Under the Microscope With Scintica

On this episode, we are featuring Mr. Terry Jordan. Terry is going to tell us a wonderful story filled with a roller coaster of emotions, ups and downs about his life, his journey through battling cancer - being an Iran-Iraq war veteran, and talking about his journey into making music. Listen to Terry's music here: https://open.spotify.com/artist/1BBW38x8aYMr9XnPRXzFaG?si=_ip54dSTTfW8_Idpn6u51A Listen to Check your Poo Today: https://open.spotify.com/track/2tFgDKdJRtCIk1rpuBfolP?si=083ffb3985854c9c Make a donation to Terry's Runners for Research charity: AACR.org/5K/TerryJordan

Welcome to another episode of Under the Microscope with Scintica. On this episode, Tyler talked with Dr. Dhanvantari about her journey in science, learned about her personal life and her current/past projects in the fields of diabetic and cardiac research. She is also involved in the diversity and inclusion group of the world molecular imaging society Dr. Savita Dhanvantari received a B.Sc. in Zoology from the University of Guelph, an M.Sc. in Zoology from Western University, and a Ph.D. in Physiology from the University of Toronto. She carried out her post-doctoral studies at the National Institutes of Health in Bethesda, MD under the supervision of Dr. Y. Peng Loh. In 2002, she joined the Lawson Health Research Institute where she is a scientist in both the Metabolism and Diabetes Program and the Imaging Program. She is also an Assistant Professor in the Department of Medical Biophysics at the University of Western Ontario, and cross-appointed to the Department of Pathology and Laboratory Medicine. Dr. Dhanvantari Research Areas: Development of GLP-1 receptor probes for imaging changes in beta cell mass, Functional molecular imaging of the pancreatic islet, Non-invasive Molecular Imaging of Cancer Growth and Metastasis Using MRI and a Novel Reporter Gene, Molecular Imaging of the pancreatic islet using dual-isotope SPECT/CT, Role of the prohormone convertases in pancreatic alpha cell function, Molecular and cellular mechanisms of the innate immune response in the development of type 1 diabetes

Welcome to another episode of Under the Microscope with Scintica. On this episode, we have two special guests, Dr. Ben Rush & Dr. Jevin Lortie. Dr.Jevin Lortie is currently conducting post-doctoral research at the University of Wisconsin - Madison in the Nutritional Sciences Department. He grew up in the Chicago, Illinois area. He was first introduced to science by experimenting with cooking and baking. His current research involves muscle imaging, gut microbiome, and heart failure. Dr. Ben Rush attended Indiana University Bloomington for his undergrad and masters in public health, where he served as a graduate student researcher. He served two years with the American corps as a personal chef. He later returned to graduate school to obtain his Ph.D. in nutritional sciences where he studied how various body composition and bio-imaging methods can capture muscle quality with the goal to use those methods in lung cancer and aging intervention. Ben is also the founder of the Deeper than Data Podcast where he explores the personal journeys, failures, and successes of scientists through storytelling and humor. Listen to the Deeper than Data Podcast: https://deeperthandata.media/ Listen to other Under the Microscope stories: https://www.scintica.com/under-the-microscope/ Learn more about Scintica: https://www.scintica.com/

Welcome to the final part of the Under the Microscope series with Dr. James Trosko! Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu,[13] could stably inhibit GJIC, while tumor suppressor genes [14], as well as multiple cancer chemo-preventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.) [15-20], and even some chemotherapeutic agents ( Lovastatin ,SAHA) [21, 22], could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC. Learn more about Dr. Trosko: https://integrativebiology.natsci.msu... Check out our other Under the Microscope stories: https://www.scintica.com/under-the-mi... Visit us at www.scintica.com for more information

