Medscape InDiscussion: Moderate to Severe Asthma

When is it time to send a child with an asthma exacerbation to the emergency department? Join Drs Michael Wechsler and Todd Florin as they discuss. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987117). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview Pediatric Asthma https://emedicine.medscape.com/article/1000997-overview Medscape InDiscussion: Pediatric Pneumonia Podcast https://www.medscape.com/viewarticle/987058 Medscape InDiscussion: Team Effort: A Multidisciplinary Approach to Severe Asthma Control https://www.medscape.com/viewarticle/969689 Medscape InDiscussion: Challenges and Opportunities: Treatment and Prevention of Moderate to Severe Childhood Asthma https://www.medscape.com/viewarticle/969691 Medscape InDiscussion: Emergency! Managing Asthma in the ER https://www.medscape.com/viewarticle/987112 CDC Asthma National Data https://www.cdc.gov/asthma/most_recent_national_asthma_data.htm Pediatric Acute Asthma Scoring Systems: A Systematic Review and Survey of UK Practice https://pubmed.ncbi.nlm.nih.gov/33145551/ PRAM Score for Pediatric Asthma Exacerbation Severity https://reference.medscape.com/calculator/534/pram-score-for-pediatric-asthma-exacerbation-severity Pediatric Asthma Severity Score Is Associated With Critical Care Interventions https://pubmed.ncbi.nlm.nih.gov/28224093/ Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department (IMPACT-ED): Protocol for a Multicenter Pilot Randomized Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391520/ The Pulmonary Index Score as a Clinical Assessment Tool for Acute Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/21130379/ Mechanisms of Hypoxemia https://pubmed.ncbi.nlm.nih.gov/28144061/ Role of Inhaled Corticosteroids for Asthma Exacerbation in Children: An Updated Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/33013097/ 2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://pubmed.ncbi.nlm.nih.gov/33280709/ Pneumonia in Children Presenting to the Emergency Department With an Asthma Exacerbation https://pubmed.ncbi.nlm.nih.gov/27270612/ Bronchiolitis https://emedicine.medscape.com/article/961963-overview Croup https://emedicine.medscape.com/article/962972-overview

Join Drs Michael Wechsler and Ian D. Pavord as they discuss the future of asthma care. Where will we be in 5 or even 10 years from now? What breakthroughs are on the horizon? Tune in to find out. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987116). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview Type 2 Inflammation in Asthma and Other Airway Diseases https://pubmed.ncbi.nlm.nih.gov/35923421/ Considering Biomarkers in Asthma Disease Severity https://pubmed.ncbi.nlm.nih.gov/34942235/ Epithelial Cell Alarmin Cytokines: Frontline Mediators of the Asthma Inflammatory Response https://pubmed.ncbi.nlm.nih.gov/36311787/ Targeting TSLP in Asthma https://pubmed.ncbi.nlm.nih.gov/35685846/ The Immunomodulatory Effects of Macrolides-A Systematic Review of the Underlying Mechanisms https://pubmed.ncbi.nlm.nih.gov/29593707/ NICE (National Institute for Health and Care Excellence) https://www.nice.org.uk/ Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://pubmed.ncbi.nlm.nih.gov/33242697/ Mechanisms of Non–Type 2 Asthma https://pubmed.ncbi.nlm.nih.gov/33160187/ Effect of Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma (AMAZES): A Randomised, Double-blind, Placebo-Controlled Trial https://pubmed.ncbi.nlm.nih.gov/28687413/ Bronchial Thermoplasty https://emedicine.medscape.com/article/2094272-overview PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network https://preciseasthma.org/preciseweb/ KIT Inhibition by Imatinib in Patients With Severe Refractory Asthma https://pubmed.ncbi.nlm.nih.gov/28514613/ JAK Inhibitors for Asthma https://pubmed.ncbi.nlm.nih.gov/34625142/ Optimizing Asthma Management: Role of Long-Acting Muscarinic Antagonists https://pubmed.ncbi.nlm.nih.gov/35933228/ Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy (FF/UMEC/VI) Versus FF/VI in Patients With Inadequately Controlled Asthma (CAPTAIN): A Double-blind, Randomised, Phase 3A Trial https://pubmed.ncbi.nlm.nih.gov/32918892/ Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes https://pubmed.ncbi.nlm.nih.gov/35549845/ Claude Bernard, the Founder of Modern Medicine https://pubmed.ncbi.nlm.nih.gov/35626738/

