Cardiology Today

Welcome to Cardiology Today – Recorded March 14, 2026. This episode summarizes 5 key cardiology studies on topics like Pressure microcatheter and Fractional flow reserve. Key takeaway: Finerenone Boosts HFpEF Quality of Life. Article Links: Article 1: Heart failure patients with reduced or mildly reduced ejection fraction: baseline characteristics of the low-dose digoxin outcome DECISION trial. (European journal of heart failure) Article 2: Finerenone and Quality of Life in Heart Failure: Component-Level Analyses and Clinical Relevance of the Kansas City Cardiomyopathy Questionnaire. (European journal of heart failure) Article 3: Infective Endocarditis After Arrythmia Device Implantation in Cardiac Surgery Patients. (Journal of the American Heart Association) Article 4: Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis. (Journal of the American Heart Association) Article 5: Clinical Validation of a Novel Pressure Microcatheter-Based Nonhyperemic Pressure Ratio (SUPREME II Study). (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/finerenone-boosts-hfpef-quality-of-life-03-14-26/ Featured Articles Article 1: Heart failure patients with reduced or mildly reduced ejection fraction: baseline characteristics of the low-dose digoxin outcome DECISION trial. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823368 Summary: This report provided the detailed baseline characteristics of patients enrolled in the D.E.C.I.S.I.O.N. trial. It established the specific clinical profile of contemporary heart failure patients with reduced or mildly reduced left ventricular ejection fraction who are receiving low-dose digoxin or placebo. The report positioned these patient characteristics against those observed in previous cardiac glycoside trials such as D.I.G. and D.I.G.I.T. minus H. F., providing a comparative context for future outcome data. The study design, a randomized, double-blind, placebo-controlled outcome trial, demonstrated its focus on evaluating digoxin’s effects in this defined population. Article 2: Finerenone and Quality of Life in Heart Failure: Component-Level Analyses and Clinical Relevance of the Kansas City Cardiomyopathy Questionnaire. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41817207 Summary: Finerenone improved the overall health status of patients with heart failure with mildly reduced or preserved ejection fraction, as measured by the aggregate 23-item Kansas City Cardiomyopathy Questionnaire score. This prespecified analysis from the F.I.N.E.A.R.T.S. minus H. F. trial contextualized these improvements, demonstrating the clinical relevance of K.C.C.Q. changes for both patients and clinicians. The findings enhance the understanding of how finerenone impacts patient quality of life in this specific heart failure population. Article 3: Infective Endocarditis After Arrythmia Device Implantation in Cardiac Surgery Patients. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823269 Summary: This nationwide registry-based study identified the risk of infective endocarditis after cardiac implantable electronic device implantation within 30 days of cardiac surgery. The study established specific risk factors associated with this complication in patients undergoing first-time cardiac surgery in Sweden. Findings demonstrated that patients in this cohort, without previous cardiac implantable electronic devices, experience an increased risk of infective endocarditis. These results highlight the need for vigilance and targeted strategies in this vulnerable patient population. Article 4: Impact of Combined Anticoagulant and Antiplatelet Therapy in Older Patients With Atrial Fibrillation: ANAFIE Subanalysis. Journal: Journal of the American Heart...

Welcome to Cardiology Today – Recorded March 14, 2026. This episode summarizes 5 key cardiology studies on topics like risk stratification and mortality. Key takeaway: Genetic Evidence for GLP1R in Heart Failure. Article Links: Article 1: Great debate: the new risk factor-weighted clinical likelihood model is useful to estimate the initial pre-test probability of obstructive coronary artery disease in individuals with suspected chronic coronary syndromes. (European heart journal) Article 2: Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. (Heart (British Cardiac Society)) Article 3: Genetic Evidence for GLP1R Agonists in Non-Ischaemic Heart Failure. (ESC heart failure) Article 4: Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair. (European journal of heart failure) Article 5: Prevalence and influence of cardiovascular kidney metabolic syndrome on outcomes after transcatheter aortic valve implantation. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/genetic-evidence-for-glp1r-in-heart-failure-03-14-26/ Featured Articles Article 1: Great debate: the new risk factor-weighted clinical likelihood model is useful to estimate the initial pre-test probability of obstructive coronary artery disease in individuals with suspected chronic coronary syndromes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41823519 Summary: The article presents the utility of the new risk factor-weighted clinical likelihood model for estimating the initial pre-test probability of obstructive coronary artery disease. The 2024 European Society of Cardiology guidelines recommend this risk factor-weighted clinical likelihood model as the initial step for individuals with suspected chronic coronary syndromes. This model combines age, sex, symptom characteristics, five clinical risk factors, and coronary calcification data, when available, to provide a numerical estimate of pre-test probability. Article 2: Cardiac amyloidosis across the spectrum of left ventricular function: multimodal functional and prognostic insights. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825942 Summary: A study of 2244 patients with cardiac amyloidosis demonstrated that many present with mildly reduced or reduced ejection fraction, not solely preserved ejection fraction as commonly perceived. The cohort included 557 patients with light chain amyloidosis, 392 with hereditary transthyretin amyloidosis, and 1137 with wild-type transthyretin amyloidosis. Recognizing cardiac amyloidosis across this full spectrum of left ventricular function, from preserved to reduced ejection fraction, is crucial for accurate diagnosis and effective risk stratification. Article 3: Genetic Evidence for GLP1R Agonists in Non-Ischaemic Heart Failure. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825483 Summary: L. P. 1 R Agonists in Non-Ischaemic Heart Failure. Glucagon-like peptide-one receptor agonists demonstrate existing cardiovascular event reduction in patients with obesity and diabetes, alongside symptomatic and functional benefits in heart failure with preserved ejection fraction. This study employed drug-target Mendelian randomization using genetic variants in the glucagon-like peptide-one receptor locus. The research revealed genetic evidence supporting the efficacy of glucagon-like peptide-one receptor activation in non-ischaemic heart failure. This genetic approach offers insights into mechanisms beyond glycaemic control or weight reduction. Article 4: Left-sided heart failure determines outcomes in patients with severe tricuspid regurgitation undergoing percutaneous repair. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41825486 Summary: This...

