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The Dr. Gabrielle Lyon Show

Medical

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are...

Location:

United States

Description:

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.

Language:

English


Episodes
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Mark Bell on Fat vs. Carbs, What’s Really Making You Fat?

4/28/2026
Most people are chasing the wrong version of strength and paying for it with pain, poor movement, and a body that breaks down faster than it should. In this episode, Dr. Gabrielle Lyon sits down with Mark Bell, elite powerlifter, entrepreneur, and founder of Slingshot, to discuss: Whether you're 25 or 75, this episode will challenge how you think about movement, muscle, and what it actually means to be strong physically and mentally. Thank you to our sponsors: Explore More from Dr. Gabrielle Lyon Find Mark Bell at: Connect with Dr. Gabrielle Lyon Chapters 00:00 – Introduction 02:48 – Mark Bell's Motto 07:00 – Mind-Body Strength Connection 10:45 – Wrestling > Powerlifting > Entrepreneurship Journey 17:37 – Rationale of Goals 22:04 – Effects of Consistency and Efficiency in Training 32:55 – Recommended Training and Lifestyle Modalities 37:32 – Artificial Exercise vs. Exercise Deficiency 37:47 – "Artificial Exercise" and "Exercise Deficiency" 39:36 – Impact of Physical Activity in Children 44:57 – Biggest Mistake in Weight Loss 50:46 – Overconsumption is a Problem 53:17 – Era of GLP-1, Peptides, and Steroids 1:02:28 – Training to Decrease Mortality 1:03:33 – Cancer Research Updates 1:04:36 – Collective Research on Supplementation 1:16:50 – Influencing Children to Engage in Physical Activities Share This Episode If you found this episode valuable, share it with someone who would benefit from it. Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Duration:01:19:37

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GLP-1 Side Effects, Risks, And Who Should Actually Be Using It | Dr. Christle Guevarra

4/21/2026
We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity. 🙌Thank you to our sponsors: 🌍 Cozy Earth - Go to https://bit.ly/4teXQhz for up to 20% off! 🤍 Timeline - Get 20% off your Mitopure order at https://bit.ly/48NFRX2 🚲 Carol Bike - Visit https://bit.ly/4tg4cxa and use code LYON for $100 off your CAROL Bike Explore More from Dr. Gabrielle Lyon: Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/ Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/ Connect with Dr. Christle Guevarra YouTube: https://bit.ly/4vDMVQa Instagram: https://bit.ly/4mxnfAc Get Dr. Christle Guevarra’s book, “Bodybuilding Anatomy”: https://bit.ly/3ODIDYd 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso ⏰Timestamps: 00:00 ​Intro of Show 07:27 Changes in the Fat Loss Landscape 12:22 Engagement in Competitive Powerlifting 17:00 Perspectives on GLP-1 Medication 31:01 Perimenopause Journey 32:02 Topamax 33:42 Urosepsis 35:03 Weight Loss Programming 36:48 Patients’ Decision to Take GLP-1 41:19 Risks and Effects on Taking GLP-1 41:57 Pancreatitis 45:30 Fen-Phen (Fenfluramine/phentermine” “Ephedra 50:22 Who Should Not Take GLP-1? 53:40 Proper Nutrition to Support Taking GLP-1 57:40 Recommendation for the New Dietary Guidelines 1:04:21 Residency and Sports Medicine Fellowship 1:06:15 Are Athletes Recommended to Take GLP-1? 1:13:26 Lack of Randomized, Controlled Trials for Peptides 1:15:30 Key Take-away’s from Dr. Christle 1:20:20 Should Women Weigh Themselves? 1:26:16 Should Women Lift Weights? 1:27:04 What’s Next for Dr. Christle? ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:22:55

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Dominique Sachse on Aging Well, HRT, and Building Muscle After 50

4/14/2026
The moment you decide to show up publicly, you open the door to opinions from people who would never say those things to your face. Dominique Sachse, journalist, author, and content creator who has lived her life on camera for over three decades, gets honest about what it costs to put yourself out there, why online cruelty is a psychology problem more than a content problem, and how “Teflon Dom” developed the thick skin to let none of it redirect her. Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe Get Dominique Sachse’s book, “Life Makeover: Embrace the Bold, Beautiful, and Blessed You”: https://bit.ly/4meV7lk Listen to "Over 50 & Flourishing" on all your favorite platforms! YouTube: https://bit.ly/4meCeyY Spotify: https://bit.ly/4cwdvTs Apple Podcasts: https://bit.ly/4bVin4s 📱Connect with Dominique Sachse: Website: https://bit.ly/41VFUfC YouTube: https://bit.ly/41YNk1C Instagram: https://bit.ly/3OgHXHU Facebook: https://bit.ly/41G41iB TikTok: https://bit.ly/4sXBbWB LinkedIn: https://bit.ly/3PYRvIf 🙌Thank you to our sponsors: 💪BodyHealth - Use the code LYON 20 to get 20% off your first order https://bit.ly/4mhPTVS 🍳Our Place - Our Place - Visit https://bit.ly/4c8OrAB and use code DRLYON for 10% off sitewide 😁Branch Basics - Get 15% off the Premium Starter Kit at https://bit.ly/48xF5NK with the code DRLYON ❤️Amp - Visit https://bit.ly/4cwLoDJ to get your AI-powered at-home gym for smarter, personalized training 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 ​Intro of Show 02:10 Dominique’s Mission 05:13 Women’s Reinvention with Aging 12:07 Handling People’s Opinions in the Media 18:03 Why Dominique Wrote “Life Makeover” 26:08 Activating One’s Faith through Life’s Challenges 29:16 Decision to Leave the News Business 34:12 Traditional Media Transitioning to Online Media 37:09 How to Curate Information 38:42 Effectively Communicating with Journalism and Research Skills 43:17 Managing Conflicts On-and-Off Air 45:28 The Aging Process 49:53 Personal Training with Body Builders 52:33 Changes in Training and Nutrition 54:49 Importance of Discipline 1:00:28 How Dominique Makes Decisions 1:04:03 Dominique’s Goal and Message 1:08:46 Midlife Wellness Protocols 1:14:29 What’s Next for Dominique? ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:21:09

