NEJM This Week - Audio Summaries

Featuring articles on CRP testing in patients with acute exacerbations of COPD, enzalutamide in metastatic prostate cancer, a monoclonal CGRP antibody for cluster headache, a CGRP receptor antagonist for migraine, and mistrust in science; a review article on hemolytic transfusion reactions; a case report of a woman with vision loss; and Perspective articles on mandatory measles vaccination in New York City; on vaccination over parental objection; on reforming the Orphan Drug Act for the 21st...

Featuring articles on apalutamide plus androgen deprivation in prostate cancer, vosoritide in children with achondroplasia, rituximab or cyclosporine in membranous nephropathy, an anti-KLHL11 autoantibody in rhombencephalitis, and establishing etiology with phage display; review articles on chronic rhinosinusitis with nasal polyps and on uncharted regions of the human genome; a Clinical Problem-Solving describing a woman who was weak and winded; and Perspective articles on esketamine for...

Featuring articles on brain activation in acutely unresponsive patients, dexmedetomidine in critically ill patients, nintedanib for interstitial lung disease, high-sensitivity troponin in suspected MI, and transcatheter aortic-valve replacement; a review article on growth hormone assessment in adults; a case report of a woman with fever and rash after heart transplantation; and Perspective articles on the ACA in limbo, on the upcoming U.S. health care cost debate, on meeting the needs of...

Featuring articles on clinical risk and therapy for breast cancer, BTK inhibition in multiple sclerosis, cardiovascular MRI vs. FFR in coronary artery disease, dual antihypertensive therapies in black Africans, and lethal strategies against tumor cells; review articles on the nonopioid treatment of pain and on heatstroke; a case report of a woman with abdominal pain and fever; and Perspective articles on misrecognition and critical consciousness, on collateral benefits of preventive...

Featuring articles on canagliflozin and renal outcomes in type 2 diabetes, antisense inhibition in Huntington’s disease, treatment of endometrial cancer, and metagenomic sequencing for CNS infection; review articles on anterior cruciate ligament tears and on the management of burns; a case report of a woman with a pelvic mass; and Perspective articles on there being no shortcuts to safer opioid prescribing, on getting coverage right for 500 million Indians, on the Hospital Readmissions...

Featuring articles on azithromycin for seasonal malaria chemoprevention, azithromycin to prevent childhood mortality in Niger, a follow-up of intensive glucose control in type 2 diabetes, and on venetoclax and obinutuzumab in CLL; review articles on cancer stem cells and on the prevention of opioid overdose; a Clinical Problem-Solving describing a disturbing decline; and Perspective articles on measles in 2019, on whether CBO forecasting is good enough for government work, on getting more...

Featuring articles on ibrutinib plus venetoclax in CLL; daratumumab, lenalinomide, and dexamethasone for myeloma; a new virus associated with illness in China, repair of abdominal aortic aneurysm; and five-year outcomes of gastric bypass; a review article on contrast-associated acute kidney injury; a case report of a man with joint pain, weight loss, and chest pain; and Perspective articles on the case of Juliana v. U.S., on a temporizing solution to “artemisinin resistance”, on disability...

Featuring articles on neuromuscular blockade for ARDS, therapy for mild asthma with a low eosinophil level, maintenance or as-needed inhaled glucocorticoids for asthma, nasal high-flow therapy for newborn infants, and control of urinary tract function; a review article on the global elimination of hepatitis; a case report of a man with cough and eosinophilia; and Perspective articles on AIDS in America, on lessons from Scott County, on realizing the value of community health workers, and on...

Featuring articles on an antibacterial envelope for cardiac devices, dabigatran in embolic stroke of unknown source, LIMS1 genomic mismatch and kidney transplant rejection, and the inhibition of PI3K in breast cancer; a review article on muco-obstructive lung diseases; a case report of a man with jaundice; and Perspective articles on the power and limits of classification, on big data and the intelligence community, and on facilitated self-service in health care.

Featuring articles on thrombolysis for stroke up to 9 hours after onset, transmission of the Nipah virus in Bangladesh, progesterone in women with bleeding in early pregnancy, a ticagrelor reversal agent, mesenchymal hamartoma of the liver and DICER1 syndrome, and inflammatory remarks about cardiovascular disease; a review article on chronic kidney disease in agricultural communities; a case report of a man with neck pain and swelling; and Perspective articles on the current opioid crisis...