Welcome to Cardiology Today – Recorded March 13, 2026. This episode summarizes 5 key cardiology studies on topics like left atrial pressure and left atrial shunting. Key takeaway: H. F. pEF Shunt System: 3-Year Safety & Function. Article Links: Article 1: Off-label underdosing of edoxaban antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease: findings from the EPIC-CAD trial. (Heart (British Cardiac Society)) Article 2: Analysis and prediction of cardiovascular research hotspots, trends and interdisciplinarity. (Heart (British Cardiac Society)) Article 3: Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study. (Heart (British Cardiac Society)) Article 4: Atrial fibrillation and the risk of sudden cardiac death: incidence, impact and implications. (Heart (British Cardiac Society)) Article 5: The ALT FLOW Early Feasibility Study 3-year Results Assessing Left Atrial to Coronary Sinus Shunting in HFpEF. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/h-f-pef-shunt-system-3-year-safety-function-03-13-26/ Featured Articles Article 1: Off-label underdosing of edoxaban antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease: findings from the EPIC-CAD trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40930594 Summary: The EPIC-CAD trial defined specific patient populations with atrial fibrillation and stable coronary artery disease receiving edoxaban antithrombotic therapy. This study investigated the clinical outcomes associated with off-label underdosing of direct oral anticoagulants in this patient cohort. Participants were randomized to either edoxaban monotherapy or a dual antithrombotic therapy regimen combining edoxaban with a single antiplatelet agent. This research therefore characterizes the comparative safety and efficacy of these two distinct antithrombotic strategies. Article 2: Analysis and prediction of cardiovascular research hotspots, trends and interdisciplinarity. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40877031 Summary: This study systematically analyzed over 2 million 512 445 cardiovascular publications to characterize research topics, trends, and interdisciplinarity. Artificial intelligence techniques, including natural language processing, were extensively utilized to extract and cluster text fragments from titles and abstracts. This comprehensive data processing approach provides a foundation for clarifying recent cardiovascular research directions and informs policy development for the academic community. Article 3: Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40866119 Summary: This study characterized electrocardiogram abnormalities in 26846 Chinese individuals aged 50 and older from the Guangzhou Biobank Cohort Study. Participants had no cardiovascular disease at baseline. Minor and major electrocardiogram abnormalities were classified based on the Minnesota Code Manual, allowing for definitive categorization of severity. Severity was specifically defined as normal, one minor, two or more minor, or major. Article 4: Atrial fibrillation and the risk of sudden cardiac death: incidence, impact and implications. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40664496 Summary: This study performed a retrospective assessment of sudden cardiac death incidence in patients with atrial fibrillation over an 11-year period, from 2007 to 2018. The analysis included individuals undergoing coronary angiography, specifically those with suspected or known coronary artery disease referred for elective angiography. The study also encompassed...

Welcome to Cardiology Today – Recorded March 12, 2026. This episode summarizes 5 key cardiology studies on topics like advanced heart failure and implanted defibrillators. Key takeaway: Target-Dose A. C. E. I. s Cut Kidney Failure in H. F. rEF.. Article Links: Article 1: Long-term outcomes of patients implanted with a HeartMate 3 left ventricular assist device – a real-world, single center, observational study. (ESC heart failure) Article 2: Effects of Metabolic Syndrome on Cardiovascular Outcomes in Non-Obese Heart Failure Patients. (ESC heart failure) Article 3: Optimised murine HFpEF models for translational pre-clinical studies. (ESC heart failure) Article 4: Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry. (European journal of heart failure) Article 5: Target-Dose Versus Below-Target-Dose ACE Inhibitors and Lower Risk of Kidney Failure in U.S. Veterans with HFrEF. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/target-dose-a-c-e-i-s-cut-kidney-failure-in-h-f-ref-03-12-26/ Featured Articles Article 1: Long-term outcomes of patients implanted with a HeartMate 3 left ventricular assist device – a real-world, single center, observational study. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812231 Summary: Left ventricular assist device therapy, particularly with the HeartMate 3, is an established treatment for advanced heart failure with reduced ejection fraction. This real-world study characterized the long-term outcomes of 176 patients receiving a HeartMate 3 device at a single center. The research provided specific findings regarding device survival and major adverse events over time in this patient population. These outcomes are crucial for understanding the durable support offered by the HeartMate 3 in clinical practice. Article 2: Effects of Metabolic Syndrome on Cardiovascular Outcomes in Non-Obese Heart Failure Patients. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812230 Summary: Previous research established an association between metabolic syndrome and adverse heart failure outcomes in patients with implanted defibrillators or cardiac resynchronization therapy. This study investigated the specific role of metabolic syndrome and its components in predicting the risk of heart failure or death in non-obese patients with these devices. It included both obese and non-obese patients from a multicenter registry to analyze these predictive relationships. The findings clarified the impact of metabolic syndrome on cardiovascular outcomes in a previously understudied non-obese heart failure population. Article 3: Optimised murine HFpEF models for translational pre-clinical studies. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812219 Summary: F. pEF models for translational pre-clinical studies. The study successfully optimized murine models for Heart Failure with preserved Ejection Fraction, or H. F. pEF, for improved translational pre-clinical studies. Researchers modified the two-hit model protocol by increasing L-NAME doses from 0.5 grams per liter to 1.75 grams per liter and extending protocol lengths from seven weeks to thirteen weeks. These changes reproduced H. F. pEF in both C57BL/6N and 6J mice, addressing previous limitations regarding sub-strain and sex. The refined three-hit model also included specific modifications, yielding more clinically representative models for H. F. pEF research. Article 4: Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810505 Summary: F. pEF Registry. The clinical effect of beta-blockers in patients with Heart Failure with preserved Ejection Fraction, or H. F. pEF, has been a subject of controversy. This...

Welcome to Cardiology Today – Recorded March 12, 2026. This episode summarizes 5 key cardiology studies on topics like heart failure with reduced ejection fraction and Conduction system pacing. Key takeaway: Polyamine Inhibition Boosts Heart Transplant Acceptance. Article Links: Article 1: Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Association of tricuspid regurgitation severity with activities of daily living and dementia in patients with heart failure: Insight from the KUNIUMI Registry Chronic Cohort. (Journal of cardiac failure) Article 3: Identifying High-Risk Subgroups for Heart Failure Among People with Diabetes: The Impact of Cancer. (Journal of cardiac failure) Article 4: Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial. (JAMA cardiology) Article 5: Model-based cost-effectiveness analysis of first-line pharmacotherapy combinations in adults with chronic heart failure and reduced ejection fraction. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/polyamine-inhibition-boosts-heart-transplant-acceptance-03-12-26/ Featured Articles Article 1: Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812731 Summary: D. 8 positive T cell differentiation. This study found polyamine metabolism was significantly upregulated in T cells during acute rejection in murine models. Inhibition of T cell polyamine metabolism promoted transplant acceptance by modulating cytotoxic C. D. 8 positive T cell differentiation. The findings demonstrated a critical role for T cell polyamine metabolism in transplant rejection and identified a potential therapeutic target. Article 2: Association of tricuspid regurgitation severity with activities of daily living and dementia in patients with heart failure: Insight from the KUNIUMI Registry Chronic Cohort. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812968 Summary: This study investigated the association of tricuspid regurgitation severity with longitudinal changes in activities of daily living and cognitive function. Researchers analyzed 1269 heart failure patients, 67.5 percent with Heart Failure with preserved ejection fraction, over a 1-year follow-up period. The investigation highlights the critical need to understand how tricuspid regurgitation impacts functional and cognitive decline in elderly heart failure patients. Article 3: Identifying High-Risk Subgroups for Heart Failure Among People with Diabetes: The Impact of Cancer. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41812967 Summary: This study examined the incidence of heart failure in individuals with diabetes mellitus and cancer compared with those having diabetes mellitus alone. Researchers established a national cohort by linking 792742 individuals aged 50 years or older from the Australian National Diabetes Services Scheme with hospital admissions and death records. The study provides important insights into identifying high-risk subgroups for heart failure among people with diabetes, specifically highlighting the impact of cancer. Article 4: Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41811324 Summary: F. Randomized Clinical Trial. The PhysioSync-H. F. randomized clinical trial compared conduction system...

