Dick Moberg's Neural Network

For the past month, we’ve had the pleasure of getting to know Florian van Leeuwen, a PhD Candidate in Statistics at Utrecht University. Florian’s PhD focuses on prediction models for many different types of complex datasets, but he has specific interests in applying these models to cases of brain injury. We’ve been hosting him in Philadelphia at Moberg Analytics, where he’s been collaborating on assessing the performance of ICP forecasting models, focusing on the use of a pre-trained transformer model for time series data. In this interview, Florian sits down with Dick to discuss what he believes should be the future of neuroscience with specific regards to brain injury and neurocritical care. The two speak on how prediction models can assist clinicians in making difficult decisions regarding individual TBI patients, and how we can make models output more reliable, precise predictions from complex multimodal data sources.

At the Pediatric Academic Societies (PAS) Annual Meeting in 2022, we had the fortune of running into Dr. Mark O'Sullivan, CEO & Co-Founder of NeuroBell, a company developing an innovative medical device that offers portable EEG monitoring, enabling real-time and automated detection of neonatal seizures at the bedside. Tune in to hear about this exciting and impactful technology!

In this conversation, Dick sits down with Dr. Julian Bösel, a Professor of Neurology at University Hospital Heidelberg in Germany. They discuss the differences between European and American neurological institutes, the role of the German Society of Neurocritical Care and Emergency Medicine (DGNI), and the challenges and future of neurocritical care. Tune in for an insightful exploration into the field of neurology!

Dr. Kainerstorfer is using diffuse correlation spectroscopy to tease out non-invasive intracranial pressure in the brain. Her early work at Carnegie Mellon has proven successful. She relates how she got into this field and her journey to Carnegie Mellon.

Brian Appavu, MD, is an assistant professor of neurology at Phoenix Children’s Hospital. He is one of the most active pediatric neurologists in the field of multimodal neuromonitoring. We caught up with Brian at the American Clinical Neurophysiology meeting in Austin, Texas. He talks about what is unique to monitoring EEG in the ICU as opposed to other applications of EEG. Brian also talks about a future that includes a closer merger of epilepsy and neurocritical care.

Debbie Kantor, a nurse practitioner turned entrepreneur, describes her smart bandage for traumatic brain injury. Debbie saw the need for a bandage that could fit on an amputee's stump and came up with a solution. She tells the story of how that invention led to the development of an intelligent bandage for head injuries.

We interview Claudio Menegusso, one of the developers of the Brain4Care Cerebral Compliance Monitor and Dr. Sergio Brasil, a neurosurgeon in Brazil who uses it. At the end of the video we show a detailed demonstration of the device operation as well as the reports it produces.

Dr. Emily Gilmore and Dr. Eric Rosenthal discuss the pioneering ELECTRO-BOOST clinical trial that will look at the relationship between EEG features seen in brain injured patients in the ICU and the patient’s outcome.

Dr. Baruch Ben Dor tells the story of his company and the Infrascanner, a device that non-invasively detects hematomas on the surface of the brain.

We talk with Ryan Myers PhD who has just spun off a company from Vivonics to commercialize their technology for the non-invasive assessment of intracranial pressure.

Jed Hartings PhD and Brandon Foreman MD talk about multimodal neuromonitoring and spreading depolarizations. They discuss the individual paths they took that led to the University of Cincinnati where they helped build one of the premier multimodal monitoring services in the U.S.

⛷️🏔️ Jamie MoCrazy's journey – from being a renowned X Games skier to surviving a devastating crash where her fatality report was filled out in the helicopter to making a full recovery and founding a non-profit for brain injury awareness – is nothing short of inspiring. Jamie has taken her story and experience and leveraged it to start the MoCrazy Strong Foundation, a nonprofit organization dedicated to educating Traumatic Brain Injury (TBI) survivors and their family caregivers on how to build a productive and fulfilling life after brain injury. Through programs, policy, and education, the MoCrazy Strong Foundation focuses on what’s possible for a patient after TBI, regardless of the outcome of their recovery. As Jamie says in this interview, “Every brain injury survivor can create a life they love. […] There’s so much variety [in finding] a way to contribute back to society, and [finding] a way for you to feel like there’s a reason you survived.” ✨🧠 🎥 In this conversation, Jamie and Dick talk about her experience surrounding the crash, the difficulty yet importance of TBI survivors remaining in contact with the TBI world, how TBI survivors can reintegrate with society after their injury, her ongoing efforts to break the stigma around TBI, and the potential for collaboration to improve TBI outcomes. In Jamie’s words, “Every aspect of brain injury, from the initial research to the end result, is so important to the whole picture. […] We definitely need to work more in collaboration […] because we all want the end result to be […] somebody who is not just living, but alive to thrive.” 💙🌎 Tune in for a motivating and uplifting conversation, and check out the links below to learn more about Jamie and contribute to her cause! Thanks for visiting Moberg Analytics and for all that you do, Jamie! ⛷️🌟 – Jamie MoCrazy – Website: https://www.mocrazystrong.org Contact (Email): info@mocrazystrong.org LinkedIn: linkedin.com/🏔-jamie-mocrazy-07b58131 Instagram: https://www.instagram.com/jamiemocraz...

Dr. Balu was an early user of multimodal neuromonitoring and one of the first to manage highly acute neurocritical care patients with the gestalt of monitoring metrics rather than individual thresholds. He relates how we got into this mode of patient management while at the University of Pennsylvania and how he set up a framework for interpreting the data. See the interview on YouTube.

Dick Moberg describes how the pandemic changed his life and set the stage for a new company focusing on the future of neurocritical care informatics. Season 2 resumes this podcast on multimodal neuromonitoring but with a focus on machine learning and informatics.

Dr. Robert Silbergleit, Professor of Emergency Medicine at the University of Michigan Medical School, and Dr. Romer Geocadin, Professor of Neurology at Johns Hopkins, discuss the ICECAP therapeutic hypothermia trial. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Dick's best friend Sheila recounts her experience being in a coma following a traumatic brain injury, while her brother Rick and her doctor Indira de Jesus share their perspectives. Dr. Claude Hemphill explains how the Curing Coma project aims to improve our understanding and treatment of comatose patients. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Dr. Barbara Riegel, Professor at the School of Nursing at the University of Pennsylvania, shares her research on improving self-care for caregivers. Dr. Tom Gillespie gives his firsthand experience on the toll that being a caregiver takes. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Dr. Jens Dreier, a professor in the Department of Neurology at the Charité university hospital in Berlin, discusses how he became involved in spreading depolarization (SD) research and explains the current applications and challenges of recording SDs. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Scott Wilson, founder of Persyst, recounts the unlikely chain of events that led to the founding of the company. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)

Dr. Jean Gotman, known as the father of automated seizure detection, recounts his early efforts to make automated seizure detection widely available. The views and opinions expressed on this podcast do not necessarily reflect those of Moberg Research, Inc. Moberg Research, Inc. makes no clinical claims or recommendations regarding the information described in this podcast. Music from https://filmmusic.io "Wholesome" by Kevin MacLeod (https://incompetech.com) License: CC BY (http://creativecommons.org/licenses/by/4.0/)