The Plants of the Gods podcast

“Plants of the Gods” has featured dozens of episodes detailing the power, potential, and pitfalls of using hallucinogenic plants and fungi – and even frogs – for healing purposes. The Psychedelic Renaissance is in full swing — but what does it look like to the indigenous peoples themselves? Anthropologist Dr. Joe Watkins of the Choctaw Nation offers his thoughtful perspective on these fascinating issues.

A mind-blowing mint? Salvia divinorum, a perennial herb in the mint family, has been used by traditional healers in Oaxaca, Mexico, to understand more about what ails a patient. Known for its potent psychoactive effects, Salvia can induce dysphoria and dissociation. But new scientific research is shedding light on the plant's unique effect on the brain, and its potential in treating psychiatric disorders. We continue our conversation with Dr. Chris McCurdy, a medicinal chemist and behavioral pharmacologist at the University of Florida, who is one of the foremost experts on this plant of the gods. Show notes: Babu, Kavita M, et al. “Opioid Receptors and Legal Highs: Salvia Divinorum and Kratom.” National Center for Biotechnology Information, U.S. National Library of Medicine, Feb. 2008, pubmed.ncbi.nlm.nih.gov/18259963/.

The tropical Asian tree kratom – a member of the same botanical family that has given us both coffee and quinine – is showing great potential for successfully treating a variety of serious afflictions, from stress to opioid withdrawal. Ironically – depending on dosage – it can act either as a stimulant or a sedative. The episode features an insightful interview with Dr. Christopher McCurdy, the leading authority on this extraordinary plant of the gods. Show notes: “About Christopher R McCurdy.” University of Florida College of Pharmacy, pharmacy.ufl.edu/profile/mccurdy-christopher/. Accessed 17 June 2025. Talesnik, Dana. “McCurdy Studies Whether Kratom Can Reduce Opioid Withdrawal, Ease Pain.” National Institutes of Health, U.S. Department of Health and Human Services, 23 June 2022, nihrecord.nih.gov/2022/06/24/mccurdy-studies-whether-kratom-can-reduce-opioid-withdrawal-ease-pain.

The lure of lost cities is a deep and enduring fascination that combines equal parts mystery, adventure, treasure, and the promise of forgotten knowledge. The existence and discovery of these ruins – whether it was King Tut's tomb or Machu Picchu – demonstrates the brilliance of ancient civilizations and their impermanence and mortality. In this episode, host Mark Plotkin recounts his experience as part of an expedition in search of the so-called "Lost City of the Monkey God," as well as the role that hallucinogens and shamanism played in helping us understand some of the artwork and cultures of these ancient peoples. Episode Notes Clottes, Jean, and David Lewis-Williams. The Shamans of Prehistory: Trance and Magic in the Painted Caves. Translated by Sophie Hawkes, Harry N. Abrams, 1998. Plotkin, Mark J. Tales of a Shaman’s Apprentice: An Ethnobotanist Searches for New Medicines in the Amazon Rain Forest. Penguin Books, 1994. Preston, Douglas. The Lost City of the Monkey God: A True Story. Grand Central Publishing, 2017. Schultes, Richard Evans, et al. Plants of the Gods: Their Sacred, Healing and Hallucinogenic Powers. Healing Arts Press, 2001. Vaz, Mark Cotta. Living Dangerously: The Adventures of Merian C. Cooper, Creator of King Kong. Villard, 2005.

The therapeutic benefits of ayahuasca are well-known and celebrated worldwide. However, when conducted by the wrong individuals, ayahuasca ceremonies can also lead to harmful outcomes. In this episode, host Mark Plotkin talks with author and explorer Robert Tindall about some of the potential risks and downsides of ayahuasca use.

Many people associate cacao (and chocolate) with its origins in Mexico, but few are aware that the plant itself is native to the rainforests of the northwest Amazon. Previous episodes of this season of "Plants of the Gods" traced the journey of cacao from the Amazon to Central America and then to Europe. In this episode, ethnobotanist Mark Plotkin continues to explore the captivating history of this remarkable treat, spanning from the American Revolution through the Industrial Revolution and into the 21st century.

The concept of uncontacted or isolated indigenous rainforest groups enthralls many people, even those who have no particular interest in rainforest conservation or tribal cultures. Yet there certainly exist dozens of these groups in Amazonia, if not more. How can we estimate what and how much they know about the healing plants of the rainforest if we do not contact them first? This episode attempts to answer this seemingly oxymoronic question.

The Amazon rainforest - teeming with unstudied plants, fungi, and shamanic cultures - has long been considered an almost inexhaustible source of healing plants and potions. In this episode - Dr. Mark Plotkin, an ethnobotanist who has been studying the plants and peoples of Amazonia for four decades - provides a detailed and incisive overview of the medicinal power and potential of the world’s greatest rainforest!

This episode delves deeply into the ethnobotany of these bizarre rainforest plants. From the ethereal ayahuasca to galvanizing guarana, we hear tales of how these species can be used for everything from curing deadly spider bites to measuring climate change.

Ethnobotanist Mark Plotkin conducts a fascinating interview with William Siff, who is a licensed acupuncturist, clinical herbalist, and ethnobotanist who practices an unusual combination of both Ayurvedic and Traditional Chinese Medicine. Bill is best known to the general public as author of the classic work, "The Plant Medicine Protocol." The interview not only covers Siff's intriguing background and healing approach but answers the questions of what is a plant, what is a food, what is a spice, what is a medicine, and which species like black pepper are all of the above!