Welcome to Cardiology Today – Recorded March 11, 2026. This episode summarizes 5 key cardiology studies on topics like morbidity and Incident heart failure. Key takeaway: New Risk Models Pinpoint Future Heart Failure. Article Links: Article 1: Cardiovascular Statistics in the United States, 2026: JACC Stats. (Journal of the American College of Cardiology) Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. (European heart journal) Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. (European heart journal) Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. (European heart journal) Article 5: Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure: The HeartSync-LBBP Randomized Clinical Trial. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/new-risk-models-pinpoint-future-heart-failure-03-11-26/ Featured Articles Article 1: Cardiovascular Statistics in the United States, 2026: JACC Stats. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41524687 Summary: The JACC Cardiovascular Statistics 2026 report found that cardiovascular disease remains the leading cause of morbidity and mortality in the United States. It provides the most up-to-date data on cardiovascular health, covering major risk factors like hypertension, diabetes, obesity, high cholesterol, and cigarette smoking. The report details conditions such as coronary heart disease, acute myocardial infarction, heart failure, and peripheral artery disease, which collectively cause most cardiovascular deaths and disability. Article 2: Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810961 Summary: The SMART2-HF model was developed and externally validated for the prediction of incident heart failure in patients with established atherosclerotic cardiovascular disease. This model addresses a critical gap, as current guideline-recommended risk assessment models do not include incident heart failure. The SMART2-HF model provides a new tool to identify patients at high risk of developing heart failure, thus informing preventive strategies. Article 3: Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810943 Summary: The SCORE2-HF risk model was developed and validated for heart failure risk estimation in European adults over 40 years of age without prior cardiovascular disease. This sex-specific, competing risk-adjusted model was derived using data from 25 prospective cohorts, involving 611778 individuals and observing 21818 incident heart failure events. The SCORE2-HF models incorporate age, smoking status, systolic blood pressure, and antihypertensive treatment status to assess risk. Article 4: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41810940 Summary: The LIFE-Preserved model was developed and validated for predicting individual short-term and lifetime risk of heart failure hospitalization or cardiovascular death. This model specifically addresses risk in patients diagnosed with heart failure with preserved ejection fraction. It provides a tool for identifying high-risk individuals who could benefit most from targeted preventive treatments, given the rising incidence and varying prognosis of this heterogeneous disease. Article 5: Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart...

Welcome to Cardiology Today – Recorded March 11, 2026. This episode summarizes 5 key cardiology studies on topics like UCP2 single nucleotide polymorphisms and pulmonary arterial hypertension. Key takeaway: New P. A. H. -C. H. D. Risk Model for Adults. Article Links: Article 1: A Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension. (Circulation) Article 2: TRIM28 Is an E3 Ligase of IRP2 Suppressing Ischemia/Reperfusion-Induced Myocardial Ferroptosis. (Circulation) Article 3: Proteomic insights into troponin elevation following COVID-19 infection. (Heart (British Cardiac Society)) Article 4: Comparative Value of HFpEF Scores for Risk Stratification in Patients with Unexplained Dyspnea. (European journal of heart failure) Article 5: Risk stratification for adult patients with pulmonary arterial hypertension associated with congenital heart disease. A scientific statement of the ESC Working Group on Pulmonary Circulation and Right Ventricular Function, the ESC Working Group on Adult Congenital Heart Disease, and the Association of Cardiovascular Nursing and Allied Professions of the ESC. (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/new-p-a-h-c-h-d-risk-model-for-adults-03-11-26/ Featured Articles Article 1: A Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41797703 Summary: This study identified that cardiac myofibroblasts contribute critically to right ventricular failure in pulmonary arterial hypertension. It also found that U. C. P. 2 single nucleotide polymorphisms predispose patients to right ventricular decompensation. The transition from a compensated to a decompensated right ventricle is a major driver of morbidity and mortality in this condition. These findings highlight a specific cellular mechanism and genetic factor that influence right ventricular failure progression. Article 2: TRIM28 Is an E3 Ligase of IRP2 Suppressing Ischemia/Reperfusion-Induced Myocardial Ferroptosis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41797698 Summary: This study found that T. R. I. M. 28 functions as an E3 ligase for Iron Regulatory Protein 2, or I. R. P. 2. The data showed that T. R. I. M. 28 suppresses myocardial ferroptosis induced by ischemia reperfusion injury. This mechanism suggests a novel pathway in preventing regulated cell death in ischemic heart disease. These findings could inform the development of new therapeutic strategies for myocardial ischemia reperfusion injury. Article 3: Proteomic insights into troponin elevation following COVID-19 infection. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41802850 Summary: This study provided significant proteomic insights into the mechanisms of cardiac troponin-I elevation in patients hospitalized with COVID-19. It clarified that elevated troponin-I often occurs even without overt myocardial injury in these patients. The findings advanced the understanding of how acute viral infections, specifically COVID-19, lead to troponin elevation. This information offers crucial interpretive guidance for clinicians managing COVID-19 patients with elevated cardiac biomarkers. Article 4: Comparative Value of HFpEF Scores for Risk Stratification in Patients with Unexplained Dyspnea. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41802264 Summary: This study established the comparative value of Heart Failure with Preserved Ejection Fraction scores for risk stratification in patients presenting with unexplained dyspnea. The findings demonstrated how these scores associate with structural...

Welcome to Cardiology Today – Recorded March 10, 2026. This episode summarizes 5 key cardiology studies on topics like comorbidities and acute myocarditis. Key takeaway: YAP Boosts Cardiomyocyte Renewal for Repair. Article Links: Article 1: GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis. (Circulation) Article 2: Clinical Spectrum of Children With Parvovirus B19-Associated Acute Myocarditis. (Circulation) Article 3: Differences in Disease Trajectory, Comorbidities, and Mortality in Sarcomeric and Nonsarcomeric Hypertrophic Cardiomyopathy. (Circulation) Article 4: YAP Induces a Prorenewal Metabolic State in Cardiomyocytes. (Circulation) Article 5: PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/yap-boosts-cardiomyocyte-renewal-for-repair-03-10-26/ Featured Articles Article 1: GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41487100 Summary: The study identified guanine-rich RNA sequence binding factor one, or GRSF1, as a regulator of cell-intrinsic branched-chain amino acid, or B. C. A. A., metabolic pathways. This post-transcriptional regulation by GRSF1 was found to contribute to the pathogenesis of heart failure. The data demonstrated that GRSF1 protects against heart failure by maintaining B. C. A. A. homeostasis. This mechanism provides a novel understanding of metabolic imbalances in cardiac dysfunction. Article 2: Clinical Spectrum of Children With Parvovirus B19-Associated Acute Myocarditis. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41487093 Summary: This multicenter retrospective observational study characterized the clinical features and outcomes of children with parvovirus B19-associated acute myocarditis. The research provided specific data on the clinical spectrum observed in pediatric patients with this condition following an outbreak of parvovirus B19 infections in 2024. The study identified patterns of disease presentation and progression in this vulnerable population. This data clarifies the understanding of a critical cardiac complication in children. Article 3: Differences in Disease Trajectory, Comorbidities, and Mortality in Sarcomeric and Nonsarcomeric Hypertrophic Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41800474 Summary: Sarcomere gene variants were found to be a key cause of hypertrophic cardiomyopathy, or H. C. M., and were associated with a worse prognosis. This multicenter longitudinal cohort study in the Sarcomeric Human Cardiomyopathy registry demonstrated significant differences in disease trajectory, comorbidities, and mortality between patients with sarcomeric and nonsarcomeric H. C. M. The data revealed how comorbidities specifically influence clinical courses and causes of death in these distinct patient groups. This finding provides crucial insights for risk stratification and personalized management strategies in hypertrophic cardiomyopathy. Article 4: YAP Induces a Prorenewal Metabolic State in Cardiomyocytes. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41797725 Summary: The study found that YAP induces a prorenewal metabolic state in cardiomyocytes. This mechanism was identified as a key factor contributing to the regenerative capacity observed in neonatal rodents. The data demonstrated that YAP helps counteract the decline in cardiomyocyte regeneration that occurs with cellular maturation. This finding provides critical insights into potential therapeutic targets for promoting cardiac repair and regeneration. Article 5: PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41797709 Summary: The study found that protein arginine methyltransferase...

