This Week in Cardiology
Medical
This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.
Location:
United States
Description:
This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.
Language:
English
Episodes
May 03 2024 This Week in Cardiology
5/3/2024
The DEDICATE trial of TAVR vs SAVR, more on renal denervation, inclisiran, and marketing disguised as science are the topics John Mandrola, MD, discusses in today’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. TAVR vs SAVR
TAVI Comparable With SAVR in Lower-Risk Aortic Stenosis
https://www.medscape.com/viewarticle/tavi-comparable-savr-lower-risk-aortic-stenosis-2024a100074o?form=fpf
DEDICATE https://www.nejm.org/doi/full/10.1056/NEJMoa2400685Partner 3 https://www.nejm.org/doi/full/10.1056/NEJMoa1814052Evolut Low Risk https://www.nejm.org/doi/full/10.1056/NEJMoa1816885Barili meta-analysis https://doi.org/10.1093/ejcts/ezab516 II. Renal Denervation
Alcohol-Mediated Renal Denervation Promising in Hypertension
https://www.medscape.com/viewarticle/alcohol-mediated-renal-denervation-promising-hypertension-2024a10007eg
TARGET 1 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069291 III. Inclisiran
Earlier Inclisiran Gives Better Long-Term LDL Reductions
https://www.medscape.com/viewarticle/earlier-inclisiran-gives-better-long-term-ldl-reductions-2024a10007d6
VICTORIAN INITIATE Trialhttps://www.jacc.org/doi/10.1016/j.jacc.2024.03.382 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:20:53
Apr 26 2024 This Week in Cardiology
4/26/2024
A listener defends colored boxes in guidelines; mysteries of non-culprit coronary lesions during PCI, and of AF ablation; and surrogate markers are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Mystery of What to Do in the Cath Lab after Fixing the Culprit Lesion – The FULL REVASC Trial
Complete Revascularization Not Superior to Culprit-Only PCI After MI
https://www.medscape.com/viewarticle/complete-revascularization-not-superior-culprit-only-pci-2024a10007ik
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149FIRE Trial https://www.nejm.org/doi/10.1056/NEJMoa2300468COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775Cohen Tweet on FULL REVASC https://x.com/djc795/status/1781361606238085532 II. AF Ablation Mysteries
New Expert Consensus on Ablation Strategies for AF
https://www.medscape.com/viewarticle/new-expert-consensus-ablation-strategies-af-2024a1000851
Bern Study of Remapping https://doi.org/10.1016/j.jacep.2024.02.026Natural History of SCAF https://doi.org/10.1016/j.jacc.2019.09.050Liverpool Study: Thermal PV Isolation in Persistent AF https://doi.org/10.1016/j.hrthm.2024.04.061 III. Surrogate Markers
JAMA: Surrugate Markers and Clinical Outcomes https://jamanetwork.com/journals/jama/fullarticle/2817850BP Surrogate Meta-analysis https://doi.org/10.1016/S0140-6736(21)00590-0JAMA:Nonfatal MI as Surrogate for Mortality https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785560 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:28:20
Apr 19 2024 This Week in Cardiology
4/19/2024
ACC Part 2: The TACT2 trial of chelation, inter-atrial shunts for HF, and triglyceride lowering; plus diltiazem and Factor Xa anticoagulants are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. TACT 2
Chelation Therapy Provides No Benefit Post-MI
https://www.medscape.com/viewarticle/chelation-therapy-provides-no-benefit-post-mi-2024a10006l5
Chelation Therapy and CV Risk: Why TACT2 Showed No Benefit https://www.medscape.com/viewarticle/chelation-therapy-and-cv-risk-why-tact2-showed-no-benefit-2024a1000761?src=
JAMA TACT 1 paper https://jamanetwork.com/journals/jama/fullarticle/1672238Diabetes Subgroup paper https://pubmed.ncbi.nlm.nih.gov/24254885/A New Look at P-values https://evidence.nejm.org/doi/abs/10.1056/EVIDoa2300003PARAGON HF https://www.nejm.org/doi/full/10.1056/NEJMoa1908655 II. Interatrial Shunts for HF
No Net HF Benefit for Interarterial Shunt Device
https://www.medscape.com/viewarticle/no-net-hf-benefit-interarterial-shunt-device-2024a10006kk
REDUCE LAP HF II https://doi.org/10.1016/S0140-6736(22)00016-2 III. Triglyceride Lowering
Early Olezarsen Results Show 50% Reduction in Triglycerides
https://www.medscape.com/viewarticle/early-olezarsen-results-show-50-reduction-triglycerides-2024a10006oz
Is It Time to Stop Treating High Triglycerides?