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The Truth about Saturated Fat, Omega-3 Fatty Acids and Total Mortality | Dr. Tom Brenna

4/7/2026
Only nine scientists were asked to advise on the 2025 Dietary Guidelines for Americans, and Dr. Tom Brenna was one of them. In this conversation, he pulls back the curtain on how dietary guidelines are actually made, why the process has never been the same twice, and what it was like to watch a decades-old saturated fat recommendation get carried forward despite a lack of evidence supporting it at the level of total mortality. This is the dietary guidelines conversation the internet has been missing: straight from someone who was actually in the room. Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe 📱Connect with Dr. Tom Brenna Website: https://bit.ly/3O3cNUv Instagram: https://bit.ly/4s7UF9N LinkedIn: https://bit.ly/4shYfyl References: https://nutrition.org/american-society-for-nutrition-calls-for-strong-science-in-national-nutrition-guidance/ https://ajcn.nutrition.org/article/S0002-9165(24)00527-6/fulltext 🙌Thank you to our sponsors: 😁Manukora - Save 31% plus $25 worth of free gifts. https://bit.ly/4sglER1 💪Timeline - Get 20% off your Mitopure order at https://bit.ly/3NkQAB5 ❤️Bon Charge - Save 15% at https://bit.ly/4cDyV1G with code DRLYON 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 ​Intro of Show 00:14 Dr. Tom Brenna’s Background 05:19 Working with IBM 08:46 Family Life 10:38 2015 vs. 2025 Dietary Guidelines for Americans 28:06 American Society for Nutrition: Behind-the-Scenes of Dietary Guidelines 32:10 History of Saturated Fat 42:17 Different Types of Fat 45:23 How Are People Eating during World War II 51:09 The Whole Milk for Healthy Kids Act of 2025 53:58 What is Saturated Fat? 57:57 Link between Saturated Fat and Cardiovascular Diseases 1:05:53 Saturated Fat vs. Total Mortality 1:13:13 Best Studies on Saturated Fat 1:14:42 Reduction of Saturated Fat = Lowered LDL Cholesterol 1:22:35 Pregnancy and Fish Consumption Myths 1:37:55 Recommended Nutrition 1:39:59 Different Types of Oil and Effects on Health 1:42:04 Omega 3’s and 6’s Recommendation 1:50:02 Omega 3 Fatty Acids and ADHD 1:50:54 What’s Next: Precision Nutrition and Genetics ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:31:33

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GLP-1 Drugs & Bariatric Surgery Explained by a Top Obesity Researcher | Dr. David Allison

3/31/2026
In a world flooded with conflicting health advice, how do you actually figure out what’s true? Dr. David Allison, one of the most rigorous scientific minds in obesity and nutrition research, shared the exact framework he uses to evaluate evidence, from peer-reviewed trials to podcast recommendations to AI-generated summaries. He explains the difference between trusting science as a process and trusting individual studies, why most nutrition epidemiology functions more like advertising than research, and how ordinary people can build a reliable filter for health claims without a PhD. Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe 📱Connect with Dr. David Allison LinkedIn: https://bit.ly/3O6quC2 🙌Thank you to our sponsors: 💪OneSkin - Get 15% off at https://bit.ly/3Q8vSFi with code DRLYON 🍳Timeline - Get 20% off a Mitopure subscription at https://bit.ly/4uYiu6C 😁Carol Bike - Visit https://bit.ly/4v7XsTp and use code LYON for $100 off your CAROL Bike 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 ​Intro of Show 03:55 Dr. David Allison’s Background 09:50 Principles vs. Scientific Data 14:48 What is Doubly-Labeled Water? 16:42 Misconceptions on Diet 21:08 Concept of Human Discomfort 24:18 Childhood Obesity 28:49 Research: What Really is the Purpose? 31:14 Can We Trust Science? 40:54 INSERT LINK: NEWSLETTER ON OBESITY AND ENERGETICS 40:54 Obesity: Causes and Treatments 50:29 Different Outcomes from Weight Loss Drugs 57:21 Safety is a Social Judgment 1:00:18 Making Decisions in a Noisy Landscape 1:08:29 Podcasts as a Good Source of Information 1:16:09 Stance on Ultra-Processed Foods and Seed Oils 1:22:50 Dr. David’s New Projects 1:29:40 How to Make Good Decisions ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:35:20

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Dr. Tommy Wood: Can Cognitive Decline Be Reversed?

3/24/2026
Up to 70% of dementia may be preventable, so why aren’t more people talking about what actually drives cognitive decline? In this episode, I’m with Dr. Tommy Wood, neuroscientist and author of “The Stimulated Mind,” to explore the lifestyle levers that protect your brain across a lifetime. Learn how white matter hyperintensities develop and whether they can reverse, what MCTs and ketones actually do for a glucose-starved brain, and why social connection may be the most underrated variable in cognitive aging. What is the one change you could make today that would most protect your brain tomorrow? Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe Get Dr. Tommy Wood’s book, “The Stimulated Mind”: https://bit.ly/4bYIUxE Listen to "Better Brain Fitness" on all your favorite platforms! YouTube: https://bit.ly/4bGqxMN Spotify: https://bit.ly/4c0OGPj Apple Podcasts: https://bit.ly/3NL7toq 📱Connect with Dr. Tommy Wood: Website: https://bit.ly/3NIV4RX YouTube: https://bit.ly/3NVWWHa Instagram:https://bit.ly/40L6w2z X: https://bit.ly/3NTpFMQ LinkedIn: https://bit.ly/4c0iETw 🙌Thank you to our sponsors: 💪Timeline - Get 35% off a Mitopure subscription at https://bit.ly/3NkQAB5 🍳Four Sigmatic - Go to https://bit.ly/4spO5wn for a free bag of their dark roast ground coffee (just pay for shipping & handling). 😁Branch Basics - Get 15% off the Premium Starter Kit at BranchBasics.com with the code DRLYON. 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 ​Intro of Show 01:52 Elite Athlete’s Brain and Emotional Regulation 06:51 How to Regulate Emotions 11:30 Mindset Impacting Hormonal Responses 15:39 Future-Proofing the Brain 19:42 Brain Development vs. Shrinkage 26:11 Dementia Types, Causes, and Prevention 39:29 Social Isolation Influencing Cognitive Function 50:00 Social Stress’ Drivers 52:34 Non-Negotiable’s to Avoid Dementia Risks 57:42 Seafood Consumption Beneficial for Brain Function 1:03:35 Alcohol and Sleep Impacting the Brain 1:10:16 Is Brain Function Recovery Possible? 1:18:43 Use of Ketones and Glucose for Cognitive Recovery 1:23:09 Power of Mindfulness 1:27:06 Get Dr. Wood’s Book ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:30:23

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HIIT vs. Moderate Intensity Exercise - Which Is Better for Your Health? | Dr. Martin Gibala

3/17/2026
Metabolic flexibility is your body’s ability to efficiently burn fat or carbohydrate depending on demand, may be one of the most important and least understood markers of long-term health. In this episode, I’m with Dr. Martin Gibala to explore the emerging science of Fat Max, why mitochondrial quality is central to both performance and longevity, and how sprint interval training produces comparable mitochondrial adaptations to traditional endurance work in a fraction of the time. Could the key to better metabolic health be less about the hours you log and more about how hard you’re willing to push? Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe Get Dr. Martin Gibala’s book, “The One-Minute Workout” here: https://bit.ly/4lxBchq Connect with Dr. Martin Gibala Website: https://bit.ly/3P8ROjd Website: https://bit.ly/3Nfz410 Instagram: https://bit.ly/40qrVhl X.com: https://bit.ly/4b9usCP YouTube: https://bit.ly/3PiVkYh Email: realexercisescience@gmail.com 🙌Thank you to our sponsors: 🛌 Cozy Earth - Go to https://bit.ly/4loRB7A for up to 20% off! 🚴 Carol Bike - Visit https://bit.ly/4b9KFYF and use code LYON for $100 off your CAROL Bike ☕ Four Sigmatic - Go to https://bit.ly/4lp0Ep2 for a free bag of their dark roast ground coffee (just pay for shipping & handling). 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 Intro of Show 01:26 What is High-Intensity Interval Training? 05:04 HIIT to Improve Health Fundamentally 08:23 Exercise Ratio for General Individuals vs. Athletes 14:29 Dr. Lyon's Workout Routine 16:47 High-Intensity Interval vs. Sprint Interval Training 20:23 New Studies on Sprint Interval Training 24:57 The One-Minute Workout 26:57 CAROL Bike Mechanics 28:59 Benefits of High-Intensity Interval Training 37:21 Fuel Utilization: Sprint Interval vs. Slow, Steady-State Training 45:38 Metabolic Flexibility Definition 46:41 Fat Max Definition and Evaluation 50:26 Zone Training Model 58:00 Designing the Health of the Nation 1:04:04 How to Improve Body Composition 1:11:40 REHIT: Reduced Exertion, High-Intensity Training 1:21:59 Does HIIT Prevent Sarcopenia? 1:27:27 VO2 Max: Factoring Age and Sex 1:34:28 Designing the Ideal Workout Week 1:39:14 Importance of Rest Intervals 1:45:14 Connect with Martin ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:46:30

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Danica Patrick Opens Up About Breast Implant Illness, Inflammation, and Starting Over

3/10/2026
The most decorated woman in motorsports history will tell you she feared losing far more than she loved winning, and that fear is exactly what drove her to the top. In this episode, I’m with racing legend Danica Patrick to unpack the psychology of elite performance, from the “blind faith” that carried her through two decades of racing to the nervous system conditioning she built starting at age 10. What would be possible for you if you learned to channel pressure instead of escaping it? Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe Listen to “Pretty Intense Podcast” on all your favorite platforms! YouTube: https://bit.ly/4cyZPrt Spotify: https://bit.ly/4riCb63 Apple Podcasts: https://bit.ly/4s4I1cH Get Danica Patrick’s book, “Pretty Intense” here: https://bit.ly/4rXdH3r 📱Connect with Danica Patrick Website: https://bit.ly/4lfA9SQ YouTube: https://bit.ly/3OVYeCk Instagram: https://bit.ly/4bht0Ni TikTok: https://bit.ly/4sCyDNf Facebook: https://bit.ly/3Nuajhw X.com: https://bit.ly/3Pdog3X LinkedIn: https://bit.ly/4cWK6mn 🙌Thank you to our sponsors: 😁Bon Charge - Save 15% at https://bit.ly/4cDyV1G with code DRLYON 💪Bodyhealth - Use the code “LYON20” to get 20% off your first order! https://bit.ly/4r2ImeF ❤️Timeline - Get 35% off a Mitopure subscription at https://bit.ly/4b2QpmQ 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 00:00 Intro of Show 02:05 Understanding the Idea of Pressure and Challenge as a Kid 05:00 Managing Wins and Losses 09:45 Automaticity to Fear 11:44 Managing Nervous System under High Pressure 17:34 Danica's Pre-Performance Rituals 20:21 Performance Becoming One's Identity 21:23 Danica Working with Dr. Lyon 26:24 Discipline for Proper Recovery 28:47 Tips for Someone Going through the Same Issues 31:01 Working with Different Doctors 34:01 Women's Intuition in Hiring 37:14 Women in Male-Dominated Industries 41:42 There Are No Shortcuts to Success 43:01 Performing in High-Pressure Situations 45:51 Importance of Having Alone Time 48:34 What is Home Energy? 51:20 Flow of State: Passion and Creativity 55:51 Medicine in the AI Era 59:32 Rapid Fire Q&A ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:04:56