Welcome to Cardiology Today – Recorded March 09, 2026. This episode summarizes 5 key cardiology studies on topics like cardiac aging and empagliflozin. Key takeaway: A. I. Mammograms Predict Heart Disease in Women. Article Links: Article 1: Silent plaque ruptures in non-obstructive lesions of non-infarct-related arteries: a multimodality, serial intracoronary imaging study. (European heart journal) Article 2: Artificial intelligence-based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality. (European heart journal) Article 3: Endothelial ZBTB16: a molecular shield against cardiac aging. (European heart journal) Article 4: Empagliflozin in De Novo vs Acute Decompensated Chronic Heart Failure: A Prespecified Analysis From EMPULSE. (JACC. Heart failure) Article 5: BRISC Deficiency Drives Heart Failure by Regulating β-Catenin K63 Ubiquitination. (Hypertension (Dallas, Tex. : 1979)) Full episode page: https://podcast.explainheart.com/podcast/a-i-mammograms-predict-heart-disease-in-women-03-09-26/ Featured Articles Article 1: Silent plaque ruptures in non-obstructive lesions of non-infarct-related arteries: a multimodality, serial intracoronary imaging study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41795942 Summary: This study revealed that silent plaque ruptures frequently occur in non-obstructive lesions within non-infarct-related coronary arteries of acute myocardial infarction patients. Researchers characterized the specific morphological features of these ruptures. The study tracked changes in rupture sites over 52 weeks, demonstrating their dynamic nature. It also identified the baseline morphology associated with new-onset ruptures, advancing understanding of coronary artery disease progression beyond the infarct-related artery. Article 2: Artificial intelligence-based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41795899 Summary: Artificial intelligence-based automatic quantification of breast arterial calcification from screening mammograms significantly predicted cardiovascular disease morbidity and mortality. This A. I. methodology demonstrated superior predictive value beyond existing PREVENT scores in a large, racially diverse cohort of 123762 women. The results establish breast arterial calcification as a robust and automatically quantifiable biomarker for cardiovascular risk. These findings support integrating A. I. assessment of mammograms into cardiovascular risk stratification for women. Article 3: Endothelial ZBTB16: a molecular shield against cardiac aging. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493057 Summary: This study identified zinc finger and B. T. B. domain-containing protein 16, or ZBTB16, as playing a critical protective role against cardiac aging. Researchers found that endothelial ZBTB16 functions as a molecular shield, counteracting age-related cardiac dysfunction. The data revealed specific epigenetically regulated mechanisms underlying endothelial cell impairment during aging. These findings provide novel insights into the molecular processes of cardiac aging and suggest potential therapeutic targets. Article 4: Empagliflozin in De Novo vs Acute Decompensated Chronic Heart Failure: A Prespecified Analysis From EMPULSE. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41793401 Summary: This prespecified analysis from the EMPULSE trial found that empagliflozin significantly improved clinical outcomes in patients hospitalized for heart failure. The sodium-glucose cotransporter 2 inhibitor demonstrated consistent efficacy, safety, and tolerability in both de novo heart failure and acute decompensated heart failure subgroups. The benefits of empagliflozin were observed early, providing critical support...

Welcome to Cardiology Today – Recorded March 07, 2026. This episode summarizes 5 key cardiology studies on topics like point-of-care devices and artificial intelligence. Key takeaway: AI Point-of-Care Cuts Heart Failure Costs. Article Links: Article 1: Management and Consequences of Genotype-Positive Familial Hypercholesterolemia. (JAMA cardiology) Article 2: Spectrum of Primary Aldosteronism and Risk of Cardiovascular Outcomes: The Atherosclerosis Risk in Communities Study. (JAMA cardiology) Article 3: AI task-shifting for echocardiographic LVEF assessment in Singapore: an economic evaluation. (ESC heart failure) Article 4: Characterising the heterogeneity of heart failure with preserved ejection fraction: moving beyond subgroups and distinguishing disease from risk. (European journal of heart failure) Article 5: Head Down Position Before Endovascular Treatment for Large Vessel Occlusion: Clinical Trial Design. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/ai-point-of-care-cuts-heart-failure-costs-03-07-26/ Featured Articles Article 1: Management and Consequences of Genotype-Positive Familial Hypercholesterolemia. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41779414 Summary: Familial hypercholesterolemia is established as a common genetic condition that causes hypercholesterolemia and significantly increases the risk for premature atherosclerotic cardiovascular disease. Current understanding of the precise prevalence, optimal management strategies, and long-term consequences of genetically confirmed familial hypercholesterolemia across the United States remains limited. This existing knowledge gap underscores the urgent requirement for comprehensive data to accurately characterize this condition. Such characterization is crucial for defining the true burden of disease and developing evidence-based lipid-lowering management strategies. Article 2: Spectrum of Primary Aldosteronism and Risk of Cardiovascular Outcomes: The Atherosclerosis Risk in Communities Study. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41779388 Summary: Mounting evidence demonstrates that renin-independent aldosteronism is a common condition that is frequently underrecognized in clinical practice. The full spectrum of aldosteronism, specifically its association with incident cardiovascular disease events, has not been comprehensively evaluated in community-dwelling older adults. A more thorough understanding of how aldosterone measures correlate with cardiovascular outcomes is essential. This information would improve risk stratification and guide preventative strategies for an underdiagnosed patient population. Article 3: AI task-shifting for echocardiographic LVEF assessment in Singapore: an economic evaluation. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41784150 Summary: Accurate assessment of left ventricular ejection fraction is crucial for heart failure diagnosis, typically requiring skilled sonographers. Artificial intelligence-enabled point-of-care devices are capable of enabling novice operators to accurately assess left ventricular ejection fraction, which leads to reduced healthcare costs. An economic evaluation conducted a cost-minimization analysis, directly comparing conventional sonographer-performed echocardiography to novice-operated artificial intelligence-enabled point-of-care devices. This analysis confirmed the economic benefits of task-shifting using artificial intelligence-enabled platforms for diagnosing left ventricular ejection fraction below 50 percent, offering a cost-effective solution. Article 4: Characterising the heterogeneity of heart failure with preserved ejection fraction: moving beyond subgroups and distinguishing disease from risk. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41782360 Summary: Heart failure with...

