AJCN In Press

In this episode, Kevin C. Klatt, PhD, RD (he/him) speaks with Editor In Chief Christopher Duggan MD MPH, Section Editor Nancy Krebs MD MS, and Early Career Editor Cora Best PhD MHS RD about the newly launched section of the American Journal of Clinical Nutrition titled “Nutrition for the Clinician”. Drs Duggan, Krebs and Best discuss the impetus for launching this new case study series and tips for prospective authors. Relevant Links: Introductory Editorial for the series Information on claiming CME credit Information for prospective authors Be sure to connect with us! Dr Best, @CoraMBest; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Kevin C. Klatt, PhD, RD (he/him) speaks with Section Editor Nancy Krebs MD MS, and Stephanie Waldrop MD MPH, both from the Section of Nutrition at the University of Colorado Anschutz Medical Center. Drs Kreb and Waldrop discuss their recent publication, the inaugural case in the new “Nutrition for the Clinician” series, detailing a case of a pediatric patient presenting with SARS-CoV-2 (COVID-19) and additional unexplained symptoms that resulted in consulting the nutrition team. Drs Kreb and Waldrop discuss the events leading up to their consultation, their approach to assessment and diagnosis of the patient, and ultimate intervention and monitoring. The case contains numerous teaching points, including nutritional adequacy on a ketogenic diet and the challenges of nutrition assessment. Relevant Links: A perform storm in a pandemic - Case Study Information on claiming CME credit Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Early Career Editor Kevin C. Klatt, PhD, RD speaks with Briana Stephenson, PhD (she/her/hers), an Assistant Professor in the Departments of Biostatistics at the Harvard TH Chan School of Public Health, about her recent publication, “Racial and ethnic heterogeneity in diets of low-income adult females in the United States: results from National Health and Nutrition Examination Surveys from 2011 to 2018” in the American Journal of Clinical Nutrition. Dr Stephenson discusses her research on robust profile clustering as an extension of latent class models to define dietary patterns in population subgroups, focusing in this analysis on low-income female adults to identify racial and ethnic differences in dietary patterns. As Dr Stephenson noted (as of March 2022), she is currently recruiting a postdoc in Statistical Methods in Population Health Disparities research. Be sure to connect with us! Dr Stephenson, @BJKstephenson; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