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Hormone Replacement Therapy, What Every Woman Needs to Know in 2026 | Dr. Heather Hirsch

3/3/2026
I’m joined by Dr. Heather Hirsch to debunk the persistent myths surrounding hormone replacement therapy and explain why the 2002 Women’s Health Initiative data was so widely misinterpreted. We discuss how optimized estrogen, progesterone, and testosterone levels can protect your heart, bones, and brain health, helping you move past "normalized suffering" and into a proactive state of longevity. Whether you are in perimenopause or well past the ten-year window, you'll learn how to navigate personalized dosing and clinical data to reclaim your vitality and extend your health span. Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe Listen to “Women’s Health by Heather Hirsch, MD” on all your favorite platforms! Apple Podcasts: https://bit.ly/4l86Mlw Spotify: https://bit.ly/4cpmiHu Get Dr. Heather Hirsch’s book, “The Perimenopause Survival Guide” here: https://bit.ly/4r2yXUd 📱Connect with Dr. Heather Hirsch: Website: https://bit.ly/4smy4qJ YouTube: https://bit.ly/3NdevSH Instagram: https://bit.ly/4sfj11P TikTok: https://bit.ly/46v6Y8s Facebook: https://bit.ly/3OLI4LA X.com: https://bit.ly/3MY4Cbm LinkedIn: https://bit.ly/4u6rjeb 🙌Thank you to our sponsors: 💪Bodyhealth - Use the code “LYON20” to get 20% off your first order! https://bit.ly/4r2ImeF 🍳Our Place - Use code “DRLYON” for 10% of sitewide. https://bit.ly/4r77SiU 😁Manukora - save 31% plus $25 worth of free gifts. https://bit.ly/4sglER1 📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST: YouTube: https://bit.ly/4boCFC3 Spotify: https://bit.ly/4cWTbLG 📱Connect with Dr. Gabrielle Lyon: Instagram: https://bit.ly/4uk9adc TikTok: https://bit.ly/3OFK3kJ X.com: https://bit.ly/4l3YlaX Facebook: https://bit.ly/3MBrJso LinkedIn: https://bit.ly/3N1nrdL Website: https://bit.ly/3NdV2kT Books: https://bit.ly/4r6ugZK Newsletter: https://bit.ly/402QCAj ⏰Timestamps: 0:00 Intro of Show 6:00 Hormone Replacement Therapy: Where Are We Now? 11:25 What is Menopausal Hormone Therapy? 13:39 How Safe is Hormone Replacement Therapy? 18:39 Access on the Studies on HRT 23:10 Risks of Hormone Replacement Therapy 27:24 Estrogen Does Not Cause Breast Cancer 31:19 Estrogen and Accelerated Bone Loss 34:51 Preventative Benefits of Estrogen 38:47 Lifespan vs. Health Span 39:22 When to Start Hormone Replacement Therapy? 45:15 Blood Markers 47:26 Progesterone: Effects, Timing, Dosage 52:38 Testosterone: Effects, FDA Approval, Benefits, Risks 1:00:44 Analysing the Numbers 1:04:13 Link of HRT and Cognitive Function 1:09:28 What Are Women Doing Wrong? ‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.

Duration:01:11:13

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Male Fertility and Sperm Health: What Your Sex Drive and Testosterone Really Mean | Dr. Michael Eisenberg

2/24/2026
Male fertility is declining, and most men have no idea why. In this episode of The Dr. Gabrielle Lyon Show, Dr. Gabrielle Lyon sits down with Dr. Michael Eisenberg, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, to break down what truly determines sperm health and reproductive success. They discuss: If you care about fertility, hormones, metabolic health, or the future of men’s health, this conversation is essential. Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com Thank you to our sponsors: BodyHealthhttps://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/Carol Bikehttps://carolbike.com/OneSkinhttps://www.oneskin.co/ Find Dr. Michael Eisenberg at: https://med.stanford.edu/eisenberglab.htmlhttps://www.linkedin.com/in/michael-eisenberg-9230a429https://x.com/DrMEisenberg Find Dr. Gabrielle Lyon at:

Duration:01:19:08

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Why You Don’t Believe in Yourself (And How to Fix It) | Dr. Shadé Zahrai