Welcome to Cardiology Today – Recorded March 07, 2026. This episode summarizes 5 key cardiology studies on topics like risk prediction model and aficamten. Key takeaway: Preventive PCI for Vulnerable Plaques. Article Links: Article 1: Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities. (European heart journal) Article 2: Great debate: preventive percutaneous coronary intervention added to optimal medical treatment should be the default treatment for non-flow-limiting vulnerable plaques. (European heart journal) Article 3: Laminopathies: natural history and risk prediction of heart failure. (European heart journal) Article 4: Senescence-related myocardial dysfunction: keeping a young heart. (European heart journal) Article 5: Aficamten in symptomatic obstructive hypertrophic cardiomyopathy: the FOREST-HCM long-term study. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/preventive-pci-for-vulnerable-plaques-03-07-26/ Featured Articles Article 1: Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41790457 Summary: Advances in clinical research revealed beneficial effects of pharmacological classes of metabolic drugs on cardiovascular outcomes. These findings demonstrate complex interactions between metabolism and cardiac pathology. Understanding the molecular and cellular mechanisms of these agents identifies new therapeutic opportunities for cardiovascular risk reduction. This suggests a paradigm shift in managing cardiovascular risk linked to metabolic disorders. Article 2: Great debate: preventive percutaneous coronary intervention added to optimal medical treatment should be the default treatment for non-flow-limiting vulnerable plaques. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41790132 Summary: Acute myocardial ischemic syndromes frequently arise from rupture or erosion of non-flow-limiting vulnerable plaques. Optimal medical therapy leaves substantial residual cardiovascular risk, prompting consideration of preventive percutaneous coronary intervention to stabilize these high-risk lesions. Contemporary intracoronary imaging techniques, including intravascular ultrasound and optical coherence tomography, effectively identify these vulnerable plaques. The clinical argument supports preventive percutaneous coronary intervention as a default treatment strategy for these lesions, aiming to reduce future major adverse cardiovascular events. Article 3: Laminopathies: natural history and risk prediction of heart failure. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41790128 Summary: This study developed a prediction model for severe heart failure events in adult-onset laminopathies, addressing the high risk faced by patients with L. M. N. A. gene variants. Researchers included 470 adults from the French L. M. N. A. nationwide registry for derivation and an independent international cohort for validation. The model provides a tool for predicting the incidence of severe heart failure events in this patient population. This advances risk stratification for laminopathy patients. Article 4: Senescence-related myocardial dysfunction: keeping a young heart. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41790041 Summary: The myocardium undergoes significant changes with aging, impacting the heart’s pumping action. These senescence-related alterations contribute to myocardial dysfunction, a process that is not yet fully understood. Identifying the mechanisms of these age-related changes is crucial for understanding pathological processes and developing targeted therapeutic strategies. These insights hold long-term implications for maintaining cardiovascular health in an aging population. Article 5: Aficamten in symptomatic obstructive...

Welcome to Cardiology Today – Recorded March 06, 2026. This episode summarizes 5 key cardiology studies on topics like breast cancer and cardiac myosin inhibitor. Key takeaway: AI Predicts Heart Failure from ECGs. Article Links: Article 1: Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy. (Journal of the American College of Cardiology) Article 2: Predicting Heart Failure From 12-Lead ECGs Using AI: A HeartShare/AMP-HF Pooled Cohort Analysis. (Journal of the American College of Cardiology) Article 3: Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multidomain, Patient-Level Analysis of the MAPLE-HCM Trial. (Journal of the American College of Cardiology) Article 4: Nuclear AGO2 exacerbates heart failure with preserved ejection fraction through myocardial ketogenesis. (European heart journal) Article 5: Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/ai-predicts-heart-failure-from-ecgs-03-06-26/ Featured Articles Article 1: Effect of Aficamten vs Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493295 Summary: Aficamten, a cardiac myosin inhibitor, was significantly more effective than metoprolol at improving exercise tolerance in patients with obstructive hypertrophic cardiomyopathy. The MAPLE-HCM trial, a head-to-head, international, double-blind, randomized study, demonstrated this definitive finding. Aficamten showed clear superiority over metoprolol in this patient population. Article 2: Predicting Heart Failure From 12-Lead ECGs Using AI: A HeartShare/AMP-HF Pooled Cohort Analysis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41493294 Summary: Artificial intelligence applied to electrocardiograms enhances the prediction of incident heart failure beyond clinical risk estimation using the PREVENT-Heart Failure equation. This electrocardiogram-artificial intelligence was specifically designed to detect both systolic and diastolic dysfunction. The pooled cohort analysis found that this scalable approach improves identification of individuals at risk for heart failure. Article 3: Aficamten in Obstructive Hypertrophic Cardiomyopathy: A Multidomain, Patient-Level Analysis of the MAPLE-HCM Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41348072 Summary: The MAPLE-HCM trial demonstrated that aficamten monotherapy provided greater improvement in exercise capacity and multiple secondary endpoints compared to metoprolol monotherapy. This multidomain, patient-level analysis further evaluated aficamten’s effects across various clinically relevant and patient-centric measures of disease burden in obstructive hypertrophic cardiomyopathy. Aficamten definitively improved outcomes compared to the traditional beta-blocker therapy. Article 4: Nuclear AGO2 exacerbates heart failure with preserved ejection fraction through myocardial ketogenesis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41784225 Summary: This study found that nuclear argonaute two exacerbates heart failure with preserved ejection fraction through myocardial ketogenesis. This mechanism contributes to cardiac dysfunction, particularly in contexts of high-fat diet. The research demonstrated a causal role for nuclear argonaute two in inducing this specific type of heart failure. These findings offer a novel understanding of disease progression for heart failure with preserved ejection fraction. Article 5: Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41780910 Summary: Breast...

Welcome to Cardiology Today – Recorded March 05, 2026. This episode summarizes 5 key cardiology studies on topics like Computed tomography angiography and Verapamil. Key takeaway: Nonobstructive Hypertrophic Cardiomyopathy: Bisoprolol vs Verapamil. Article Links: Article 1: Finerenone in Type 1 Diabetes and Chronic Kidney Disease. (The New England journal of medicine) Article 2: Coronary Atherosclerosis in Liver Transplant Recipients and Population Controls: A Nationwide Study Using Protocolized CT Angiography. (Journal of the American College of Cardiology) Article 3: Intravascular Imaging- vs Angiography-Guided Complex PCI: 5-Year Outcomes From a Randomized Trial. (Journal of the American College of Cardiology) Article 4: Beta-Blocker (Bisoprolol) vs Calcium-Channel Blocker (Verapamil) in Nonobstructive Hypertrophic Cardiomyopathy: A Randomized Triple-Crossover Physiologic Trial. (Journal of the American College of Cardiology) Article 5: Heart Failure Quality of Care Among Asian Patients in the United States. (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/nonobstructive-hypertrophic-cardiomyopathy-bisoprolol-vs-verapamil-03-05-26/ Featured Articles Article 1: Finerenone in Type 1 Diabetes and Chronic Kidney Disease. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41780000 Summary: Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has demonstrated improvements in kidney and cardiovascular outcomes in patients with type two diabetes and chronic kidney disease. This established benefit prompted a phase three trial evaluating finerenone’s efficacy and safety in adults with type one diabetes and chronic kidney disease. The study included patients with an estimated glomerular filtration rate between 25 and less than 90 milliliters per minute per 1.73 meters squared, who also presented with albuminuria. This research directly addresses the potential therapeutic application of finerenone for improving outcomes in a distinct diabetic population. Article 2: Coronary Atherosclerosis in Liver Transplant Recipients and Population Controls: A Nationwide Study Using Protocolized CT Angiography. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41778959 Summary: This nationwide cross-sectional study definitively characterized the prevalence and severity of coronary atherosclerosis in liver transplant recipients compared to control subjects. Researchers utilized protocolized research-coronary computed tomography angiography in both groups to overcome previous limitations of clinically indicated imaging or retrospective studies. This standardized approach provided a more robust assessment of coronary atherosclerotic burden. The study established a comprehensive profile of atherosclerotic disease in liver transplant patients. Article 3: Intravascular Imaging- vs Angiography-Guided Complex PCI: 5-Year Outcomes From a Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41778943 Summary: This randomized trial provided crucial long-term clinical outcomes comparing intravascular imaging-guided percutaneous coronary intervention with angiography-guided percutaneous coronary intervention for complex coronary artery lesions. The study definitively evaluated two distinct approaches for revascularization, assigning eligible patients in a two to one ratio to receive either imaging guidance or angiography guidance. This robust comparison established a clearer understanding of the relative long-term efficacy of each technique. The findings inform optimal strategies for percutaneous coronary intervention in challenging cases. Article 4: Beta-Blocker (Bisoprolol) vs Calcium-Channel Blocker (Verapamil) in Nonobstructive Hypertrophic Cardiomyopathy: A Randomized Triple-Crossover Physiologic Trial. Journal:...

