This Podcast Will Kill You

Exactly Right

This podcast might not actually kill you, but Erin Welsh and Erin Allmann Updyke cover so many things that can. In each episode, they tackle a different topic, teaching listeners about the biology, history, and epidemiology of a different disease or...

Location:

United States

Genres:

Medical

Science Podcasts

Networks:

Exactly Right

My Favorite Murder

Description:

This podcast might not actually kill you, but Erin Welsh and Erin Allmann Updyke cover so many things that can. In each episode, they tackle a different topic, teaching listeners about the biology, history, and epidemiology of a different disease or medical mystery. They do the scientific research, so you don’t have to. Since 2017, Erin and Erin have explored chronic and infectious diseases, medications, poisons, viruses, bacteria and scientific discoveries. They’ve researched public health subjects including plague, Zika, COVID-19, lupus, asbestos, endometriosis and more. Each episode is accompanied by a creative quarantini cocktail recipe and a non-alcoholic placeborita. Erin Welsh, Ph.D. is a co-host of the This Podcast Will Kill You. She is a disease ecologist and epidemiologist and works full-time as a science communicator through her work on the podcast. Erin Allmann Updyke, MD, Ph.D. is a co-host of This Podcast Will Kill You. She’s an epidemiologist and disease ecologist currently in the final stretch of her family medicine residency program. This Podcast Will Kill You is part of the Exactly Right podcast network that provides a platform for bold, creative voices to bring to life provocative, entertaining and relatable stories for audiences everywhere. The Exactly Right roster of podcasts covers a variety of topics including science, true crime, comedic interviews, news, pop culture and more. Podcasts on the network include My Favorite Murder with Karen Kilgariff and Georgia Hardstark, Buried Bones, That's Messed Up: An SVU Podcast and more.

Language:

English

Episodes

Ep 207 Tear Gas: How can a chemical weapon be “humane”?

4/14/2026

Tear gas is an expected, normalized part of protests today. But its use in international war is banned. How can that be? That’s just one of the questions we investigate in this episode. First, we take you through the long history of tear gas and its emergence alongside deadlier chemical weapons before discussing how its use became routine, fueled by industry interests. Then we delve into what’s in tear gas that causes the painful physical reaction and consider whether claims of non-toxicity are backed up by research (spoilers: not really). This is an info-packed episode that will leave you with many questions answered, but not all of those answers will be satisfying. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:15:20

Ep 206 Oropouche Virus: More than a smidge worrisome

4/7/2026

Though discovered relatively recently, Oropouche virus has been making headlines as an emerging vector-borne infectious disease on the rise. Not transmitted by the usual suspects (like ticks and mosquitoes), this virus is instead spread through the bites of midges or no-see-ums. Since these arthropods are already widely distributed and their range is growing thanks to climate change, this is a recipe for potential disaster. In this episode, we take you through the story of Oropouche virus, from how it makes us sick to what the construction of a highway has to do with its discovery, from surprising prevalence statistics to the history of One Health. Tune in for the full scoop on this midge and the virus it carries. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:12:38

Ep 205 Cancer Part 4: Where do things stand today?

3/31/2026

For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re using this final installment in our cancer miniseries to show some appreciation. To grasp the impact that screening and prevention can have, we also need to consider the global landscape of cancer prevalence and incidence - where is it decreasing? Where is it on the rise? Where can intervention or prevention make an impact? As we’ve shown over these four episodes, science and medicine has accumulated a wealth of information about cancer - but the striking racial and socioeconomic disparities in cancer incidence and mortality in the US and around the world demonstrates that that knowledge has not been applied equally. Any proposal to reduce the global cancer burden must address the systemic issues driving these disparities. Tune in for a thought-provoking reflection on the status of cancer today. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:19:29

Ep 204 Cancer Part 3: How do we treat it?