Happy 2023 from everyone at the American Journal of Clinical Nutrition! In this episode, our Early Career Editor Kevin C. Klatt, PhD, RD chats with AJCN Editor in Chief, Christopher Duggan MD, MPH, and Academic Editor, Deirdre (DeeDee) Tobias, ScD, as they all reflect on the past year at AJCN and dive into some our top papers for the year. Find more about Drs. Duggan and Tobias, and all of our editors: https://ajcn.nutrition.org/editorialboard Papers discussed in this episode: A link to the top cited and top Altmetric papers at AJCN in 2022 can be found at the following link: https://tinyurl.com/4n4tpstb. Be sure to connect with us on twitter ( Dr. Tobias:@deirdre_tobias; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Early Career Editor Kevin C. Klatt, PhD, RD speaks with Harry Jarrett, PhD, Helene McNulty, PhD, RD, MRIA and Mary Ward, PhD, RD about their recent publication, “Vitamin B6 and riboflavin, their metabolic interaction and relationship with MTHFR genotype, in adults aged 18-102 years” in the American Journal of Clinical Nutrition. The authors discuss the rationale for looking at Vitamin B2 and B6 status marker interactions, including MTHFR genotype, and provide epidemiological evidence in support of riboflavin functional status (the erythrocyte glutathione reductase activation coefficient or EGRAC) being a determinant of Vitamin B6 (PLP) status. Paper Discussed in this Episode: Vitamin B6 and Riboflavin, Their Metabolic Interaction and Relationship With MTHFR Genotype, in Adults Aged 18-102 Years Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with a Christopher Gardner, PhD, and Matthew Landry, PhD, RD about their new study published in the American Journal of Clinical Nutrition titled “Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial”. In this Episode, Drs Gardner and Landry detail the rationale for undertaking this trial and its design, the challenges in both improving and assessing adherence in free-living diet assignment trials, and the nuances in accounting for medication changes in dietary intervention studies. Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt; Dr Gardner, @GardnerPhD; Dr Landry, @TheGuyititian.. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with a distinguished team of authors about their recent work published in the American Journal of Clinical Nutrition titled “Metagenomic profile of the fecal microbiome of preterm infants consuming mother's own milk with bovine milk-based fortifier or infant formula: a cross-sectional study”. In this episode, we dive into the rationale for this newest work examining the relationship between the mode of feeding for preterm infants and the metagenomic potential of their microbiome, as well as discussing emerging methods for characterizing the microbiome composition and function and the challenges of identifying how environmental factors influence this. Be sure to connect with us! AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with Mark A. Levine, MD, Section Chief of the Molecular and Clinical Nutrition Section of the Digestive Disease Branch at the National Institutes of Health. Dr. Levine’s laboratory conducts basic, translational and clinical research to better understand Vitamin C kinetics in health and disease and its potential role in disease prevention and treatment. In this episode, Dr. Levine details his groups’ recently accepted publication titled “Abnormal urinary loss of vitamin C in diabetes: prevalence and clinical characteristics of a vitamin C renal leak”, detailing the pharmacokinetics of vitamin C during depletion-repletion studies in individuals with diabetes and non-diabetic controls, defining evidence for a vitamin C renal leak in diabetes and clinical predictors of such a phenomenon. Be sure to connect with us on twitter! NIH: @NIHClinicalCntr @NIDDKgov; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD and Young Career Editor Kevin C. Klatt, PhD, RD speaks with Dylan McKay, PhD, Assistant Professor of Food and Human Nutritional Sciences at the University of Mannitoba and senior author of the recently published AJCN manuscript, “Genosets for APOE and CYP7A1-rs3808607 variants do not predict LDL cholesterol lowering upon intervention with plant sterols in a randomized, double-blind, placebo-controlled trial”. In this episode, we dive into the potential to predict LDL-lowering through a nutraceutical intervention (i.e. plant phytosterols) using genetic variants and more broadly, discuss the emerging field of nutrigenetics and the need for rigor and application of gold-standard clinical trial designs in the field. Be sure to connect with us on twitter Dr. MacKay: @DylanMacKayPhD; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD speaks with first author, Sachelly Julián-Serrano and leader author, Rachael Z Stolzenberg-Solomon, of the recently published AJCN manuscript “Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies”. In this episode, we dive into genetic epidemiology approaches, iron metabolism, and the risk of PDAC with our 2 guest authors from the Division of Cancer Epidemiology and Genetics at the National Cancer Institute. Be sure to connect with us on twitter ( Sachelly Julián-Serrano: @sachellyjs; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

Happy New Year from everyone at the American Journal of Clinical Nutrition! In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD sits down (literally, in person!) to talk with AJCN Editor in Chief, Christopher Duggan MD, MPH, and Academic Editor, Deirdre (DeeDee) Tobias, ScD, and reflect on 2021 at AJCN. Find more about Drs. Duggan and Tobias, and all of our editors. Papers discussed in this episode: Insect ProteinPURE Red MeatVegan Diets & ChildrenVitamin D & CovidCoffee, Genetics and CVDCarbohydrate-Insulin Model Be sure to connect with us on twitter ( Dr. Tobias:@deirdre_tobias; AJCN: @AJCNutrition; Dr. Klatt: @kcklatt. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website: https://nutrition.org/publications/.

