Science Magazine Podcast

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the Church of the Brethren, had an excess of healthy human volunteers. The “Normals” recruited from these Anabaptist churches were surprisingly happy, even as they went through sometimes painful procedures. In this follow-up episode, we hear about how the sources of normal human subjects changed in the 1960s and why NIH researchers felt they needed to expand their search for normal people. We also learn about the first death in the program and the shifting motives on the parts of the researchers and volunteers. Final episode drops next Tuesday, April 21. All Normals episodes In this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Ken Naas, former Normal patient Cindy Jansen, former Normal patient Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People’s History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, freelance science journalist Hannah Richter joins host Sarah Crespi to discuss NASA’s plans to send a nuclear-powered spacecraft to Mars in less than 3 years. Having not launched a fission reactor to space in more than 60 years, the organization faces many technical and bureaucratic hurdles to make that deadline. Next on the show, Aaron Sandel, associate professor in the Department of Anthropology at the University of Texas at Austin and co-director of the Ngogo Chimpanzee Project, reports this week in Science on what looks like a chimpanzee civil war. The unprecedented violent split occurred in a large chimp colony that has been tracked by researchers for decades. Now, scientists are asking: What can the lethal division of a chimp community teach us about human conflict? This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale. It had pretty much everything in place: It had the building, it had recruited all of these amazing researchers—it was the healthy human bodies NIH didn't have. Where it found those volunteers and what happened next is the story of The Normals. Starting on 7 April, the Science Podcast will be releasing a new three-part limited series called The Normals. We'll hear from some of the original “Normals,” follow the program through the decades, and see what's happening with healthy human subject research today. All Normals episodes Appearing in this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People’s History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, a new path to calculating the Hubble constant. This value for the universe’s speed of expansion is typically determined in one of two ways, one favored by cosmologists, the other by astronomers. But the resulting values from these methods are consistently different. Staff Writer Daniel Clery joins host Sarah Crespi to discuss how reappearing bursts from deep space, lensed by gravity, could resolve the dispute over the speed of the expanding universe. Next on the show, freelance producer Elah Feder talks with Mauro Costa-Mattioli, principal investigator at Altos Labs’ Institutes of Science, about tuning the “integrated stress response” (ISR) in mouse brains. The ISR pathway turns off much of protein synthesis in cells as a response to stressors such as viral infections or oxygen deprivation. The ISR is overactive in some models of cognitive dysfunction—suggesting the downregulated protein synthesis may hamper brain functions such as memory formation. In his paper, Costa-Mattioli and colleagues show turning on the ISR pathway causes memory problems in mice and turning off the ISR can restore function in mouse models of Alzheimer’s disease and Down syndrome. Although this research was in mice, it suggests cognitive dysfunction associated with many different disorders may involve the ISR—making it a good therapeutic target. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, Deputy News Editor Martin Enserink talks about so-called resurrection plants. These specialized plants can survive up to 95% water loss, whereas most plants struggle when their water levels dip below 60%. We also hear from Jill Farrant, a professor of molecular and cell biology at the University of Cape Town, about her work dissecting the desiccation survival pathways in resurrection plants and how they might be repurposed to protect crop plants from drought. Next on the show, we’ve all heard of chatbots praising their users for asking the most basic of questions. This bias toward sycophancy extends beyond pleasantries into relationship advice the artificial intelligence (AI) doles out to users. Myra Cheng, a Ph.D. candidate in computer science at Stanford University, joins the show to talk about how this tendency for AIs to be agreeable can lead users to have more confidence in their opinions, to the detriment of their relationships with others. Warning, this last segment contains spoilers for the movie and book Project Hail Mary by Andy Weir. If you’ve seen the movie or don’t mind a bit of extra context, you will hear an analysis of planetary science in the film with astrophysicist and associate curator at the American Museum of Natural History, Jacqueline Faherty. Read the full film review. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, we discuss a finding that’s likely to reignite debate over how humans first spread through the Americas. In the late 1990s, a site in southern Chile called Monte Verde forced archaeologists to adjust their views of the peopling of South America because it dated to about 14,500 years before present, which challenged the prevailing idea of when human inhabitants appeared on the continent. Contributing Correspondent Lizzie Wade joins host Sarah Crespi to discuss new results published in Science that suggest Monte Verde is nowhere near that old. See the paper and related commentary. Next on the show, we talk about groundwater, a vital source of water for both drinking and agriculture that’s often overused and depleted. Producer Meagan Cantwell talks with Scott Jasechko, a professor of water resources with the University of California, Santa Barbara’s Bren School of Environmental Science & Management, about the many different approaches to improving groundwater supplies and what has worked where, which he reviews in this week’s issue of Science. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, freelance journalist Evan Howell traveled to Cape Blossom, Alaska, where the receding coastline has revealed an ancient trove of glacial ice that may have survived for 350,000 years—making it the oldest ice in the Northern Hemisphere. Now researchers just need to figure out how to date it. Next on the show, tracking wolves and ravens in Yellowstone National Park shows the birds don’t follow the wolves in hope of a meal, but instead remember and revisit frequent wolf kill sites. Matthias-Claudio Loretto, assistant professor in the Research Institute of Wildlife Ecology at the University of Veterinary Medicine Vienna, discusses how this might change the way we think about scavengers’ strategies for finding their ephemeral food sources. Finally, Claire Bedbrook, the Helen Hay Whitney and Wu Tsai neuroscience postdoctoral fellow at Stanford University, discusses her work tracking African turquoise killifish over their life span. By capturing behaviors over the course of the fish’s entire lives, her team was able to observe behaviors that could be used to predict whether a fish would live a short or long life. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, a peek into the roiling seas of U.S. science policy. ScienceInsider Editor Jocelyn Kaiser talks about shifting leadership at the National Science Foundation and the Centers for Disease Control and Prevention as well as a dip in funding rates by the National Institutes of Health. Staff Writer Robert F. Service covers proposed restrictions on access by international researchers and students to the National Institute of Standards and Technology. Contributing Correspondent Warren Cornwall talks about the Department of Energy’s rush to loosen radiation exposure standards. Senior International Correspondent Richard Stone discusses why an accusation of nuclear weapons testing in China could spark a new round of weapons testing in the United States and Russia. Next on the show, this year’s children’s book roundup features everything from a look at space law to a clever wartime spider farmer. Senior Editor Valerie Thompson joins host Sarah Crespi to discuss the books and the reviews of them, written by Science staffers (and sometimes their kids). This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, producer Meagan Cantwell talks to Contributing Correspondent Warren Cornwall about his visit to Brazil, where he observed firsthand what it takes for researchers to understand why bird populations in the Amazon and beyond are shrinking. Next on the show, Raouf Belkhir, an M.D.-Ph.D. student at the University of Pittsburgh School of Medicine and Carnegie Mellon University, joins host Sarah Crespi to discuss his Science Advances paper on a newly refined way to map awake patients’ brains during neurosurgery. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, Newsletter Editor Christie Wilcox, Associate Online News Editor Michael Greshko, and intern Perri Thaler share their experiences from the AAAS annual meeting in Phoenix. Christie recorded on location with David Rand regarding his prize-winning Science paper on using a large language model to combat conspiracy theories. Check out the live version of his team’s Debunk Bot. Michael chats with host Sarah Crespi about the foggy outlook of science in the United States as funding levels and graduate positions decline, and the bright sunshine of young students presenting science posters. And finally, Perri shares her reporting on OpenAI’s contribution to theoretical physics announced at the meeting. Next on the show, we hear about the “bouba-kiki” effect—the tendency for people, no matter their language, to associate round shapes with the nonword bouba and spiky shapes with the nonword kiki. Maria Loconsole, a postdoctoral researcher in the Comparative Cognition Lab at the University of Padova, joins the podcast to discuss why her team looked for this effect in freshly hatched chickens. It turns out these baby birds also make these associations, which suggests the effect has less to do with language and more to do with how vertebrate brains are set up to experience the world. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, more than half of all dogs going through service animal training don’t make it to graduation. Producer Kevin McLean journeys with Online News Editor David Grimm to Canine Companions, one of the biggest organizations in the United States for training working dogs. At the facility, they meet puppies in preparation and learn about the behavioral testing and genetics that could be used to improve service animal schooling. Also appearing in this segment: Emily Bray, assistant professor in the College of Veterinary Medicine at the University of Arizona Brenda Kennedy, chief veterinary and research officer at Canine Companions Next on the show, Kishalay De, assistant professor at Columbia University and associate research scientist at the Flatiron Institute, talks about observing the birth of a stellar black hole in the nearby Andromeda galaxy. He recounts how his team looked for this elusive event and describes what we can learn from observing it in the decades to come. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, host Sarah Crespi and Staff Writer Adrian Cho talk football and the latest science behind helmets engineered to reduce head injuries. Have better materials and testing led to fewer concussions and chronic traumatic encephalopathy in players? Next on the show, more than 100,000 people die from opioid overdoses in North America per year. Although much study has gone into addiction research, less attention has been paid to the biological details of overdose itself. John Strang, a professor in the National Addiction Centre at King’s College London, joins the podcast to discuss the questions researchers could be asking about overdose, and how to partner with drug addicted people to find solutions. This week’s episode was produced with help from Podigy. Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, how do we protect astronauts when they leave the shelter of Earth’s protective magnetic fields and face the slow, constant bombardment of space radiation? Freelance science journalist Elie Dolgin joins host Sarah Crespi to discuss what we know about the damage from high-velocity particles and the research being done to curb their biological toll. Next on the show, modeling the fall of fossil fuels during the decarbonization of energy systems, with civil engineer and environmental sociologist Emily Grubert and historian and engineer Joshua Lappen, both at the University of Notre Dame. The pair wrote a policy forum on predicting chokepoints or “minimum viable scales” in the decline of fossil fuel networks—in effect, when a system might get too small to maintain its function. Understanding how to keep things online until they are no longer needed is important to maintain energy for all, as renewables grow and mines, pipelines, and refineries shrink. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up with Jennie Erin Smith, Science’s new senior biomedicine reporter, we delve into: autobrewery syndrome, when microbes inside the human gut make too much alcohol; how doctors can use a public repository, the Mexican Biobank, to guide patient care; and preliminary findings that surgery on the brain’s plumbing shows promise for Alzheimer’s disease. Next on the show, it’s tough to calculate when and where deorbiting spacecraft might enter the upper atmosphere and then eventually hit the ground. Benjamin Fernando, a seismologist and planetary scientist at Johns Hopkins University, has shown that sonic booms created by fast-moving space debris shake seismic sensors, giving clues to angle of re-entry, breakup dynamics, and final location. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, freelance science journalist Sofia Quaglia talks about her visit to the Galápagos archipelago and how researchers there are working to restore the islands to their former ecological glory. Next on the show, Antarctica’s deep ice coating obscures the hills and valleys on its surface, making the continent’s response to climate change one of the biggest unknowns in predicting sea level rise over the next century. Helen Ockenden, a glaciologist at Grenoble Alpes University, joins the podcast to discuss how her team used satellite imagery and the physics of ice flows to fill in the missing details of Antarctica’s subglacial surface. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, scholars are on a quest to find Leonardo da Vinci’s DNA. With no direct descendants, the hunt involves sampling the famous polymath’s papers, paintings, and distant cousins. Contributing Correspondent Richard Stone talks with host Sarah Crespi about what researchers hope to learn from Leonardo’s genes and the new field of “arteomics.” Next on the show, new evidence for poisoned arrows from 60,000 years ago complicates our picture of hunting during the Pleistocene. Sven Isaksson, a professor of archaeological science at Stockholm University, joins the podcast to discuss the discovery of poisonous residues on microliths—the tiny, worked stone points used on arrows and spearheads. These findings could push back the origins of this toxic technology by 50,000 years. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, the best images of exoplanets right now are basically bright dots. We can’t see possible continents, potential oceans, or even varying colors. To improve our view, scientists are proposing a faraway fleet of telescopes that would use light bent by the Sun’s gravity to magnify a distant exoplanet. Staff Writer Daniel Clery joins host Sarah Crespi to discuss where to aim such a magnificent telescope and all the technological pieces needed to put it together. Next on the show, expert voices columnist and Johns Hopkins University mathematician Emily Riehl discusses her recent essay on communication woes in the math community. The complex concepts, jargon, and the slow pace of understanding a proof all add up to siloed subdisciplines and potentially more errors in the literature. Alex Kontorovich, a professor in the math department at Rutgers University, also joins to discuss how proof assistant computer programs and machine learning could help get mathematicians all on the same page. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, Online News Editor David Grimm joins host Sarah Crespi to talk about this year’s best online news stories—top performers and staff picks alike. Together they journey the scientific gamut, from bird feeders’ influence on hummingbird beak evolution to the use of “artificial spacetimes” to guide tiny robots through their environments. Next on the show, a discussion of this year’s pick for Breakthrough of the Year with producer Meagan Cantwell and News editor Greg Miller. They also touch on some other top finds from this year, including the first confirmed Denisovan skull, rice that can beat the heat, custom gene editing, and progress on xenotransplantation. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, we’ve likely only found about half the so-called city-killer asteroids (objects more than 140 meters in diameter). Freelance science journalist Robin George Andrews joins host Sarah Crespi to discuss the upcoming launch of NASA’s Near-Earth Object Surveyor, an asteroid hunter that will improve our ability to look for large objects that might crash into Earth, particularly those hiding in the Sun’s glare. Next on the show, freelancer producer Elah Feder talks with Wendy Valencia-Montoya, an organismic and evolutionary biology Ph.D. candidate at Harvard University, about heated conversations between plants and their pollinators. Her work suggests infrared radiation might be the oldest cue for animals to come hither, more ancient than color. This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

First up on the podcast, Science celebrates 100 years of quantum mechanics with a special issue covering the past, present, and future of the field. News Contributing Correspondent Zack Savitsky joins host Sarah Crespi to talk about a more philosophical approach to quantum physics and the mysterious measurement problem. Next on the show we have Anne Goujon, program director at the International Institute for Applied Systems Analysis in Laxenburg, Austria. She talks about her Expert Voices column on the uncertain future of demography and how the field is grappling with new theories on what happens after the global population peaks. How will different countries deal with falling populations? Will they try to reverse the trend? What are the goals going into the next century? This week’s episode was produced with help from Podigy. About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices