Siim Land Podcast

Professor Kristen Hawkes is a pioneering anthropologist whose work helped bring the grandmother hypothesis to the spotlight of human evolution research. Through fieldwork and evolutionary theory, she argued that older women may have played a crucial role in shaping the human life course, not just by living longer, but by helping feed and support grandchildren. That idea helped reframe menopause, longevity, and family cooperation as possible drivers of what makes humans distinct and what explains our longer lifespans. Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 01:05 How Kristen started to think about the paradox of grandmother longevity 09:15 What accounts for variation in adult mortality across lifespan 13:40 Difference in male and female longevity 17:20 Why human babies are very dependent 20:05 Bon Charge sponsorship 21:10 Dynamics of human social evolution and longevity 23:05 How longer weening period in human babies contributes to our intelligence 29:35 Weening and intelligence 34:25 Evolutionary explanation for grandparents 36:35 The contribtion of hunting success vs gathering to children size in Hadza 47:05 Does the grandmother hypothesis make sense 48:15 Role of DHA and seafood in human brain evolution 51:35 Social hierarchy of grandparents in the Hadza 56:01 Grandfathers 01:08:35 Role of grandparents in the modern world My 2026 longevity routine: https://youtu.be/OceysodInIo Start rewinding your biological clock: https://www.siimland.co/course

Dr. Uri Alon is a physicist-turned-biologist, a professor at the Weizmann Institute, and one of the leading thinkers exploring how complex biological systems work. In this episode, we discuss his research on the effects of genetics, lifestyle, environment, and luck on human lifespan. Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 00:55 How big of a role does genetics play in longevity 06:25 How important is lifestyle vs genetics 08:25 How big of a role does lifestyle play in longevity 12:55 Why is lifestyle less impactful than genetics 15:25 Bon Charge sponsorship 16:30 Genes of people who live to 110 18:55 Why lifestyle matters a lot if you have bad genes 21:45 What leads to aging 22:45 What’s the maximum human lifespan 25:20 Why nobody has lived over 122 yet 27:05 Strategies to extend lifespan beyond normal 34:05 What made Uri interested in longevity as a physicist 36:25 Recurring patterns in human longevity and aging 38:40 Simplest analogie for aging 49:15 Surprising role of luck in longevity 54:55 How to practically extend your lifespan 59:30 What Uri needs to discover next about aging Dr Uri Alon Lab YouTube channel with Systems Aging courses: https://www.youtube.com/@alonlab9733/videos My 2026 longevity routine: https://youtu.be/OceysodInIo Start rewinding your biological clock: https://www.siimland.co/course P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ Timestamps: 00:00 Intro 00:36 Lifestyle bracket 06:50 Lifestyle bracket winners 11:47 Join my online community 18:46 Medicine / pharmaceutical bracket 19:20 Medicine /pharmaceutical bracket winners 22:32 Geroscience bracket 33:13 Geroscience winners 35:00 Biohacking bracket 40:16 Biohacking bracket winners 43:04 Final 8 winners 46:32 Final 4 winners 49:23 Final 2 winners Vote yourself for the Longevity Bracket: https://www.optispan.life/longevity-bracket My 2026 longevity routine: https://youtu.be/OceysodInIo Start rewinding your biological clock: https://www.siimland.co/course

