Solving the Puzzle with Dr. Datis Kharrazian

In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance. Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions. Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Identifying high hydrogen peroxide symptoms 03:06 Addressing brain fog and fatigue 08:11 Combating jet lag with supplements 12:01 Understanding hormone breakdown genetics 13:36 Finasteride side effects and solutions 19:18 Importance of Selenium and Zinc 21:10 Initial treatment and Dutch test results 25:50 Podcast resources and disclaimers 26:53 End of the episode reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception. We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Understanding types of pain 04:57 How mood affects pain perception 08:02 Why visceral pain feels external 12:04 How pain signals are amplified 15:58 How pain is blocked 19:44 How the brain processes pain 22:12 Understanding central pain syndromes 26:01 Explaining brain pathways for pain 30:06 Podcast outro and resources 31:09 Closing message and reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps impacting mood, energy, and neurological health. Whether you're a practitioner seeking a sharper clinical eye or simply want to optimize your well-being, this episode supplies you with insights and tools to decode your body's signals and restore balance. Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Signs of vitamin A deficiency 06:21 Vitamin E and K deficiencies 07:30 Fermented foods and vitamin K 10:48 Understanding methylation and B vitamins 16:42 Effects of vitamin B6 on sleep 18:25 Signs and symptoms of B12 deficiency 23:37 Identifying causes of muscle cramps 25:57 Recognizing magnesium deficiency signs 30:20 Signs of potassium and zinc issues 31:28 Wrapping up and resources offered Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from dryness and discoloration to eczema, rosacea, and more. Whether you're a practitioner or someone interested in optimizing your own health, this episode bridges complex science and practical tips you can apply today. Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Skin health and nutritional basics 03:56 Vitamin A and bruising 07:41 Eating healthy fats and fish 12:14 Identifying allergies and histamine response 15:07 Using food sensitivity tests 19:14 Testing for sensitivities and allergies 21:16 Food sensitivities and sweating 25:26 Talking about severe jaundice 27:59 Health effects of silver supplements 30:30 Closing and resources for listeners Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special emphasis on autoimmunity. Join us as Dr. Booth shares how discovering autoimmune markers in her own and her daughter’s bloodwork inspired a deep dive into strategies for managing and calming autoimmune conditions. We explore the evolution of her clinical approach, the challenges of educating and supporting patients, and the power of group care and community in fostering healing. Dr. Darla Booth, DC, AFMC specializes in helping patients with complex health issues identify their root cause, improve symptoms, and stack habits to optimize their health with functional medicine protocols. Her care complements the support patients receive through Western medicine; taking a big picture approach to health through lab work analysis, lifestyle adjustments, and nutritional support. Chiropractic and other conservative, natural care options for adults and children are Dr. Booth's specialties. She is skilled in nutritional counseling for food allergies, cranial therapy, TMJ treatment, and more. To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Discovering autoimmunity in bloodwork 03:56 Launching an autoimmune program 07:08 Starting group coaching sessions 11:56 Helping clients rebuild health 13:20 Addressing leaky gut in autoimmune 19:00 Understanding digestion and gut health 21:52 Creating a treatment plan 23:58 Small shifts for immune health 26:47 Prioritizing health and wellness choices 29:43 How food impacts your body 33:57 Functional medicine's credibility and impact 37:18 Using RUPA and Fullscript 39:48 Resources for practitioners and individuals Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Liz Lipsky, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-focused physical assessment. Dr. Lipsky explains how simple observations like cracks in a friend’s tongue over dinner or dark circles under a child’s eyes, can become powerful clues in solving chronic and complex health puzzles. She emphasizes the importance of integrating physical assessments with patient history, lifestyle intake forms, and lab data, demonstrating how even a five-minute exam can shape the entire care plan. Through case stories and practical examples, Dr. Lipsky illustrates the vital role nutrition professionals play in the healthcare team, and why rediscovering hands-on assessment is a key to better outcomes in our modern, often rushed medical world. Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "Nutrition-Focused Physical Assessment" 03:37 "Body Clues and Nutrition Insights" 09:48 "Chronic Health Needs Lifestyle Focus" 12:28 "Nutrition's Power in Healing" 17:21 "Riboflavin for Odor Relief" 19:05 "First Impressions Matter" 22:47 Cooking, Nutrition, and Self-Care 26:08 "Functional Medicine Training Hub" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optimizing basic factors like sleep, movement, and stable blood sugar isn’t just “wellness” advice, but can actually be game changers for patients struggling with conditions such as leaky gut, Hashimoto’s, fibromyalgia, or neuropathic pain. Datis Kharrazian unpacks the science behind mitochondrial bioenergetics and reveals how even the tiniest steps, like improving circadian rhythm or addressing subtle nutritional imbalances can help untangle the complex web of chronic illness. You’ll also learn about the connection between mitochondrial dysfunction, increased pain sensitivity, and how negative neuroplasticity can turn temporary pain into a lasting syndrome. Whether you’re a practitioner, a patient, or someone passionate about functional medicine, this episode will empower you to look beyond protocols and focus on the underlying mechanisms that drive recovery. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Circadian Rhythm Improves Recovery 09:38 Mitochondria, Calcium, and Chronic Pain 10:46 Chronic Pain Linked to ER Stress 15:42 Mitochondrial Health Relieves Chronic Pain 17:34 "Fibromyalgia Mechanisms and Pain Reduction" 21:41 "Functional Medicine Training Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue and pain syndromes. If you've ever wondered why fatigue and pain are such stubborn and complex complaints, or why so many patients feel stuck despite having normal lab results, this conversation is for you. Dr. Kharrazian explores the critical role of cellular energy production—specifically mitochondrial bioenergetics—in recovery from injury and in managing conditions like fibromyalgia and chronic fatigue syndrome. He breaks down how disruptions in energy pathways can cascade into mood issues, pain syndromes, and overall decreased resilience, and explains why simply treating symptoms isn’t enough. This episode also underscores the importance of going beyond a “one-solution” mindset, urging practitioners to delve deeper into the mechanisms that affect their patients’ energy levels. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "Understanding Fatigue and Bioenergetics" 04:58 "ATP: Key to Energy and Health" 08:00 "Optimizing Energy and Resilience" 11:34 Mitochondria and Fatigue Factors 15:57 Anemia and Energy Function Insights 17:48 Mitochondria: Origins and Clinical Relevance 20:56 "Inherited vs. Acquired Mitochondrial Issues" 23:50 Mitochondrial Function and Enzymes 27:31 "Functional Medicine & Health Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Dr. Dave Rakel introduces the ECHO model for medical decision making, a practical framework that evaluates four key factors: Efficacy (evidence of benefit), Cost, Harm (evidence of harm), and Opinion (patient preferences and bias). He emphasizes that treatment decisions should balance not only how well something works, but also its potential risks and how it aligns with patient values. He explains his evidence-versus-harm rating system, grading evidence from A to C and potential harm from 1 to 3. The ideal intervention has strong evidence with minimal harm, but he notes that therapies with moderate evidence and low risk may often be preferable to those with stronger evidence and greater potential harm. Dr. Rakel also discusses the growing role of AI in medicine, comparing tools like Gemini, Perplexity, and Open Evidence. While AI can assist with research, he stresses that informed clinicians using these tools thoughtfully provide the best outcomes. Finally, he shares clinical insights, including the use of low-dose naltrexone for fibromyalgia, the broad utility of amitriptyline, the cognitive risks associated with