The NACE Clinical Highlights Show

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. USDA Dietary Guidelines 2025-2030. Discussion by: Guest: Phillip Leiberman, MD Resident Family Medicine Residency Program Jefferson Health - Abington 2. The Effect of Substituting Wate for Artificially Sweetened Beverages on Glycemic and Weight Measures in People With Type 2 Diabetes: The Study of Drinks With Artificial Sweeteners (SODAS), a Randomized Trial – Diabetes Care 2025. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 3. Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation The DECAF Randomized Clinical Trial – JAMA 2025. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 4. Exercise for the Treatment of Depression. Cochrane Database of Systematic Reviews 2026 Discussion by: Guest: Aaron Sutton - Behavioral Specialist Family Medicine Residency Program Chief Wellness Officer for Graduate Medical Education Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. Candesartan for Migraine Prophylaxies. The Lancet 2025 . Discussion by: Guest: Max Schidt, MD Resident - Family Medicine Residency Program Jefferson Health - Abington 2. One vs two dose HPV vaccination for prevention of HPV infection – The New England Journal of Medicine 2025. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 3. The Surpass CVOT trial for prevention of MACE in people with Diabetes – The New England Journal of Medicine 2025. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 4. The New American Cancer Society Guidelines for Screening for cervical cancer – that includes self swab for HPV. Discussion by: Guest: Amy Clouse, MD Associate Director - Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/responding-to-the-science-biologics-in-practice-in-copd-10511 Summary This enduring podcast activity provides pulmonologists and clinicians managing COPD with timely updates on the evolving role of biologics management. Featuring expert discussions, the program explores recent GOLD guideline revisions, the integration of new and emerging biologic therapies, and evidence-based decision-making based on clinical trial data and real-world practice. Covering guidelines, clinical trials, and clinical scenario, this activity emphasizes the translation of complex data into practical strategies. Learners will gain improved knowledge and competence related to patient selection, eosinophil thresholds, and clinical decision making. This podcast was recorded and is being used with permission of the presenters. Learning Objectives This activity is accredited for CME/CE Credit The National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.25 contact hours (which includes 0.25 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported by an independent medical education grant from GSK and an independent educational grant from Regeneron Pharmaceuticals, Inc and Sanofi. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/personalized-antidepressant-choices-for-better-outcomes-in-mdd-10266 Summary Emphasizing a measurement-based, patient-centered model, this is an enduring podcast/webcast designed for psychiatrists who seek to refine their approach to managing major depressive disorder (MDD). Despite an expanding array of pharmacologic options, many patients continue to experience side effects and residual symptoms that undermine adherence and long-term recovery. Led by Drs. Gregory Mattingly and Gerald Maguire, this activity equips clinicians with evidence-based strategies to compare the nuanced risk–benefit profiles of antidepressants and apply them to individualized treatment plans. This podcast was recorded and is being used with permission of the presenters. Learning Objectives This activity is accredited for CME/CE Credit This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the ACCME to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners® (AANP) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the AANP as an approved provider of nurse practitioner continuing education. Provider number 121222. This activity is approved for 0.75 contact hours (which includes 0.75 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/adhd-sleep-and-symptom-control-10355 Summary Early-morning symptom control remains a critical gap in ADHD management, often contributing to family stress and impaired daily functioning. In this podcast/webcast activity, Dr. Joel Young and Jo Hughes, DMSc, PA-C, CAQ-PSY, explore the limitations of traditional ADHD medications in achieving full-day coverage and discuss available strategies to improve early-morning outcomes. Learners will gain practical insights into the clinical use of nighttime-dosed medications, including an innovative delayed-release/extended-release stimulant, and understand the pharmacologic characteristics that contribute to its efficacy in providing sustained symptom control. This podcast was recorded and is being used with permission of the presenters. Learning Objective Examine This activity is accredited for CME/CE Credit This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the ACCME to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners® (AANP) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the AANP as an approved provider of nurse practitioner continuing education. Provider number 121222. This activity is approved for 0.50 contact hours (which includes 0.50 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported by an educational grant from Collegium Pharmaceutical, Inc. Please visit http://naceonline.com to engage in more live and on demand CME/CE content. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. FDA change in Boxed Warning Label for Hormone Replacement Therapy. Discussion by: Guest: Anupriya Grover Wenk, DO Faculty - Family Medicine Residency Program Jefferson Health - Abington 2. Evolocumab in Patients without a Previous Myocardial Infarction or Stroke – The New England Journal of Medicine 2025. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 3. AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program – JAMA. Discussion by: Guest: Neil Skolnik, MD Professor of Family and Community Medicine Sidney Kimmel Medical College Thomas Jefferson University Associate Director - Family Medicine Residency Program Jefferson Health – Abington 4. Incremental effect of healthy lifestyle habits when taking GLP-1 RA medications on Cardiac Risk Reduction. Discussion by: Guest: Joe Gonella, MD Resident– Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/personalizing-adhd-management-using-methylphenidate-10448 Summary Effective ADHD management demands more than symptom control—it requires personalized treatment strategies aligned with the patient’s unique daily functional needs. Through clinical case examples and pharmacologic comparisons, learners will explore how tailoring treatment using immediate-release (IR), extended-release (ER), and delayed-release/extended-release (DR/ER) methylphenidate (MPH) formulations can optimize symptom control aligned with patients’ daily routines and responsibilities. In this podcast/webcast activity, Joel Young, MD, and Jo Hughes, DMSc, PA-C, CAQ-PSY will highlight practical strategies for implementing personalized ADHD treatment plans, with a focus on the unique benefits of evening-dosed DR/ER-MPH in addressing early-morning and evening functional impairments. This podcast was recorded and is being used with permission of the presenters. Learning Objectives This activity is accredited for CME/CE Credit This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the ACCME to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners® (AANP) through the joint providership of the National Association for Continuing Education (NACE) and GlobalHealthXchange. NACE is accredited by the AANP as an approved provider of nurse practitioner continuing education. Provider number 121222. This activity is approved for 0.50 contact hours (which includes 0.50 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported by an educational grant from Collegium Pharmaceutical, Inc. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults – Annals of Internal Medicine 2025. Discussion by: Guest: Kathryn Donnelly, DO Resident - Family Medicine Residency Program Jefferson Health - Abington 2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Obesity – The New England Journal of Medicine 2025. Discussion by: Guest: Ajay Rau, MD Chief - Section of Endocrinology, Diabetes and Metabolism Lewis Katz School of Medicine at Temple University 3. Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation. New England Journal Of Medicine 2025. Discussion by: Guest: Jasmin Walker, MD Resident – Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity – The New England Journal of Medicine 2025. Discussion by: Guest: Anupryia Grover-Wenk, DO Resident - Family Medicine Residency Program Jefferson Health - Abington 2. Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes. – The New England Journal of Medicine 2025.Discussion by: Guest: Samantha Traslaviña, DO Resident– Family Medicine Residency Program Jefferson Health – Abington 3. Cycling and education intervention versus usual physiotherapy care for the treatment of hip osteoarthritis in the UK (CLEAT): a pragmatic, randomised, controlled trial. Lancet Rheumatology 2025. Discussion by: Guest: Sean Cleary, DO Resident– Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial JAMA 2025. Discussion by: Guest: Philip Lieberman, MD Resident- Family Medicine Residency Program Jefferson Health - Abington 2. Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial. New England Journal of Medicine 2025 Discussion by: Guest: Donna Ryan, MD Professor Emerita at Pennington Biomedical Baton Rouge, LA, USA 3. Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial. Alzheimer’s Research & Therapy. Discussion by: Guest: Kathryn Donnelly, DO Resident– Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/targeting-cause-emerging-therapies-menopausal-vms-10267 Summary This enduring podcast activity explores groundbreaking advancements in the treatment of menopausal vasomotor symptoms (VMS), emphasizing non-hormonal therapies. Dr. Andrea Singer and Dr. Genevieve Neal-Perry discuss the underlying biology of menopause, particularly the role of neurokinin (NK) receptors, and introduces the science behind new therapeutic agents, as well as their clinical trial data. This podcast was recorded and is being used with permission of the presenters. Learning Objective Discuss the clinical trial data for new and emerging non-hormonal therapies This activity is accredited for CME/CE Credit The National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.25 contact hours (which includes 0.25 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported in part by an educational grant from Bayer HealthCare Pharmaceuticals Inc. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit: https://www.mycme.com/courses/personalizing-care-identifying-the-right-patients-for-new-treatments-10268 Summary Dr. Genevieve Neal-Perry and Dr. Andrea Singer focus on practical strategies in the personalized management of menopausal vasomotor symptoms (VMS). The discussion covers the importance of routine and individualized screening for VMS, with attention to healthcare disparities and the diverse ways menopause is discussed and experienced across populations, before covering patient selection criteria for newer non-hormonal treatments. This podcast was recorded and is being used with permission of the presenters. Learning Objectives This activity is accredited for CME/CE Credit The National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The National Association for Continuing Education designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.25 contact hours (which includes 0 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com. Summary of Individual Disclosures Please review faculty and planner disclosures here. Disclosure of Commercial Support This educational activity is supported in part by an educational grant from Bayer HealthCare Pharmaceuticals Inc. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications: 1. Antihypertensive Medication Timing and Cardiovascular Events and Death The BedMed Randomized Clinical Trial JAMA 2025. Discussion by: Guest: Susan Kuchera, MD Director of the Family Medicine Residency Program Jefferson Health - Abington 2. Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy. 2025. Discussion by: Guest: Eden Miller, MD Diabetes and Obesity Specialist Bend, Oregon 3. As-Needed Albuterol–Budesonide in Mild Asthma. The New England Journal of Medicine. Discussion by: Guest: Dylan Selden, MD Resident– Family Medicine Residency Program Jefferson Health – Abington Medical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.