2/17/2026
Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com Self-doubt holds more people back than lack of skill or intelligence. In this episode, Dr. Gabrielle Lyon sits down with Dr. Shadé Zahrai to explore the science of confidence, self-trust, and peak performance. They break down why confidence comes after action, how self-image shapes success, and the four psychological drivers that determine whether you thrive or stay stuck. You will learn how body language influences perception, why high performers plan for failure, how perfectionism leads to burnout, and the subtle communication habits that undermine credibility. Most importantly, you will discover how to build what Dr. Zahrai calls Big Trust so you can back yourself before you feel ready. If you struggle with overthinking, imposter thoughts, or feeling capable but not fully confident, this conversation will give you practical tools to change how you show up. CHAPTERS 00:00 – The Science of Confidence vs Self-Doubt 03:21 – What Is the Opposite of Self-Doubt? 04:23 – Why Self-Trust Comes Before Confidence 05:00 – 5 Body Language Signals That Make You Look Confident 09:21 – How Posture and Physiology Affect Confidence 11:56 – The Psychology of Self-Doubt (PhD Research Explained) 14:23 – What Makes People Truly Successful? 15:00 – The Self-Image Blueprint That Shapes Your Success 18:15 – The 4 Drivers of Self-Trust: Acceptance, Agency, Autonomy, Adaptability 22:56 – Why Most People Lack Self-Awareness 25:22 – The Scar Experiment: How Beliefs Shape Reality 28:15 – Can You Predict Success in 15 Minutes? 29:43 – The 2 Types of Self-Doubt (Healthy vs Destructive) 31:38 – Why Visibility Is Critical for Career Success 33:46 – Which Self-Trust Skill Is Easiest to Improve? 38:24 – Why High-Potential People Stay Stuck 41:00 – Michael Phelps’ Visualization Strategy for Success 45:00 – How to Stop Overthinking and Rumination 58:10 – Self-Improvement vs Perfectionism vs Burnout 1:09:23 – The 4 Inner Critics That Sabotage You 1:12:35 – The Burnout Warning Sign Most High Achievers Ignore 1:17:12 – When Purpose Turns Into Obsession 1:20:15 – Why High Performers Need Creative Hobbies 1:23:52 – What Is Peak Performance, Really? 1:26:12 – Big Trust vs Confidence: What’s the Difference? 1:29:04 – 3 Daily Habits to Build Self-Trust 1:31:49 – Communication Mistakes That Kill Credibility 1:36:48 – Stop Over-Apologizing at Work 1:42:17 – Audit Your Circle: The Social Influence Effect 1:49:12 – Why Training Alone Doesn’t Build Confidence 1:50:00 – Final Thoughts on Living Without Regret Thank you to our sponsors: Timelinehttps://www.timeline.com/drlyonBodyHealthhttps://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/Four Sigmatichttp://foursigmatic.com/gabrielle Find Dr. Dr. Shadé...

Duration:01:34:49

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How to Eat for Strength, Metabolism, and Longevity

2/10/2026
Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com This episode brings together standout moments from The Forever Strong Experience, packed into one powerful episode. Featuring highlights from: Dr. Mark HymanThe Dr. Hyman ShowYoung ForeverFood Fix UncensoredLayne Norton, PhDMichelle Shapiro, RDQuiet the DietAlan Aragon, MSAlan Aragon’s Research Review In this mashup, they break down: Perfect if you’re tired of conflicting nutrition advice and want clear, evidence-based guidance you can actually use. Thank you to our sponsors: Our Place - Visit https://www.fromourplace.com/DRLYON and use code DRLYON for 10% off sitewide. Four Sigmatic - Go to http://foursigmatic.com/gabrielle for a free bag of their dark roast ground coffee (just pay for shipping & handling). Cozy Earth - Go to https://www.cozyearth.com/DRLYON for up to 20% off! Chapters: 00:00:00 The truth about nutrition 00:01:06 Why is it so hard to follow health advice? 00:03:07 What actually holds people back from progress? 00:05:26 When “clean eating” backfires 00:05:57 The nutrition “rule” that does more harm than good 00:06:37 Why medicine got obsessed with BMI and fat 00:08:47 Body composition fundamentals: what to do first 00:10:53 “Rules” for better body composition (practical guidelines) 00:13:20 Do you have to lift heavy to build muscle? 00:16:24 Strength vs hypertrophy: what matters most as you age 00:17:46 Sponsor: Our Place + What if muscle were taught as an organ system? 00:20:14...

Duration:01:17:45

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Protein First: How the New Dietary Guidelines Shift Nutrition

2/3/2026
Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com In this episode, Dr. Gabrielle Lyon sits down with Dr. Donald Layman, one of the world’s leading protein researchers and a key contributor to the newly released U.S. Dietary Guidelines. They explore why the old food pyramid failed, how nutrition science became driven by ideology instead of evidence, and what the updated guidelines finally get right about protein, fats, and carbohydrates. Dr. Layman explains why the long-standing protein recommendation of 0.8 g/kg was never intended for optimal health and how higher protein intake supports body composition, metabolic health, and nutrient adequacy. The conversation also dives into controversial topics including saturated fat, carbohydrate tolerance, animal versus plant protein, and the limitations of epidemiology in nutrition research. Gabrielle and Dr. Layman discuss how dietary guidelines shape school lunches, hospitals, and public institutions, and why a protein-first framework empowers individuals to make better nutrition decisions, especially as we age. This episode offers a clear, science-backed roadmap for understanding modern nutrition — cutting through misinformation and outdated dogma to focus on strength, longevity, and real-world application. Thank you to our sponsors: Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Bon Charge - Save 15% at https://boncharge.com/ with code DRLYON Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 00:00 Why Dietary Guidelines Exist and Why This Moment Matters 01:20 The Hidden Origins of the Food Pyramid (World War II + Public Health) 02:55 The Original Protein RDA: A Basement Number, Not Optimal Health 05:50 Why the Old Guidelines Focused on What Not to Eat 07:25 Why Protein Was Avoided for Decades 08:50 Nitrogen Balance: Why It Never Predicted Health Outcomes 11:10 Epidemiology vs Controlled Trials in Nutrition Science 13:05 How the Protein Evidence Was Evaluated for the New Guidelines 14:15 Why Higher Protein Improves Weight, Fat Loss, and Lean Mass 15:35 Is “Too Much Protein” Actually Dangerous? 16:40 Nutrient Deficiencies Risk on Low-Protein Diets 17:35 Animal vs Plant Protein: Bioavailability and Amino Acids 18:45 Why 0.8 g/kg Was Never Better Than Higher Protein 20:15 Empowering Consumers Instead of One-Size-Fits-All Nutrition 21:10 How Guidelines Shape School Lunches, Hospitals, and the Military 23:05 Protein-First Meal Planning Explained 24:50 Why the First Meal Matters More as You Age 27:15 Does Protein Distribution Matter After 50? 30:00 Protein, Satiety, and Appetite Control 31:05 Why “Ounce Equivalents” Between Plant and Animal Protein Don’t Work 34:05 The Saturated Fat Myth and Why the 10% Rule Persists 38:30 Where Saturated Fat Really Comes From in the Modern Diet 39:45 Updated Fruit, Vegetable, and Grain