Join host Dr. Mark Plotkin, ethnobotanist and founder of the Amazon Conservation Team, we continue our discussion about cacao. In this episode, Dr. Plotkin sheds light on the often-overlooked contributions of Maria Sibylla Merian, a pioneering naturalist whose groundbreaking work in the Amazon predated that of many famous explorers. Discover how this remarkable woman, who began as an artist in 17th-century Germany, became one of the first Europeans to scientifically document the plants, animals, and cultures of the Amazon. Dr. Plotkin also shares his favorite episodes from the "Plants of the Gods" podcast, including stories of Ayahuasca, absinthe, and even how apes use plants for medicinal purposes. Tune in to explore the rich tapestry of the Amazon and the extraordinary individuals who have helped us understand its wonders.

In this episode of Plants of the Gods, join us as we continue delving into the rich and complex world of chocolate. Our guest, Denise Castronovo, founder of Castronovo Chocolates, shares her journey from tasting fine Swiss chocolates as a child to sourcing cacao directly from the Northwest Amazon. She works with indigenous and local communities to ensure ethical practices and the highest quality ingredients. Denise explains the difference between mass-produced and artisanal chocolate, highlighting the latter's 600+ flavor notes influenced by cacao varietals. Join us as we explore chocolate's ancient origins, modern artisanal production, and the importance of sustainability in the chocolate industry.

In this episode of "Plants to the Gods," we continue our discussion about cacao and chocolate. Join us as Dr. Mark Plotkin delves into the rich history of chocolate and its entanglement with capitalism. Learn how the cacao plant, originally cherished by the Olmecs, Aztecs, and Mayas, went from the rainforests of the northwest Amazon to becoming a global commodity. Discover the fascinating story of how a clever candy maker leveraged the fame of Babe Ruth to sell his new chocolate bar, leading to a surprising courtroom battle over the iconic name. Accompany us as we explore the journey of cacao through empires, revolutions, and into our favorite confections today.

Today, we kick off Season 6 of Plants of the Gods, as host Dr. Mark Plotkin of the Amazon Conservation Team explores the fascinating history of cacao, highlighting its ancient origins in the Amazon rainforest and its transformation into the beloved chocolate consumed worldwide today. From its discovery by indigenous peoples in South America to its role in the highly sophisticated Mayan and Aztec cultures as a sacred and valued commodity, cacao's journey is a testament to its enduring significance across centuries and continents. Join Dr. Plotkin as he uncovers the delicious botanical, cultural, and economic legacy of this remarkable plant in a journey through the history of chocolate.

In this season finale of Plants of the Gods, join host Dr. Mark Plotkin as we learn about everything mushrooms, which are truly having a moment! Drawing from an article he published in HerbalGram, Dr. Plotkin provides an overview of how our daily lives are transformed by fungi, in the past, present and the future. From Pink Floyd to hit TV show “The Last of Us”, from magic mushrooms to our favorite dishes, we wrap up season five with learning about the ways fungi continue to shape our story.

In this episode of Plants of the Gods, join host Dr. Mark Plotkin in conversation with colleague Dr. Bruce Hoffman, Senior Manager of Scientific Research at ACT, as we learn about the ethnobotany of Amazonian lianas. Dr. Hoffman is a conservation biologist focusing on flora of the Guianas, with 20 years of experience in conducting biodiversity inventories and monitoring and assessing plant populations. He has worked with local and indigenous communities in both Guyana and Suriname. Learn more in this penultimate episode of Season 5 of Plants of the Gods!

In this episode of Plants of the Gods, join ethnobotanists Dr. Mark Plotkin and Dr. Gary Nabhan in conversation as we learn about the power of the desert and its plants and animals, from mescal to tequila to magic toads. Dr. Nabhan is a McArthur Genius award-winning ethnobotanist and desert conservation biologist with 50 years of botanical, cultural and conservation research experience. In his seminal works “Gathering the Desert" and "The Desert Smells Like Rain,” Dr. Nabhan offers distinct yet interconnected explorations of the desert landscape, its people, and their unique relationship with nature. Catch some of this insight first-hand in this exclusive two-part episode of Plants of the Gods!

In this episode of Plants of the Gods, join ethnobotanists Dr. Mark Plotkin and Dr. Gary Nabhan in conversation as we learn about the power of the desert and its plants and animals, from mescal to tequila to magic toads. Dr. Nabhan is a McArthur Genius award-winning ethnobotanist and desert conservation biologist with 50 years of botanical, cultural and conservation research experience. In his seminal works “Gathering the Desert" and "The Desert Smells Like Rain,” Dr. Nabhan offers distinct yet interconnected explorations of the desert landscape, its people, and their unique relationship with nature. Catch some of this insight first-hand in this exclusive two-part episode of Plants of the Gods!

Shauheen Etminan, PhD, is the co-founder of VCENNA, a CNS drug discovery biotech company inspired by the ethnobotany and wisdom of ancestral medicinal practices for mental wellness treatment. Born and raised in Iran, Shauheen’s heritage and background in chemical engineering fueled his interest in studying the intersection of plants, chemicals, religion and ancient wisdom. In this episode of Plants of the Gods, join us as Dr. Mark Plotkin and Dr. Shauheen Etminan discuss the fascinating history of mind-altering substances in Zoroastrianism.

Coffee is the most widely consumed mind-altering plant product in the world. The human species arose in or near the Rift Valley in East Africa, the northern edge of which abuts the forests of Ethiopia in which the coffee plants originated. The drunk monkey hypothesis proposes that human consciousness was born when our ancestors ingested fermented grapes. The stoned ape hypothesis suggests that the consciousness is due to proto humans consuming magic mushrooms. In the second half of two-part episode, Mark Plotkin discusses the botanical history of coffee, the specialty coffee movement, and how coffee has played a role in popular culture.