BIOACTIVE

In this episode of the Bioactive Podcast, Dr. Hemant Bid joins Dr. Riley Kirk discussing the often-overlooked world of acidic cannabinoids aka Raw or Unactivated cannabinoids, such as CBGA, THCA, and CBDA. He shares his extensive background in cannabis research and education, emphasizing the therapeutic potential of these compounds, which are non-psychoactive and interact with various non-cannabinoid targets in the body. The conversation also delves into extraction techniques for preserving these cannabinoids, their role in plant defense, and the future of research in this area. Dr. Bid highlights the importance of personalized medicine and the need for more education and understanding in the field of medical cannabis. Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Follow Dr. Bid on LinkedIn https://www.linkedin.com/in/hemant-kumar-bid-bs-ms-phd-ms-pharmacology-60aabb15/ Sign Up for Emails! ⁠www.AppliedPharmacognosy.org⁠ Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bioactive Podcast, Dr. Riley Kirk shares a 2025 year-in-review and announces exciting news about teaching a cannabis chemistry and pharmacology course at Vermont State University next Spring. Riley then dives into a Q&A packed with highly requested cannabis education topics, answering real listener questions about nanoemulsification safety, whether CBN truly helps with sleep, and the pros and cons of dabbing concentrates. She also breaks down how to talk to family about cannabis use, the science behind THC:CBD ratios, why “indica vs. sativa” is largely a myth, and how different strain chemistries influence effects. Riley explains the difference between live resin vs. live rosin vape cartridges, how nano cannabis products work in the body, and whether already-vaped cannabis is still edible or effective. If you are curious about cannabis science, consumption methods, harm reduction, or understanding how cannabinoids and terpenes really work, this episode is packed with practical insights. Riley closes with a warm holiday message and a look ahead at what’s coming in 2026. Topics covered: cannabis chemistry, nano THC safety, CBN for sleep, dabbing benefits, THC/CBD ratios, terpene science, talking about cannabis with family, live resin vs. live rosin, cannabis education, pharmacology, cannabis myths, and more. Chapters 00:00 Reflecting on the Year and Future Plans 02:47 Q&A: Exploring Cannabis and Pharmacology 05:56 Creating Custom Cannabis Experiences 08:27 Understanding CBN and Its Effects 10:37 Dabbing: Benefits and Drawbacks 26:37 Understanding Dabs: Pros and Cons 29:03 Coming Out of the Green Closet 32:36 Engaging with the Cannabis Science Community 35:11 Balancing THC with CBD 38:47 THC and Seizure Treatment 41:16 Debunking the Indica vs. Sativa Myth 46:12 Vape Cartridges: Live Resin vs. Live Rosin 52:03 Using Vaped Cannabis for Edibles VTSU Course Information: For non-matriculated students (those not fully enrolled in VTSU), form: https://connect.vermontstate.edu/register/NonMatricStudents Section and Number: HUM-2710-S01, Course 1 title: Cannabis as Medicine Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Sign Up for Emails! www.AppliedPharmacognosy.org Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Riley Kirk has Jordan River on the podcast to discuss the intricacies of indoor cannabis cultivation, sharing personal experiences and insights on various aspects of growing. They cover topics such as the challenges of transitioning plants from outdoor to indoor environments, the importance of consistency in care, effective watering techniques, and the management of temperature and light. Additionally, they delve into soil health, pest management, and the processes of harvesting, drying, and curing cannabis. The discussion emphasizes practical tips for both novice and experienced growers, highlighting the importance of observation and adaptation in successful gardening. They also delve into various aspects of cannabis cultivation, including the peel test for assessing dryness, the benefits of co-planting with vegetables, and the critical factors in drying and curing cannabis. They also discuss outdoor growing techniques, best practices for storing cannabis, and the innovative use of CO2 enhancement in grow tents. The dialogue further explores the timing for outdoor planting, the nuances of transplanting auto flowers, and the challenges faced by growers in prohibition states. Finally, they touch on the exciting intersection of coffee and cannabis, highlighting the potential for a unique beverage experience. Chapters 00:00 Introduction to Indoor Growing Challenges 08:17 Understanding Plant Care and Consistency 14:58 Temperature and Light Management 22:56 Watering Techniques and