Professor Michael Crawford is a renowned scientist and Director of the Institue of Brain Chemistry and Human Nutrition in Imperial College London. He’s known for his research demonstrating the essential role of omega-3s specifically DHA in brain development and human evolution. He’s been pioneering this research since the 70s and he’s 95 years old himself. Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 01:00 How Dr Crawford started researching DHA and omega-3s 04:00 Relationship between DHA and brain structure across species 07:00 How DHA drove the evolution of the human brain 12:20 Did humans evolve because of hunting land animals or consuming seafood 16:10 How a waxy fatty layer covering human babies makes us so different from other land animals 19:50 Bon Charge sponsorship 20:50 How the early stages of human brain evolution might have looked like 24:20 Why did DHA allow our brains to develop so well 27:20 Declining IQ and brain health conditions 31:00 Behavioral disorders and DHA 34:05 Iodine and other nutrients for brain development 36:55 Dr Crawford’s amazing cognition at the age of 95 39:20 How much DHA would people need per day 41:40 Is fish high in heavy metals 46:40 Omega-3s from meat 50:20 Plant-based omega-3s 51:20 Bottleneck for cranial capacity for land animals 54:55 Supplementing vs eating seafood 56:20 Omega-6 vs omega-3s 57:30 What needs to be done for fixing nutrition 01:03:30 Can you catch up with lost brain development 01:06:00 Are omega-3s easily oxidized 01:07:35 Advice for young researchers 01:10:05 Dr Crawford’s book My 2026 longevity routine: https://youtu.be/OceysodInIo 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Dr. Benjamin Blue is the Chief Executive Officer of Ora Biomedical, where he leads the company’s mission to develop therapies that target the biology of aging to prevent and treat disease. Dr. Blue holds a Ph.D. in Molecular Medicine and Mechanism of Disease (M3D) from the University of Washington School of Medicine and a B.S. in Biochemistry from the University of Oregon. Timestamps: 00:00 Intro 00:35 The Million Molecule Challenge to find the enxt longevity molecule 05:15 How many molecules has Ora Biomedical tested 06:45 Most remarkable results in life extension so far 10:45 The process of finding life extension molecules 16:05 What’s the maximum life extension seen 17:15 Join our online community 18:15 Common supplements seen to extend lifespan 21:55 Disappointing molecules for life extension 26:50 Aspects of health and longevity 30:45 Investigating radiation in space and aging 34:35 Likelihood of finding a molecule that extends lifespan by 200-300% 41:05 How does it translate to humans 48:25 Peptides effect on lifespan 52:05 Bottleneck in the longevity science 56:25 What compounds has Ben started taking himself Dr Ben Blue Twitter: https://x.com/benblueAK Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ My 2026 longevity routine: https://youtu.be/OceysodInIoStart rewinding your biological clock: https://www.siimland.co/course

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ Timestamps: 00:00 Intro 00:41 Experts framework for bloodwork 03:41 What can bloodwork tell you about your health and what not 18:21 Brad’s top 3 most useful biomarkers 20:21 Matt’s top 3 most useful biomarkers 21:11 Is testosterone testing worth it on the population level 29:01 Michael’s top 3 most useful biomarkers 31:46 Matt’s most misleading biomarker 34:01 Brad’s most misleading biomarker 34:41 Biological age tests 37:22 Join my online community 38:23 ApoB 44:45 HDL cholesterol 48:50 Is low LDL associated with increased mortality 58:45 Blood sugar markers 01:02:12 How important are glucose spikes 01:12:12 How often should you take bloodtests 01:15:35 Liver markers 01:19:30 When you shouldn’t measure everything 01:22:40 Galleri cancer blood test 01:25:17 Cost of bloodworkMatt Kaeberlein PhD is a biogerontologist and professor at University of Washington: https://www.youtube.com/@UCSna7385c3Xg_4Too92NKMw Michael Lustgarten PhD is an exercise scientist and longevity researcher: https://www.youtube.com/@UCT1UMLpZ_CrQ_8I431K0b-g Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield My 2026 longevity routine: https://youtu.be/OceysodInIo