anticholinergic burden, and research linking processed foods, alcohol, and sugar to cognitive decline—while showing that shifting toward whole foods may significantly reduce that risk. This guest speaker Master Class is part of the Kharrazian Institute Functional Medicine Education Program. To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 "Balancing Evidence and Harm" 05:52 "Integrative Medicine: Art and Science" 08:16 "PPI Use: Risks and Bias" 10:03 "Risks of Long-Term PPI Use" 15:06 "Top Drugs for Fibromyalgia" 17:04 "Life's Essential 9 Explained" 21:22 "Optimizing Health to Prevent Dementia" 23:51 Best and Worst Brain Beverages 29:13 Functional Medicine Training Resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this lecture, Dr. Dave Rakel explores the placebo effect—"the ability to stimulate self-healing without deception"—and reveals how perception, connection, and empathy are among the most powerful healing mechanisms available to practitioners. Dr. Rakel unpacks the neuroscience of perception, showing how our conditioned minds create physical responses that determine health or disease. He shares groundbreaking research: optimists live six years longer than pessimists, stress perception correlates with fibromyalgia pain severity, and how we view food (guilt vs. celebration) affects cortisol and weight gain. Through compelling studies, he demonstrates that therapeutic touch activates healing more effectively than pills, that clinician empathy measurably shortens the duration of the common cold and boosts immune markers (IL-8 and neutrophils), and that perceiving a caring connection can equal 8mg of morphine for pain relief. This guest speaker Master Class is part of the Kharrazian Institute Functional Medicine Education Program. To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 0:00 - The Placebo Effect: Self-Healing Without Deception 8:20 - Perception Science: How Beliefs Create Physical Responses 16:15 - Stress Perception & Disease: The Cortisol Cascade 22:50 - Why SSRIs Barely Beat Placebo 26:35 - Psychedelic Placebo Study: 65% Had Spiritual Experiences 34:10 - Why Touch Beats Pills: Manual Therapy vs. Drugs 42:30 - The Clinician Effect: Empathy = 8mg Morphine 46:50 - Common Cold Study: Empathy Reduces Duration & Boosts Immunity 55:40 - Patient 406: The Cost of Disconnection Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this Practitioner Spotlight, Dr. Dave Boyton—a Cincinnati-based functional medicine specialist—shares how he transformed his practice by integrating neurological assessment with functional medicine. After his wife was misdiagnosed with multiple autoimmune conditions, Dr. Boynton dove deep into functional medicine and discovered what most practitioners miss: the neurological component. Dr. Boyton reveals why hypoglycemia isn't just "getting hangry"—it's frontal lobe dysfunction that sabotages healing. He explains why most functional medicine exams are inadequate, how he turned his intake into a "show and tell" experience that builds patient confidence, and why cookie-cutter protocols fail chronically ill patients. To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Functional Medicine Journey 05:46 "Chiropractic, Neurology, and Individualized Care" 10:00 Ambassadors of Hope in Healthcare 11:59 Tinnitus Neurology Exercises Explained 17:13 "Prioritizing Health and Wellness" 21:20 Passion Key for Functional Medicine 22:58 Evolving Functional Medicine Insights 26:36 "Functional Medicine Training Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, our guest speaker, certified physician assistant Danielle Valoras explores breast implant illness (BII)—a clinical reality that remains widely misunderstood despite affecting millions of women. She unpacks why BII lacks an official diagnosis code, yet presents with a consistent constellation of symptoms, including fatigue, brain fog, joint pain, rashes, anxiety, and autoimmune-like conditions that are frequently misdiagnosed as fibromyalgia, chronic fatigue syndrome, or menopause. Danielle emphasizes the need for practitioners to consider implantable devices as contributors to immune burden. She discusses pattern recognition, the role of explantation in recovery, and why normal lab work doesn't rule out BII. Whether you're a healthcare professional, someone affected by breast implants, or curious about the intersection of implantable devices and chronic illness, this episode offers evidence-based insights you can use right away. Join us as