Duration:00:51:15

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The Forever Strong PLAYBOOK: Your 6-Week Field Manual for Muscle-Centric Longevity

1/27/2026
Order The Forever Strong PLAYBOOK: https://drgabriellelyon.com/playbook/ Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com In this solo episode, Dr. Gabrielle Lyon shares the deeper mission behind The Forever Strong PLAYBOOK and the philosophy that has guided her work for decades. This conversation is not about trends, quick fixes, or aesthetics. It is about building strength as a lifelong responsibility and understanding why skeletal muscle is the foundation of health, resilience, and independence across the lifespan. Dr. Lyon introduces the Forever Strong ethos and walks through the four foundational pillars that support a strong life: how to think, how to eat, how to move, and how to recover. She explains why information alone does not change behavior and why clarity, discernment, and disciplined action are the true drivers of lasting health. Throughout the episode, Dr. Lyon challenges conventional narratives around aging, nutrition, exercise, and recovery. She reframes longevity through the lens of muscle span, the length of time a person lives with healthy, functional skeletal muscle, and explains how physical strength supports metabolic health, emotional regulation, and cognitive resilience. This episode is an invitation to step out of confusion and into a clear framework for living with intention. Strength is not something we inherit. It is something we build, choice by choice, day by day. Thank you to our sponsors: Timeline - https://www.timeline.com/drlyonFour Sigmatichttp://foursigmatic.com/gabrielle Find Dr. Gabrielle Lyon at: Timestamps: 00:00 – The Forever Strong Mission 01:15 – The Forever Strong Ethos 06:00 – Muscle as the Organ of Longevity 09:40 – How to Think 10:24 – Using the Body to Train the Mind 19:41 – Discernment and Mental Strength 28:43 – How to Eat 38:10 – Protein, Carbohydrates, and Metabolic Health 48:04 – Food Quality and Nutrient Density 51:30 – How to Move 57:59 – Training for Strength and Sustainability 1:06:39 – How to Recover 1:12:00 – Forever Strong Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked

Duration:01:12:58

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You Don’t Need Confidence, Just Do THIS | Leila Hormozi

1/20/2026
Pre-order The Forever Strong PLAYBOOK today to unlock over $400 in free bonuses and learn how to build the muscle, resilience, and metabolic health that actually determine how well you age. https://drgabriellelyon.com/playbook/ Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com In this episode, Gabrielle Lyon sits down with Leila Hormozi to discuss the journey from grit to empathy in both personal and professional life. Leila shares candid stories of building her first business, the sacrifices involved, and how her experiences in fitness shaped her entrepreneurial mindset. The conversation explores the value of failure, the importance of discipline, and what it truly takes to achieve business success, reflecting on the unique challenges and rewards that women encounter in leadership roles. Gabrielle and Leila also open up about balancing ambition, relationships, and personal well-being. They address how to build trust, practice self-belief, and handle the pressures of being public figures with authenticity. You will find practical insights on navigating discomfort, the importance of continuous growth, and on creating a fulfilling life based on clear priorities and honest reflection. The episode is filled with relatable stories and actionable advice for anyone focused on self-development and leadership. Chapters: 0:00 – From Grit to Empathy: How Leila’s Perspective Shifted 1:33 – Why Fitness Built the Foundation for Business Success 3:38 – Confidence, Self-Belief, and the Difference Between Rookie and Seasoned Entrepreneurs 8:23 – Discomfort, Anxiety, and Paying the Price for Growth 12:58 – Becoming Public-Facing and Outgrowing the Persona You Created 16:01 – Creating Content Without a Funnel or Ego-Driven Motives 19:32 – Why Fewer Women Teach Business at Scale 22:42 – What Actually Makes a Business Legitimate 24:23 – Trust, Relationships, and Learning to Trust Yourself 26:38 – Success vs Happiness and the Tradeoffs People Ignore 31:56 – Sacrifice by Season: Constraints, Focus, and Capacity 35:14 – Personal Trade-Offs and the Real Cost of Success 36:50 – Growth Levels Are About Exposure, Not Time 37:25 – Why You Should Stress Yourself Out More (Short-Term) 43:04 – Social Media, Authenticity, and Being Fully Human 46:15 – Reading Psychology and Understanding Culture 48:19 – Maintaining Relationships Between High Achievers 54:19 – Renegotiating Relationship Roles as Life Evolves 59:54 – Belief Is an Output, Not an Input 1:04:07 – Changing Your Relationship With Discomfort 1:04:55 – What’s Next: Expansion, Health, and Long-Term Vision Thank you to our sponsors: OneSkinhttps://www.oneskin.co/BodyHealthhttps://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/Bon Chargehttps://boncharge.com/ Find Leila Hormozi at:

Duration:01:07:58

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Willpower vs. Systems: Why Your Diet Fails & How to Fix Your Relationship w/ Food | Sohee Carpenter

