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HUMAN PROOF OF CONCEPT

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Every human needs medical treatment at some point. Yet the life sciences and venture capital industries – the dual engines driving medical discoveries – could scarcely be more specialized and exclusive. Human Proof of Concept is the podcast that demystifies the inner workings of venture-backed medical innovation, providing access and insights from the key players who shape the space. Listen in on the conversation with today’s business leaders, from VC partners to the biotech C-suite, exploring what they do and how they think. Hosted by Harvard PhD turned venture capitalist Janelle R. Anderson, Human Proof of Concept elucidates the ways in which the relative few bring new medicines, technologies, and hope to the many.

Every human needs medical treatment at some point. Yet the life sciences and venture capital industries – the dual engines driving medical discoveries – could scarcely be more specialized and exclusive. Human Proof of Concept is the podcast that demystifies the inner workings of venture-backed medical innovation, providing access and insights from the key players who shape the space. Listen in on the conversation with today’s business leaders, from VC partners to the biotech C-suite, exploring what they do and how they think. Hosted by Harvard PhD turned venture capitalist Janelle R. Anderson, Human Proof of Concept elucidates the ways in which the relative few bring new medicines, technologies, and hope to the many.
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Location:

United States

Description:

Every human needs medical treatment at some point. Yet the life sciences and venture capital industries – the dual engines driving medical discoveries – could scarcely be more specialized and exclusive. Human Proof of Concept is the podcast that demystifies the inner workings of venture-backed medical innovation, providing access and insights from the key players who shape the space. Listen in on the conversation with today’s business leaders, from VC partners to the biotech C-suite, exploring what they do and how they think. Hosted by Harvard PhD turned venture capitalist Janelle R. Anderson, Human Proof of Concept elucidates the ways in which the relative few bring new medicines, technologies, and hope to the many.

Twitter:

@humanPoC

Language:

English

Contact:

(617) 580-0572


Episodes

Don Nicholson of Nimbus: Making it Rain

9/30/2017
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Nimbus Therapeutics is in the business of building structures. Molecular yes, but corporate too — they're unique and fit-for-purpose. CEO Don Nicholson explains it all: the partnerships, the code names, the high energy water, the bowling, the rapping. And how, at any given time, fully half of Amazon’s cloud computing power may be in use to create your next medicine.

Duration: 00:38:18


Giving it his best Schadt

8/31/2017
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Eric Schadt may enjoy the simple things in life — high velocity, a good polo shirt — but he is the first to admit that life is not simple. Living things are such complex systems, in fact, that our best chance to promote wellness is to understand them as vast information networks. To do so, Eric is unleashing maximum scale and bringing the firepower of math to bear. He endeavors to monitor and modify humans-slash-networks, both as CEO of the new genomics startup Sema4, and as Dean for...

Duration: 00:31:09


Alix Lacoste: Druggable Jeopardy!

7/31/2017
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Alix Lacoste was once a self-described “lost soul” from France who made her way to California, ran out of money, and studied filmmaking in community college. Today she is a subject matter expert at IBM’s internal venture: Watson. You may remember IBM Watson from such disruptions as winning Jeopardy against humans in 2011. Now it is disrupting Drug Discovery as part of its effort in (human) health. Alix discusses some examples of how it’s tackling that challenge, including partnering with...

Duration: 00:32:57


Patently Scott Kamholz

6/30/2017
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Strong patent protection has always been a cornerstone of the biotech industry — and table stakes in a VC deal. But inter partes review has significantly changed the game in the last 5 years. Enter Scott Kamholz. Scott is once, twice, three times a doctor: Medicinae, Philosophiae, and Juris. He went from partner at a law firm, to patent judge, became a foremost expert in inter partes review, and then back to private practice at Covington & Burling with 250 IPR cases under his belt. Whether...

