Better Brain Fitness (a Brainjo Production)

Can a shingles vaccine cut your dementia risk by 20%? A series of landmark studies — published in Nature, Cell, and JAMA — say yes. In this episode, Tommy unpacks the research: how natural experiments in four countries produced one of the most compelling signals in dementia prevention, what might explain the effect beyond infection prevention, and what it means for your own vaccination decisions. In this episode: 00:00 — Introduction 00:52 — The new data on shingles vaccination and Alzheimer's risk 01:48 — The Stanford group and their regression discontinuity methodology 03:15 — How birthday-based eligibility creates a natural experiment (Wales, Canada, Australia) 05:28 — Results: a ~20% reduction in dementia diagnoses across all countries 06:52 — The Cell paper follow-up: benefits at every disease stage (unimpaired → MCI → dementia) 07:55 — Shingrix vs. Zostavax: the US natural experiment and a potentially larger effect 09:08 — Why does it work? Preventing illness, avoiding bed rest and disuse, immunomodulation 11:29 — Neuroinflammation and possible immune system "tuning" effects 12:27 — The sex difference: greater benefit in women in most (but not all) studies 15:52 — Summary of the evidence and what it means for dementia prevention strategy 17:36 — Josh's take: number needed to treat analysis 19:15 — Heterogeneous pathways to dementia and why vaccination fits the toolkit 21:13 — Practical advice: when to get vaccinated, repeat dosing, and personal risk assessment 25:36 — Wrap-up and how to submit questions Links & Resources: The Stimulated Mind To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

A recent study published in Nature Medicine claims a blood test can predict when you'll develop Alzheimer's disease, and it got a lot of attention. But how well does it actually work, and should you rush out and get tested? In this episode, we break down the study behind the headlines to understand what it really shows, where the major limitations lie, and what it means for anyone thinking about getting this kind of test. Topics and Questions Covered What P-Tau 217 is and why it's become the leading blood-based biomarker in Alzheimer's research. How researchers built a predictive "clock" from blood test data and what that process required. The important distinction between having pathology in your brain and actually developing dementia. Who should and should not be getting tested. What a large Norwegian population study reveals about the overlap between pathology and normal cognitive function. How biomarkers like this might eventually fit into a broader, more personalized approach to prevention. and more! -------------- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

In this episode, we discuss a study published in PLOS One that compared living brain tissue to post-mortem brain tissue and found dramatic molecular differences between the two. The findings raise serious questions about decades of Alzheimer's research built on post-mortem analysis and may help explain why pharmaceutical treatments for the disease have been so disappointing Study: A Study of RNA Splicing and Protein Expression in the Living Human Brain -------------- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

In this episode, we dig into a recent McGill University study on computerized cognitive training and its effects on brain chemistry in older adults. What you'll learn: Why certain brain training games reversed a decade of age-related cognitive decline in just 10 weeks—and how researchers finally measured actual biological changes in the brain The critical difference between activities that genuinely enhance your brain versus mental junk food like Candy Crush or Solitaire The single organizing principle you can use to evaluate whether any cognitive activity is actually helping your brain or wasting your time To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

Much of what we talk about on Better Brain Fitness resolves around the demand-driven decline model we published. Well...a new study just published in Nature Communications gave that model the best test to date, and the results are pretty darn exciting. So of course we had to do an episode about it! The study looks at the relationship between brain aging and creative activities like music, dance, art, and video gaming. Tommy walks through the study and explains why this matters for anyone thinking about their long-term cognitive health. What You'll Learn: A more sensitive way to measure brain aging than structural scans The connection between music, dance, art, and video gaming on brain aging The effect of 30 hours of video gaming on brain aging, the kinds of video games that have the greatest impact (and why traditional "brain games" haven't been as successful) What this research tells us about whether cognitive decline is reversible The dose-response relationship between complex activities and brain health To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

In this episode, we tackle a question from listener Carolyn in Michigan about the potential cognitive impacts of long-term hearing loss. What You'll Learn: The research linking hearing loss to increased dementia risk and what the evidence actually shows How hearing aids impact the risk of cognitive decline The mechanisms behind why hearing loss might affect brain health Practical strategies for maintaining cognitive health when dealing with hearing loss Innovative technologies for hearing loss that could provide new forms of cognitive stimulation To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

You may have heard the alarming headline about a recent study that showed the typical brain had about a teaspoon of microplastics inside of it. And that amount appears to be increasing each year. In equally alarming fashion, that same study also revealed that those with dementia had over 5 times the amount of plastic in their brains as those without. Needless to say, it's an issue worth paying attention to. So, in this episode, we break down what is known about microplastics and their impact on brain health, and we discuss the specific measures we're both taking to reduce our own exposure to microplastics and enhance their clearance. Because brain plasticity is a great thing, but a plastic brain is not! ----- To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

Click here to grab Ben's new book, "Why Your Brain Needs Friends"! To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

Click here to pre-order a copy of Dr. Wood's book, The Stimulated Mind! To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

Click here to check out James's book, Regenerative Performance. To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to the free Better Brain Fitness newsletter, join us when we record live, and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Click here to pre-order Dr. Wood's book, "The Stimulated Mind." Click here to grab Dr. Turknett's bestselling book, "Anyone Can Play Music" Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

06To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness Substack newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.

To submit a question for us to answer on the podcast, go to brainjo.academy/question. To subscribe to The Better Brain Fitness newsletter and get our Guide and Checklist to essential blood tests and nutrients, go to: betterbrain.fitness. To learn more about how you can boost brain fitness with neuroscience-based musical instruction, head to brainjo.academy. Intro and Outro music composed and produced by Julienne Ellen.