Rheumnow Podcast

Dr. Jack Cush reviews the news and info reports the day before ACR 2025.

DERM on RheumNow PODCAST (October 2025) Skin important Citations and Content curated for dermatologists – addressing Psoriasis, PsA, CLE, vasculitis, HS, other CTD skin disorders. dermatology drugs, biiologics, JAKs - their use, efficacy and side effects. Features Dr. Jack Cush, Editor at RheumNow.com. SHOW NOTES 1. Skin Biopsies to Predict Scleroderma Outcomes? 2. Fibromyalgia in PsO & PsA is linked to greater treatment complexity and shorter biologic therapy survival. Retro matched 1:4 cohort study 61K PsO& 244K controls. FM prevalence 3.3% (OR 1.45). In PsA w/ FM, req more biologics w/ decr biologic survival (6 vs 10yrs) w/ incr switching (HR 1.82) https://buff.ly/TCc6Kc8 3. Guselkumab FDA Approved for Pediatric Psoriasis and Psoriatic Arthritis https://rheumnow.com/news/guselkumab-fda-approved-pediatric-psoriasis-and-psoriatic-arthritis 4. Sonelokimab (SLK) is a nanobody that inhibits IL-17 A&F. Phase 2 ARGO trial 207 active PsA pts Rx w/ SLK 120-mg or 60-mg q4wks or PBO or adalimumab. ACR50 at wk 12 was 60-mg WI=46%; 120-mg WI=46%; PBO 20%. PASI90: 60mg 77% vs 120mg 59% vs PBO 15% https://t.co/ra0NqvUEru https://t.co/FXT6kkXUzH 5. Turkish study of 799 psoriasis pts - 30% had concurrent onset PsO & PsA & in 70% there was a long transition time (~13 yrs) from PsO-to-PsA. Factors assoc w/ prolonged interval included Depression, fatigue, scalp PsO(OR 7), nail PsO (3.2), +Fhx & enthesitis ever (OR 2) https://t.co/wqtSbeQ2vz 6. Mediterranean Diet Efficacy in Psoriasis 7. Gender Complexities in Psoriatic Arthritis Treatment Outcomes

Dr. Jack Cush reviews the news and journal reports, discusses pediatric reports, pregnancy data, diet and nutrition and more.

Dr. Jack Cush reviews the news, FDA approvals, and journal articles. In this episode: HMGCR Abs, FDA approvals and Cush eats crow.

Dr. Jack Cush reviews the news, journal reports and important associations in rheumatology from the past week on RheumNow.com.

Our final webinar in this month's Rheum to Breathe: ILD campaign brings together ILD experts to discuss best practices in diagnosis, screening, and monitoring, covering: tools, labs, and imaging; timing and frequency of screening; ILD screening in RA; and, referral strategies. Panelists: Shane Shapera, MD Elana Bernstein, MD Bryant England, MD Moderator: Jack Cush, MD

Experts Dr. Jeffrey Curtis and Dr. Kevin Winthrop discuss best practices for shared decision-making, how to talk with patients about the risks of poorly controlled RA, and ways to use a new tool for visualizing the long-term safety of a JAKi.

QD clinics on ILD - lessons from the Clinic; brought to during the "Rheum to Breathe" ILD campaign ILD QD Clinic #4 ILD QD Clinics - Worsening Breathlessness in SSc ILD: The Pressure Is On ILD QD clinics on ILD #1 - Be Careful What you Look For

Rheum to Breathe Rx Update ILD Treatment and Guidelines Part 4: Rheum + Pulm Collaborations in ILD including The Rheumatologist and Pulmonologist: Different approaches to the same patient (Dr. Paul Dellaripa and Dr Rachel Putman).