1/13/2026
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com In this episode, Dr. Gabrielle Lyon is joined by Sohee Carpenter, PhD, to explore the complex intersection of psychology, eating behavior, and resistance training. Dr. Carpenter shares her personal journey from struggling with eating disorders to becoming a leading expert in sports science, offering a unique perspective on why high achievers often struggle with diet adherence. They dive deep into the science of behavior change, emphasizing that willpower is a finite resource and that true success lies in building automatic, cognitively effortless habits. Dr. Carpenter debunks common fitness myths, including the necessity of "lifting heavy" and the supposed ineffectiveness of circuit training, while providing practical strategies like "habit stacking" and "designing for laziness" to help listeners navigate their own health journeys. Chapter Markers - 0:00 - Intro: The finite nature of exercise vs. the 24/7 challenge of nutrition. - 1:22 - Meet Sohee Carpenter, PhD: Her academic journey from Stanford Biology to a PhD in Sports Science. - 4:33 - Personal Struggles: Overcoming anorexia, bulimia, and long-term binge eating. - 5:41 - Cultural Pressures: Growing up with the beauty standards of Korea vs. the US. - 8:38 - The Fitness Hobbyist: Discovering weights and the "clean eating" trap in 2011. - 13:10 - The Career Pivot: Choosing Psychology and Fitness over Medical School. - 17:52 - The Binge-Restrict Cycle: Why trying "harder" and being stricter backfires. - 21:54 - Defining RMR: Understanding Resting Metabolic Rate as your caloric floor. - 29:26 - Binge Eating Triggers: Emotion regulation and poor stress coping mechanisms. - 33:10 - The Freedom of No "Food Noise": Intuitive eating as a learned skill. - 36:08 - Gentle Nutrition: The "Add, Don’t Restrict" mindset. - 38:46 - The Willpower Battery: Why habits are superior to brute force discipline. - 45:47 - Habits and Environment: How to "Design for Laziness". - 50:00 - Habit Stacking: Pairing new behaviors with existing daily rituals. - 55:04 - Last Chance Syndrome: The logic of a binge and the "all or nothing" mentality. - 1:00:13 - Cognitive Distortions: Catastrophizing and the "bird's eye view" reframe. - 1:04:36 - Dichotomous Thinking: Why black-and-white mindsets lead to binging. - 1:06:48 - Intrinsic vs. Extrinsic Motivation: Finding a "why" that lasts. - 1:12:34 - Identity Change: Perceiving yourself as the person you want to become. - 1:14:27 - Resistance Training for Women: Determining the ideal frequency and style. - 1:19:16 - National Muscle Health Month: Elevating muscle as a pillar of health. - 1:21:39 - The "Heavy Lifting" Myth: Using rep ranges and reps in reserve (RIR). - 1:26:13 - The Circuit Training Study: Similar muscle gains in 25 minutes less time. - 1:29:44 - Training Fasted: Dispelling misconceptions for women’s metabolic health. - 1:30:57 - Running while Pregnant: Staying capable and medically cleared. - 1:33:34 - Final Takeaways: Incremental change and a holistic view of health. Thank you to our sponsors: Four Sigmatic - Go to http://foursigmatic.com/gabrielle for a free bag of their dark roast ground coffee (just pay for shipping & handling). Cozy Earth - Go to https://www.cozyearth.com/DRLYON for up to 20% off! Our Place - Visit

Duration:01:35:01

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The Gut-Muscle-Immune Axis: How Mitophagy Rewires Your Body for Longevity

1/6/2026
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com Are your immune cells aging faster than you are? In this episode, Dr. Gabrielle Lyon sits down with Dr. Anurag Singh, a leading physician-researcher and Chief Medical Officer at Timeline, to discuss a groundbreaking discovery: the gut-muscle-immune axis. While we often focus on muscle mass for longevity, new research published in Nature Aging reveals that our immune system undergoes a similar decline, with youthful sentinel cells (naive CD8 T-cells) dropping by 75% as we reach age 50. Dr. Singh explains how mitophagy —the targeted recycling of damaged mitochondria—is the key to "rewiring" an aging immune system to fight infection 20% more effectively. In this episode: Alzheimer’s of the Muscle: Why sporadic inclusion body myositis (sIBM) is often misdiagnosed as simple aging. The Power of Urolithin A: How this postbiotic compound induces mitophagy to increase mitochondrial abundance by 20% in just 28 days. Immune Imprinting: Why children get 6-8 colds a year while adults only average 2-4. Repurposing Longevity Drugs: Dr. Singh’s take on Metformin, Rapamycin, and GLP-1s for life extension. The 1:1 Exercise Rule:Why 150 minutes of moderate activity is the threshold for mitochondrial biogenesis. Thank you to our sponsors: BodyHealth - Use the code LYON 20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/ Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 0:00 - Can You Tell If Your Immune System Is Healthy? 1:37 - Alzheimer’s of the Muscle: Muscle-Immune Dysfunction 5:59 - The Thymus Design Flaw: Why Our Immune "Ammo" Disappears 8:44 - Naive CD8 T-Cells: The Elite Forces of Immunity 12:24 - The Axis of Aging: Mitochondria and Immune Cells in Muscle 16:15 - Mitophagy vs. Autophagy: Targeted Cellular Recycling 19:11 - Study Review: Rewiring the Immune System with Urolithin A 24:13 - Mitochondrial Remodeling: Switching from Glucose to Fatty Acids 27:45 - The Trifecta: Gut-Muscle-Immune Axis Connection 31:13 - Parkinson’s and the PINK1/Parkin Mitophagy Pathway 35:04 - Clinical Results: Improving Leg Strength in 4 Months 38:51 - Joint Health: Can We Remodel Cartilage with Mitophagy? 43:34 - Targeted Mitophagy Inducers: Exercise vs. Postbiotics 46:44 - Precision Nutrition: The Ideal Muscle Longevity Supplement 53:33 - Why Alzheimer’s is Now Considered an Inflammatory Disease 1:00:13 - The Placebo Effect: You Cannot Deceive the Immune System 1:03:13 - Lymphocyte Counts: The Clinical Marker for Immune Aging 1:08:14 - Rapamycin and Metformin: The Future of Longevity Drugs 1:11:42 - Optimal Dosing: Why 1,000mg of Urolithin A is the Standard 1:15:13 - Sports Medicine: Reducing Muscle Damage Markers (Creatine Kinase) 1:20:03 - The Final Frontier: Brain Aging and Selenium Repair Connect with Dr. Anurag Singh Instagram: @timeline_longevity Website: https://www.timeline.com Find Dr. Gabrielle Lyon at:

