The Joe Cohen Show

In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues. Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin. He concludes by weighing the pros and cons of AKG. Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we delve into the pivotal role of the BHMT gene within the body's methylation process. We discuss how the BHMT enzyme is essential for catalyzing a vital reaction that transforms homocysteine into methionine. Additionally, we cover the importance of betaine in enhancing the methylation cycle. Betaine acts as a methyl donor, particularly in the reaction facilitated by the BHMT enzyme, making it crucial for reducing homocysteine levels and supporting cardiovascular and neurological health. We also explore the complexity of methylation pathways and emphasize the need for a comprehensive evaluation of multiple genes to truly understand and optimize methylation. Be sure to follow our podcast for more expert insights into how betaine, methylation, and genetics can be leveraged to optimize both body and brain health. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease. Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels. Joe draws on personal experiences to compare the negatives against the significant positives of niacin, as he explores niacin's biochemical effects, particularly its interaction with proteins such as 2PY, 4PY, and VCAM1, all linked to cardiovascular health. Throughout the episode, Joe examines the importance of dosage, sharing insights into the varying effects of low versus high doses of niacin. Join Joe as he navigates the complexities of niacin use, advocating for a well-informed, nuanced approach to its benefits and risks. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making. Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders. The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions. Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety. If you're interested in learning more about how your DNA and genetics affect your health: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe takes questions from SelfDecode members, answering questions like: What makes SelfDecode different from other DNA companies? How does the recommendations engine work? Can you find out if a certain supplement is right for you? Plus, he shares some of his genetic predispositions and how they correlate with his lab levels! - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1. We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators. Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups. We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

This episode was originally published on April 12, 2015. Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry. They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold exposure, water quality, and the necessity of questioning mainstream nutritional advice. Next, they focus on aligning with nature's design through sunlight exposure, understanding electron flow, optimizing DHA intake, and reducing exposure to non-native EMFs. These conversations aim to encourage curiosity over conforming, urging listeners to consider the interconnectedness of their biology with their environment in the pursuit of optimal health. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters. Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition. We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health. From increased breakdown linked to mood disorders to decreased activity associated with elevated neurotransmitter levels, we unravel the complex interplay between genes and mental well-being. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe dives into the world of personalized wellness with Lauren Sambataro and Renee Belz, known as The Biohacker Babes. With roots in wellness and holistic dentistry, The Biohacker Babes bring their wealth of expertise as health entrepreneurs, nutritional consultants, and holistic lifestyle coaches to the table. In this enlightening conversation, we explore the pivotal role of lab testing in crafting personalized health regimens, emphasizing essential tests such as CBC, CMP, and functional lab tests. The Biohacker Babes also dive into the complexities of hormone regulation, genetic predispositions, and the profound impact of stress, diet, and environment on overall health, as well as discuss advanced testing methodologies including organic acids tests, the GI MAP test, and the Dutch test, designed to fine-tune health interventions for maximum effectiveness. Join us as we navigate the landscape of personalized wellness with the Biohacker Babes, unlocking the secrets to a vibrant, thriving life. - Visit https://thebiohackerbabes.com/ - Check out @biohacker_babes on Instagram - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (1:10) - Important lab tests for Biohacker Babes (5:45) - Digestion (10:30) - Amino acids (15:09) - Analyzing Joes biochemistry (22:47) - Heavy metals testing (29:52) - CGM & HRV (41:57) - Epigenetic aging tests (44:42) - Continuing with digestion (51:55) - Food sensitivities (55:01) - GI Mapping

