Talking Biotech with Dr. Kevin Folta

In this episode of the Talking Biotech podcast, Dr. Jackie Douglas discusses the emerging field of neoantigens and their significance in cancer immunotherapy. Neoantigens, which are unique to cancer cells, offer a promising target for personalized immunotherapies. The conversation covers the formation of neoantigens, the role of HLA alleles in their presentation, recent advances in research, and various therapeutic strategies being explored. Challenges such as patient response variability and the need for affordable treatments are also highlighted, along with the potential for future developments in the field.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Derek Small, co-founder and CEO of Syndeoo, focusing on the increasing prevalence of neurological disorders and the challenges in developing effective therapies. They discuss the importance of synaptic function in mental health and neurodegenerative diseases, the innovative Boost platform for drug development, and the potential of event-driven pharmacology. The conversation highlights the hope for new treatments in the pipeline for conditions like depression and Alzheimer's disease.

Listener Request! The YouTube channel Veritasium has been recognized by scientists and the public as a great source for scientific information. So what happened in the recent episode? The episode originally entitled "Exposing the Monsanto Conspiracy" attempts to link the historic horrors of Agent Orange and contaminated herbicides with current claims against the herbicide glyphosate. To build the story this science channel relies on horrible sources and poor scholarship to build the illogical conclusion that because a company had a bad past, and anti-biotech activists and money-hungry lawyers build a narrative, then the herbicide must cause cancer. This, despite the overwhelming consensus from independent research and regulatory bodies that says there is no evidence of carcinogenicity at dietary or occupational exposure levels. This episode is designed to help the scientific listener understand the actual evidence and how even traditionally good communications efforts can become vehicles for anti-scientific campaigns.

Anti-vaccination activists, including the US Health and Human Services Secretary, decry the risk of vaccination. In two recently developed vaccines the emerging story is that there is risk in not being vaccinated. Analysis of large data sets shows that over the last 20 years, those vaccinated with the HPV vaccine have a lower incidence of cervical, penile and anal cancers, as they should. But they also show lower incidence of other cancers as well, such as lung, blood and nervous system cancers. The shingles vaccines seem to have protective effects against dementia, heart disease and stroke. All of thse findings suggest that broader vaccination may have public health benefit. More importantly, these may be strategies against vaccine hesitancy, as families don't remember the sourge of polio and measles, but they likely know someone with cancer or dementia. These findings could be a way to nucleate a shift in vaccine perception among evidence deniers.

In this episode of the Talking Biotech podcast, Dr. Andrey Zarur, CEO of Greenlight Biosciences, discusses the innovative applications of RNA technology in agriculture. The conversation covers the challenges of food security, the role of RNA in pest control, and the regulatory advantages of RNA-based products. Dr. Zarur highlights the efficacy and safety of RNA insecticides, fungicides, and herbicides, as well as the company's efforts to address bee health. The discussion also touches on public perception and the importance of transparent communication in biotechnology. 00:00 Introduction to RNA and Its Role in Agriculture 02:02 Challenges in Global Food Production 05:07 The Promise of RNA Technology 10:05 Regulatory Landscape for RNA-Based Solutions 13:52 Stability and Application of RNA Products 18:00 Product Development and Efficacy of RNA Pesticides 19:48 Targeting Specific Pests with RNA Technology 26:51 AI in RNA Design and Future Prospects 30:01 Innovative Approaches to Pest Control 32:41 Targeting Specific Pests with RNA Technology 35:22 Challenges in Regulatory Approval and Public Perception 38:02 Engaging with the Public and NGOs 42:46 Addressing the Varroa Mite Crisis in Beekeeping 49:18 Developing RNA Solutions for Weed Management

Summary In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Robert Tarone, a retired scientist with extensive experience in cancer statistics and experimental design. They discuss the controversial IARC monograph that classified glyphosate as a probable human carcinogen, the flaws in the evaluation process, and the implications of this classification on legal actions against glyphosate manufacturers. Dr. Tarone critiques the evidence used by IARC, emphasizing the lack of credible data linking glyphosate to cancer, and highlights the importance of rigorous scientific methodology in evaluating such claims.

In this episode of the Talking Biotech podcast, Kevin Folta and Dr. David Zaruk discuss the complexities surrounding glyphosate, particularly in light of the IARC Monograph 112 published a decade ago. They explore the implications of the reclassification of glyphosate as a probable carcinogen, the ensuing litigation, influence and corruption, and the ethical concerns regarding scientific integrity. The conversation delves into the role of the media, the influence of litigation finance, and the future of glyphosate in agriculture, emphasizing the need for transparency and evidence-based discussions over jury decisions.

This conversation explores the domestication of pigs, highlighting their importance in human society, the historical evidence of their domestication, and innovative research methods used to study their relationship with humans. Dr. Jiajing Wang from Dartmouth College discusses the significance of dental calculus in elucidaing pig diets and behaviors, as well as the complex interactions between humans and pigs throughout history.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta speaks with Dr. Pascal Geldsetzer about the relationship between the shingles vaccine and dementia. They discuss the prevalence of shingles, the current vaccination rates, and the potential implications of shingles vaccination on cognitive decline. The data come from a clever analysis of public health data that revealed this surprising result. Dr. Geldsetzer shares insights from his research, which suggests that the shingles vaccine may significantly reduce the risk of developing dementia. The conversation also covers the methodology behind the research, findings from various populations, and future directions for further studies in this area.

