NEJM This Week - Audio Summaries

Featuring articles on medical vs. surgical treatment for refractory heartburn, prasugrel or ticagrelor in acute coronary syndromes, long-term outcomes of immunotherapy in melanoma, statins from childhood in familial hypercholesterolemia, and preexisting conditions; a review article on lipid management for the prevention of cardiovascular disease; a case report of a woman with rapidly progressive ataxia; and Perspective articles on democratizing evidence production, on the cost of applying to...

Featuring articles on complete or culprit-lesion-only PCI for myocardial infarction, risk factors for macular telangiectasia, two speeds of increasing milk feeding volumes, testis tissue transplantation, and an algorithm-aided prediction of patient preferences; a review article on Zika virus infection; a case report of a woman with headache and somnolence; and Perspective articles on proposals to redesign Medicare Part D, on Medicare drug-price negotiation, on talking about toxicity, and on...

Featuring articles on ticagrelor in patients with stable coronary artery disease and diabetes, ligelizumab for chronic spontaneous urticaria, isoniazid in pregnant and postpartum women with HIV, community-wide screening for tuberculosis in Vietnam, and interpreting cancer mortality; a review article on neurosyphilis; a Clinical Problem-Solving describing the element of surprise; and Perspective articles on the States’ new fix for drug pricing, on colleagues unknown, and on medical training...

Featuring articles on ustekinumab for ulcerative colitis, vedolizumab versus adalimumab for ulcerative colitis, managing asthma in black children, a CRISPR–Cas9 deletion of CCR5 in hematopoietic stem cells, and the Lasker Award for HER2 discoveries; review articles on an update on the pathogenesis of and clinical aspects of COPD; a case report of a woman with lung cancer and chest pain; and Perspective articles on losing Hahnemann, on sustained animus toward Latino immigrants, and on...

Featuring articles on antithrombotic therapy for atrial fibrillation with stable coronary artery disease, a polypill in an underserved population, induction chemotherapy in nasopharyngeal carcinoma, maribavir for CMV reactivation, and creating a learning health system through randomized testing; a review article on anemia of inflammation; a case report of a boy with vomiting; and Perspective articles on contingent knowledge and looping effects, on Tweetorials and the return to why, and on...

Featuring articles on roxadustat in patients not receiving dialysis, roxadustat treatment for anemia in dialysis, benralizumab for COPD, n–3 fatty acids in pregnancy and preterm delivery, the Medicaid work requirement in Arkansas, and pivotal studies of adaptive immunity; a review article on the treatment of hypertension in patients with asthma; a case report of a woman with dyspnea and chest pain; and Perspective articles on U.S. immigration and compound disadvantage, on parenting during...

Featuring articles on a GABA type A–receptor modulator for depression, a trial of treatments for varicose veins at 5 years, inhaled GM-CSF for pulmonary alveolar proteinosis, mitapivat for red-cell pyruvate kinase deficiency, and death by stereotype; review articles on immune thrombocytopenia and on mobile devices and health; a Clinical Problem-Solving describing a terminal event; and Perspective articles on morbidity and mortality in the pre-Roe era, on health care refusal and the Trump...

Featuring articles on dolutegravir-based regimens for HIV in South Africa, dolutegravir vs. 400 mg of efavirenz for HIV-1 in Cameroon, neural-tube defects and antiretroviral treatment, oral semaglutide and cardiovascular outcomes in diabetes, pediatric drug research and labeling, and crystalline findings in asthma; a review article on adrenal crisis; a case report of a girl with head trauma during a sailboat race; and Perspective articles on a lethal hidden curriculum, on practicing what we...

Featuring articles on air pollution and mortality in 652 cities, serelaxin in acute heart failure, selinexor in refractory myeloma, myocardial viability in ischemic cardiomyopathy, and human health on an ailing planet; a review article on drug effects on the thyroid; a case report of a woman with opioid use disorder and suicidal ideation; and Perspective articles on a new era of climate medicine, on combating EPA rollbacks, on prescription drug monitoring programs, and on the comfort of the...

Featuring articles on teplizumab in relatives at risk for type 1 diabetes, complement blockade for neuromyelitis optica spectrum disorder, BRAF and MEK inhibition in melanoma, liraglutide in children and adolescents with diabetes, the “All of Us” research program, and recognition for discoveries in DNA repair; a review article on autoimmune hemolytic anemia; a case report of a pregnant woman with abdominal pain; and Perspective articles on reproductive (in)justice, on reevaluating U.S....