https://www.medscape.com/viewarticle/990126
NEJMhttps://www.nejm.org/doi/full/10.1056/NEJMoa2402309 Substantial Triglyceride Reduction With Plozasiran
https://www.medscape.com/viewarticle/substantial-triglyceride-reduction-plozasiran-2024a10006wf?icd=login_success_email_match_norm
JAMA Cardiologyhttps://jamanetwork.com/journals/jamacardiology/article-abstract/2817469 IV. Diltiazem and Factor Xa inhibitors
JAMA Vanderbilt University Paperhttps://jamanetwork.com/journals/jama/fullarticle/2817546 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:28:46
Apr 12 2024 This Week in Cardiology
4/12/2024
ACC Recap #1: DanGer Shock (plus a sobering JAMA research letter on Impella use), REDUCE-AMI, PREVENT, and EMPACT-MI are the topics John Mandrola, MD, covers in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. DanGer-Shock Trial
Impella CP Improves Survival in STEMI, Cardiogenic Shock https://www.medscape.com/viewarticle/impella-cp-improves-survival-stemi-cardiogenic-shock-2024a10006kz
Impella Saves Lives in Cardiogenic Shock, but Patient Selection Key https://www.medscape.com/viewarticle/1000659
Published DanGer Shock Study https://www.nejm.org/doi/full/10.1056/NEJMoa2312572JAMA Research letterhttps://jamanetwork.com/journals/jama/article-abstract/2817457 II. REDUCE-AMI Trial
New Data Question Beta-Blockers Post-MI With Preserved EF https://www.medscape.com/viewarticle/new-data-question-beta-blockers-post-mi-preserved-ef-2024a10006y8
Beta-Blockers Post-MI Past Their Expiration Date: REDUCE-AMI https://www.medscape.com/viewarticle/1000663
REDUCE-AMI paperhttps://www.nejm.org/doi/full/10.1056/NEJMoa2401479Meta-analysis: Beta Blockers for MIhttps://doi.org/10.1016/j.amjmed.2014.05.032 III. PREVENT Trial
Preventive PCI for Vulnerable Plaques Reduces Cardiac Events
https://www.medscape.com/viewarticle/preventive-pci-vulnerable-plaques-reduces-cardiac-events-2024a10006tc
Preventive Coronary Stents: Not There Yet
https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr
PREVENThttps://doi.org/10.1016/S0140-6736(24)00413-6 IV. EMPACT MI trial of Empagliflozin in the Post-MI setting
Empagliflozin Fails to Reduce Events After Acute MI
https://www.medscape.com/viewarticle/empagliflozin-fails-reduce-events-after-acute-mi-2024a10006kn
EMPACT-MI: Another SGLT2 Inhibitor Miss in Post-MI Care https://www.medscape.com/viewarticle/1000684EMPACT MI https://www.nejm.org/doi/10.1056/NEJMoa2314051DAPA MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286PARADISE MI https://www.nejm.org/doi/full/10.1056/NEJMoa2104508Kaul thread https://x.com/kaulcsmc/status/1776611935842165029Kaul paper https://www.ahajournals.org/doi/full/10.1161/circulationaha.116.022537 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:29:08
Apr 05 2024 This Week in Cardiology
4/5/2024
Statins and diabetes, AAD in patients with heart disease, tricuspid valve interventions, and an ACC preview are the topics John Mandrola, MD, discusses in this week’s podcast.This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Statins and Diabetes
Meta-analysis in Lancet-Diabetes https://doi.org/10.1016/S2213-8587(24)00040-8Editorial https://doi.org/10.1016/S2213-8587(24)00059-7NEJM Paper on Gene Variants and DM https://www.nejm.org/doi/full/10.1056/nejmoa1604304JAMA Paper on Gene Variants and DM https://jamanetwork.com/journals/jama/fullarticle/2565289 II. Anti-arrhythmic Drugs in Patients With Serious Heart Disease
UPenn Paper on AADs for PVC Suppression https://doi.org/10.1016/j.jacep.2024.01.021Three Questions for Evidence-Based Cardiac EP https://www.ahajournals.org/doi/full/10.1161/circoutcomes.110.957381CAST trial https://www.nejm.org/doi/full/10.1056/NEJM199103213241201 III. Tricuspid Valve Interventions
FDA Clears TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-clears-triclip-tricuspid-regurgitation-2024a100068o
FDA Panel in Favor of TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n
Slides for Trisend IITRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525 IV. ACC Preview
Mandrola's Three Trials to Look for at the 2024 American College of Cardiology Scientific Sessions
https://www.medscape.com/viewarticle/1000613
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:26:43
Mar 29, 2024 This Week in Cardiology Podcast