3/24/2026

A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple notebooks to delineate all of the various therapies currently in development. It is nothing short of a revolution. Of course, no revolution is perfect, and many cancer treatments are ineffective or carry risks of serious side effects. In part 3 of our cancer series, we delve into all facets of cancer treatment, from the history of their development to how they actually work. Tune in to learn how far we’ve come and where we might go from here in our perennial quest to treat and cure cancer. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:32:47

Special Episode: Lawrence Ingrassia & A Fatal Inheritance

3/17/2026

For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in your lifetime, a condition known as Li-Fraumeni Syndrome. Journalist Lawrence Ingrassia belongs to one of those families; he has lost his mother, three siblings, and a nephew to cancer. In this TPWKY book club episode, Ingrassia joins me to discuss his book A Fatal Inheritance: How a Family Misfortune Revealed a Deadly Medical Mystery, where he weaves together his family’s story with that of the scientists who sought to uncover the cellular drivers of cancer. Tune in for a heartbreaking and inspiring journey. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:00:45:30

Ep 203 Cancer Part 2: Why does it happen?

3/10/2026

Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a cell cancerous are those that, under other circumstances, are beneficial, essential even, for an individual’s growth and survival. How is that possible? In the second installment in our series, we’re putting cancer under the microscope to consider the qualities that underlie a cancer cell’s success in our body. By placing cancer in an evolutionary framework, we can not only understand why cancer is so darn prevalent, but we can also leverage that knowledge to devise new approaches to treatment - working with evolution rather than against it. If you’ve ever wondered why we haven’t come up with a cure for all cancer or why some animals get cancer more than others, this is the episode for you. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:18:30

Ep 202 Cancer Part 1: What is it?

3/3/2026

Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowledge that will help make sense of this multifaceted disease. We begin our four-part series on cancer by asking a deceptively simple question: what is cancer? As we’ll discover over the course of these episodes, there is not one answer but many. After all, cancer is not one disease but many. In this first episode, we examine the clinical definitions of cancer - when someone receives a cancer diagnosis, how is that determined, and what does that mean? Viewing that question through a historical lens reveals our changing understanding of cancer and how that knowledge filters into the public perception of this disease. With cancer diagnoses on the rise, it’s tempting to label cancer a disease of the 20th or 21st centuries. But is that the case? Tune in to find out. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:36:20

Special Episode: Jon Adams and Edmund Ramsden & Rat City

2/24/2026

What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” experiments from the mid-20th century revealed a behavioral dark side that emerged as space grew increasingly limited, ultimately leading to complete population collapse. As headlines conveyed dire warnings about global overpopulation, Calhoun’s work served to reinforce those fears and shape our understanding of the importance of personal space. In this week’s TPWKY book club episode, Jon Adams and Edmund Ramsden join me to discuss their book, Rat City: Overcrowding and Urban Derangement in the Rodent Universes of John B. Calhoun. Tune in for a fascinating a tour through Calhoun’s bizarre and influential research, which even inspired a beloved (if a little creepy) children’s book and movie, Mrs. Frisby and the Rats of NIMH. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:00:56:25

Ep 201 Poop Part 2: Flushed away

2/17/2026

Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate sewer systems have revolutionized health and hygiene by whisking our poop far away where we don’t have to think about it. But that poop has gotta go somewhere, and eventually, not thinking about it isn’t going to be an option. Similarly, not thinking about our individual poop is asking for disaster, since what we produce can reveal a great deal about our gut and overall health. In this episode, we explore the problems that poop can cause on both the individual and population level. From constipation to fiber, and the Great Stink to communal poop sponges, we’re continuing our journey into the curiously fascinating world of poop. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:21:54

Ep 200 Poop Part 1: How the sausage gets made

2/10/2026

It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so, we’re going to bring it back into mind as we delve into the rich world of poop. This episode, the first of a two-part miniseries on poop, features a wide cast of characters all with some role in the production or management of poo, like our intestinal tract with its sphincters and microbiota, dung beetles that perform the duties so crucial for ecosystem function, and the sperm whale that produces a revered substance used in perfumes. We’re going behind the scenes to understand how the sausage really gets made (in a manner of speaking) and why we need a big perspective shift to stop seeing poop as waste and start seeing it as a resource. Correction: EW says that elephants poop 15 pounds a day, but in reality it’s more like 10x that - 150-200 pounds! Sorry for the mistake - we noticed it while listening through. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:11:56

