The Pharma Lab Show

Today, we take a different approach on the Pharma Lab show. There are a lot of challenges when it comes to making mixture standards for solid state analytical methods. Simon conducts a live episode where he discusses the different approaches and how to evaluate them. Join us as we discuss: Requirements for the ideal solid state mixture standards Laboratory mixed standards are usually the largest source of error in a method How to evaluate sources of error from measurement apparatus and...

How far is the Pharmaceutical 3D Printing Revolution? In this episode, Simon speaks with Professor Mo Maniruzzaman, Assistant Professor in Pharmaceutics and Drug Delivery Assistant Professor in Pharmaceutics and Drug Delivery, The University of Texas at Austin. They speak about: How he became passionate about 3D printing How far are we from personalized medicine through 3D printing? How will Personalized “Pill Printing” evolve as the industry grows

Crystal structure prediction (CSP) has been a vital part of the mission of XtalPi, an artificial intelligence and quantum physics based pharmaceutical technology company aiming to improve the speed, scale, novelty, and success rate of drug discovery and development. Chandler Greenwell, an applications scientist at XtaPi, shares how CSP is revolutionizing the field. We discuss: How polymorphism relates to CSP Insights that CSP can provide for de-risking the polymorph landscape Future...

Spray drying has become one of the go-to techniques for the manufacture of amorphous dispersions and inhalable formulations due to the ability to control solvent content, morphology, size, and density of the resulting particulates in the dried powder. X-ray computed tomography is a new technique for this spray dried dispersion application. Peter Oberta, Managing Director at Rigaku, co-authored the study on this new approach and he joins the show to explain everything you need to know. We...

For successful rational indexing, you can’t just make a guess and refine. Each unit cell is defined by six parameters, meaning there could be billions of potential solutions. Your probability of being correct is abysmal. Your best approach is to use advanced indexing tools. Machine learning can transform rational indexing from an intellectual challenge into the click of a button. In this episode, Simon Bates , VP of Science and Technology at Rigaku, speaks with us about the problem that...

Pairwise distribution function (PDF) can be a very useful tool for pharmaceutical professionals, especially when characterizing active pharmaceutical ingredients. Using PDF approaches you can confirm — and even solve — the molecular structure itself of new materials that we haven’t been able to properly analyze up until now. In this episode, Simon Bates, VP of Science and Technology at Rigaku, shares why PDF and total diffraction combined together are so powerful in confirming molecular...

X-ray technology has come a long way in the past 20 years. Using x-ray imaging, we can now characterize drug products and solid dosage forms — taking a closer look without the destruction of the drug. In this episode, I talk with Aya Takase, Director of X-ray Imaging at Rigaku Americas Corporation, about how x-ray technology has progressed during her time in the industry and what the future holds. In this episode we discuss: - An overview of x-ray imaging - The multiple use cases of...

Research into the benefits of polymorphs is proceeding at a revolutionary rate. What does the future hold for these exciting prospects and the companies who are investing these innovations? Join Simon Bates, our host for this episode and Business Development Manager at Rigaku Americas Corporation, as he engages in a lively roundtable discussion with six industry experts on the future of polymorphs and current challenges. What we talked about: - Stunning evolutionary advances in the field...

In this episode, a roundtable of distinguished guests discuss the impact and challenges of polymorphism. You’ll hear from these life science and pharmaceutical experts: - Eyal Barash, Life Sciences Patent Attorney and Founder at Barash Law - Steve Byrn, Professor and Dept. Head at Purdue University - Mansoor Khan, Professor and Vice Dean, Presidential Impact Fellow, Rangel College of Pharmacy, Texas A&M University - Ken Morris, University Professor, Director Lachman Institute for...

For this inaugural episode of The Pharma Lab, we wanted to have a detailed discussion around amorphous APIs, why they’re so important, the misconceptions around amorphous materials, and the future of amorphous material development. So we sat down with Dr. Ann Newman, a Pharmaceutical Consultant at Seventh Street Development Group, and Dr. Kenneth Morris, University Professor Emeritus at Long Island University, for a discussion all about: - The differences between amorphous and a...

It’s hard to imagine how new drugs could be developed without appropriate analytical support. This podcast aims to provide it. Rita Richa, Producer at Sweet Fish Media, talks with Simon Bates, the host of the show and Business Development Manager at Rigaku Americas Corporation, and Chris Carolan, Director of Marketing at Rigaku Americas Holding, about what to expect on The Pharma Lab Show. What we talked about: - Understanding the analytical needs of customers - Providing a platform for...