In this episode of AJCN In Press, AJCN’s Inaugural Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with members of the all-star, global team behind the recent November 2021 Issue Supplement of the American Journal of Clinical Nutrition, focusing on the impact of small quantity lipid-based nutrient supplements (SQ-LNS) in global child health. In this conversation, Dr. Klatt and the author team discuss the rationale behind utilizing SQ-LNS, the strengths of individual participant data meta-analyses of randomized controlled trials, and their findings related to SQ-LNS’ impact on malnutrition, growth, developmental outcomes and micronutrient status. The full Issue Supplement discussed in this podcast can be found here. An additional previous manuscript published in AJCN and mentioned in the podcast assessing the impact of SQ-LNS on all cause-mortality can be found here. Be sure to connect with us on Twitter: Dr. Klatt, members of the authorship team (tagged throughout this thread from Dr. Stewart) and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. See also full journal supplement: Volume 114, Issue Supplement_1, November 2021 See also journal article: Lipid-based nutrient supplements and all-cause mortality in children 6–24 months of age: a meta-analysis of randomized controlled trials

In this episode of AJCN In Press, AJCN’s Inaugural Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with Georgia D. Tomova, MSc and PhD candidate, and Peter WG Tennant, PhD, at the Leads Institute for Data Analytics and the Alan Turing Institute for Data Science and Artificial Intelligence. Ms. Tomova and Dr. Tennant are co-leaders of the Causal Inference Interest Group at the Alan Turing Institute and their interests mutually lie within the field of causal inference and methods and their applications to epidemiology and health sciences, including nutrition. This episode discusses the rationale for and findings of a recent publication by Tomova, Arnold, Gilthorpe and Tennant exploring and comparing the most common approaches to energy intake adjustment in nutritional epidemiology using causal diagrams and simulated data. Be sure to connect with us on Twitter: Dr. Klatt, Georgia Tomova, Peter Tennant, and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. See also journal article: Adjustment for energy intake in nutritional research: a causal inference perspective

In this episode of AJCN In Press, AJCN’s Inaugural Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with YuHan Chiu, MD, PhD, a postdoctoral fellow in the Department of Epidemiology at Harvard University. Dr. Chiu is a fellow in the laboratory of Miguel Hernán, MD, DrPH, and the Kolokotrones Professor of Biostatistics and Epidemiology and focuses on applying causal inference methodologies to dietary data in epidemiological studies. In this episode, Drs. Klatt and Chiu discuss Dr. Chiu’s recent publication in AJCN estimating the effect of a theoretical randomized controlled trial, or ‘target trial’, assessing the impact of adhering to the American Heart Association 2020 Food-Based Dietary Goals. Dr. Chiu provided a really excellent history of the causal inference revolution in epidemiology, and compares and contrasts these approaches with conventional analyses in nutritional epidemiology. In addition to the reading Dr. Chiu’s paper, be sure to check out an associated commentary on the article by AJCN’s own Academic Editor Deirdre Tobias, ScD, and Martin Lajous, MD, ScD. Be sure to connect with us on Twitter: Dr. Klatt and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related articles: Estimating the effect of nutritional interventions using observational data: the American Heart Association's 2020 Dietary Goals and mortality What would the trial be? Emulating randomized dietary intervention trials to estimate causal effects with observational data

In this episode of AJCN In Press, AJCN’s Inaugural Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with Jessica Fanzo, PhD and Lorraine Brennan, PhD, both Associate Editors at AJCN respectively leading two new research categories: Food Systems and The Environment, and Nutrigenomics and Precision Nutrition. In this episode, Drs Fanzo and Brennan discuss the rationale behind developing these 2 new journal sections, what prospective authors and readers should know about the sections, and their insights on the future of nutrition research. Learn more about the influential scholarship of these two distinguished editors and podcast guests in the “Meet the Editors” section of the AJCN Website. Interested in more specifics about these two new research categories? Check out the accompanying AJCN introductory manuscripts authored by Dr Fanzo, Dr Brennan, and colleagues. Be sure to connect with us on Twitter: Dr. Klatt and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related articles: The importance of food systems and the environment for nutrition Nutrigenomics: lessons learned and future perspectives