In this episode of The Joe Cohen Show, we dive deep into the world of dopamine. We'll be focusing on the role of genetics, specifically the DRD2 gene, in regulating dopamine levels and how it affects your brain's reward system, motivation, and susceptibility to addiction. Here's what you can expect to learn: How the DRD2 gene influences dopamine D2 receptors and their impact on pleasure-seeking behaviors. Understanding the variants of the DRD2 gene and its link to dopamine receptor. How genetics can affect motivation, reward processing, and potentially lead to a dopamine imbalance. The importance of maintaining balanced dopamine levels for optimal cognitive function. Join us as we explore the fascinating world of dopamine and genetics! If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Join us for an enlightening roundtable discussion featuring health experts Joe Cohen, Kris Gethin, Tim Gray, and Siim Land as they dive deep into the world of health optimization. In this episode, our expert panel explores a wide range of health tests and biomarkers, from basic to advanced, and what they mean for your health, including VO2 max assessments, heart rate variability, full-body MRI scans, gut microbiome analysis, and food sensitivity testing. We also discuss topics like EMF and heavy metal sensitivity, shedding light on how these factors can impact overall health. Get exclusive insights into the advanced wellness center AIWO and its groundbreaking solutions, and discover how AIWO's cutting-edge approach is revolutionizing health and wellness. But it's not just about theory—our panelists also share their personal experiences and tips gained throughout their own health journeys. From overcoming obstacles to achieving peak performance, they provide actionable advice to help you optimize your health and live your best life. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) Introduction (00:21) The AIWO Experience (47:31) Heart Rate Variability (53:11) VO2 max (56:22) Joe's Favorite Supplement for Recovery (58:39) Sound changes here (01:05:33) EMF & Heavy Metal Sensitivity (01:13:29) Digestive Enzymes (01:20:22) Kris' Top Health Hack

Love is in the air as we dive into the science behind relationships. In this episode, we explore the fascinating world of oxytocin, affectionately known as the "love hormone," and its connection to the OXTR gene. Responsible for encoding the oxytocin receptor, this gene plays a crucial role in shaping our social bonds, empathy levels, and even cognitive abilities. We discuss groundbreaking research, including the 'happy marriage study,' which unveils intriguing insights into how our genetic variations may influence our relationship dynamics. We uncover how oxytocin, influenced by the OXTR gene, extends beyond social bonding, playing a pivotal role in enhancing cognitive functions. Could our brain development be intricately tied to our social interactions? Join us on this journey through the science of love and genetics. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose. Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques. The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging. Amitay also delves into the science of skin renewal, the role of vitamins and metabolites in skin health, and offers practical advice on creating an effective skincare regimen tailored to individual needs and skin types. - Use code “SELFDECODE” for 10% off younggoose.com - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions. Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns. Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a night owl, as well as its influence on sleep disorders and mood. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine. Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes. Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels. They provide invaluable insights into personalized supplements tailored to address individual genetic predispositions and health needs. Explore the latest advancements in methylation and homocysteine management, and discover actionable strategies for promoting longevity and optimal well being. - Visit @drbenlynch on Instagram - Use code "SelfDecode10" to get 10% off seekinghealth.com If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠ Timestamps: (0:00) - Intro (1:09) - State of the genetics industry (20:07) - MTHFR and methylation (1:04:59) - Is overmethylating real? (1:12:06) - Riboflavin and other B vitamins (1:18:06) - How many supplements does Ben take a day? (1:31:54) - Epigenetics and other alternative tests

In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life. But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years? We uncover the research behind this startling revelation and discuss the implications for our health and well-being. Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better longevity. If you're interested in learning more about how your DNA and genetics affect your health, you can: - Check out SelfDecode: ⁠https://selfdecode.com/⁠ - Join Joe’s online community: ⁠https://thejoecohenshow.com/⁠

Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith. Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome. From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more. Michael shares some practical strategies for enhancing gut health and addressing chronic conditions. Join Joe and Michael as they explore the pivotal role of lifestyle changes, targeted supplements, and personalized DNA data in achieving optimal well-being. - Learn more about Michael’s practice at https://www.planetnaturopath.com/ - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Michael Smith (01:51) - Michael's process with patients (10:34) - Important health data points (19:21) - Looking at gut health (27:35) - Food sensitivities and gut health (32:56) - Other alternative markers and tests (38:44) - Going through test results

Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness. These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is your gateway to the best health advice we've uncovered in Season 5. - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/ Timestamps: (0:00) - Intro (0:16) - Oz Garcia (8:31) - Methylation (17:44) - Michael Lustgarten (24:26) - Optimal Lab Levels (29:37) - Matt Kaeberlein (46:34) - Immune System

Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness. Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component! - Check out SelfDecode: https://selfdecode.com/ - Join Joe’s online community: https://thejoecohenshow.com/