Best Practices 27:19 Understanding Living Soil and Its Ecosystem 29:03 Light Cycles and Their Importance in Growth 31:03 Indoor vs Outdoor Growing: Key Differences 32:37 The Debate on Bud Washing: Pros and Cons 35:39 Drying and Curing: Best Practices 40:20 The Science of Drying: Metrics That Matter 42:41 Co-Planting: Growing Food Alongside Cannabis 45:27 Pre-Harvest Moisture and Air Turbulence in Drying 50:40 Topping Outdoor Plants: Timing and Techniques 57:08 Storing Cannabis: Best Practices for Longevity 58:07 Innovative Storage Solutions for Cannabis 01:00:45 Enhancing Plant Growth with CO2 and Mushrooms 01:04:32 Best Practices for Outdoor Cannabis Growing 01:08:40 Transplanting Auto Flowers: Tips and Tricks 01:09:41 Navigating Growing in Prohibition States 01:14:52 The Intersection of Coffee and Cannabis Take the Homegrow Survey https://ilgm.com/resources/landing/state-of-the-homegrow Learn More About Growcast/ Join the Community https://growcast.com/ Free Grow Guide from Growcast https://growcast.com/guide/ Follow Growcast on IG: @Growcast ​​Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Sign Up for Emails! www.AppliedPharmacognosy.org Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bioactive Podcast, Dr. Riley Kirk and Dr. Miyabe Shields dive into the world’s largest study on infused cannabis beverages, exploring how cannabinoid-based drinkables are transforming wellness, social drinking culture, and public health. They sit down with Tyler and Kevin from MoreBetter who designed and executed this groundbreaking study. They break down the study design, participant demographics, and key findings, including data showing a reduction in alcohol consumption, improved sleep and mental health outcomes, and insights into why consumers are turning to cannabis beverages as a safer, more accessible alternative. The discussion also gets technical, unpacking how emulsification and formulation science influence onset, absorption, and overall product efficacy. Whether you’re a formulator, researcher, or just a curious consumer, this episode brings evidence-based clarity to one of the fastest-growing segments of the cannabis industry. This conversation is more important than ever right now as hemp beverages are about to become illegal with the new legislation around THC in hemp products. What You’ll Learn How cannabinoid-infused beverages are reshaping the future of social consumption Key results from the world’s largest infused drink study What emulsification means for onset, bioavailability, and effects The surpris ing connection between cannabis beverages and reduced alcohol intake How these findings could influence public policy and consumer education Episode Timestamps 00:00 – Introduction to the Study 05:01 – Study Design & Participant Demographics 15:01 – Key Findings on Alcohol Consumption 25:01 – The Science of Emulsification 35:01 – Impact on Sleep & Mental Health 45:01 – Policy & Education Implications 55:01 – Closing Thoughts & Future Directions Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Read the Full Beverage Report: www.MoreBetter.ltd Follow MoreBetter on social media: @MoreBetter.ltd Sign Up for Emails! www.AppliedPharmacognosy.org Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Alex Eckman shares his journey in the cannabis industry, from being a medical patient to pursuing a degree in cannabis chemistry at Lake Superior State University. He discusses the evolution of cannabis education, the importance of research, and his findings on vape carts and microplastics. Alex also addresses the challenges facing the Michigan cannabis market and his aspirations for the future, emphasizing the need for education and informed decision-making in the industry. Chapters 00:00Introduction and Background 03:00 The Landscape of Cannabis Education 06:07 Academic vs. Industry Experience 09:05 Research Opportunities in Cannabis 11:53 Vape Cart Research and Findings 14:57 Concerns About Microplastics in Vape Products 17:57 Future Research Directions 20:55 Conclusions and Reflections 31:57 Informed Choices in Cannabis Consumption 34:06 The Importance of Research and Consumer Safety 37:14 Navigating the Cannabis Job Market 40:32 Challenges in the Michigan Cannabis Industry 43:48 Regulatory Changes and Their Impact 46:39 The Evolution of Cannabis Pricing in Michigan 51:26 Home Growing: Opportunities and Challenges 53:51 The Future of the Michigan Cannabis Market 54:31 Reflections on Experience in Ohio's Cannabis Market 57:46 The Entrepreneurial Spirit in Cannabis 01:01:42 Looking Ahead: Opportunities and Optimism Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including MOTHER EARTH: Rooted in Nature. Back by Experience. ⁠⁠https://www.mother-earthproducts.com/ ⁠⁠ Follow Alex on social media: @AlexEckmanCanna CRC Video on Microplastics: https://youtu.be/fauGztO8Z0Q?si=4Tbjkm15cVJ3tcbv Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