Duration:01:23:47

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The Joint Health Blueprint: Preventing Arthritis, Frozen Shoulder, and Bone Loss as You Age

12/30/2025
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com If you are only focusing on building muscle, you are missing half the equation for long-term mobility. In this mashup episode, Dr. Gabrielle Lyon brings together top orthopedic experts to discuss the critical importance of joint and tendon health. While muscle develops relatively quickly, your tendons and ligaments can take 6 to 9 months to fully adapt to a new training stimulus. This gap is where most injuries happen. We dive deep into the biological mechanics of tendons, the"athletic accommodation timeline," and why you must progressively overload your connective tissue—not just your muscle bellies. You will learn: The Menopause Connection:Osteoporosis Prevention:The Frozen Shoulder Mystery:Injury Recovery & Prehab:The History of Muscle: Stop training until you break. Learn how to track your progress, prioritize stability over raw mobility, and design a life built for anti-fragility. 0:00 - The Gap Between Muscle and Tendon Adaptation 1:32 - What Are Tendons? Visco-Elasticity and Force Dissipation 4:36 - The Rotator Cuff: Stabilizing the "Golf Ball on a Tee" 6:40 - The Athletic Accommodation Timeline: Why 6-9 Months Matters 8:36 - Progressive Overload for Connective Tissue, Not Just Muscle 11:36 - GLP-1s and Bone Health: Does Ozempic Increase Fracture Risk? 14:34 - Preventing Osteoporosis: The Power of Impact Training 18:15 - Bisphosphonates vs. Mechanical Loading for Bone Quality 21:10 - The Hidden History of Muscle: From Galen to Ancient Greece 26:48 - The Myth of "Pneuma" and the Soul in the Muscle 30:55 - Supercompensation: The "Gift from Zeus" in Performance 36:35 - Defining Impact Exercise: Why "Flight" is Better for Bones 39:48 - Building Your Base: Why Bone Health is Won Before Age 30 42:38 - Oral Contraceptives and Peroperative Blood Clot Risks 45:21 - The Hard Truth: How Nicotine Destroys Orthopedic Healing 47:55 - Testosterone and Muscle Mass vs. Bone Density in Women 51:41 - Relative Energy Deficiency in Sport (RED-s) and Stress Fractures 55:53 - Long-Term Menopause Consequences: Mobility and Hip Fractures 1:01:58 - Tendinopathy Treatments: Needle Tenotomy, 10X, and PRP 1:07:26 - Full Thickness vs. Incomplete Tendon Tears 1:12:05 - Prehab is Real: The...

Duration:02:29:50

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Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT

12/23/2025
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com Thank you to our sponsors: BodyHealthbodyhealth.comDRLYON save 31% plus $25 worth of free gifts.BON CHARGEhttps://boncharge.comfromourplace.com/DRLYON and use code DRLYON for 10% off Find Dr. Gabrielle Lyon at: https://drgabriellelyon.com/new-patient-inquiry/https://institute-for-muscle-centric-medicine.ck.pagehttps://www.amazon.com/exec/obidos/ASIN/1668085623 Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. Timestamps: 0:00 - FDA Lifts Blackbox Warning on HRT 1:08 - Definitions: Viralization & Androgens 3:08 - The New Landscape of Women's Health 4:46 - Gold Standard Testing: Mass-Spec 5:52

Duration:01:02:35

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Dr. Jen Ashton on Unimaginable Loss, Mental Health, and Post-Traumatic Growth

12/16/2025
If you or someone you know is experiencing suicidal thoughts, emotional distress, or a mental health crisis, call or text 988, or chat via 988lifeline.org. Support is available 24/7. You are not alone, and help is available. Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com Dr. Gabrielle Lyon sits down with renowned medical correspondent and OB/GYN, Dr. Jen Ashton, for a profoundly personal and candid conversation about navigating life's most intense tragedies while maintaining a public career. Dr. Ashton bravely opens up about the devastating suicide of her first husband, a world-class surgeon, 18 days after their divorce was finalized. She shares the raw reality of being in clinical shock and how the immense tragedy became an unexpected catalyst for post-traumatic growth. Dr. Ashton, who holds a Master's degree in Nutritional Sciences, also brings her medical expertise to current health debates: The Power of Fitness:resistance trainingThe Hormone Misinformation Crisis:Women's Health Initiative (WHI)GLP-1 Myths:The Problem with Extremes:nuanced, moderate positionFinding Love Again: About Jen Ashton: Retiring stiff paper gowns and unrelatable medical advice, Dr. Jennifer Ashton, a Board-certified Ob-Gyn, author, and TV medical correspondent, breaks the barrier between doctor and patient. Affectionately referred to as your all-in-one ‘BFF’/Ob-Gyn, Dr. Jennifer Ashton marries an unparalleled medical background with an accessible‘girl’s-girl’ attitude. Though Dr. Ashton can easily speak to the latest beauty and fashion trends, this Ivy League graduate means business when it comes to women’s health. Thank you to our sponsors: Timeline -https://timeline.com/LYONOneSkinhttps://www.oneskin.co Find Jen Ashton at: https://a.co/d/0HvOeSH

Duration:01:27:21