we explore the structural and immunological mechanisms driving breast implant illness, providing practitioners with evidence-based insights to support the millions of women affected worldwide. Register at https://pages.kharrazianinstitute.com/breast-implant-illness For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Breast Implant Illness Symptoms Data 03:41 Breast Implants and Hidden Symptoms 07:10 "Understanding Breast Implant Illness" 13:00 Navigating Breast Implant Shame 16:04 Breast Implant Illness Awareness Growing 17:26 "Understanding Symptoms and Triggers" 20:55 Explantation for Improved Health 24:20 Health Advice: Consult First Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, our guest speaker, certified physician assistant Danielle Valoras explores the essential role of the lymphatic system in women with breast implants. She explains how the lymphatic system serves as the body's drainage and immune defense network, and how disruptions in lymph flow, particularly from foreign objects such as silicone implants, can trigger a cascade of chronic inflammation, hormone imbalance, and systemic symptoms. Whether you're a healthcare professional, someone affected by breast implants, or just curious about functional medicine solutions for complex health puzzles, this episode has evidence-based insights you can use right away. Join us on February 21, 2026, as we explore the structural and immunological mechanisms driving breast implant illness, providing practitioners with evidence-based insights to support the millions of women affected worldwide. Register at https://pages.kharrazianinstitute.com/breast-implant-illness For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, certified physician assistant Danielle Valores shares her expertise cultivated from over two decades in medicine—and a decade devoted to functional medicine—by diving into an issue affecting millions: breast implants and their true impact on women’s health. Drawing from both scientific research and her firsthand clinical experience working with the breast implant population for the past eight years, Danielle Valores unpacks the complex history, construction, and ongoing health controversies surrounding these devices. From the origins of breast implants in the late 19th century to modern-day procedures and the growing global health crisis affecting up to 10 million women, Danielle Valores guides listeners through discoveries about complications, systemic symptoms, and regulatory oversights. She highlights the urgent need for clinicians to recognize and support patients facing breast implant-related illnesses—a topic that’s often misunderstood or overlooked in mainstream medicine. Join us on February 21, 2026, as we explore the structural and immunological mechanisms driving breast implant illness, providing practitioners with evidence-based insights to support the millions of women affected worldwide. Register at https://pages.kharrazianinstitute.com/breast-implant-illness For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "History of Breast Implants" 05:43 "Breast Implant Safety Updates" 08:18 Global Breast Implant Crisis 11:57 Breast Implant Risks and Reporting 16:16 Silicone's Systemic Impact Explained 18:50 "Platinum, Implants, and Health Risks" 22:12 Breast Implant Risks & Inflammation 24:31 Silicone Implants: Rupture Risks 29:24 "Silicone Risks and FDA Concerns" 31:45 Functional Medicine Training Resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Yousef Elyaman breaks down the essential nutritional strategies for reversing fatty liver disease—from macronutrient optimization to the evidence-based power of the Mediterranean diet—making complex dietary interventions immediately actionable for practitioners and patients. We explore why replacing carbohydrates with protein and saturated fats with unsaturated fats reduces hepatic fat content, how over 10,000 phytonutrients from colorful plant foods support liver detoxification in ways supplements cannot replicate, and the critical balance between omega-3 and omega-6 fatty acids. Dr. Yousef Elyaman reveals why the Mediterranean diet reduces liver fat even without weight loss—showing improvements in hepatic steatosis and insulin sensitivity independent of caloric restriction—and reviews the SMILES trial demonstrating significant mood improvements through dietary intervention alone. You'll discover practical ultra-processed food replacements patients can sustain long-term, which micronutrient