CONTENT WARNING: IF YOU HAVE STRUGGLED WITH A DIFFICULT BIRTH EXPERIENCE THIS STORY MAY NOT BE BENEFICIAL TO LISTEN TO Dr. Riley Kirk shares her postpartum journey, discussing her high-risk pregnancy due to ICP, the challenges of early induction, and her return to cannabis use for mental well-being. She emphasizes the importance of self-advocacy, mental health, and the healing power of cannabis, while also expressing gratitude for her supportive community. 00:00 Introduction and Pregnancy Update 5:00 High-Risk Pregnancy and ICP 8:00 Managing ICP and Induction 15:00 Birth Experience and Recovery 30:00 Postpartum Challenges and Cannabis 40:27 Advocacy and Future Plans Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including Botanicare: Quality-minded growers choose Botanicare. From CalMag to CocoGro, their line supports healthy roots, heavy flowers, and serious results. Feed your plants with purpose, choose Botanicare. https://www.botanicare.com/ Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Riley Kirk welcomes international cannabis consultant, researcher, and author Russ Hudson to explore the fascinating world of flavonoids—an often overlooked but powerful group of compounds found in cannabis and everyday foods. In this episode, Russ shares his journey from the underground cannabis market to scientific research, and together they break down what flavonoids are, how they impact plant color, health, and resilience, and why they matter for human nutrition and wellness. Discover the latest research on cannabis-specific flavonoids, their potential medicinal benefits, and practical tips for boosting flavonoids in your diet. More About Russ Hudson: Russ Hudson is an international cannabis consultant, researcher, and the author of The Big Book of Terps - the world's largest scientific resource on terpenes and synergy in cannabis, and The Formidable Book of Flavonoids, a companion textbook. Russ has dedicated more than 30 years to cannabis, working with the private social clubs of Spain, the coffeeshops and suppliers of the Netherlands, and cannabis, hemp, and CBD producers in Germany, Switzerland, Portugal, and other EU countries, while also specializing as a cannabis licensing, compliance, and regulatory affairs expert in many US states. Russ has been arrested and jailed for cultivation and trafficking, he has been the subject of a Vice documentary, he has written a children's book about cannabis, and he currently researches and collaborates with the world's leading cannabinoid, terpene, flavonoid, and other scientists. Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including MOTHER EARTH: Rooted in Nature. Back by Experience. ⁠⁠https://www.mother-earthproducts.com/ ⁠⁠ Keep up with Dr. Riley Kirk: ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠ ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In part two of Dr. Riley Kirk's conversation with Dr. Janice Makela, MD, they delve into the complexities of cannabis use among the elderly, discussing its potential benefits and risks for sleep and mental health matters. The conversation also covers the importance of low dosing, the role of the endocannabinoid system, and the challenges of integrating cannabis into traditional medical practices. Big thanks to Dr. Janice for answering so many questions from the Bioactive community! Find out more about Dr. Janice Makela, MD: ⁠https://www.janicemakelamd.com/⁠ Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including MOTHER EARTH: Rooted in Nature. Back by Experience. ⁠https://www.mother-earthproducts.com/ ⁠ Keep up with Dr. Riley Kirk: ⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠ ⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠ ⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Host Dr. Riley Kirk is joined by Dr. Janice Makela, MD for part one of a two part episode; the conversation was so interesting they couldn't cut it short! They discuss the evolving landscape of cannabis medicine, particularly for the geriatric population. She emphasizes the importance of education for both patients and physicians, addressing common misconceptions and the need for responsible dosing. The discussion covers various consumption methods, including edibles and tinctures, and highlights the potential benefits and risks associated with cannabis use in older adults. Dr. Makela also shares insights on the importance of safe and legal access to cannabis products. The discussion delves into the risks associated with smoking, including bronchitis and COPD, and highlights the