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 00:20 Zone 2 cardio 01:20 Barbell back squat 01:38 Pistol squats 02:21 Split squats 02:58 Deadlift 03:26 Pullups 04:40 Pushups 05:44 Barbell row 07:35 Dumbbell row 07:42 Overhead press 08:29 Dumbbell shoulder press 09:01 HIIT 09:35 Delt flies 11:30 Incline bench press 12:21 Decline bench press 12:55 Dips 13:14 Handstand pushups 14:29 Bon Charge sponsorship 15:31 Leg press 16:36 Biceps curls 17:05 Triceps extension 17:19 Yoga 17:45 Hamstring curls 18:41 Knee extension 19:00 Calf raises 20:14 Hammer curls 20:50 Wrist curls 21:30 Farmer carries 22:21 Trap shrugs 22:41 Neck curls 24:20 Good mornings 25:41 Hanging knee raises 26:11 Hanging leg raises 26:58 Sprinting 27:31 Deadhang 28:18 Kettlebell swings 28:59 Rope climb 29:59 Front lever 31:34 Planche 33:05 Crunches 34:00 Back extensions 34:31 L-sit 35:33 L-sit pullups 36:40 Plyometrics 37:11 Walking lunges 37:46 Hip thrust 38:28 Planking 39:20 Cycling 40:30 Soccer 41:50 Basketball 42:11 Volleyball 42:50 Tennis 43:19 Skating 43:35 Skiing 44:08 Mobility 44:31 Gymnastics 45:45 Hockey 46:13 Weighted vest walking 46:45 Track and field 47:00 Golf 48:00 Baseball 48:35 Rowing 48:50 Stair climber 49:30 Jump rope 49:51 Combat sports 50:51 Stretching 52:00 Burpees 52:55 Box jumps 53:30 Medicine ball 53:58 Sled push / pull 54:12 Sandbag 54:55 Wood chopping 56:10 Turkish get-up 57:00 Muscle up 57:40 Skin the cat 58:39 Agility ladders 59:28 Swimming 59:55 Shadow boxing 01:01:10 Animal flow 01:01:55 Ab wheel rollout 01:02:32 Front squat 01:03:28 Stiff leg deadlift 01:03:40 Chi ups 01:04:08 Seal row 01:05:00 Javelin throw 01:05:30 Heavy throws 01:06:28 Olympic weightlifting 01:07:54 Walking 01:08:18 Suitcase carry 01:08:50 Bosu ball squat 01:09:45 Assault bike 01:10:10 Dancing 01:10:47 Handstand 01:11:15 Hiking 01:11:45 Conclusion My 2026 longevity routine: https://youtu.be/OceysodInIo 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ Timestamps: 00:00 Intro01:15 TB4 05:02 Thymosin alpha 1 09:44 Join our longevity community 10:43 Epitalon 15:26 MOTS-c 19:30 Humanin 21:32 Cerebrolysin 23:49 Semax 24:40 CJC1295 (Ipamorelin) 26:31 MK677 (Ibutamoren) 28:26 Tesamorelin 29:12 IGF-1 LR3 29:45 Copper GHK 32:22 Retatrutide 33:55 Melanotan 2 35:30 Final overview and rankingMy 2026 longevity routine: https://youtu.be/OceysodInIo100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyiStart rewinding your biological clock: https://www.siimland.co/course

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Top Health Factors and Biomarkers That Matter the Most 17:44 Bon Charge sponsorship 18:50 Glycine and cancer risk 22:05 Can supplements improve IQ and cognition 25:19 Best autophagy routines 31:24 Thoughts on young plasma exchange 35:26 Injectible NAD and glutathione 38:05 Too high cortisol from time restricted eating 42:35 Benefits of mini trampolines My 2026 longevity routine: https://youtu.be/OceysodInIo 100 Health Biomarkers Ranked: https://youtu.be/SgKp5mm0ALI?si=M7YkYo6Lelci7kOQ

Dr. Elie Abirached is a Harvard alumnus, and founder of Restore. He is the creator of the Limitless Human methodology, a science driven framework designed to reduce biological age, enhance resilience, and optimise long term health. Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 00:16 How Elie got into fitness and wellness 07:00 Why recovery is not enough 11:14 How Elie got a VO2 max of 70 in his 50s 16:20 Bon Charge sponsorship 17:15 Why VO2 max is such a good biomarker of overall health 19:25 Elie's scientific approach to increase VO2 max 22:30 Low intensity vs high intensity training 27:16 How to know your true maximum heart rate 34:25 How often should you test VO2 max 36:20 Elie's go-to workouts 44:18 Elie's go-to recovery strategies 48:44 Elie's nutrition 55:10 Elie's supplementation 01:00:24 How to start: beginners and advanced individuals Dr Elie Abirached's YouTube channel: https://www.youtube.com/@DrElie-biohacking Dr Elie Abirached's Instagram: https://www.instagram.com/elie.truth