Duration: 00:35:00


Joe Allen on the Bayh-otechnology Industry

5/31/2017
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If you work in biotech, or venture capital, if you pay taxes, or take medicine… you really ought to know the name Joe Allen. He worked tirelessly behind the scenes in Washington to get the Bayh-Dole Act passed into law. Sponsored by Senators Birch Bayh and Bob Dole, and passed at the last possible opportunity in a lame duck session of Congress in 1980, it is the legislation that realigned the incentives of the patent system to enable small biotech companies and their investors to flourish....

Duration: 00:36:17


Deborah Dunsire: Business XTuition

4/30/2017
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Deborah Dunsire was a general practitioner in South Africa when a motorcycle drove her into industry. And that side trip, ultimately routing her to Boston, is still going on. She built the North American Oncology unit at Novartis, launched Gleevec, ran Millennium after the millennium, realized the value in Velcade, took a foray into Forum, and recently announced her latest role, President and CEO of XTuit Pharmaceuticals.

Duration: 00:35:40


The Art of Pappas

3/31/2017
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Art Pappas had an extensive, international career in the pharma industry before going on to form his eponymous VC firm in the 90s. Pappas Ventures has been partnering with pharma ever since: licensing assets from them, selling portfolio companies to them, syndicating with them, and managing venture funds for them. But perhaps most notable is the list of pharma and strategic limited partners they brought together to invest in their newest fund — Pappas V — it's a record, even for them.

Duration: 00:35:01


Stacey Seltzer on VC: Timing Timing Timing

2/28/2017
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If the mantra in real estate is location location location, for venture capital it might just be timing timing timing. Stacey Seltzer made the move from big pharma into venture capital during a financial crisis and has gone on to build a wildly diverse portfolio of healthcare companies at Aisling Capital. She takes us on a tour of some of the highlights, and reveals what venture capitalists do for fun.

Duration: 00:31:07


Daily Digestif featuring Marc Pelletier

1/11/2017
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Marc was a podcaster before it was cool. That is, 2006. While producing over 100 hours of interviews on his show “Futures in Biotech” he confirmed his own future was in biotech, starting one and then another. Bypassing his jazz guitar talents and multiple black belts, he launched Aeromics out of Yale to develop the world’s 1st clinical candidate targeting a water channel for the treatment of brain swelling in stroke. And then there’s Dodo Omnidata, Inc. which is developing a read/write...

Duration: 00:17:20


Daily Digestif featuring Sara Demy

1/10/2017
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If Biotech Showcase is the farm team for JPM, then Sara Demy is the coach. She literally got high fives as her new conference burst onto the scene, bust out of its first two locations, and now boasts 400 companies and 1,000 investors. And there are new offspring offerings in the Demy-Colton family as well...

Duration: 00:14:31


Daily Digestif featuring Martin Lehr

1/9/2017
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After a run-in with Joe Biden’s entourage, Marty Lehr joined me on the first full day of the 35th Annual J.P. Morgan Healthcare Investing conference. He discussed his prior life at Osage University Partners, his current life at Context Therapeutics, and how his romantic life once dictated his professional life.

Duration: 00:15:42


Glen de Vries has his Head in the Cloud

12/8/2016
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In 1999 Glen de Vries started a tech company in his 5th floor walkup - very much the NYC equivalent of a garage in Silicon Valley. Today Medidata Solutions continues to transform human drug studies with their clinical cloud platform. They are approaching 3M patients and a $3B market cap. Glen explains how he plans to reach escape velocity with no exit strategy. And how he keeps his feet on the dance floor and head in the cloud.

Duration: 00:32:19


Francois Nader: Be Small But Think Big

9/30/2016
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Today, Francois Nader is merely President of the Jesra Foundation, trustee of the New Jersey Chamber of Commerce, Chairman of Acceleron Pharma (XLRN), Director of ArRETT Neuroscience, Clementia Pharma, and Advanced Accelerator Applications (AAAP), and Advisory Board member of the Open Future Institute. But you might remember him from such former roles as President, CEO and Executive Director of NPS Pharma (NPSP now Shire) prior to its $5.2B acquisition, Venture Partner at Care Capital,...