deficiencies (zinc, copper, vitamin D, B-vitamins, vitamin E) drive MASH progression, and how nitrate-rich vegetables boost nitric oxide production to combat both fatty liver and hypertension. Join us for an online livestream where you'll master the functional medicine strategies that reverse fatty liver. Register now at https://pages.kharrazianinstitute.com/elyaman-fatty-liver For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Nutrient-Dense Eating for Recovery 05:57 "Risks of Ultra-Processed Foods" 09:05 Omega 6 vs Omega 3 Ratio 12:39 "Foods for Health and Wellness" 14:44 "Benefits of Mediterranean Diet" 18:19 Mediterranean Diet: Mood & Mortality Boost 21:19 "Key Nutrients for Insulin Sensitivity" 26:09 "Reducing Liver Fat with Diet" 28:15 "Functional Medicine Training & Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Yousef Elyaman breaks down the essential mathematics of metabolism—from calculating basal metabolic rate to understanding the 3,500-calorie rule for weight loss—making complex concepts immediately actionable for practitioners and patients. We explore the critical distinction between fat loss and muscle preservation, why body composition matters more than the number on the scale, and how strategic protein intake and exercise can help preserve metabolic rate during caloric restriction. Dr. Yousef Elyaman shares evidence-based insights on various fasting protocols—from the foundational 12:12 time-restricted eating to modified alternate-day fasting—and reviews the latest research showing how these approaches reduce intrahepatic triglycerides, improve insulin sensitivity, and even reverse markers of liver fibrosis. Join us for an online livestream where you'll master the functional medicine strategies that reverse fatty liver. Register now at https://pages.kharrazianinstitute.com/elyaman-fatty-liver For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 "Ketogenic Diet Facts Quiz" 05:37 "Tracking Body Composition Effectively" 08:41 "Understanding and Testing Your BMR" 12:47 "Protein's Role in Fat Loss" 15:38 "Healthy Eating and Fasting Tips" 17:08 Sustainable Fasting vs. Extreme Fasts 23:21 "Body Fat, BMR, and Metabolism" 26:15 "Solving the Puzzle Podcast Summary" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Yousef Elyaman, a leading functional medicine doctor, takes us into the pathogenesis of fatty liver disease, sharing his expertise on the underlying imbalances and physiological mechanisms that contribute to this complex condition. We explore how functional medicine looks beyond traditional diagnostics and treatments, focusing instead on the root causes—whether that’s insulin resistance, genetics, diet, gut health, or hormone imbalances. Dr. Elyaman breaks down how comorbidities like obesity, diabetes, cardiovascular disease, and thyroid dysfunction are interconnected and why identifying these drivers is critical for lasting, meaningful change. If you’re ready to connect cutting-edge science with practical strategies for chronic health challenges, join us for a masterclass in functional medicine with Dr. Yousef Elyaman. This episode is packed with insights you can apply immediately to improve patient outcomes or your own health journey. Join us for an online livestream where you'll master the functional medicine strategies that reverse fatty liver. Register now at https://pages.kharrazianinstitute.com/elyaman-fatty-liver For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/⁠ ⁠ For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/⁠ ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ Timestamps: 00:00 Fatty Liver: Causes & Comorbidities 05:52 "Fructose, Insulin Resistance, and AGEs" 09:33 "Insulin's Role in Fat Regulation" 12:05 Triglycerides, LDL, and Heart Disease 15:41 Fatty Liver and Iron Overload 19:39 "SIBO and Digestive Health" 21:28 Gut Health and Fatty Liver Connection 25:32 "Functional Medicine Training & Resources" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Datis Kharrazian explores longevity medicine and the hallmarks of aging and disease. How do early signs of loss of resilience—like cognitive decline or changes in physical appearance—offer clues about our biological age? What can cutting-edge studies, such as the Dunedin Longitudinal Study, teach us about predicting poor aging trajectories and preventing chronic diseases like cardiovascular issues and cancer, before they silently take hold? Dr. Kharrazian uncovers the mechanisms underlying tissue degeneration, explores