Dr. Daniel Promislow, DPhil, is a Senior Scientist and Scientific Advisor at the HNRCA. He has worked for over 30 years on the biology of aging and has published over 180 papers. Currently, he's working on the Dog Aging Project Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps:00:0000:26 What is the Dog Aging Project02:26 Size and longevity in dogs06:06 Why dog ownership is associated with longevity11:06 Bon Charge sponsorship12:00 What lifestyle makes dogs live longer17:10 Diet for dog longevity19:25 Intermittent fasting for dogs24:20 Calorie restriction for dogs28:35 Exercise for dogs31:55 Rapamycin for dogs45:40 Other longevity compounds for dogs57:35 Supplements for dogs My 2026 longevity routine: https://youtu.be/OceysodInIo 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ Timestamps:00:00 Intro00:00 Panel members introduction05:20 Recap of our week at AIWO18:30 Blood marker testing20:40 Longevity World Cup competition30:00 DEXA scan36:35 Physiotherapy and posture analysis37:55 Skin anti-aging treatments41:55 Exosomes and stem cells for skin anti-aging49:20 Unique tests we did at AIWO52:45 Social experience at the retreat Inka Land YouTube: https://www.youtube.com/@iaminkaland Dr Joy Kong YouTube: https://www.youtube.com/@JoyKongMD Dave Pascoe YouTube: https://www.youtube.com/c/davepascoesurl Adam Ficsor YouTube: https://www.youtube.com/@nopara73 Check out our next retreat: https://www.siimland.co/retreat My 2026 longevity routine: https://youtu.be/OceysodInIo 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyiStart rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Timestamps: 00:00 Why does longevity matter 03:25 Tracking for preventing chronic diseases 06:14 Advanced longevity therapies we’re excited about 10:30 How long would you like to live 14:25 Will longevity technology become available to everyone 17:27 Big moonshots in longevity 23:32 What does the life of a 70 year old look like in 2040 26:32 Most important step towards your longevity you should take today 28:10 Most overhyped and underrated longevity product 30:25 Emotional health 33:40 Research on mushrooms Panel discussion at Copenhagen Health Week 2025: https://www.youtube.com/@CPHHW/videosWith Julian Assa and Jürgen MehrtensStart rewinding your biological clock: https://www.siimland.co/course

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps:00:00 Intro00:44 My results in 202506:19 Body composition goals16:00 Bon Charge sponsorship16:52 My 2025 fitness results25:05 My 2026 fitness goals30:25 My workout plan for 202635:05 My nutrition plan for 202643:27 My supplement protocol for 202646:37 My sleep routine and goals48:47 My bloodwork results for 2025 and goals for 202601:01:07 Auxiliary routines01:05:05 ConclusionGet to top 1% health: https://youtu.be/8M9uHhFf26c Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Start rewinding your biological clock: https://www.siimland.co/course

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps: 00:00 Intro 00:15 100 supplements ranked from worst to best 57:00 Bon Charge sponsorship 57:55 How to eliminate microplastics and heavy metals from your body feat Dr Anil Bajnath 01:27:20 Nutrition masterclass with Physionic and Dr Greg Potter 02:27:25 Exercise masterclass with Physionic and Dr Greg Potter 03:17:15 Best performing video of the year 03:29:30 Top underrated video of the year 03:36:14 Sleep and circadian clock dysfunction feat Dr Greg Potter 04:04:38 Skin anti-aging masterclass with Dr Alexis Ortega Get to top 1% health: https://youtu.be/8M9uHhFf26c

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/ Timestamps: 00:00 Intro 00:15 Zone 2 cardio 01:44 Napping 03:03 Walking 05:09 Polyphasic sleeping 06:47 Mouth breathing 07:52 Soleus pushups 09:40 Stretching 11:10 Mobility 12:03 Yoga 13:20 HIIT 14:20 Sprinting 14:48 Plyometrics 16:12 Morning sunlight 17:05 Evening sunset 17:52 Blocking out blue light 19:12 Red light therapy 20:37 Infrared light 21:43 Supplements 23:30 Education 25:20 Problem solving 26:14 Weight lifting 26:56 Bilingualism 27:10 Sunbathing 28:54 Tanning beds 30:06 Coffee and teas 31:28 Low carb diet 33:26 Low fat high carb diet 34:04 Vegan diet 34:36 Vegetarian diet 35:00 Carnivore diet 37:07 Paleo diet 37:45 Calisthenics 39:15 Mediterranean diet 40:20 Sugar diet 40:58 Hydration 41:42 Smoking 42:00 Alcohol 43:40 Vaping 44:00 Mouth tobacco 44:35 Hyperbaric oxygen therapy (HBOT) 45:40 Sauna 47:09 Total plasma exchange 47:53 Meditation 48:49 Religion 50:10 Purpose 51:30 Mindfulness 52:14 Intermittent fasting 53:15 Low calorie diet 55:40 If it fits your macros diet 57:30 Pet ownership 58:57 Marriage 01:00:57 Ice bath 01:01:57 Having children 01:03:29 Social health 01:04:23 Having fun and play 01:04:40 Mental health 01:05:03 Extended fasting 01:07:07 Forest bathing 01:08:02 Fasting mimicking diet 01:09:10 Juice fasting 01:09:41 Dry fasting 01:11:16 Protein restriction 01:12:17 Hot baths 01:13:40 Time-restricted eating 01:14:10 Circadian mismatch 01:14:50 Sleep consistency 01:15:23 Chronic stress 01:16:00 Junk food 01:16:25 Water filtration 01:16:50 Air filtration 01:17:00 Outdoor pollution 01:17:20 Sitting lifestyle 01:17:43 Sleep 7-8 hours 01:18:09 Regular bloodtests 01:18:40 Continuous glucose monitoring 01:19:19 Exercise snacks 01:19:57 Standing workdesk 01:20:53 Nasal breathing 01:21:03 Breathing exercises 01:21:38 Recreational drugs and weed 01:22:26 Peptides 01:23:30 HRT & TRT 01:27:04 Sleep 4-6 hours 01:27:28 Stem cell therapy 01:28:17 Team sports 01:28:40 Steroid cycle 01:29:10 Grounding 01:29:32 Mouth taping 01:29:51 Artificial sweeteners 01:31:30 Hypochondria 01:33:50 Overview My 2025 supplement list guide: https://www.siimland.co/supplement-list-2025 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi Get to top 1% health: https://youtu.be/8M9uHhFf26c Start rewinding your biological clock: https://www.siimland.co/course