benefits of using vaporizers over traditional smoking methods. The speakers also discuss the efficacy of cannabis topicals for pain relief and their role in wound care, and the importance of considering drug interactions. The speakers advocate for a cautious approach to cannabis use, especially among older adults and those with existing health conditions. Please consult your physician or health care team for questions that relate specifically to your health. Find out more about Dr. Janice Makela, MD: https://www.janicemakelamd.com/ Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including MOTHER EARTH: Rooted in Nature. Back by Experience. https://www.mother-earthproducts.com/ Keep up with Dr. Riley Kirk: ⁠⁠https://www.bioactivepodcast.com/⁠⁠ ⁠⁠https://www.youtube.com/@cannabichem⁠⁠ ⁠⁠https://instagram.com/cannabichem⁠⁠ ⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bioactive Podcast, I sit down with Jürgen Bickel, Managing Director and Co-Founder of STORZ & BICKEL, the legendary German company behind the Volcano, Mighty, Venty and Crafty vaporizers. We dive deep into: - What dry herb vaping is and how it works - Why vaporizing cannabis may be a healthier option compared to smoking - The science behind medical-grade vaporizers and what makes STORZ & BICKEL devices trusted by patients and professionals worldwide - Which herbs (beyond cannabis) you can safely vaporize for wellness and relaxation - How vapor quality, temperature control, and engineering impact your cannabis experience. Whether you’re a medical cannabis patient, wellness enthusiast, or adult-use consumer curious about switching it up from combustion, this episode offers insight into one of my personal favorite ways to consume- dry herb vaping. We’re giving away TWO legendary vaporizers: A Volcano Vaporizer (the classic desktop powerhouse) A Mighty Vaporizer (the portable medical-grade vape) To enter, just fill out a quick survey about dry herb vaping. https://forms.gle/Upce2XnHXFHugRNu7 Learn more about Storz and Bickel Products: https://www.storz-bickel.com/en-us/ Follow Storz and Bickel and Jürgen Bickel on Instagram: S&B: @ Storz.Bickel Jürgen: @ Jurgen_Bickel Want Exclusive Content and ad-free episodes? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Thank you to the sponsors of this episode, including General Hyrdoponics trusted by growers for over 40 years, General Hydroponics’ Flora Series is the gold standard in hydro nutrients. Consistent, powerful, and proven in the lab and the field, because your plants deserve nothing less. Learn more and find products at https://generalhydroponics.com/. And special shoutout to HiNote for making our trip to MaryJane Berlin possible! Keep up with Dr. Riley Kirk: ⁠https://www.bioactivepodcast.com/⁠ ⁠https://www.youtube.com/@cannabichem⁠ ⁠https://instagram.com/cannabichem⁠ ⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Devin Melnyk shares his journey from the gray market of cannabis cultivation to working with one of the largest licensed producers in Canada. He discusses the evolution of the cannabis industry, the differences between the Canadian and U.S. markets, and the importance of community in cannabis culture. Devin also tells us about the new HiNote app, designed to help users track their cannabis experiences and connect with others in the community. Find out more about HiNote: https://www.hinote.ai/ https://www.instagram.com/hinote.ai/ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

This week we are headed to Germany, this podcast was recorded at the world's largest cannabis expo called Mary Jane Berlin. I had the opportunity to jointly host and record a podcast with Lauren Avenius, the CEO of Node Labs. She is doing some ground breaking work with cannabis breeding and genetics and is doing an amazing job connecting people across the industry. Her work also encompasses other companies like Four20Pharma and Compound Genetics. This conversation covers everything from strain specific effects, understanding dosing and consumption methods, and how our own genetics and the plant genetics may influence our experience. Thank you to our sponsor for this episode GAVITA: For over 40 years, Gavita has been the trusted name in horticultural lighting, setting the benchmark for performance, reliability, and innovation. ⁠https://gavita.com/category/led-grow-lights/⁠ IG: @gavitanorthamerica Enter the MaryJane x Node Labs Giveaway https://forms.gle/nex2aBdDB4JT7g6D6 Follow lauren on Instagram and LinkedIn: @Lavenius https://www.linkedin.com/in/laurenavenius/ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, host Dr. Riley Kirk and guest Dr. Jaap De Roode discuss the fascinating field of zoo pharmacognosy, exploring how animals medicate themselves