Welcome to Cardiology Today – Recorded March 04, 2026. This episode summarizes 5 key cardiology studies on topics like risk stratification and left ventricular diastolic dysfunction. Key takeaway: Atrial Cardiomyopathy Imaging Improves Risk Stratification. Article Links: Article 1: Burden of chronic kidney disease and outcomes following hospitalisation for heart failure. (Heart (British Cardiac Society)) Article 2: Role of Imaging Techniques in Monitoring Atrial Cardiomyopathy and Atrial Failure: A Scientific Statement. (ESC heart failure) Article 3: MUTTON-HF: Rationale and Design of a Study of an Indigenous Food is Medicine Intervention. (Circulation. Heart failure) Article 4: Sex Differences in Outcomes of Young Adults Hospitalized With First Myocardial Infarction From 2011 to 2022. (Journal of the American Heart Association) Article 5: Associations Between Sustained Methamphetamine/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/atrial-cardiomyopathy-imaging-improves-risk-stratification-03-04-26/ Featured Articles Article 1: Burden of chronic kidney disease and outcomes following hospitalisation for heart failure. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41775525 Summary: This five-year longitudinal cohort analysis established chronic kidney disease as a significant comorbidity influencing outcomes following heart failure hospitalization. The study demonstrated a framework for comparing clinical events, healthcare resource utilization, and direct costs between heart failure patients with and without a chronic kidney disease diagnosis. This investigation highlights the critical impact of chronic kidney disease on patient management and economic burden within this population. Article 2: Role of Imaging Techniques in Monitoring Atrial Cardiomyopathy and Atrial Failure: A Scientific Statement. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41774767 Summary: This scientific statement established atrial cardiomyopathy as a distinct pathological entity characterized by structural, functional, and electrical abnormalities. It demonstrated that early identification and longitudinal monitoring of atrial remodeling are crucial for improving risk stratification, guiding therapeutic decisions, and assessing treatment response. The statement concluded that clinical evaluation alone is insufficient, thereby highlighting the essential role of advanced imaging techniques in detecting and monitoring these abnormalities to improve patient outcomes. Article 3: MUTTON-HF: Rationale and Design of a Study of an Indigenous Food is Medicine Intervention. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41766529 Summary: This study established nutrition insecurity as a major driver of poor cardiovascular health within Indigenous communities. It designed MUTTON-HF (Medically Utilized Tailored Traditional Foods to Optimize Nutrition in Heart Failure), an Indigenous culturally tailored “food is medicine” intervention. The design demonstrated a community-based-participatory method for utilizing traditional precontact foods to improve heart failure outcomes and quality of life in these populations. Article 4: Sex Differences in Outcomes of Young Adults Hospitalized With First Myocardial Infarction From 2011 to 2022. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744115 Summary: This analysis found that acute myocardial infarction hospitalizations are increasing in young adults aged 18 to 54 years in the United States between 2011 and 2022. The study identified sex-based differences in outcomes for young adults hospitalized with their first myocardial infarction. It established in-hospital mortality as the primary endpoint,...

Welcome to Cardiology Today – Recorded March 03, 2026. This episode summarizes 5 key cardiology studies on topics like P16 positive cells and adiponectin. Key takeaway: P16 Cells Drive Post-MI Cardiac Remodeling. Article Links: Article 1: Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D. (Circulation) Article 2: Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials. (Circulation) Article 3: PAM-VT 2 Study: Long-Term Scar Evolution and Ablation Lesion Assessment by Late Gadolinium Enhancement Cardiac Magnetic Resonance After Ventricular Tachycardia Ablation. (Circulation) Article 4: Small Extracellular Vesicle External Surface Adiponectin-Mediated Adipocytes/Cardiomyocytes Communication in Diabetic Ischemic Heart Failure. (Circulation) Article 5: P16+ Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated Recruitment of Cytotoxic Lymphocytes. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/p16-cells-drive-post-mi-cardiac-remodeling-03-03-26/ Featured Articles Article 1: Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41487088 Summary: Myocardial recovery, characterized by reduced ventricular dilatation and improved systolic function, occurs in a subset of patients with heart failure. This phenomenon is most common in patients receiving left ventricular assist device therapy, with these patients experiencing improved outcomes and quality of life. The study found that myocardial recovery with mechanical circulatory support is directly linked to alternative splicing and subcellular localization of C. A. M. K. two D. This discovery identifies specific molecular mechanisms for initiating cardiac reverse remodeling. Article 2: Aortic and Iliac Calcifications as Predictors of Aortic Dissection, Aneurysm Rupture, and Peripheral Vascular Disease: A Prospective Cohort Study from the DANCAVAS Trials. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41766556 Summary: This prospective cohort study from the Danish Cardiovascular Screening trials established that aortic and iliac calcifications serve as predictors of serious aortic events. The study found a direct association between these calcifications and outcomes such as aortic dissection and aneurysm rupture. Additionally, the data demonstrated that aortic and iliac calcifications predict major adverse limb events, including peripheral revascularization and lower limb amputation. These findings highlight the clinical significance of calcification burden in forecasting severe cardiovascular and peripheral vascular outcomes. Article 3: PAM-VT 2 Study: Long-Term Scar Evolution and Ablation Lesion Assessment by Late Gadolinium Enhancement Cardiac Magnetic Resonance After Ventricular Tachycardia Ablation. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41766535 Summary: Late gadolinium enhancement cardiac magnetic resonance, or LGE-C. M. R., is a useful tool for identifying ventricular tachycardia, or V. T., substrate in patients with structural heart disease. The P. A. M. V. T. two study systematically assessed the long-term evolution of scar and ablation lesions using serial post-ablation LGE-C. M. R. This assessment revealed how ventricular scar tissue and ablation lesions evolve over extended periods following ventricular tachycardia ablation. The findings support the crucial role of post-procedural LGE-C. M. R. in evaluating ablation success and understanding long-term myocardial changes. Article 4: Small Extracellular Vesicle External Surface Adiponectin-Mediated Adipocytes/Cardiomyocytes Communication in Diabetic Ischemic Heart Failure. Journal:...

