that could help end the pandemic. Understanding and modeling the 3D structures of tiny, ever-shifting protein...

Duration:00:32:43

Covid-19 Tracing Inside Companies, with SaferMe's Clint Van Marrewijk

6/1/2020
Harry's guest this week is the founder and CEO of a New Zealand firm, SaferMe, that had developed proximity-based smartphone apps for worker safety. When the coronavirus came along, their apps turned out to be a great way to help companies build their own "contact tables" to identify, test, and isolate SARS-CoV-2 carriers. In epidemiology, contact tracing is the art of determining who has crossed paths with an infected individual, so that those exposed can be alerted and can take...

Duration:00:29:53

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