Special Episode: Nicola Twilley & Frostbite

2/3/2026

For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from how they taste to what we eat, refrigeration has dramatically - and quite recently - changed our relationship to food, our health, and the environment. As Nicola Twilley describes in Frostbite: How Refrigeration Changed our Food, Our Planet, and Ourselves, progress, as it so often does, comes at a cost. Twilley, who also cohosts the award-winning food podcast Gastropod, joins us in this week’s TPWKY book club episode to discuss the surprising history and tenuous future of refrigeration. You’ll never look at your fridge the same way again. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:00:03

Ep 199 Sleep Part 2: Predictably unpredictable

1/27/2026

Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to public health guidelines. Why is that? Hypotheses abound, but many point the finger of blame at different aspects of modern society such as screen time, artificial light, a sedentary lifestyle. These narratives suggest that sleep in industrialized societies today is not just different but worse than in centuries past. Is that the truth? How did humans sleep in yesteryear, and what can that tell us about sleep today? In the conclusion to our sleep two-parter, we explore the many ways that humans sleep and the wide array of consequences when we don’t get enough (or too much) of it. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:10:47

Ep 198 Sleep Part 1: Sleeping with one eye open

1/20/2026

Sleep is a universal experience. It’s not just the lion that sleeps tonight - it’s also the butterfly, the chicken, the jellyfish, the dog, the snake, the worm, and of course the human. What is this widespread physiological process whose spell we are all under? What purpose (or purposes) does it serve? Why do we sleep the way we do? These are just some of the questions we’re going to get into in this week’s episode, the first half of our two-parter on sleep. We break down the different components of sleep in humans before diving deep into how animals sleep and what drives the different patterns we see. Night owl or daybird? Light sleeper or deep slumberer? Frequent naps or one big chunk? One eye open or both eyes closed? Tune in as we unravel some of the mysteries of sleep. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:14:00

Special Episode: Daniel Stone & American Poison

1/13/2026

The widespread use of leaded gasoline in the 20th century led to one of the world’s biggest public health and environmental disasters, the effects of which are still present today. Since its development in the 1920s, leaded gasoline has been linked to premature death, cognitive impairment, and behavioral issues in millions around the globe. How was such a toxic substance permitted to be sold, despite the tireless efforts of industrial medicine warriors like Alice Hamilton? In American Poison: A Deadly Invention and the Woman Who Battled for Environmental Justice, award-winning author and historian Daniel Stone tells the story of leaded gasoline - its heroes, its villains, and the lessons we can learn. What will emerge as this generation’s leaded gasoline? PFAS? Microplastics? Something else entirely? History doesn’t have to repeat, but it will unless we heed the lessons of the past. Tune in for a fascinating episode! Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:00:57:32

Ep 197 Detox: Enemas for everyone

1/6/2026

Ah, the new year. After the last month and a half of indulgent food and drink, disrupted schedules, and laying around the house, who doesn’t feel like they’re in need of a whole-body cleanse? There are plenty of companies who are more than happy to provide that product or service that promises to flush away toxins from your skin, gut, blood, brain, you name it. But what exactly are they selling you? In this episode, we explore the deep roots of the ever-expanding detox industry and the concept behind its billions of dollars in revenue: detoxification. What does detoxification even mean? Is there any truth to the claims that a certain diet or superfood or supplement or colonic or drink or enema or chelation therapy can “detoxify” you? Tune in to find out how many synonyms for scam we can come up with. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:16:24

From the Vault - Endometriosis: Menstrual Backwash (Ep 88)