why resilience is central to healthy aging, and explains how functional medicine clinicians can use biomarkers and in-depth assessments to help shift morbidity later in life. Whether you’re a healthcare practitioner, a nutrition enthusiast, or facing chronic health challenges, this episode bridges the gap between complex science and actionable steps you can implement right now. Learn functional longevity strategies from Dr. Datis Kharrazian. Discover how to use personalized nutrition, diet, and lifestyle approaches to optimize healthspan. Enroll in the Longevity Mastery Program at: https://pages.kharrazianinstitute.com/longevity https://drknews.com/online-courses/ https://kharrazianinstitute.com/ https://afnlm.com/ 00:00 "Longevity, Wellness, and Disease" 03:51 "Pace and Markers of Aging" 09:02 "Aging Mechanisms and Disease Links" 13:33 Aging, Resilience, and Clinical Outcomes 14:52 "Hallmarks of Aging Explained" 20:11 "Aging Tissues and Inflammation" 22:18 Mitochondria, Aging, and Vascular Health 25:59 Cancer Warning Signs 32:21 "Aging's Role in Cancer Progression" 33:13 "Functional Health Solutions Podcast" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Dr. Kharrazian covers the physiological mechanisms that drive aging and how you can take proactive steps to slow disease progression and extend your healthspan. Learn the foundational concepts of geroscience, the difference between anti-aging appearance medicine and true longevity medicine, and actionable clinical strategies for healthier longevity. You’ll learn why maintaining resiliency is key to a healthy, vibrant life, what laboratory markers and lifestyle interventions actually make a difference, and how to spot early signs of aging before they become disease. If you’re passionate about functional medicine, working with chronic patients, or simply want to invest in your own healthy future, this conversation is packed with the essentials you need. Learn functional longevity strategies from Dr. Datis Kharrazian. Discover how to use personalized nutrition, diet, and lifestyle approaches to optimize healthspan. Enroll in the Longevity Mastery Program at: https://pages.kharrazianinstitute.com/longevity https://drknews.com/online-courses/ https://kharrazianinstitute.com/ https://afnlm.com/ 00:00 "Exploring Aging, Health, and Longevity" 04:43 "Understanding Geroscience and Longevity" 09:46 "Hallmarks of Aging Explained" 13:36 "Addressing Chronic Inflammaging Challenges" 17:15 "Aging Pathophysiology in Practice" 18:41 "Restoring Physiological Resiliency" 24:11 Extending Human Lifespan Potential 25:47 "Secrets of Longevity: Jean Calment" 29:28 "Longer Lives, Declining Quality" 32:32 "Functional Medicine Resource Hub" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Datis Kharrazian bridges complex science with practical strategies you can use right away, focusing on the fascinating concept of biological age versus chronological age. You’ll learn why some people seem to age slower or faster than their years might suggest, and discover how factors like sleep, fasting, diet, and resilience are key to longevity and vibrant health. Datis Kharrazian dives into personalized clinical models, exploring mechanisms such as inflammation, cellular senescence, and genetic influences—and explains why resilience is the central feature in successful aging, healthspan, and overall wellness. Whether you’re a healthcare professional looking to advance your functional medicine expertise or someone seeking effective strategies for chronic health challenges, this episode lays the groundwork for integrating functional medicine and geroscience into everyday practice. Learn functional longevity strategies from Dr. Datis Kharrazian. Discover how to use personalized nutrition, diet, and lifestyle approaches to optimize healthspan. Enroll in the Longevity Mastery Program at: https://pages.kharrazianinstitute.com/longevity https://drknews.com/online-courses/ https://kharrazianinstitute.com/ https://afnlm.com/ 00:00 "Biological vs. Chronological Age" 04:25 "Inflammaging and Cellular Health Strategies" 08:49 "Resilience: Key to Longevity" 12:03 "Intermittent Fasting and Longevity" 13:00 "Longevity Research and Key Pathways" 19:25 "Genetics and Resilience in Aging" 21:03 "Resilience: Key to Healthy Aging" 23:23 "Enhancing Resiliency Through Geroscience" 27:39 "Inflammatory Resiliency and Intolerances" 30:40 "Geroscience: Aging and Resilience" Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.