Welcome to Cardiology Today – Recorded March 02, 2026. This episode summarizes 5 key cardiology studies on topics like loop diuretics and retrospective cohort study. Key takeaway: Tricuspid Regurgitation Etiologies Defined. Article Links: Article 1: Hybrid durable Biventricular Assist Device Implantation with Berlin Heart EXCOR Pulsatile RVAD and a Continuous Flow LVAD. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: SGLT2 inhibition in Patients with Type 2 Diabetes and CKD Experiencing a Deterioration in Estimated Glomerular Filtration Rate to 2. (Journal of cardiac failure) Article 3: Survival and Risk Profile of Patients With Significant Tricuspid Regurgitation by Etiology. (Journal of the American Heart Association) Article 4: Impact of Sociodemographic Characteristics on Outcomes in Obstructive Hypertrophic Cardiomyopathy. (Journal of the American Heart Association) Article 5: Cohort Study of Initial Diuretic Dosing and Outcomes Among Patients Hospitalized for Congestive Heart Failure: Insights From the Cardiovascular Quality Improvement and Care Innovation Consortium. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/tricuspid-regurgitation-etiologies-defined-03-02-26/ Featured Articles Article 1: Hybrid durable Biventricular Assist Device Implantation with Berlin Heart EXCOR Pulsatile RVAD and a Continuous Flow LVAD. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41765060 Summary: Patients experiencing biventricular failure or right ventricular failure after continuous-flow left ventricular assist device implantation face high mortality due to limited durable right ventricular assist device options. This study describes a hybrid ventricular assist device approach, combining a continuous-flow left ventricular assist device with a Berlin Heart EXCOR pulsatile right ventricular assist device. This therapeutic strategy addresses critical cardiogenic shock and late-onset right ventricular failure. The hybrid approach offers a novel option where conventional right-sided continuous-flow left ventricular assist devices are costly, complex, or off-label. Article 2: SGLT2 inhibition in Patients with Type 2 Diabetes and CKD Experiencing a Deterioration in Estimated Glomerular Filtration Rate to 2. Journal: Journal of cardiac failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41765341 Summary: This post-hoc analysis from the CREDENCE trial investigated the efficacy and safety of S. G. L. T. two inhibitors in patients with type two diabetes and chronic kidney disease experiencing an estimated glomerular filtration rate deterioration to less than 20 milliliters per minute per 1.73 meters squared. The analysis provided crucial data to address current limitations in understanding S. G. L. T. two inhibitor use for this specific patient population. It specifically evaluated the association between decreasing estimated glomerular filtration rate and both efficacy and safety outcomes. Article 3: Survival and Risk Profile of Patients With Significant Tricuspid Regurgitation by Etiology. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41757445 Summary: This multisite retrospective study provided a comprehensive classification of significant tricuspid regurgitation by its etiology, an area previously not well studied regarding survival impact. The investigation defined three distinct etiologies for tricuspid regurgitation of moderate or greater severity: primary tricuspid regurgitation due to primary valvular pathology, lead-associated tricuspid regurgitation from lead interactions, and secondary tricuspid regurgitation stemming from other causes such as right ventricular dilation. This detailed...

Welcome to Cardiology Today – Recorded March 01, 2026. This episode summarizes 5 key cardiology studies on topics like mycotic genitourinary infections and sodium glucose co-transporter two inhibitors. Key takeaway: Rivaroxaban Extends Cancer P. E. Benefit Across P. S.. Article Links: Article 1: Long-term prognosis in Takotsubo Syndrome compared to Heart Failure: Observations from a global federated research network. (ESC heart failure) Article 2: Genitourinary tract infections and SGLT2 inhibitors in heart failure: an EMPEROR-Pooled analysis. (European journal of heart failure) Article 3: Long-Term Clinical Outcomes of Acute Myocardial Infarction Based on Institutional Experience With IVUS. (Journal of the American Heart Association) Article 4: Extended Anticoagulation Therapy With Rivaroxaban for Cancer-Associated Low-Risk Pulmonary Embolism According to Different Performance Status Scores: Insights From the ONCO PE Randomized Trial. (Journal of the American Heart Association) Article 5: Effects of Cardiac Resynchronization Therapy on Cardiovascular and Noncardiovascular Hospitalization: A MADIT-CRT Long-Term Follow-Up. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/rivaroxaban-extends-cancer-p-e-benefit-across-p-s-03-01-26/ Featured Articles Article 1: Long-term prognosis in Takotsubo Syndrome compared to Heart Failure: Observations from a global federated research network. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41761829 Summary: This retrospective observational study established a cohort of adult patients with Takotsubo syndrome and heart failure discharged between 2018 and 2022 to directly compare their long-term clinical outcomes. It characterized the three-year risks for all-cause death, major adverse cardiovascular events, and acute heart failure in these distinct patient populations. The findings provide a direct comparative analysis of long-term prognosis, which is crucial for differentiating patient management strategies. This data clarifies differential clinical trajectories and informs targeted therapeutic approaches for Takotsubo syndrome versus heart failure. Article 2: Genitourinary tract infections and SGLT2 inhibitors in heart failure: an EMPEROR-Pooled analysis. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41762689 Summary: The EMPEROR-Pooled analysis found a significant impact of genitourinary tract infections and mycotic genitourinary infections on outcomes in heart failure patients, known to be associated with increased mortality risk. Results showed that sodium glucose co-transporter two inhibitors are associated with these types of infections, which often lead to treatment discontinuation. The analysis delineated the occurrence of genitourinary infections in both men and women with heart failure receiving sodium glucose co-transporter two inhibitors. This work provides essential evidence for clinicians to weigh the benefits and risks of sodium glucose co-transporter two inhibitors, guiding strategies to maintain treatment adherence. Article 3: Long-Term Clinical Outcomes of Acute Myocardial Infarction Based on Institutional Experience With IVUS. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41757462 Summary: This retrospective analysis of 9752 patients with acute myocardial infarction treated with second-generation drug-eluting stents established that intravascular ultrasound-guided percutaneous coronary intervention improves patient outcomes. The study found that the prognostic association of intravascular ultrasound-guided percutaneous coronary intervention in acute myocardial infarction patients does differ based on a center’s level of intravascular ultrasound use. This outcome indicates that institutional experience with intravascular ultrasound is a critical factor influencing the long-term...