3/29/2024
Intermittent fasting, anticoagulation decisions, heterogenous treatment effects, frailty in HF, the importance of the ECG, and industry conflicts are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Intermittent Fasting
No, Intermittent Fasting Won't Kill You
https://www.medscape.com/viewarticle/1000544
NEJM Paper on Time-Restricted Eating https://www.nejm.org/doi/full/10.1056/NEJMoa2114833JAMA TREAT Clinical Trialhttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2771095 II. Stroke Prevention with OAC
Shah Meta analysis of Vitamin K Agonists in AFhttps://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.123.010269 III. Heterogenous Treatment Effects in Trials
Pivotal CV Trials May Not Apply to Complex Patients
https://www.medscape.com/viewarticle/989129
Analysis of 8 Trials of Multimorbidity and Treatment Responsehttps://doi.org/10.1016/j.amjmed.2024.01.028 IV. Frailty and HF
Circulation Outcomeshttps://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010416 V. ECG in LBBB
JAMA Cardiology:Revised Definition of LBBB https://jamanetwork.com/journals/jamacardiology/fullarticle/2816973 VI. Industry Payments to Doctors
JAMA:Payments to US Physicians by Specialtyhttps://jamanetwork.com/journals/jama/fullarticle/2816900 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:28:36
Mar 22 2024 This Week in Cardiology
3/22/2024
p>Obesity drugs as ASCVD-modifiers, HR monitors, when journals publish obvious facts, and effect scores and sorting out signals from RCTs are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Denmark Notes
II. FDA approval of Semaglutide
FDA Approves Semaglutide for Cardiovascular Risk Reduction
https://www.medscape.com/viewarticle/fda-approves-semaglutide-cardiovascular-risk-reduction-2024a10004ix
Select Trial III. PPG Monitor Accuracy
Research Letter https://doi.org/10.1016/j.jacc.2024.01.024 IV. AAD and Bradycardia
Anti-arrhythmic Drugs Linked to Bradycardia in Patients With AF
https://www.medscape.com/viewarticle/anti-arrhythmic-drugs-linked-bradycardia-patients-af-2024a10004vw
JACCpaper on AAD Adverse Effects https://doi.org/10.1016/j.jacc.2024.01.013 V. Finding Signals in RCTs
JAMApaper on Treatment Effects of Oxygen TargetsDANISH trialhttps://www.nejm.org/doi/full/10.1056/nejmoa1608029LAFFLIN et al. Scoring System to Assess Generalizability of Trial Results https://doi.org/10.1177/2047487318815967 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:26:19
Mar 08 2024 This Week in Cardiology
3/8/2024
Plastics and heart disease, MINT trial letters-to-the-editor and Bayes theorem, and Brugada syndrome are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Plastics and Heart Disease
Plastic Particles in Carotid Plaques Linked to CV Events
https://www.medscape.com/viewarticle/plastic-particles-carotid-plaques-linked-cv-events-2024a10004ge
Plastics and ASCVD Study https://www.nejm.org/doi/full/10.1056/NEJMoa2309822Review https://www.nejm.org/doi/full/10.1056/NEJMra2300476Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2400683 II. MINT trial LTE and Bayes Theorem
In MI With Anemia, Results May Favor Liberal Transfusion: MINT https://www.medscape.com/viewarticle/998376
The MINT Study https://www.nejm.org/doi/full/10.1056/NEJMoa2307983Letter-to-the-Editor https://www.nejm.org/doi/full/10.1056/NEJMc2400982Likelihood Ratio https://www.cebm.ox.ac.uk/resources/ebm-tools/likelihood-ratios III. Brugada Syndrome
The EHJ paper: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae133/7623123
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:26:53
Mar 1 2024 This Week in Cardiology
3/1/2024
The Western AF meeting, aspirin, cannabis use, LVEF in athletes, and shared decision making before ICD implantation are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. ASA in Primary Prevention
Campbell Meta-analysis https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.065420Swedish Observational study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.028321ASPREE https://www.nejm.org/doi/full/10.1056/NEJMoa1805819 II. Cannabis
Cannabis Use Tied to Increased Cardiovascular Risk
https://www.medscape.com/viewarticle/cannabis-use-tied-increased-cardiovascular-risk-2024a10003yr
It Sure Looks Like Cannabis Is Bad for the Heart, Doesn’t It?
https://www.medscape.com/viewarticle/1000250
Journal of the AHAObservational Study https://www.ahajournals.org/doi/full/10.1161/JAHA.123.030178 III. Low EF in Athletes
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.063777 IV. ICDs and Shared Decision-Making
Association of a Medicare Mandate for Shared Decision-Making With Cardiac Device Utilization https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2815017 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:28:35
Feb 23 2024 This Week in Cardiology
2/23/2024
Reading incidental CAC on chest CT scans, exercise benefits in women vs men, PCI with or without imaging, and trial non-reporting are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Incidental CAC on Chest CT
Incidental CACTweetWhen Does a Calcium Score Equate to Secondary Prevention?: Insights From the Multinational CONFIRM Registry https://doi.org/10.1016/j.jcmg.2023.03.008 II. Exercise
Health Gains of Exercise Greater in Women?
https://www.medscape.com/viewarticle/health-gains-exercise-greater-women-2024a10003fv
Sex Differences in Association of Physical Activity With All-Cause and Cardiovascular Mortality III. PCI With or Without Imaging
Intravascular Imaging in PCI: Time for a Guideline Update?
https://www.medscape.com/viewarticle/995677
Meta-analysis paper Lancet https://doi.org/10.1016/S0140-6736(23)02454-6Imaging uptake paper https://doi.org/10.1093/eurheartj/ehad430 IV. Trial Non-reporting
The Ghost Research Haunting Nordic Medical Trials
https://www.medscape.com/viewarticle/ghost-research-haunting-nordic-medical-trials-2024a10003gz
Manuscript/preprint https://www.medrxiv.org/content/10.1101/2024.02.04.24301363v1#T10Nissen (Rosiglitazone) https://www.nejm.org/doi/10.1056/NEJMoa072761 You may also like:
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Questions or feedback, please contact news@medscape.net
Duration:00:28:49
Feb 16 2024 This Week in Cardiology
2/16/2024
An update in trial interpretation, CI, and P-values; percutaneous tricuspid Interventions; and news on HDL and humility in Medicine are the topics John Mandrola, MD, covers in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Evidence of Absence Is not Absence of Evidence
Feb 09, 2024 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1000101
ARCADIA Trial https://jamanetwork.com/journals/jama/fullarticle/2814933FOURIER Trial https://www.nejm.org/doi/full/10.1056/nejmoa1615664Sample Size Calculator https://clincalc.com/stats/samplesize.aspx II. Tricuspid Valve Interventions
FDA OKs First Transcatheter Tricuspid Valve Replacement
https://www.medscape.com/viewarticle/fda-oks-first-transcatheter-tricuspid-valve-replacement-2024a10002dq
FDA Panel in Favor of TriClip for Tricuspid Regurgitation
https://www.medscape.com/viewarticle/fda-panel-favor-triclip-tricuspid-regurgitation-2024a100037n
Cardiothoracic Surgical Trials Network Study https://www.nejm.org/doi/full/10.1056/NEJMoa2115961TRILUMINATE https://www.nejm.org/doi/full/10.1056/NEJMoa2300525KAUL Tweet on ATTR Cardiomyopathy https://twitter.com/kaulcsmc/status/1753552603534016622?s=20APOLLO B trial https://www.nejm.org/doi/full/10.1056/NEJMoa2300757Al-Lamee Tweet on Sham Controls https://x.com/rallamee/status/1758236588570562736 III. HDL Cholesterol
Rationale paper — AEGIS https://doi.org/10.1016/j.ahj.2020.10.052Press Release AEGIS II https://www.prnewswire.com/news-releases/csl-announces-top-line-results-from-the-phase-3-aegis-ii-trial-evaluating-the-efficacy-and-safety-of-csl112-apolipoprotein-a-i-human-302059156.html You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:23:59
Feb 09 2024 This Week in Cardiology
2/9/2024
Beta-blocker withdrawal in HFpEF, the ARCADIA trial, food as medicine, and bariatric surgery are the topics John Mandrola, MD, discusses in today’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. HFpEF and Heart Rate
PRESERVE HF Substudy https://jamanetwork.com/journals/jamacardiology/fullarticle/2814596PRESERVE HF Original https://doi.org/10.1016/j.jacc.2021.08.073 II. ARCADIA trial