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps:00:00 What level of sports performance is unhealthy04:15 How much protein is bad for aging and longevity11:45 Bon Charge sponsorship12:45 Do I want to reach the longevity escape velocity16:40 Absorbing supplements through the skin18:40 Optimal level of testosterone for longevity22:50 Should you cycle supplements on and off27:26 How I managed to follow a healthy lifestyle in my 20s31:07 How much red light therapy can you do per day33:10 Role of stress in longevity39:35 What to do against smog and air pollution43:50 Training fast twitch muscle fibers instead of lifting weights48:30 My all out supplement stack 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Jon Berner, MD PhD is a board certified Psychiatrist from Seattle with 27 years of experience. He's also published several scientific papers. Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Timestamps:00:00 Intro00:20 Why Dr Berner became interested in lithium04:50 Lithium’s benefits in Alzheimer’s and dementia10:50 Lithium’s effects on mTOR and autophagy12:50 Bon Charge sponsorship13:40 Clinical evidence for lithium in dementia18:20 What’s the optimal dose for lithium26:25 Lithium for bipolar and hyperactive brains29:25 Lithium as potential treatment in neurodegeneration31:55 Lithium’s effects on kidneys34:20 Personal experience with taking lithium40:40 Is it safe to take lithium prophalactically over the counter47:55 Rapamycin synergy with lithium51:45 AI and human development Dr Berner's practice: https://www.woodinvillepsychiatric.com/ 100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Yip (Zico) Tszho is the Chief Executive of Lonvi Biosciences, a longevity-drug start-up, in Shenzhen, China. They're developing pharmaceuticals for extending human lifespan. We discuss their first senolytic called PCC1. Timestamps:00:00 Intro00:15 Articles about a pill making people live to 15002:50 What is PCC1 and how is it made07:10 How much can targeting senescence extend lifespan12:25 Bon Charge sponsorship13:15 Dose of PCC1 for senolytic and senomorphic effects18:30 PCC1 extending lifespan in mice by 9.4%23:20 Absorption rate of PCC1 and other senolytics27:10 Senolytics for young vs old age31:10 Human study on PCC134:40 What’s the optimal dose for senolytics38:05 Biomarkers of cell senescence40:10 Senolytic benefits on skin and retina46:35 What’s going on in Chinese longevity science52:10 Future direction of PCC1PCC1 studies: https://lonvibio.com/pages/science

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland Brady Holmer is a science writer and researcher with a Master's degree in Human Performance from the University of Florida Timestamps:00:00 Intro00:40 Why heat acclimation has performance benefits08:10 How to train heat acclimation12:40 Bon Charge sponsorship13:30 Benefits of the sauna for fitness18:25 Saunas and injury recovery22:30 Cold exposure and exercise performance26:45 Cooling down during and before exercise31:40 How often to train heat acclimation and sauna37:05 Sauna and HRV38:10 How long to stay in the sauna41:15 Electrolytes and dehydration acclimation46:25 Differences between men and women in heat acclimation47:00 Does heat acclimation have longevity benefits49:05 Does cold exposure have longevity benefits54:30 Which research should be done more on heat acclimation First podcast with Brady about VO2 max: https://youtu.be/xLDaFhN6h8I Brady Holmer Twitter: https://x.com/B_Holmer Brady Holmer website: https://www.bradyholmer.com/Start rewinding your biological clock: https://www.siimland.co/course