Welcome to Cardiology Today – Recorded March 01, 2026. This episode summarizes 5 key cardiology studies on topics like Organ transplantation outcomes and Warm ischemia. Key takeaway: H. I. V. Donor Hearts Safely Used in Transplant.. Article Links: Article 1: Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Early experience in heart transplantation utilizing donors with HIV. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 3: Cardiac function recovery after 20-min hands-off using thoracoabdominal-normothermic regional perfusion. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: The Time is Upon Us-The Beginning of the End of Donor Heart Reanimation In Donation After Circulatory Death Transplantation. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 5: Improved DCD Heart Transplant Function Through Ferroptosis Blockade in a Model of Experimental Normothermic Ex Vivo Perfusion. (Transplantation) Full episode page: https://podcast.explainheart.com/podcast/h-i-v-donor-hearts-safely-used-in-transplant-03-01-26/ Featured Articles Article 1: Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41297731 Summary: Females who undergo heart transplantation exhibit a reduced risk for cardiac allograft vasculopathy. This study found sex-biased immune rewiring as a potential underlying mechanism contributing to this differential risk. Understanding these sex-specific molecular patterns provides insight for improved risk stratification and precision immunosuppressive strategies in both adult and pediatric transplant recipients. This suggests sex-specific immunologic outcomes are significant after heart transplantation. Article 2: Early experience in heart transplantation utilizing donors with HIV. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40998274 Summary: I. V. A single-center observational study investigated early outcomes of heart transplantation in 10 H. I. V.-positive recipients. Of these, 4 received organs from Human Immunodeficiency Virus positive donors and 6 from H. I. V.-negative donors. At 6 months, survival rates were similar, with 100 percent for recipients of H. I. V.-positive organs and 83 percent for recipients of H. I. V.-negative organs. Crucially, the study reported no Human Immunodeficiency Virus transmission from H. I. V.-positive donors to their recipients. Article 3: Cardiac function recovery after 20-min hands-off using thoracoabdominal-normothermic regional perfusion. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40947079 Summary: An Italian center performed heart transplantation from donation after circulatory death, utilizing thoracoabdominal-normothermic regional perfusion. The study demonstrated successful cardiac function recovery in donor hearts. This recovery was achieved despite a 20-minute period of functional warm ischemia, a duration relevant to legal mandates for death declaration. The findings highlight the feasibility of this technique for expanding the donor pool while...

Welcome to Cardiology Today – Recorded February 28, 2026. This episode summarizes 5 key cardiology studies on topics like myocardial infarction and ventricular contractility. Key takeaway: Macrophage Burden Predicts MACE Post-Endarterectomy. Article Links: Article 1: Heart failure in the elderly: epidemiology, mechanisms, and management. (European heart journal) Article 2: Switching from warfarin to direct oral anticoagulants in frail elderly Asian patients with atrial fibrillation: a Korean nationwide study. (European heart journal) Article 3: Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy. (European heart journal) Article 4: Myocardial Microcirculation Combined With Lactate Measurements Predicts Ventricular Contractility in a Canine DCD Orthotopic Heart Transplantation During Ex Situ Machine Perfusion. (Transplantation) Article 5: Long Troponin T to Separate Troponin Elevations Among Patients With Atrial Fibrillation Versus Myocardial Infarction. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/macrophage-burden-predicts-mace-post-endarterectomy-02-28-26/ Featured Articles Article 1: Heart failure in the elderly: epidemiology, mechanisms, and management. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41760079 Summary: The majority of patients with heart failure (H. F.) are of advanced age. The lifetime risk for developing H. F. is approximately 25 percent, with a sharp increase in incidence observed after the age of 70. While the lifetime risk is nearly equal for men and women, women show a higher propensity to develop heart failure with preserved ejection fraction (H. F. pEF), whereas men are more prone to heart failure with reduced ejection fraction (H. F. rEF). Article 2: Switching from warfarin to direct oral anticoagulants in frail elderly Asian patients with atrial fibrillation: a Korean nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41758696 Summary: A previous European trial found that switching from well-managed warfarin to direct oral anticoagulants (DOACs) in frail elderly patients with atrial fibrillation was associated with a higher bleeding risk. This underscores the clinical importance of evaluating the safety and effectiveness of such switches in diverse populations. Understanding outcomes in frail elderly Asian patients is particularly crucial due to potential demographic and clinical differences impacting anticoagulant management. This research addresses a significant therapeutic challenge in optimizing anticoagulation for a vulnerable patient group. Article 3: Carotid plaque macrophage burden and inflammatory lipid-associated macrophage markers predict secondary major adverse cardiovascular events after endarterectomy. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41758068 Summary: This study found that the burden of macrophages within carotid plaques and specific inflammatory lipid-associated macrophage markers serve as predictors for secondary major adverse cardiovascular events (MACE) following endarterectomy. The data establishes a direct link between the cellular content of atherosclerotic lesions and future cardiovascular outcomes. These findings indicate that detailed characterization of macrophage populations in carotid plaques provides crucial prognostic information. This information can guide risk stratification for patients after carotid endarterectomy. Article 4: Myocardial Microcirculation Combined With Lactate Measurements Predicts Ventricular Contractility in a Canine DCD Orthotopic Heart Transplantation During Ex Situ Machine Perfusion. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41757830 Summary: This canine orthotopic heart transplantation study demonstrated that...

Welcome to Cardiology Today – Recorded February 27, 2026. This episode summarizes 5 key cardiology studies on topics like left ventricular ejection fraction and clinical outcomes. Key takeaway: LVEF Not Enough: Heart Failure Phenotyping Shift. Article Links: Article 1: Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry. (ESC heart failure) Article 2: Costs and outcomes in Finnish heart failure patients treated with left ventricular assist device or heart transplant. (ESC heart failure) Article 3: Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis. (Journal of the American Heart Association) Article 4: Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association. (Journal of the American Heart Association) Article 5: Misperception in Heart Failure Phenotyping: Moving Beyond the Chamber to the Myocardium. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/lvef-not-enough-heart-failure-phenotyping-shift-02-27-26/ Featured Articles Article 1: Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41746839 Summary: The Shock-POL registry, encompassing data from nine Polish cardiology centers, characterized the current management and outcomes of acute myocardial infarction-related cardiogenic shock. This registry evaluated patients hospitalized throughout 2023, identifying parameters of current care for this critical condition. Findings reveal that acute myocardial infarction-related cardiogenic shock carries an overall mortality rate exceeding 50 percent. The study documented clinical practices and patient outcomes in a real-world setting. Article 2: Costs and outcomes in Finnish heart failure patients treated with left ventricular assist device or heart transplant. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41739853 Summary: This retrospective study provided a real-world comparative analysis of clinical outcomes and healthcare costs for Finnish advanced heart failure patients treated with heart transplantation or left ventricular assist device therapy. The study evaluated 78 patients across three categories: those receiving heart transplantation as a first procedure, and patients undergoing elective or urgent left ventricular assist device implantation. The data characterized the three-year outcomes and associated healthcare expenditures for these significant interventions at Helsinki University Hospital. It established patterns in resource utilization and patient trajectories for these advanced heart failure treatment options. Article 3: Sex-Difference of Associations Between Cigarette Smoking and Myocardial Fibrosis: The Multi-Ethnic Study of Atherosclerosis. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744134 Summary: This cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis cohort established the relationship between cigarette smoking and interstitial myocardial fibrosis. The study utilized extracellular volume and native T1 time, measured by cardiac magnetic resonance, as markers for myocardial fibrosis. It characterized sex-specific differences in these associations at a population level. The findings illuminate how smoking impacts myocardial fibrosis, which is critical given its known association with cardiovascular events, heart failure, and death. Article 4: Multimodality Approach to Coronary Ischemic Testing in Pediatric Patients: A Scientific Statement From the American Heart Association. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41744120 Summary: This Scientific Statement from the American...