ARCADIA Main Paper: Apixaban vs ASA https://jamanetwork.com/journals/jama/fullarticle/2814933KAMEL’s AF and Stroke Paper 10.1161/STROKEAHA.115.012004AVERROES Substudy -- 10.1016/S1474-4422(12)70017-0 III. Food as Medicine
Food-As-Medicine Trial results: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2812982NPR Story https://www.npr.org/sections/thesalt/2017/05/08/526952657/fresh-food-by-prescription-this-health-care-firm-is-trimming-costs-and-waistline IV. Bariatric Surgery
Weight Loss Surgery Yields Long-Term BP Control in Obesity
https://www.medscape.com/viewarticle/weight-loss-surgery-yields-long-term-bp-control-obesity-2024a10002le
Gateway RCT https://doi.org/10.1016/j.jacc.2023.11.032 You may also like:
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Questions or feedback, please contact news@medscape.net
Duration:00:25:50
Feb 02 2024 This Week in Cardiology
2/2/2024
FDA approves PFA for AF ablation, flawed comparisons of TEER vs MV surgery and PCI vs CABG, and cardiologists struggling with board exams are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. PFA
FDA Okays Boston Scientific PFA System for Paroxysmal AF
https://www.medscape.com/viewarticle/fda-okays-boston-scientific-pfa-system-paroxysmal-af-2024a1000275
Pulsed-Field Ablation for AF: The Promise and the Reality
https://www.medscape.com/viewarticle/995675
ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291EU-PORIA Registry https://doi.org/10.1093/europace/euad185Tomlinson/Mandrola Editorial https://www.jacc.org/doi/10.1016/j.jacc.2020.07.032 II. TEER vs MV Surgery
EHJ Paper https://doi.org/10.1093/eurheartj/ehae046 III. ISCHEMIA Post-Hoc Studies
JACC Post-Hoc ISCHEMIA Trialhttps://doi.org/10.1016/j.jacc.2023.11.002Main ISCHEMIA paper https://www.nejm.org/doi/full/10.1056/nejmoa1915922FAME 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2112299 IV. Board Exams
More Cardiologists Failing the Boards, Why and How to Fix?
https://www.medscape.com/viewarticle/more-cardiologists-failing-boards-why-and-how-fix-2024a10001oi
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Duration:00:27:45
Jan 26 2024 This Week in Cardiology
1/26/2024
LAAO, more evidence that stable CAD is stable, CRT benefit over the long-term, and AF monitoring after stroke are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. LAAO
This Week in Cardiology Podcast, Dec 15, 2023 https://www.medscape.com/viewarticle/999282
European Heart Journal paper https://academic.oup.com/eurheartj/article/45/3/214/7471675LAAOS 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2101897 II. CAD after Transcatheter Aortic Valve Implantation
Cleveland Clinic Observational study https://doi.org/10.1093/eurheartj/ehae019ACTIVATION trial https://doi.org/10.1016/j.jcin.2021.06.041 III. Cardiac Resynchronization Therapy
Original RAFT 2010 https://www.nejm.org/doi/full/10.1056/nejmoa1009540Long-term RAFT https://www.nejm.org/doi/full/10.1056/NEJMoa2304542Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2312419 IV. AF Monitoring After Stroke
Japanese Observational Study https://www.ahajournals.org/doi/10.1161/JAHA.123.031508ARTESIA https://www.nejm.org/doi/full/10.1056/NEJMoa2310234NOAH https://www.nejm.org/doi/full/10.1056/NEJMoa2303062LOOP substudy https://jamanetwork.com/journals/jamaneurology/fullarticle/2795865CRYSTAL AF https://www.nejm.org/doi/full/10.1056/nejmoa1313600 You may also like:
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Duration:00:29:35
Jan 19 2024 This Week in Cardiology
1/19/2024
Listener feedback on antiplatelet therapy after PCI, bempedoic acid, off-Label PFO Closure, and palliative care are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback on Antiplatelet Therapy After PCI
Long-term Clopidogrel Has Advantages After Coronary Stenting
https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8
Host Exam Study; Extended FU of Host-Exam https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062770 II. Bempedoic Acid
This Week in Cardiology July 7, 2023 https://www.medscape.com/viewarticle/994089
NEJM:Bempedoic Acid and CV Outcomes JAMA:Primary Prevention Analysis https://jamanetwork.com/journals/jama/fullarticle/2806646 JAMA-Cardiology:Total Events Analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2813647/ III. Off-Label PFO Closure