Join Drs Mike Wechsler and Anthony Gerber as they discuss how rapid advances in technology are changing asthma management. What's working? What's not? Tune in to find out. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987115). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective https://pubmed.ncbi.nlm.nih.gov/34379316/ Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management https://pubmed.ncbi.nlm.nih.gov/31706485/ Apps for Asthma Self-Management: A Systematic Assessment of Content and Tools https://pubmed.ncbi.nlm.nih.gov/23171675/ Effectiveness of a Digital Inhaler System for Patients With Asthma: A 12-Week, Open-Label, Randomized Study (CONNECT1) https://pubmed.ncbi.nlm.nih.gov/36038131/ Artificial Intelligence: Exploring the Future of Innovation in Allergy Immunology https://pubmed.ncbi.nlm.nih.gov/37160554/

The field of asthma genetics and pharmacogenetics is rapidly evolving. What does that mean for patients experiencing asthma? Join Drs Michael Wechsler and Benjamin Raby as they discuss. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987114). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy https://pubmed.ncbi.nlm.nih.gov/31178722/ The Human Genome Project https://www.genome.gov/human-genome-project Methacholine Challenge Test https://www.ncbi.nlm.nih.gov/books/NBK547716/ Obesity and Asthma https://pubmed.ncbi.nlm.nih.gov/33032723/ The Cytokines of Asthma https://pubmed.ncbi.nlm.nih.gov/30995510/ Bronchial Allergen Challenge of Patients With Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa https://pubmed.ncbi.nlm.nih.gov/30185520/ ORMDL3 and Allergic Asthma: From Physiology to Pathology https://pubmed.ncbi.nlm.nih.gov/31376405/ New Insights Relating Gasdermin B to the Onset of Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/35580164/ Hereditary and Acquired Ichthyosis Vulgaris https://emedicine.medscape.com/article/1112753-overview The Role of Filaggrin in Atopic Dermatitis and Allergic Disease https://pubmed.ncbi.nlm.nih.gov/31622670/ Precision Medicine in Childhood Asthma https://pubmed.ncbi.nlm.nih.gov/30649013/

Join Drs Mike Wechsler and Mario Castro as they discuss the diagnosis and treatment of allergic asthma in the clinic. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987113). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Asthma: A Syndrome Composed of Heterogeneous Diseases https://pubmed.ncbi.nlm.nih.gov/18681077/ Allergic Endotypes and Phenotypes of Asthma https://pubmed.ncbi.nlm.nih.gov/32037107/ Comorbidities and the Impact of Atopic Dermatitis https://pubmed.ncbi.nlm.nih.gov/31034875/ Biomarkers for Diagnosis and Prediction of Therapy Responses in Allergic Diseases and Asthma https://pubmed.ncbi.nlm.nih.gov/32893900/ 2023 GINA Report for Asthma https://pubmed.ncbi.nlm.nih.gov/37302397/ Pulmonary Function Testing in the Diagnosis of Asthma: A Population Study https://pubmed.ncbi.nlm.nih.gov/22030804/ Using Fractional Exhaled Nitric Oxide Measurement in Clinical Asthma Management https://pubmed.ncbi.nlm.nih.gov/34673021/ 2020 NAEPP Guidelines Update and GINA 2021-Asthma Care Differences, Overlap, and Challenges https://pubmed.ncbi.nlm.nih.gov/34718214/ Understanding the Key Issues in the Treatment of Uncontrolled Persistent Asthma With Type 2 Inflammation https://pubmed.ncbi.nlm.nih.gov/33542055/ 2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://pubmed.ncbi.nlm.nih.gov/33280709/ Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy: A Randomized Trial https://pubmed.ncbi.nlm.nih.gov/21536936/ Dupilumab Efficacy in Patients With Uncontrolled, Moderate-to-Severe Allergic Asthma https://pubmed.ncbi.nlm.nih.gov/31521831/ Efficacy of Tezepelumab in Patients With Evidence of Severe Allergic Asthma: Results From the Phase 3 NAVIGATOR Study https://pubmed.ncbi.nlm.nih.gov/36507576/ The Evolving Landscape of Immunotherapy for the Treatment of Allergic Conditions https://pubmed.ncbi.nlm.nih.gov/37170653/ Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf

Join Drs Mike Wechsler and Josh Kosowsky as they work through the management of a patient presenting with moderate to severe asthma in the ER. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987112). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview National Center for Health Statistics - Asthma https://www.cdc.gov/nchs/fastats/asthma.htm Beta2-Agonists https://www.ncbi.nlm.nih.gov/books/NBK542249/ Noninvasive Ventilation Procedures https://emedicine.medscape.com/article/1417959-overview The Use of Heliox in Critical Care https://pubmed.ncbi.nlm.nih.gov/25024941/ High-Flow Nasal Cannula: A Promising Oxygen Therapy for Patients With Severe Bronchial Asthma Complicated With Respiratory Failure https://pubmed.ncbi.nlm.nih.gov/32211084/ Anti-IL-5 Therapies for Asthma https://pubmed.ncbi.nlm.nih.gov/35838542/ Recent Advances in the Inhibition of the IL-4 Cytokine Pathway for the Treatment of Allergen-Induced Asthma https://pubmed.ncbi.nlm.nih.gov/34948449/ Targeting TSLP in Asthma https://pubmed.ncbi.nlm.nih.gov/35685846/ National Hospital Ambulatory Medical Care Survey: 2020 Emergency Department Summary Tables https://www.cdc.gov/nchs/data/nhamcs/web_tables/2020-nhamcs-ed-web-tables-508.pdf FDA Approves Drug Combination Treatment for Adults With Asthma https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-combination-treatment-adults-asthma

Drs Wechsler, Bacharier, and Phipatanakul discuss moderate to severe childhood asthma. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969691). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources: Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network https://preciseasthma.org/preciseweb/ Inhaled Corticosteroid Therapy in Children: An Assessment of the Potential for Side Effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC475319/pdf/thorax00304-0005.pdf Inhaled Corticosteroids in Children: Effects on Bone Mineral Density and Growth https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(14)70024-4 Aerochamber https://aerochamber.com/ Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview Using Impulse Oscillometry in Clinical Practice https://www.medscape.com/viewarticle/862265 Global Initiative for Asthma Guidelines https://ginasthma.org/ National Asthma Education Prevention Program Guidelines https://www.nhlbi.nih.gov/health-topics/asthma-management-guidelines-2020-updates Omalizumab Prescribing Information https://www.gene.com/download/pdf/xolair_prescribing.pdf Mepolizumab Prescribing Information https://gskpro.com/content/dam/global/hcpportal/en_US/Prescribing_Information/Nucala/pdf/NUCALA-PI-PIL-IFU-COMBINED.PDF Benralizumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/3647bed4-ce91-4fe7-9bc5-32dbee73f80a/3647bed4-ce91-4fe7-9bc5-32dbee73f80a_viewable_rendition__v.pdf Dupilumab in Children With Uncontrolled Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2106567 Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf Tezepelumab Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/e306dc06-d580-4457-b15f-9f28545ad63a/e306dc06-d580-4457-b15f-9f28545ad63a_viewable_rendition__v.pdf Preventing Asthma in High Risk Kids (PARK) With Omalizumab: Design, Rationale, Methods, Lessons Learned and Adaptation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887056/