using natural substances. He shares insights from his research on monarch butterflies and honeybees, highlighting the role of toxic compounds and fungi in animal health. The discussion also touches on the implications for agriculture, the importance of biodiversity, and the potential for learning from animal behaviors in medicine. Dr. De Roode emphasizes the need for more research in this area and the significance of maintaining natural ecosystems for the health of both animals and humans. Key Takeaways Zoo pharmacognosy is the study of how animals medicate themselves. Monarch butterflies use toxic milkweed compounds to combat parasites. Honeybees may use fungi to treat infections in their colonies. Animal medication can be a learned behavior or instinctual response. Diversity in diet is crucial for animal health and resilience. Propolis serves as both a cement and a medicinal substance for bees. Observational studies provide insights into animal medication behaviors. Animals can change their behavior based on their health needs. Research on animal medication can inform agricultural practices. Understanding animal medication can lead to new discoveries in human medicine. Chapters 00:00 Introduction to Zoo Pharmacognosy 04:08 Research Focus: Monarch Butterflies and Honeybees 10:58 Defining Animal Medication vs. Self-Medication 14:59 Examples of Animal Medication in Nature 18:20 Chimpanzees and Traditional Healing 24:38 Learning and Sharing Medicinal Knowledge in Animals 26:14 The Fascinating World of Animal Self-Medication 28:53 Agricultural Practices and Animal Health 32:38 The Importance of Choice and Diversity in Animal Diets 33:37 Studying Animal Behavior and Medicating Practices 35:56 Recreational Use of Plants by Animals 40:56 Addressing Animal Anxiety and Depression 43:52 Natural Products in Animal Medicating 46:21 Evolution of Medicating Behaviors in Animals 48:21 Cannabis and Animal Self-Medication 51:31 Researching Fungi and Bees 55:20 Insights from 'Doctors by Nature' Thank you to our sponsor for this episode GAVITA: For over 40 years, Gavita has been the trusted name in horticultural lighting, setting the benchmark for performance, reliability, and innovation. https://gavita.com/category/led-grow-lights/ IG: @gavitanorthamerica Follow Dr. De Roode’s research: https://biology.emory.edu/people/bios/faculty/de-roode-jaap.html Follow Dr. De Roode on IG and LinkedIn IG @jaapderoode LI: https://www.linkedin.com/in/jaap-de-roode-04a6a6237/ Read or listen to Doctors by Nature https://www.amazon.com/Doctors-Nature-Other-Animals-Themselves/dp/069123924X Check out my book Reefer Wellness! ⁠⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Join us for a deep dive into the world of cannabis science with Dr. Miyabe Shields and host Dr. Riley Kirk cofounders of the Network of Applied Pharmacognosy. NAP is a nonprofit focused on studying the real world uses of cannabis and other natural products as well as the biochemical mechanisms. In this episode, we discuss the latest updates on biochemistry projects, the importance of enzymes in the endocannabinoid system, and the exciting findings from the Science of Smokability study. Discover how community insights are shaping research and the future of cannabis as a medicine. The role of enzymes in the endocannabinoid system. Understanding cannabis puff profiles, The impact of water activity on cannabis quality, Community-driven research and advocacy Upcoming projects and collaborations #CannabisScience #EndocannabinoidSystem #NAPTIMEPodcast #CannabisResearch #CommunityAdvocacy Timestamps: 0:00 - Introduction to NAPTIME Bioactive Podcast 2:00 - Overview of the Network of Applied Pharmacognosy 5:15 - Discussion on Biochemistry and Endocannabinoid System 12:30 - Importance of Enzymes in Cannabis Interaction 13:00 - Science of Smokability: Water Activity and Quality 20:45 - Community Insights and Research Advocacy 30:00 - Discussion on Cannabis Strain-Specific Effects 35:20 - Chemical Diversity Theory and Its Implications 40:00 - Personal Experiences and Anecdotes 45:30 - Upcoming Projects and Collaborations 50:00 - Challenges in Cannabis Research and Advocacy 55:15 - Conclusion and Call to Action 58:00 - Closing Remarks and Thank You Sign Up For NAP’s Email List/Newsletter or Donate: www.AppliedPharmacognosy.org Read the Science of Smokeability Paper https://www.cannabissciencetech.com/view/impact-of-water-activity-on-the-chemical-composition-and-smoking-quality-of-cannabis-flower-the-science-of-smokability-phase-i-results Order my book Reefer Wellness! ⁠⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Dr. Michele Ross discusses the complexities of cannabis use during pregnancy, sharing her personal experiences and