Rheum to Breathe Rx Update ILD Treatment and Guidelines Part 3: ILD Assessment and Management including: Biomarkers in ILD (Dr. Elena Joerns), How to Assess ILD in Patients (Dr. Janet Pope) and Management of SSc ILD (Dr. Alicia Hinze)

Rheum to Breathe Rx Update ILD Treatment and Guidelines Part 2: ILD Treatment including: RA-ILD Treatment Update (Dr. Bryant England), Do DMARDS Affect CTD-ILD Outcomes? (Dr. Elizabeth Volkmann), Non-pharmacologic Treatment of ILD (Dr. Jon Giles) and Transplantation: A real option! (Dr. John Joerns)

Rheum to Breathe Rx Update ILD Treatment and Guidelines Part 1: ILD Guidelines including: ACR/CHEST Guidelines for SSc ILD (Dr. Sindhu Johnson), ERS/EULAR Clinical Practice Guidelines (Dr. Anna-Maria Hoffman-Vold) and ILD Guideline Caveats and Concerns (Dr. Jeffrey Sparks).

Dr. Jack Cush reviews the news and journal articles from RheumNow.com. Pool therapy, Fibrosis, NSIE's and whats best for knee OA.

QD clinics on ILD - lessons from the Clinic; brought to during the "Rheum to Breathe" ILD campaign ILD QD Clinic #3 ILD QD Clinic: Application of the ACR CHEST Guidelines to Two Cases ILD QD Clinic: Progressive RA-ILD Management ILD QD Clinic: Beyond the Numbers in Newly Diagnosed ILD

In this journal club, we will discuss two pivotal studies in ILD, the FIBRONEER study and the RECITAL study: Nerandomilast in Patients with Progressive Pulmonary Fibrosis, Maher, T.M. et al. NEJM. 2025 May 19. doi: 10.1056 Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial, Maher T.M., et al. Lancet 2023 Jan;11(1). doi: 10.1016 Panelists: Toby Maher, MD Shervin Assassi, MD Jack Cush, Moderator

Content curated for dermatologists and skin deep HCPs – on Psoriasis, CLE, vasculitis, HS and dermatology drugs use, efficacy and side effects and more. Features Dr. Jack Cush, Editor at RheumNow.com. SHOW NOTES: 1. SMILE Study: A randomized, placebo-controlled trial of hydroxychloroquine in incomplete lupus https://t.co/NnrA8ohiGX 2. Equal Safety of JAK Inhibitors and TNF Inhibitors in H2H IMID trials JAMA systematic review. https://t.co/HI1KBKZiXR 3. SMART study - Single vs. Split Dose Methotrexate https://t.co/lizsrtVHwf 4. Vegan diets don’t work in RA - Metanalysis of 7 studies https://t.co/jeh6gN5Byg 5. No association between IL-17 inhibitors & MACEs (vs TNFi Rx) https://t.co/fJuPFYKnSr https://t.co/Vscnsq0DTA 6. Successful Phase 3 UP-AA Trial evaluating Upadacitinib in Alopecia Areata (AA) https://t.co/8p1FvJx0s0 7. Anifrolumab effective & safe in refractory Cutaneous LE - OL Study in 15 CLE https://t.co/umEYz0XDyt 8. "Never doubt that a small group of thoughtful, committed citizens can change the world; indeed, it's the only thing that ever has." - Margaret Mead https://t.co/OFGN223bPa

Dr. Jack Cush reviews the news and journal reports from this week on RheumNow.com. Today we cover GLP-1 agonists, acupuncture, what JAKs wont do & an FDA Pink Slip.

This deep dive into controversies in interstitial lung disease explored complex topics including IPAF, methotrexate, systemic autoimmune rheumatic disease vs. connective tissue disease distinctions, and the evolving role of anti-fibrotic therapy. Panelists: Jeffrey Sparks, MD, Janet Pope, MD, Elena Joerns, MD Jack Cush, MD - Moderator

Dr. Peter Nash, Australia, reports highlights from a range of sessions presented at the APLAR 2025 Congress in Fukuoka, Japan. Hot Topics in AxSpA Precision Medicine in PsA PSA Therapeutic Update CAR T Therapy with Immunomediated Diseases Imaging Use of Micro CT Low Radiation for PsA

"QD clinics on ILD - lessons from the Clinic; brought to during the "Rheum to Breathe" ILD campaign. Here are the individual video titles and links: ILD QD Clinic: Stick or twist (when not to change treatment) https://youtu.be/sdGPsvcfyzQ ILD QD Clinic: Interstitial Lung Disease with Positive SSA and Rash https://youtu.be/1H10_VR8t_0 ILD QD Clinic Video: RA and Bronchiectasis https://youtu.be/-StSi3v8ew8