Summary In this episode of the Talking Biotech Podcast, Kevin Folta speaks with Maria Rodtersman, a Ph.D. candidate at UC Davis, about her research on developing wheat to reduce gluten content, specifically targeting immunogenic proteins that trigger celiac disease. They discuss the significance of wheat as a staple crop, the differences between celiac disease and gluten sensitivity, and the use of radiation-induced mutations, the old-school brute force genetic methods used to create wheat lines with lower immunogenicity. The conversation also covers the challenges of wheat's hexaploid nature, the testing of modified wheat for bread quality and immunogenicity, and the future directions of this research. Bluesky @dubcovskylab.bsky.social‬

The elucidation of DNA's structure led to questions about how it was replicated. Today's Talking Biotech Podcast commemorates the landmark experiments by Dr. Franklin Stahl, who died recently at the age of 95. The experiments have beed described as amont the most elegant in the history of biology, and used a simple test to determine the physical nature of DNA replication. This is a must-know story for the molecular biologist, and a spectacular example of a clever and definitive experiment for anyone that appreciates science.

In this episode of the Talking Biotech Podcast, Dr. Kevin Folta discusses the challenges of misinformation in food science with Dr. Cami Ryan and Connie Dickman. They explore the role of social media and traditional media in spreading misinformation, the difficulties scientists face in communicating effectively, and the importance of peer review and other information-honing strategies to reinforce legitimate claims and de-fuse false information. The conversation emphasizes the need for better communication strategies, building trust with the public, and the necessity of teaching critical thinking and media literacy to consumers.

In this episode of the Talking Biotech Podcast (464) host Dr. Kevin Folta engages with journalist and author Michael Grunwald about his book 'We Are Eating the Earth.' They discuss the complex relationship between food production, climate change, and biotechnology, emphasizing the need for multifaceted solutions rather than single silver bullet approaches. Grunwald shares insights from his journey into understanding food production's impact on the environment, agroecology and regenerative farming, the challenges of public perception regarding biotechnology, and the importance of innovative practices in agriculture. The conversation also touches on the issues of food waste, biofuels, and the necessity for government investment in agricultural research and technology. You can buy Mike's book here: https://www.simonandschuster.com/books/We-Are-Eating-the-Earth/Michael-Grunwald/

In this episode of the Talking Biotech podcast, Dr. Roger Cone discusses the complexities of obesity and eating disorders, emphasizing the role of brain circuits in regulating feeding behaviors. He explains the significance of GLP-1 agonists and melanocortin receptors in developing therapeutic approaches for conditions like obesity, anorexia, and cachexia. The conversation highlights the potential of combining these therapies to enhance treatment efficacy and the implications for public health. But most importantly, the approaches offer potential new therapies to address anorexia and cachexia that may prove to be as effective as GLP1 agonists have been for addressing obesity.

This episode of the Talking Biotech podcast features Dr. Anita Shukla discussing the critical issue of antibiotic resistance and the innovative engineering solutions being explored to combat it. The conversation covers the evolutionary nature of antimicrobial resistance (AMR), the importance of antibiotics in healthcare, and the collaborative efforts of the Engineering Research Visioning Alliance (ERVA) to identify research priorities and strategies. Dr. Shukla emphasizes the need for novel therapeutic approaches, improved drug delivery systems, and the integration of advanced detection methods to address the growing challenge of AMR.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta interviews Dr. Sarah Taber, who shares her journey from agricultural consulting to running for Ag Secretary in North Carolina. It is mostly a story of dedication to changing the norms and changing the rules to benefit more farmers, trying to break deeply entrenched interests to create real change. The conversation explores the challenges facing North Carolina agriculture, the need for innovative ideas to shift from traditional crops to more profitable produce, and the political landscape that influences agricultural policies. Sarah discusses her motivations for running, the strategies she employed during her campaign, and the lessons learned from the experience. The episode concludes with insights on the future of agriculture in North Carolina and advice for aspiring politicians.

In this episode of the Talking Biotech podcast, Dr. Kevin Folta discusses the current state of avian influenza, particularly the H5N1 strain, its history, zoonotic potential, and the implications for both poultry and human health. Into 2025 it was being detected in wild birds,domestic flocks, cattle and humans. Where did it go? He highlights the importance of surveillance, the impact of the virus on domestic poultry production, and the ethical concerns surrounding euthanization methods. Folta also explores potential solutions, including vaccination and transgenic strategies that go unused although they are known to be effective. Finally, what is the status of emergency response? The strategic stockpiles are gone, new mRNA strategies have been defunded. With no desire to protect animals and government policy failing to take precautions to protect humans, an avian influenza pandemic may be devastating. The current situation is discussed.

This episode of the Talking Biotech podcast delves into the evolutionary significance and domestication history of corn (maize). Dr. Kevin Folta hosts a discussion with Regina Fairbanks and Dr. Jeffrey Ross-Ibarra from UC Davis, exploring the traits that enabled maize's domestication, the role of the TGA gene, and the implications for modern breeding. The conversation highlights the importance of understanding maize's genetic diversity and how modern tools may be used to unravel long standing questions about maize domestication.

In this episode of the Talking Biotech podcast, Kevin Folta and Luis Ventura discuss the recent constitutional ban on genetically engineered corn in Mexico. They explore the implications of this regulation, the disinformation surrounding it, and the challenges faced by Mexican farmers. The conversation also touches on the broader impact of this ban on biotechnology in Latin America and the potential economic consequences for trade between Mexico and the United States.

This conversation explores the complex relationship between corn and Mexico, focusing on its cultural, economic, and agricultural significance. The discussion highlights the moratorium on genetically engineered (GM; GMO) corn, the public perception of biotechnology, and the impact of environmental NGOs on policy decisions. The conversation also delves into the perspectives of farmers regarding the need for access to biotechnology and the implications of recent presidential decrees on corn production in Mexico.