Featuring articles on voxelotor in sickle cell disease, vitamin D and the prevention of diabetes, familial chylomicronemia syndrome and apolipoprotein C-III, and an ACO model for underserved areas; a review article on pheochromocytoma and paraganglioma; a case report of a woman with palpitations, abdominal pain, and vomiting; and Perspective articles on abortion rights in peril, on putting an end to conversion therapy, on the sustainable discovery and development of antibiotics, and on...

Featuring articles on transfusion in African children with severe anemia, ibrutinib–rituximab or chemoimmunotherapy in CLL, a fractional dose of yellow fever vaccine, the response to immune checkpoint inhibition, and the long arc of big data in medicine; a review article on gene therapy; a Clinical Problem-Solving describing a diagnosis to chew on; and Perspective articles on it being time for another contraception revolution, on saving the endangered physician-scientist, on what blackface...

Featuring articles on ribociclib in hormone-receptor–positive breast cancer, olaparib in pancreatic cancer with repair defects, vena cava filters in severely injured patients, erdafitinib in urothelial cancer, and the ongoing Ebola outbreak in the DRC; a review article on measles; a case report of a 52-year-old man with fever, cough, and hypoxemia; and Perspective articles on the opportunity of CBD, on the implications of an aging rural physician workforce, on postacute care, and on...

Featuring articles on universal HIV testing and treatment in Africa, systolic and diastolic blood pressure and cardiovascular risk, health care spending and quality 8 years into global payment, and cracking down on CRISPR-Cas9; a review article on drug-induced liver injury; a case report of a woman with weakness, dark urine, and dysphagia; and Perspective articles on the right and left hands of the state, on sodium-intake reduction and the food industry, and on a “never event” that could...

Featuring articles on CRP testing in patients with acute exacerbations of COPD, enzalutamide in metastatic prostate cancer, a monoclonal CGRP antibody for cluster headache, a CGRP receptor antagonist for migraine, and mistrust in science; a review article on hemolytic transfusion reactions; a case report of a woman with vision loss; and Perspective articles on mandatory measles vaccination in New York City; on vaccination over parental objection; on reforming the Orphan Drug Act for the...

Featuring articles on brain activation in acutely unresponsive patients, dexmedetomidine in critically ill patients, nintedanib for interstitial lung disease, high-sensitivity troponin in suspected MI, and transcatheter aortic-valve replacement; a review article on growth hormone assessment in adults; a case report of a woman with fever and rash after heart transplantation; and Perspective articles on the ACA in limbo, on the upcoming U.S. health care cost debate, on meeting the needs of...

Featuring articles on clinical risk and therapy for breast cancer, BTK inhibition in multiple sclerosis, cardiovascular MRI vs. FFR in coronary artery disease, dual antihypertensive therapies in black Africans, and lethal strategies against tumor cells; review articles on the nonopioid treatment of pain and on heatstroke; a case report of a woman with abdominal pain and fever; and Perspective articles on misrecognition and critical consciousness, on collateral benefits of preventive...

Featuring articles on azithromycin for seasonal malaria chemoprevention, azithromycin to prevent childhood mortality in Niger, a follow-up of intensive glucose control in type 2 diabetes, and on venetoclax and obinutuzumab in CLL; review articles on cancer stem cells and on the prevention of opioid overdose; a Clinical Problem-Solving describing a disturbing decline; and Perspective articles on measles in 2019, on whether CBO forecasting is good enough for government work, on getting more...

Featuring articles on neuromuscular blockade for ARDS, therapy for mild asthma with a low eosinophil level, maintenance or as-needed inhaled glucocorticoids for asthma, nasal high-flow therapy for newborn infants, and control of urinary tract function; a review article on the global elimination of hepatitis; a case report of a man with cough and eosinophilia; and Perspective articles on AIDS in America, on lessons from Scott County, on realizing the value of community health workers, and on...

Featuring articles on an antibacterial envelope for cardiac devices, dabigatran in embolic stroke of unknown source, LIMS1 genomic mismatch and kidney transplant rejection, and the inhibition of PI3K in breast cancer; a review article on muco-obstructive lung diseases; a case report of a man with jaundice; and Perspective articles on the power and limits of classification, on big data and the intelligence community, and on facilitated self-service in health care.