What are the social and environmental determinants of asthma? Drs Wechsler, Cardet, and Kraft have a wide-ranging discussion about the science, publications, and their experience as clinicians. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969690). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview The School Inner-City Asthma Intervention Study: Design, Rationale, Methods, and Lessons Learned https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557648/ 2020 Focused Updates to the Asthma Management Guidelines: A Report From the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group https://www.jacionline.org/article/S0091-6749(20)31404-4/fulltext Allergic and Environmental Asthma https://emedicine.medscape.com/article/137501-overview Comparing Asthma Treatments: A Study Focusing on African-American, Hispanic, and Latino Adults -- The PREPARE Study for PeRson EmPowered Asthma Relief https://www.pcori.org/research-results/2016/comparing-asthma-treatments-study-focusing-african-american-hispanic-and-latino-adults-prepare-study-person-empowered-asthma-relief Percentage of People With Asthma Who Smoke https://www.cdc.gov/asthma/asthma_stats/people_who_smoke.htm Associations Between Historical Residential Redlining and Current Age-Adjusted Rates of Emergency Department Visits Due to Asthma Across Eight Cities in California: An Ecological Study https://linkinghub.elsevier.com/retrieve/pii/S2542-5196(19)30241-4 Socioeconomic Status and Asthma Control in African American Youth in SAGE II https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257058/ Combatting the Health Consequences of Poverty and Stress https://www.hsph.harvard.edu/news/magazine/fall09wrights/ Designing Clinical Trials to Address the Needs of Childhood and Adult Asthma: The National Heart, Lung, and Blood Institute's AsthmaNet https://www.jacionline.org/article/S0091-6749(13)01638-2/fulltext AsthmaNet Best African American Response to Asthma Drugs (BARD) https://biolincc.nhlbi.nih.gov/studies/asthmanet_bard/ Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899291/ Primary Adherence to Controller Medications for Asthma Is Poor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342835/ Asthma and African Americans https://minorityhealth.hhs.gov/omh/browse.aspx?lvl=4&lvlid

Drs Wechsler and Jackson discuss their partnerships with nurses, asthma educators, psychologists, speech therapists, and other specialists when diagnosing and treating patients with severe asthma. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969689). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Asthma https://emedicine.medscape.com/article/296301-overview Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma https://jamanetwork.com/journals/jama/fullarticle/2598265 Churg-Strauss Disease https://emedicine.medscape.com/article/1178795-overview Aspergillosis https://emedicine.medscape.com/article/296052-overview Chronic Obstructive Pulmonary Disease (COPD) https://emedicine.medscape.com/article/297664-overview Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview#a9 Esophageal Manometry https://emedicine.medscape.com/article/1891791-overview Obstructive Sleep Apnea (OSA) https://emedicine.medscape.com/article/295807-overview Granulomatosis With Polyangiitis (GPA, formerly Wegener Granulomatosis) https://emedicine.medscape.com/article/332622-overview Anti-IL–5 Therapy in Patients With Severe Eosinophilic Asthma https://www.medscape.com/viewarticle/900560 Strongyloidiasis Infection FAQs https://www.cdc.gov/parasites/strongyloides/gen_info/faqs.html

Drs Wechsler and Akuthota discuss novel therapies in severe asthma treatment, including precision medicine, biomarkers, and new biologic agents. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969688). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Omalizumab https://reference.medscape.com/drug/xolair-omalizumab-343444 Mepolizumab https://reference.medscape.com/drug/nucala-mepolizumab-1000034 Bronchial Thermoplasty https://emedicine.medscape.com/article/2094272-overview Eosinophilic Asthma and Sputum Eosinophilia https://www.webmd.com/asthma/eosinophilic-asthma-defined Role of T2 Inflammation Biomarkers in Severe Asthma https://reference.medscape.com/medline/abstract/26574724 Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry https://linkinghub.elsevier.com/retrieve/pii/S2213-2198(21)00311-1 Dupilumab Prescribing Information https://www.regeneron.com/downloads/dupixent_fpi.pdf FDA Approves Cinqair to Treat Severe Asthma https://www.fda.gov/news-events/press-announcements/fda-approves-cinqair-treat-severe-asthma Benralizumab https://reference.medscape.com/drug/fasenra-benralizumab-1000213 Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) https://emedicine.medscape.com/article/333492-overview Hypereosinophilic Syndrome https://emedicine.medscape.com/article/202030-overview Anti-IL-5 Therapy in Patients With Severe Eosinophilic Asthma – Clinical Efficacy and Possible Criteria for Treatment Response https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-018-0689-2 Mepolizumab for Severe Eosinophilic Asthma (DREAM): A Multicentre, Double-blind, Placebo-Controlled Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60988-X/fulltext Allergic and Environmental Asthma https://emedicine.medscape.com/article/137501-overview FDA Approves Maintenance Treatment for Severe Asthma https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-maintenance-treatment-severe-asthma Tezepelumab in Adults and Adolescents With Severe, Uncontrolled Asthma https://www.nejm.org/doi/full/10.1056/NEJMoa2034975 Efficacy and Safety of Itepekimab in Patients With Moderate-to-Severe Asthma https://www.nejm.org/doi/10.1056/NEJMoa2024257 The Targeted Eosinophil-Lowering Effects of Dexpramipexole in Clinical Studies https://www.sciencedirect.com/science/article/abs/pii/S107997961630328X CRTH2 Antagonists in Asthma: Current Perspectives https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733922 Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) https://preciseasthma.org/preciseweb/ A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype https://clinicaltrials.gov/ct2/show/NCT04718389