insights as a neuropharmacologist and fibromyalgia patient. The discussion highlights the lack of comprehensive research on the effects of cannabis, the comparative safety of cannabis versus traditional medications, and the stigma surrounding its use. Dr. Ross emphasizes the importance of advocacy, education, and support systems, including the role of doulas, in navigating the challenges faced by pregnant women considering cannabis as a treatment option. In this conversation, Dr. Michele Ross discusses the complexities of cannabis use during pregnancy, breastfeeding, and its effects on fertility and mental health. She emphasizes the importance of conscious use, tracking consumption, and the potential benefits and risks associated with cannabis. The discussion also touches on tapering off cannabis and pharmaceuticals, exploring other medicinal plants, and the need for community support among mothers. Dr. Ross highlights the lack of solid research on long-term effects of cannabis exposure and encourages individuals to seek personalized care from qualified professionals. Chapters 00:00 Introduction and Context Setting 05:01 The Role of Cannabis in Women's Health 10:13 Understanding Risks and Benefits of Cannabis During Pregnancy 14:59 Comparative Analysis: Cannabis vs. Traditional Medications 19:47 The Importance of Research and Anecdotal Evidence 25:03 Addressing Stigma and Misconceptions 30:11 The Future of Cannabis Research in Pregnancy 31:23 Legal Complexities of Cannabis Use During Pregnancy 36:36 Navigating Stigma and Support in Cannabis Use 41:40 The Role of Doulas and Healthcare Professionals 46:01 Tapering Cannabis Use and Consumption Methods 56:00 Understanding Cannabis and Fertility 01:02:04 Breastfeeding and Cannabis: Safety and Concerns 01:05:26 The Role of Cannabinoids in Breast Milk Production 01:08:40 Exploring Other Natural Remedies for Mothers 01:10:40 The Future of Botanical Medicine in Motherhood 01:13:12 Mental Health, SSRIs, and Cannabis Interactions 01:18:31 Long-term Effects of Cannabis Exposure on Children 01:21:38 Resources for Expecting and New Mothers Follow Dr.Ross; Instagram and LinkedIn @MicheleRoss Check out Dr. Ross’s amazing books & learn more! https://drmicheleross.com/books/ Order my book Reefer Wellness! ⁠⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Riley Kirk shares her personal journey through pregnancy, focusing on her experiences with cannabis use, tapering down her consumption, and the emotional and physical changes she faced. She discusses the importance of mental health during this time, the role of her supportive partner, and the diagnosis of intrahepatic cholestasis of pregnancy (ICP). The conversation also touches on the gender reveal process and the complexities of navigating a high-risk pregnancy. In this conversation, Riley Kirk shares her personal journey with Intrahepatic Cholestasis of Pregnancy (ICP), a rare liver condition that can occur during pregnancy. She discusses the emotional and physical challenges she faced, the medical treatments available, and the lifestyle changes she made to manage her symptoms. Riley emphasizes the importance of mental health support and community during this difficult time, and reflects on her experiences as a pregnant woman in the cannabis community. She also expresses gratitude for the support she received from friends and family, and looks forward to continuing the conversation about women's health and pregnancy in future episodes. THE MAIN TAKEAWAY OF THIS EPISODE IS TO BE YOUR OWN ADVOCATE DURING PREGNANCY. PHYSICIANS KNOW A LOT BUT YOU ARE THE EXPERT ON YOUR OWN BODY. (THERE'S ALSO A SECRET SEED GIVEAWAY IF YOU CLICK THE PATREON LINK) Chapters 00:00 Introduction to Pregnancy Journey and Cannabis Use 03:11 Discovering Pregnancy and Initial Reactions 05:55 Tapering Down Cannabis Consumption 08:48 Methods of Consumption and Personal Preferences 12:01 Managing Migraines and Mental Health During Pregnancy 15:11 The Role of Supportive Partners 18:00 Gender Reveal and Early Testing 20:51 High-Risk Pregnancy and ICP Diagnosis 27:14 Understanding Intrahepatic Cholestasis of Pregnancy (ICP) 30:00 The Emotional Toll of High-Risk Pregnancy 33:07 Treatment Options and Medical Anomalies 35:53 Lifestyle Changes and Natural Remedies 40:09 Mental Health and Support During Pregnancy 44:01 Reflections on Pregnancy and Community Support 49:00 Looking Ahead: Future Topics and Conversations Preorder my book Reefer Wellness! ⁠⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Host Dr. Riley Kirk and Dr. Anurag Agrawal discuss the intricate relationship between monarch butterflies and milkweed, exploring themes of coevolution, chemical ecology, and the ecological arms race. He explains how