NEJM This Week

Featuring articles on gastric and gastroesophageal junction cancer, pulmonary sarcoidosis, graft-versus-host disease, gastroenteritis in children, the rapid recovery of donor hearts after circulatory death, and an on-table reanimation of a pediatric heart from donation after circulatory death; a review article on fragile X disorders; a case report of a woman with neck swelling and dysphagia; and Perspectives on vaccine policy, on new mammography tools, and on the second life of Jacqui B.

Featuring articles on mild asthma, cardiovascular risk factors, stroke, advanced breast cancer, and transforming health care; a review article on juvenile idiopathic arthritis; a case report of a man with headache and ataxia; and Perspectives on who will care for America, on hospital financial assistance policies, and on libraries burned, and a life lived.

Featuring articles on structured exercise after chemotherapy for colon cancer, and treatments in obesity, in head and neck cancer, and in patients at high risk for cardiovascular events; a review article on forensic pathology; a Clinical Problem-Solving on caving in to pressure; a Sounding Board on climate change and human health; and Perspectives on the corporatization of U.S. health care, on self-neglect in older people, on Medicare drug price negotiation, and on the autopsy report.

Featuring articles on routine cerebral embolic protection for TAVI, and treatments for cirrhosis due to MASH, BRAF V600E metastatic colorectal cancer, and Pompe’s disease; a new review article series on medical education; a case report of a woman with dyspnea on exertion; and Perspectives on addressing ultraprocessed foods, on the costs of dismantling DEI, and on a brother’s keeper.

Featuring articles on mismatch repair–deficient tumors, generalized myasthenia gravis, HER2-mutant non–small-cell lung cancer, a Corynebacterium diphtheriae outbreak, and hereditary and sporadic papillary kidney cancer; a review article on unruptured intracranial aneurysms; a case report of a man with respiratory failure and shock after kidney transplantation; and Perspectives on medical AI and clinician surveillance, on pathobiology, and on unrest.

Featuring articles on treatments for pulmonary fibrosis, for obesity and overweight, for severe hemophilia B, and for a rare genetic disease; a review article on malnutrition in older adults; a case report of a man with a nasopharyngeal mass; a Medicine and Society on John Collins Warren; and Perspectives on undermining women’s health research, on addressing antifungal drug resistance, and on conversations that matter in maternal medicine.

Featuring articles on metabolic dysfunction–associated steatohepatitis, lung nodules, breast cancer, and improving birth outcomes; a review article on hemoglobinopathies; a Clinical Problem-Solving on from where it stems; and Perspectives on U.S. research leadership at a crossroads, on health care in an evolving immigration landscape, and on carrying hope while facing a crisis.

Featuring articles on pulmonary arterial hypertension, oral semaglutide and cardiovascular outcomes, giant-cell arteritis, the loss of subsidized drug coverage and mortality, and neutralizing venom toxins; a review article on cancer of unknown primary site; a case report of a man with fever, nausea, and respiratory failure; and Perspectives on primary care and the free market, federal cuts at the VA, the GINA gap, and the meaning of goodbye.

Featuring articles on multiple sclerosis, narcolepsy type 1, antiretroviral therapy in children with HIV, and porcine kidney xenotransplantation; a review article on Ph-positive acute lymphoblastic leukemia; a case report of a woman with peritonsillar swelling and bleeding; and Perspectives on the power of physicians in dangerous times, on community health centers, on AI-driven clinical documentation, and on driving Jackson.

Featuring articles on high-risk smoldering multiple myeloma, M. tuberculosis infection, type 2 diabetes, uncontrolled hypertension, and lymphoma; a review article on the chemistry of food; a case report of a man with weight loss, weakness, and anorexia; and Perspectives on the dismantling of foreign-assistance efforts, on the crushing weight of nonclinical demands in primary care, and on the last dose.

Featuring articles on lipoprotein(a), familial polycythemia, leukocyte adhesion deficiency, COPD, and on policies on reducing alcohol consumption; a review article on addressing alcohol use; a Clinical Problem-Solving on gazing into a crystal ball; and Perspectives on death and taxes, on cancer metastases, and on a good innings.

Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid’s mandate for children and adolescents.

Featuring articles on obinutuzumab in active lupus nephritis, tecovirimat for mpox, treatments for paroxysmal atrial fibrillation, and gene therapy for hemophilia B; a review article on enteral nutrition in hospitalized adults; a case report of a woman with cough and weight loss; and Perspectives on withdrawal of the United States from the WHO, on what’s next for nicotine, on the value zeitgeist, and on doctors in revolution and war.

Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts toward equity and on breaking the sacred promise.

Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopathy; and Perspectives on physician shadowing, application overload, medical school grading, and impersonal personal statements.

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.

Featuring articles on breast cancer, bloodstream infection, subarachnoid hemorrhage, scrub typhus, and birth-related mortality; a review article on the evaluation and treatment of infertility; a case report of a woman with altered mental status and acidemia; and Perspectives on advancing transgender health amid policy threats, on evidence-based work design, and on what an oncologist had wished she had done for a grieving father.

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.

Featuring articles on H5N1 infection, chronic subdural hematoma, achondroplasia, and B-cell acute lymphoblastic leukemia; a review article on carceral health care; a case report of a woman with weakness, back pain, and pancytopenia; and Perspectives on the changing approach to addiction, on the moral injury of inhaler prescribing, and on how one size fits … some.

Featuring articles on ventricular tachycardia, chronic lymphocytic leukemia, chronic kidney disease, kidney allografts, and a low-dose yellow fever vaccine; a review article on tubal ectopic pregnancy; a case report of a man with abdominal pain; and Perspectives on reducing the financial toxicity of rapidly approved drugs, on resilience, and on the death of an unlikable man.