Circulation Outcomes Paperhttps://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.123.010200 IV. Palliative Care
JAMA: Palliative Care Consultation You may also like:
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Questions or feedback, please contact news@medscape.net
Duration:00:29:51
Jan 12 2024 This Week in Cardiology
1/12/2024
GLP-1s and BaroStim Neo revisited, a new drug for transthyretin amyloid CM, clopidogrel vs ASA years after PCI and stent, and statins are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. GLP-1s and Obesity, BaroStim Neo Revisited
FDA Expands Label for CVRx Barostim System in HF https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx
JAMA Cardiology Special Communication – BDP https://jamanetwork.com/journals/jamacardiology/fullarticle/2810726
II. ATTR Cardiomyopathy
ATTRibute-CM NEJM paper https://www.nejm.org/doi/full/10.1056/NEJMoa2305434
Circulation Review of TTR https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.111.078915
ATTR-ACT (Tafadimis) https://www.nejm.org/doi/10.1056/NEJMoa1805689
III. Clopidogrel vs ASA Years After PCI
Long-term Clopidogrel Has Advantages After Coronary Stenting
https://www.medscape.com/viewarticle/long-term-clopidogrel-has-advantages-after-coronary-stenting-2024a10000c8
Stop DAPT Original Trial
STOP DAPT at 5 Years https://doi.org/10.1016/j.jacc.2023.10.013
Network Meta-analysis of P2Y-I vs ASA https://doi.org/10.1016/j.jcin.2022.08.009
IV. Statin Use
Statin Use Remains Low for At-Risk Patients
https://www.medscape.com/viewarticle/999043
Annals of Internal Medicine Observational Study https://doi.org/10.7326/M23-1915
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Questions or feedback, please contact news@medscape.net
Duration:00:26:36
Jan 05 2024 This Week in Cardiology
1/5/2024
Neuro-modulation in HF, private equity owned hospitals, HCM, SCD and ICD re-evaluated, and peer review are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Neuromodulation for HFrEF
FDA Expands Label for CVRx Barostim System in HF
https://www.medscape.com/viewarticle/fda-expands-label-cvrx-barostim-system-hf-2023a1000wsx
BeAT HF trial https://doi.org/10.1016/j.jacc.2020.05.015
II. Private Equity Takeover of US Hospitals
Hospital Adverse Events Rise After Private Equity Acquisition
https://www.medscape.com/viewarticle/hospital-adverse-events-rise-after-private-equity-2023a1000wya
Changes in Hospital Adverse Events and Patient Outcomes Associated With Private Equity Acquisition: https://jamanetwork.com/journals/jama/article-abstract/2813379
RSS audio: https://bi.medscape.com/pi/editorial/studio/audio/2024/core/999557.mp3
III. Hypertrophic Cardiomyopathy
Positive Topline Results for SEQUOIA-HCM Trial in OHCM
https://www.medscape.com/viewarticle/positive-topline-results-sequoia-hcm-trial-ohcm-2023a1000wu9
IV. The ICD gets a ReLook
Study to Examine Routine ICD Implantation Post Heart Attack
https://www.medscape.com/viewarticle/study-examine-routine-icd-implantation-post-heart-attack-2023a1000wmd
PROFID Site https://profid-project.eu/profid-ehra-trial/
Declining Risk of Sudden Death in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
V. Peer Review
Prevalence of Short Peer Reviews in 3 Leading General Medical Journals -- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2812883
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Questions or feedback, please contact news@medscape.n
Duration:00:25:03
Dec 15 2023 This Week in Cardiology
12/15/2023
FDA approves PFA, breakthrough in PAH, residual leaks after percutaneous LAAO, OAC in low to intermediate risk people are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. FDA Approves PFA
FDA Approves First Pulsed Field Ablation System for AF https://www.medscape.com/viewarticle/fda-approves-first-pulsed-field-ablation-system-af-2023a1000vit
- PULSED AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064329
- ADVENT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
- MANIFEST https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064959