monarchs have adapted to survive the toxic compounds in milkweed, the challenges they face due to habitat destruction and pesticides, and the importance of conservation efforts. The discussion highlights the fascinating dynamics of species interactions and the need for community involvement in preserving biodiversity. Chapters 00:00 Introduction to Monarchs and Milkweed 06:32 The Co-evolutionary Dance 11:32 Monarchs vs. Milkweed: The Arms Race 20:14 The Role of Cardiac Glycosides 30:01 Sequestration and Survival Strategies 31:37 The Journey of Monarch Butterflies 37:30 Understanding Monarch Population Decline 46:49 Human Impact on Monarchs and Conservation Efforts 54:01 Exploring Other Fascinating Insects Follow Dr.Agrawal’s research: https://ecologyandevolution.cornell.edu/anurag-agrawal https://agrawal.eeb.cornell.edu/ Read or listen to Monarchs and Milkweed https://www.amazon.com/Monarchs-Milkweed-Migrating-Remarkable-Coevolution/dp/0691166358 Preorder my book Reefer Wellness! ⁠⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠ www.Patreon.com/Cannabichem⁠⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠⁠https://www.appliedpharmacognosy.org/⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bioactive Podcast, Dr. Allyn Howlett—renowned neuroscientist and pioneer in cannabinoid research—shares her groundbreaking journey into the study of cannabis and the discovery of the CB1 receptor. Originally focused on neuronal hormones, Dr. Howlett recounts how her curiosity led to one of the most pivotal findings in medical cannabis science: the identification of the brain’s first cannabinoid receptor. She dives into the mechanisms of THC, the function of cannabinoid receptors in the brain and body, and the discovery of the endocannabinoid system. The conversation explores the historical development of cannabinoid research, the barriers posed by the pharmaceutical industry, and the evolving relationship between academia and drug development. Dr. Howlett also discusses the future of cannabinoid science—including targeted therapies, pain relief, and the medical potential of cannabis compounds. This episode offers an essential look at the scientific foundation behind cannabis medicine and its impact on legalization, healthcare, and public perception. 🔬 Keywords: CB1 receptor, endocannabinoid system, THC, cannabis research, Dr. Allyn Howlett, cannabinoid receptors, medical cannabis, neuroscience, cannabis and pain relief, cannabis legalization, targeted cannabinoid therapies. Follow Dr.Howlett's research: https://school.wakehealth.edu/faculty/h/allyn-howlett Preorder my book Reefer Wellness! ⁠https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156⁠ ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠ www.Patreon.com/Cannabichem⁠ 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem ⁠https://www.appliedpharmacognosy.org/⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation, Dr. Riley Kirk and Dr. Josh Kaplan delve into the complexities of cannabis research, particularly focusing on CBD and its therapeutic potential for conditions like epilepsy. Dr. Kaplan shares his journey into cannabis research, highlighting the significance of understanding CBD's mechanisms, the role of GPR55 in seizure management, and the challenges of dosing CBD effectively. They also discuss the entourage effect, the importance of personalized medicine, and the ongoing research into terpenes and their interactions with cannabinoids. The conversation emphasizes the need for further exploration in cannabis research to develop safe and effective therapies, especially for vulnerable populations like children. In this conversation, Josh Kaplan discusses the therapeutic potential of CBD, particularly in relation to traumatic brain injuries and neurodegenerative diseases. He emphasizes the safety of CBD compared to THC and explores its role in preventative treatments. The conversation also delves into ongoing clinical trials, particularly within the NFL, and the challenges faced in cannabis research, including dosing and the variability of individual responses to cannabinoids. Kaplan highlights the importance of understanding the entourage effect and the need for more personalized approaches in cannabis treatment. More about Dr. Kaplan: Dr. Kaplan is an Associate Professor in the Behavioral Neuroscience Program. His expertise is in neurophysiology, neuropharmacology, and animal behavior techniques, which his lab uses to study the therapeutic benefits and developmental consequences of cannabis in pre-clinical rodent models. His research seeks to optimize cannabinoid and terpene compositions to maximize benefit and minimize adverse consequences. Dr. Kaplan has a strong passion for teaching