Welcome to part 3 of the Under the Microscope series with Dr. James Trosko! Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, pthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu,[13] could stably inhibit GJIC, while tumor suppressor genes [14], as well as multiple cancer chemo-preventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.) [15-20], and even some chemotherapeutic agents ( Lovastatin ,SAHA) [21, 22], could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC. Learn more about Dr. Trosko: https://integrativebiology.natsci.msu... Check out our other Under the Microscope stories: https://www.scintica.com/under-the-mi... Visit us at www.scintica.com for more information

Welcome to part 2 of the Under the Microscope with Dr. James Trosko. Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu, could stably inhibit GJIC, while tumor suppressor genes, as well as multiple cancer chemopreventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.), and even some chemotherapeutic agents (Lovastatin ,SAHA), could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC. In this first episode, Dr. Trosko is going to walk us through his amazing journey in science. Learn more about Dr. Trosko: https://integrativebiology.natsci.msu.edu/alumni-and-friends/alumni-profiles/trosko-james-e/ Visit us at www.scintica.com for more information

Welcome to part 1 of the Under the Microscope with Dr. James Trosko. Dr. James Trosko received his Ph.D. in radiation genetics. Later, Dr. Trosko did a postdoctoral fellowship at Oak Ridge National Laboratory (1963-66) under Drs. Ernest Chu, Sheldon Wolf, and Richard B. Setlow in DNA damage/repair and in vitro mutagenesis. He issued the first paper showing that normal human cells could repair their UV-damaged DNA. Moreover, He was highlighted on the cover of Cancer Research as one of the researchers who linked gap junctions to the carcinogenesis process. He created the term, “epigenetic toxicology”, after showing that most of the toxic chemicals in the environment (TCDD, PBB, PCB, DDT, Dieldrin, Adrin, toxaphene, phthalates, PFOA, etc.) were (a) not genotoxic and (b) could inhibit GJIC, reversibly at non-cytotoxic concentrations. Also, his lab discovered that oncogenes, such as src, ras, raf, neu, could stably inhibit GJIC, while tumor suppressor genes, as well as multiple cancer chemopreventive agents ( green tea components, caffeic acid ethyl ester, genistein, beta-sitosterol, resveratrol, retinoids, carotinoids, kaempherol, etc.), and even some chemotherapeutic agents (Lovastatin ,SAHA), could either prevent the inhibition of GJIC by tumor promoters or increase GJIC in tumor cells, deficient in GJIC. In this first episode, Dr. Trosko is going to walk us through his amazing journey in science. Learn more about Dr. Trosko: https://integrativebiology.natsci.msu.edu/alumni-and-friends/alumni-profiles/trosko-james-e/ Visit us at www.scintica.com for more information

Dr. Anand Narayanan has an interdisciplinary background in engineering, biology, and physiology, with specialized training in cardiovascular sciences, in lymphatics while at Texas A&M University and in heart and blood vascular adaptations now at Florida State University, having also studied cardiovascular-coupled organ system adaptations including cerebral, musculoskeletal, and gastrointestinal physiology. He has more than 10 years of physiology and immunology experience, in various research areas including auto-immune conditions, old age, exercise training, etc. His current research focuses on the interaction between the immune system and how it affects cardiovascular physiology.

Dr. Young's current research area is the neurobiology and biophysics of sensory systems, and particularly audition, in reptiles. Audition in this group is remarkably diverse, including pressure-coupled tympani in some taxa; tympanic and non-tympanic ears; elaborate stapedial dampening systems; separate low-frequency and high-frequency auditory pathways; as well as integration with pressure and/or vibration detection systems. A second area of research is the neurobiology of venom secretion, storage, and activation.

Kristine Deleon – Pennell, PhD Dr. DeLeon-Pennell was trained in cardiovascular sciences at Baylor University, University of Texas Health Science Center San Antonio, and the University of Mississippi Medical Center. She has >10 years’ experience with all aspects of the inflammatory and fibrotic components of cardiac remodeling following myocardial infarction (MI). In particular, she has extensive training in matrix metalloproteinase (MMP) biology, extracellular matrix remodeling, and cardiac aging research.