12/30/2025

This episode originally aired on January 11th, 2022. Chances are you know someone with endometriosis, or perhaps you’re affected yourself. But despite its incredibly high prevalence, endo remains almost criminally understudied, undertreated, and underacknowledged. In this episode, we aim to shed light on many aspects of endometriosis, first by examining the “what” and “how” of this disease: what’s actually going on inside your body with endometriosis and how does it cause the symptoms that it does? Then we turn our sights to the why, exploring not only the possible evolutionary origins of this disease but also the deep historical roots contributing to the struggle many people still face today in obtaining a diagnosis. We discuss how although hysteria is no longer a valid medical diagnosis, it has left its mark on medicine in the form of implicit bias that leaves many people feeling unlistened to and unbelieved. We then wrap up the episode with a look at endometriosis by the numbers and some current research that leaves us feeling slightly more hopeful about the growing awareness of this disease and the need for effective treatments. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:02:11:35

From the Vault - Hepatitis B: Hepatiti, Take 2 (Ep 89)

12/23/2025

This episode originally aired on January 25th, 2022. In light of the recent changes by RFK jr’s Advisory Committee on Immunization Practices (ACIP) to eliminate the universal birth dose of the hepatitis B vaccine in the US, a decision which will result in preventable infections and deaths in this country every year, it seems timely to remind everyone of the global consequences of this incredibly prevalent pathogen. This week, we’re dipping a toe back into the vast waters of hepatitis viruses, this time with a focus on hepatitis B. The hepatitis B virus, though second to be named, was first to be discovered, and effective vaccines and treatments have been available for decades. Yet the global prevalence of this virus remains staggering, with nearly 300 million people chronically infected and 1.5 million new infections annually. So what’s going on? In this episode, we weave our way through the complicated biology of this virus and its deadly potential, the strange history of its identification that shows that you don't have to be looking for something to find it, and the current status of this virus that underlines how safe, effective tools for disease prevention are only as good as our delivery infrastructure. We are also so excited to be joined by Dr. Su Wang, Medical Director for the Center for Asian Health & Viral Hepatitis Programs at the Cooperman Barnabas Medical Center and outgoing President of the World Hepatitis Alliance. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:30:51

Ep 196 Health Myths: Fact or fiction?

12/16/2025

Did your grandma ever warn you against going out in the cold with wet hair because “you’ll catch your death”? Or have you ever tossed a few more carrots into your shopping basket in the hope that they’ll improve your vision? There are countless health myths about how to prevent or treat disease, what food will give you superhuman powers or turn your kid into a whirlwind of energy. But is there any truth to them? Let’s find out. In this episode, we review a handful of the most popular health myths, exploring their origins and scouring them for any scrap of truth. Tune in to learn whether these myths are fact, fiction, or somewhere in between! Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:01:06:16

Special Episode: Dr. Homer Venters & Outbreak Behind Bars

12/9/2025

[Content warning: self-harm, suicide, violence] In this day and age, we are equipped with an abundance of tools and knowledge to fight the spread of disease. Yet what good does that toolkit do if we lack the resources or the will to implement it where it is needed? One area of great need is our correctional facilities, our prisons, jails, immigration detention centers, and juvenile detention centers. In these settings, communicable disease is often allowed to spread unchecked, leading to high rates of morbidity and mortality. Meaningful change is needed, but what might that look like? In this week’s TPWKY book club episode, Dr. Homer Venters joins us to discuss his latest work, Outbreak Behind Bars: Spider Bites, Human Rights, and the Unseen Danger to Public Health. As the former Chief Medical Officer of the New York City jail system and through his current role as a federal monitor of health services in several jail and prison settings, Dr. Venters has extensive firsthand knowledge of the barriers that prevent adequate medical care to be delivered to these populations. And he has evidence-based solutions. Tune in for a necessary discussion of this humanitarian crisis. Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:00:55:59

Ep 195 Salt Part 2: The Substance

12/2/2025

We ended last week’s episode on a bit of a cliffhanger: is salt actually bad for us and if so, why does there still seem to be a debate? This week’s episode holds all the answers. We’re sifting through the noise to figure out what salt actually does in our bodies, how it might impact our health, and why we crave this delicious substance. If you’ve ever wondered how we’ve arrived at the maximum daily sodium intake (2300 mg for adults) and why salt impacts blood pressure, then this is the episode for you! Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu See omnystudio.com/listener for privacy information.

Duration:00:53:03