Drs Michael Wechsler and Mario Castro discuss precision medicine for moderate to severe asthma and the past, present, and future of clinical trials. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969686). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals. Resources Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE) Network https://preciseasthma.org/preciseweb/ Asthma https://emedicine.medscape.com/article/296301-overview The Many 'Buckets' of Severe Asthma: Moving Toward Personalized Managements https://www.jaci-inpractice.org/article/S2213-2198(17)30379-3/pdf What is Fractional Exhaled Nitric Oxide (FeNO) in Pulmonary Function Testing?https://www.medscape.com/answers/303239-77907/what-is-fractional-exhaled-nitric-oxide-feno-in-pulmonary-function-testing Periostin is a Systemic Biomarker of Eosinophilic Airway Inflammation in Asthmatic Patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626285/ Asthma Workup Approach Considerations https://emedicine.medscape.com/article/296301-workup PrecISE: Precision Medicine in Severe Asthma: An Adaptive Platform Trial With Biomarker Ascertainment https://www.jacionline.org/article/S0091-6749(21)00352-3/fulltext KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma https://www.nejm.org/doi/full/10.1056/NEJMoa1613125 PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study https://clinicaltrials.gov/ct2/show/NCT04129931 Designing Clinical Trials to Address the Needs Of Childhood And Adult Asthma: The National Heart, Lung, and Blood Institute's AsthmaNet https://www.jacionline.org/article/S0091-6749(13)01638-2/pdf Severe Asthma Research Program http://www.severeasthma.org/ Airways Clinical Research Centers https://www.lung.org/research/airways-clinical-research-centers Lung Health Cohort Study: Making History https://www.lung.org/research/lung-health-cohort-study

Listen in as Drs Michael Wechsler and Geoffrey Chupp discuss real-world examples of how they use precision medicine in their own clinics to treat moderate to severe asthma. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/969685). The topics and discussions are planned, produced, and reviewed independently of the advertiser. This podcast is intended only for US healthcare professionals. Resources Theophylline (Rx) https://reference.medscape.com/drug/theo-24-theochron-theophylline-343447 Merged Affinity Network Association Clustering: Joint Multi-Omic/Clinical Clustering to Identify Disease Endotypes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195153/ How Is the Type 2 (T2 High) Subtype of Asthma? https://www.medscape.com/answers/137501-198413/how-is-the-type-2-t2-high-subtype-of-asthma Targeting Interleukins to Treat Severe Asthma https://www.medscape.com/viewarticle/771133_4 Asthma Workup https://emedicine.medscape.com/article/296301-workup ImmunoCAP for IgE-Mediated Hyperreactivity Analysis https://www.bioagilytix.com/immunocap-platform-for-immunogenicity-testing/ Bronchiectasis https://emedicine.medscape.com/article/296961-overview T-Helper Type 2–Driven Inflammation Defines Major Subphenotypes of Asthma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742757/ Efficacy and Safety of Tralokinumab in Patients With Severe Uncontrolled Asthma: A Randomised, Double-blind, Placebo-Controlled, Phase 2b Trial https://linkinghub.elsevier.com/retrieve/pii/S2213-2600(15)00197-6 Mepolizumab for Prednisone-Dependent Asthma With Sputum Eosinophilia https://www.nejm.org/doi/full/10.1056/nejmoa0805435 Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma https://www.nejm.org/doi/full/10.1056/nejmoa0808991 Effect of Azithromycin on Asthma Exacerbations and Quality of Life in Adults With Persistent Uncontrolled Asthma (AMAZES): A Randomised, Double-blind, Placebo-Controlled Trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31281-3/fulltext A Randomized, Open-Label, Pragmatic Study to Assess Reliever-Triggered Inhaled Corticosteroid in African American/Black and Hispanic/Latinx Adults With Asthma: Design and Methods of the PREPARE Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130188/ PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study https://clinicaltrials.gov/ct2/show/NCT04129931