In this episode of AJCN In Press, AJCN’s Inaugural Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with PhD candidate, Jessica Johnson, at the Institute of Arctic Biology at the University of Alaska Fairbanks. Ms. Johnson is a member of the Diane M. O’Brien Laboratory and focuses her research on how we can utilize naturally occurring stable isotope ratios in circulating metabolites as biomarkers of dietary intake. In this episode, we discuss Ms. Johnson’s recent first author publication in AJCN, “The carbon isotope ratios of nonessential amino acids identify sugar-sweetened beverage (SSB) consumers in a 12-wk inpatient feeding study of 32 men with varying SSB and meat exposures“. We dive deep into this really novel study, touching on stable isotopes, controlled feeding trials, essential and non-essential amino acids, and emerging biomarkers of intake for use in experimental and observational nutrition studies. Previous related work from the O’Brien Laboratory published in AJCN may be of interest to readers, as well as a related commentary on the use of stable isotope ratios in nutritional epidemiology. Be sure to connect with us on Twitter: Dr. Klatt and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related article: The carbon isotope ratios of nonessential amino acids identify sugar-sweetened beverage (SSB) consumers in a 12-wk inpatient feeding study of 32 men with varying SSB and meat exposures

In this episode of AJCN In Press, we travel across the pond, so to speak, and chat with Professor Kevin Whelan, Professor of Dietetics and Head of Department of Nutritional Sciences at King’s College London, United Kingdom about his recent publication in AJCN. Dr. Whelan is a renowned investigator in the fields of gastroenterology and dietetics, having undertaken and led extensive research on pre- and pro-biotics, fiber, the gut microbiome, and gastrointestinal health and disease. His research and teaching efforts have received national and international recognition, including Dr. Whelan being appointed as a Fellow of the British Dietetic Association and delivering the prestigious Dr. Elsie Widdowson Memorial Lecture. Be sure to connect with us on Twitter: Dr. Whelan, Dr. Klatt, and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related article: Food-related quality of life is impaired in inflammatory bowel disease and associated with reduced intake of key nutrients

Happy New Year from everyone at The American Journal of Clinical Nutrition! In this episode, Dennis M. Bier MD Young Career Editor Kevin C. Klatt, PhD, RD (virtually) sits down to talk with AJCN Editor-in-Chief, Christopher Duggan MD, MPH, and Academic Editor, Deirdre (DeeDee) Tobias, ScD, and reflect on the past year at AJCN. Stay tuned for Drs. Duggan and Tobias deep dive into some of the top Altmetric scoring papers from 2020! Find out more about Drs. Duggan and Tobias, and all of our editors. Be sure to connect with us on Twitter: Dr. Tobias, Dr. Klatt, and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related Articles: Strengthening national nutrition research: rationale and options for a new coordinated federal research effort and authority Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood—Meat Eating Alternative Trial (SWAP-MEAT) Association between regional selenium status and reported outcome of COVID-19 cases in China

AJCN’s Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD chats with Regan Bailey, PhD, MPH, RD about her and colleagues’ newly published AJCN manuscript, “High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES.” Dr. Bailey is an epidemiologist and Professor in the Department of Nutrition Science at Purdue University, where her research focuses on improving methods of measuring nutritional status, and better understanding the relationship of nutritional status to health across the lifecycle. In addition to her numerous publications and accolades, Dr. Bailey recently served on the 2020-2025 USDA Dietary Guidelines for Americans Advisory Committee and was recently one of 100 new members elected to the National Academies of Medicine - we are truly grateful to have such a distinguished guest to kick off this podcast! Be sure to connect with us on Twitter: Dr. Bailey, Dr. Klatt, and AJCN. Find all of the publications from the American Society for Nutrition (@nutritionorg; @jnutritionorg) at our website. Related Article: High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES

AJCN In Press is a new podcast from the American Journal of Clinical Nutrition (AJCN), the leading primary research journal in nutrition and dietetics and one of the four official journals from the American Society for Nutrition. AJCN In Press features interviews between a primary author on a recently published AJCN manuscript and the podcast host, AJCN’s own Dennis M. Bier Young Career Editor, Kevin C. Klatt, PhD, RD. Be sure to subscribe to stay up to date on cutting edge nutrition science, from the basic sciences to epidemiology and clinical interventions. Follow us on Twitter @AJCNutrition @nutritionorg @jnutritionorg.