and communicating science. His scientific writing specializes in the science of cannabis and its medicinal utility. He was included in High Times' 100 Most Influential People in Cannabis (2018) and Cannabis Newsletter's Top 100 (2021). Follow Dr.Kaplan’s research: https://wp.wwu.edu/kaplanlab/ Preorder my book Reefer Wellness! https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156 Seed Giveaway Thank you to Royal Queen Seeds and Last Green Valley Seeds for donating to this week's giveaway! To enter, fill out the form below, winners will be selected at random. https://forms.gle/1vWtsBMGaux9x5Mf6 ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one. www.Patreon.com/Cannabichem 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem https://www.appliedpharmacognosy.org/ Timestamps: 00:00 Introduction to Cannabis Research and Its Importance 03:04 The Journey into CBD and Epilepsy 06:00 Understanding CBD's Mechanism of Action 08:54 The Role of GPR55 in Seizure Management 12:00 Exploring the Entourage Effect 14:53 Challenges in Dosing CBD for Multiple Conditions 18:02 Personalized Medicine and Endocannabinoid System 21:01 Researching Terpenes and Their Effects 24:01 Future Directions in Cannabis Research 34:12 The Therapeutic Potential of CBD 36:34 Traumatic Brain Injury and CBD Research 39:34 Clinical Trials and NFL Studies 48:01 Challenges in Cannabis Research 54:27 Dosing and Efficacy of CBD 01:00:24 The Entourage Effect and Individual Variability Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Bioactive Podcast, Dr. Riley Kirk interviews David Sandelman from Cannatrol, delving into the intricate processes of drying and curing cannabis. David shares his journey into the cannabis industry, emphasizing the importance of controlling environmental conditions to achieve optimal drying and curing results. The conversation explores the science behind water activity, the significance of terpene retention, and the implications of traditional drying methods like the 60-60 method. David highlights the impact of drying rates on the final product and discusses the potential for enzymatic processes to enhance the curing experience. The episode concludes with insights into the variability of different cannabis cultivars and the importance of post-harvest practices in maximizing quality. In this conversation, Riley Kirk and David from Cannatrol delve into the intricacies of drying and curing cannabis, emphasizing the importance of strain specificity and the role of technology in enhancing the quality of cannabis products. They discuss methods for rehydrating overly dry cannabis, adjusting water activity for different products, and effective storage techniques for harvested cannabis. The conversation also touches on the significance of terpenes, the potential for using Cannatrol for other herbs, and the encouragement of experimentation with the technology. David shares insights on achieving consistent drying and curing processes, and the conversation concludes with practical advice for growers. Timestamps 00:00 Introduction to Drying and Curing Cannabis 03:46 The Science Behind Drying and Curing 12:50 Understanding Water Activity in Cannabis 14:43 The Importance of Terpene Retention 21:43 The 60-60 Method: Origins and Implications 26:31 The Rate of Drying and Its Effects 31:05 The Role of Enzymatic Processes in Curing 34:26 Understanding Strain Specificity in Drying and Curing 36:04 Rehydrating Cannabis: Enhancing Quality and Experience 38:41 Adjusting Water Activity for Different Products 41:43 Home Drying and Curing Techniques 43:49 Storing and Managing Harvests Effectively 45:37 The Importance of Terpenes in Cannabis 46:50 Exploring Other Uses for Cannatrol 49:40 Encouraging Experimentation with Cannatrol 51:40 Achieving Consistent Drying and Curing 53:40 Final Thoughts on Drying and Curing Process Learn more from Cannatrol: Instagram @Cannatrol Website: https://www.cannatrols.com/ Seed Giveaway Make sure to comment the magical words on Instagram to be eligible to win some seeds from OR comment the same thing on the FREE Patreon post. Winners will be notified by next week and the next giveaway will be in two weeks when the next episode of Bioactive drops! Preorder my book Reefer Wellness! https://www.amazon.com/Reefer-Wellness-Understanding-Cannabis-Medicine/dp/0593847156 ✨ Want Exclusive Content? Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one. www.Patreon.com/Cannabichem 🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more! Keep up with Dr. Riley Kirk: https://www.bioactivepodcast.com/ https://www.youtube.com/@cannabichem https://instagram.com/cannabichem https://www.appliedpharmacognosy.org/ Learn more about your ad choices. Visit megaphone.fm/adchoices