Featuring articles on TAVR in low-risk patients, brain deposition of tau in living former NFL players, and BCMA-directed CAR T cells in myeloma; review articles on hypoparathyroidism and on stem-cell research and clinical application; a Clinical Problem-Solving describing repetition; and Perspective articles on building on the ACA to achieve universal coverage, on turning drug rebates into discounts in Medicare Part D, and on counting your blessings.

Featuring articles on pembrolizumab for PML, HCV-positive organ donors, a centrifugal-flow or axial-flow left ventricular assist device, tagraxofusp in blastic plasmacytoid dendritic-cell neoplasm, and stomaching drug delivery; a review article on hazardous chemical emergencies and poisonings; a case report of a man with alcohol withdrawal and altered mental status; and Perspective articles on the hypertension hot potato, on creating a Center for Innovation within the VA, and on the ROC...

Featuring articles on early or delayed cardioversion for atrial fibrillation, antithrombotic therapy in atrial fibrillation after PCI or an acute coronary syndrome, correction of SCID-X1 with gene therapy, an anti-CD4 antibody for HIV-1, and valuations of surgical procedures in the Medicare fee schedule; a review article on catheter ablation of ventricular arrhythmias; a case report of a man with weakness and difficulty chewing; and Perspective articles on structural racism, on a Belmont...

Featuring articles on coronary angiography after cardiac arrest, verubecestat in prodromal Alzheimer’s disease, genetic risk of Hirschsprung’s disease, sleuthing glutaminase deficiency, and boning up on irisin; review articles on obstructive sleep apnea in adults and on hepatocellular carcinoma; a case report of a man with HIV infection and chronic kidney disease; and Perspective articles on universal standards of care for Ebola, on lactates and local knowledge, and on physicians as border...

Featuring articles on pneumatic compression for venous thromboprophylaxis, preconception thyroid antibodies and levothyroxine, andexanet for bleeding related to factor Xa inhibitors, and interleukin-5 receptor blockade in hypereosinophilic syndrome; a review article on machine learning in medicine; a Clinical Problem-Solving describing a dangerous detour; and Perspective articles on pharmacologic research in pregnant women, on an epidemic of suspicion, on studying metastatic-cancer...

Featuring articles on a shorter regimen for multidrug-resistant tuberculosis, volatile or total intravenous anesthetics for CABG, anastrozole plus fulvestrant in metastatic breast cancer, darolutamide for castration-resistant prostate cancer, changes in practice after malpractice claims, and pancreatic differentiation and the beta cell; a review article on mucinous ovarian carcinoma; a case report of a man with progressive dyspnea; and Perspective articles on opioid use disorder and...

Featuring articles on treatments for renal-cell carcinoma, psychosis with stimulants for ADHD, diagnosing pulmonary embolism in pregnancy, GC gene deletion and vitamin D-binding protein deficiency, and Europe's Plan S; a review article on Helicobacter pylori infection; a case report of a man with atrial fibrillation, depression, and anxiety; and Perspective articles on social distance and mobility, on public-private partnerships in global health, and on being informed.

Featuring articles on short-course TB prevention in HIV, prophylactic antibiotics for miscarriage surgery, the safety and efficacy of bempedoic acid, ATP citrate lyase and cardiovascular disease, initial opioid prescriptions in the United States, and preventing preeclampsia; a review article on medical issues in civilian spaceflight; a case report of a woman with vision loss, headaches, and oral ulcers; and Perspective articles on taking aim at contraceptive coverage, on the FDA's proposed...

Featuring articles on patient safety and resident duty-hour rules, sleep and alertness in a duty-hour trial, longer-term sequelae from Ebola virus infection, and a comparison of four treatments for actinic keratosis; a review article on clinical genome editing; a Clinical Problem-Solving describing gasping for a diagnosis; and Perspective articles on a path forward for genome editing, on an effective innovation agenda, and on the undulations of a long career.

Featuring articles on omadacycline for community-acquired bacterial pneumonia and for skin infections, sacubitril-valsartan in acute decompensated heart failure, and RNA interference for acute intermittent porphyria; review articles on depression in the primary care setting and on organoids; a Clinical Problem-Solving describing the devil in the details; and Perspective articles on metatarsals, meaning, and medicine; on protecting payments for primary care; on risk compensation and clinical...