Duration: 00:33:10


Bill Newell: Sutro has an Unfair Advantage

8/31/2016
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Bill Newell is a lawyer turned large molecule wrangler. He’s CEO of Sutro Biopharma, and their special sauce - literally - lets them manipulate and manufacture antibodies with the kind of control scientists have had over small molecules for decades. Where other biotechs find scientific challenges can threaten their survival, with Sutro it comes down to strategic challenges. And Bill has led them to enviable partnerships, capital, and optionality. Sutro has an unfair advantage: Bill Newell

Duration: 00:34:13


Brian Bloom: Hockey Sticks and Cheerleaders Do Not Go Together

7/31/2016
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Home or away, Brian Bloom is recognized for his wildly successful conference and boutique investment bank. With a mission to uncover and cultivate Canadian life sciences companies through scientific focus and range of services, Bloom Burton & Co., which he co-founded in 2008, has risen swiftly to be profitable and globally unique. And its Bloom Burton Healthcare Investor Conference achieved actual hockey stick growth since it broke onto the Canadian biotech scene 5 years ago. But hockey...

Duration: 00:33:24


Kate Bingham, a Voice of Reason from the UK

6/30/2016
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Brexit isn't the only newsworthy and dismal problem out there. Consider a couple of others - some VCs would rather not touch them with a ten foot pole, yet Kate Bingham is taking a stab at them: There's Alzheimers. This past October, SV Life Sciences where she is Managing Partner, became the fund manager of the Dementia Discovery Fund. Launched with a charity and six pharmas at the table, and $100M in the bank, the fund brings a fresh operating model to the tired approach. And then there's...

Duration: 00:34:38


Sven Jacobson Doesn’t Have a Swelled Head

5/23/2016
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Have you heard the one about the guy who founded a biotech startup in the middle of Manhattan? Around a repurposed, hydrolysable, insoluble small molecule? To treat massive strokes, traumatic brain injury, and other neuro indications? Using a highly translatable rodent model? During the financial crisis? Unpartnered? And who spent $1M per year to generate randomized, placebo-controlled, double-blind PhII results that show a 50% reduction in mortality from strokes that were too big for...

Duration: 00:33:18


Colin Cahill’s Venrock Diagram

4/30/2016
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Colin Cahill swears he didn’t grow up wanting to be a life science venture capitalist. But you would think he had planned it from his very first job cleaning glassware. His path from there to Venrockmay appear linear after the fact, but at the time it was based on serendipity plus a hunch he should stay close to both science and business for as long as possible. In this episode, Colin deconstructs some of the great VC mysteries: How do they decide which deals to do, since “there’s no...

Duration: 00:32:24


Greg Verdine will not take “undruggable” for an answer

3/7/2016
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Greg Verdine has evolved from merely being a Harvard prof, to consulting for big pharma, to startingbiotech companies, to being a Venture Partner, and even to co-foundinga non-profit institute – not just sequentially, but largely in parallel. He has teamed up with Third Rock Ventures, TPG Biotech, AppleTree Partners, and he unveils his brand new gig with WuXi Ventures. Greg co-founded the biotechs Enanta (ENTA), Tokai (TKAI), Gloucester (now Celgene), Aileron, Warp Drive, WaVe (WVE), and...

Duration: 00:30:10


The Multivalent Mathai Mammen

2/2/2016
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In the late nineties, a company named "Advanced Medicine" came together with the 4Cs of entrepreneurship in place: a concept, co-founders, capital, and some well-placed cold-calls. Mathai Mammen was one of those co-founders, still living in a dorm at the time. The company's investors evolved, it renamed itself, went public, and ultimately split into two independent companies: Innoviva (INVA) and Theravance Biopharma (TBPH). Today, Mathaiis the SVP of R&D atTheravance Biopharma. Under his...

Duration: 00:42:10

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