II. Pulmonary HTN
Positive Topline Data for Sotatercept in PAH: STELLAR
https://www.medscape.com/viewarticle/982407
- STELLAR https://www.nejm.org/doi/10.1056/NEJMoa2213558
- Editorial on STELLAR https://www.nejm.org/doi/full/10.1056/NEJMe2300324
III. Peri-Device Leaks
- Greek Meta-analysis https://doi.org/10.1093/eurheartj/ehad828
IV. Intermediate Risk AF – Norwegian Study
- Stroke and bleeding risk in atrial fibrillation with CHADS-VASC risk score of one: the Norwegian AFNOR study AFNOR Study https://doi.org/10.1093/eurheartj/ehad659
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Questions or feedback, please contact news@medscape.net
Duration:00:29:05
Dec 08 2023 This Week in Cardiology
12/8/2023
Three aspects of the recent AF guideline documents and a possible new treatment of POTS are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I AF Guidelines
ACC/AHA Issue Updated Atrial Fibrillation Guideline
https://www.medscape.com/viewarticle/998956
- Guideline doc: https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193
- CASTLE AF https://www.nejm.org/doi/full/10.1056/nejmoa1707855
- Analysis of US Inpatient Sample https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/1471-2261-14-73
- RAFT AF https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.057095
- Beta Blockers in AF https://pubmed.ncbi.nlm.nih.gov/25193873/
Section 2 AF Guidelines – EARLY Rhythm Control Gets Emphasis
- STOP AF https://www.nejm.org/doi/full/10.1056/NEJMoa2029554
- EARLY AF https://www.nejm.org/doi/full/10.1056/nejmoa2029980
- EAST https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
- Natural History of AF https://www.jacc.org/doi/abs/10.1016/j.jacc.2019.09.050
Section 3 AF Guidelines – Dubious Upgrade of percutaneous LAAC
- PROTECT and PREVAIL Meta-analysis 5-year https://doi.org/10.1016/j.jacc.2017.10.021
- PINNACLE FLX https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.120.050117
II. Postural Orthostatic tachycardia Syndrome
Vagus Nerve Stimulation Promising In POTS
https://www.medscape.com/viewarticle/998913
- Stavrakis et al. Noninvasive VNS for POTS https://doi.org/10.1016/j.jacep.2023.10.015
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Questions or feedback, please contact news@medscape.net
Duration:00:28:20
Dec 01 2023 This Week in Cardiology
12/1/2023
More from AHA including SGLT2 inhibitors, blood transfusion after MI; cracks in the armor of Factor XI inhibitors; and renal denervation are the topics John Mandrola, MD, covers in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. DAPA MI
Potential Dapagliflozin Benefit Post-MI Is Not a 'Mandate'
https://www.medscape.com/s/viewarticle/998378
- NEJM Evidence: Dapagliflozin After MI https://evidence.nejm.org/doi/full/10.1056/EVIDoa2300286
II. Blood Transfusion Strategy Post MI
In MI With Anemia, Results May Favor Liberal Transfusion: MINT
https://www.medscape.com/viewarticle/998376
- MINT NEJM -- https://www.nejm.org/doi/full/10.1056/NEJMoa2307983
- REALITY https://jamanetwork.com/journals/jama/fullarticle/2776201
- PROTECTED TAVR - https://www.nejm.org/doi/full/10.1056/NEJMoa2204961
III. FACTOR XI
Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA
https://www.medscape.com/viewarticle/998418
Asundexian Phase 3 AF Study Halted for Lack of Efficacy
https://www.medscape.com/viewarticle/998665
- Abelacimab for VTE https://www.nejm.org/doi/full/10.1056/NEJMoa2105872
IV. Renal Denervation
FDA Panel Split on Efficacy of Spyral Renal Denervation
https://www.medscape.com/viewarticle/995800
FDA OKs Symplicity Renal Denervation System for Hypertension
https://www.medscape.com/viewarticle/998664
- SPYRAL HTN OFF MED -- https://doi.org/10.1016/S0140-6736(20)30554-7
- SPRYAL HTN On Meds (Pilot Lancet 2018 ) https://doi.org/10.1016/S0140-6736(18)30951-6
- SPRYAL HTN ON Meds (Expansion Pilot) https://doi.org/10.1016/j.jacc.2023.08.045
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https://www.medscape.com/features/public/machine
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Questions or feedback, please contact news@medscape.net
Duration:00:27:48