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This Week in Microbiology

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Episodes

202: This frass doesn’t stink

8/8/2019
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Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt Guest: Julie Wolf Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic. How wood-feeding beetlesdeconstruct lignocellulose(PNAS)Meet the Microbiologist hosted by Julie WolfBacteria thatdegrade PET plastic(Micr Res Ann)Microbiology resource of the month(ASM) Morgan Vague’sTED talkPacific...

Duration:01:01:40

201: Microbiology papers for first year students

7/26/2019
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Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students. Become a patron of TWiM. Links for this episode: Paradigm shifts, paradigm drifts (pdf)IntroducingTHOR(mBio)Engineering bacteriophagesto treat mycobacterial infection (Nat Med)Biofilmsby Colter (Int Microbiol)Life in a worldwithout microbes(PLoS Biol)Reduction of cholerain Bangladeshi villages (PNAS)Placentagoes viral (PLoS Biol)#OMG (jpg)#OMG illustration by...

Duration:01:23:56

200: In the company of Elio

7/12/2019
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Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms. VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app. Become a patronof TWiM. Links for this episode Elio’s profileElio’s memoirsElio’s first paper, 1952 (J Bact)In...

Duration:01:01:25

199: PhD Balance

6/28/2019
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From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review. Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt Guests: Susanna L. Harrisand Alex Politis Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM Links for this episode PhD...

Duration:01:15:15

198: Unexpectedly pathogenic bacteriophages

6/1/2019
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The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Bacteria on theoutside of paramecia(ISME)Phage triggerantiviral immunity(Science)Image creditLetters read Music used on TWiM is composed...

Duration:01:00:22

197: Intercellular microbial trade

4/26/2019
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The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components. Become a patron of TWiM. Links for this episode: Take the TWiM listener surveyBacteria store energy for gutless worms(PNAS)Paracatenulaon TWiM #21E. coliextracts nutrientsfrom host cells (Cell) Image credit Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your...

Duration:01:10:24

196: I hear you

3/28/2019
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The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function. Links for this episode: Ambrosia beetles, ethanol, andfarmed fungi(PNAS) Cleaved cochlinprotects the inner ear (Cell Host Microbe)Importance of flossing(ADA) Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld...

Duration:01:03:37

195: Gingipain in the Alzheimer brain

3/4/2019
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Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Immunity to Cas9 protein in humans(Nat Med)P. gingivalis and Alzheimer’s disease(Science) Clinical trial of COR388 in AD...

Duration:01:14:31

194: Standard imperial procedure

2/14/2019
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Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli. Become a patron of TWiM. Links: Bacteria help dengue virus in mosquito guTWiV 479Minicells for disposal of damaged goodsTWiM Listener survey Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld...

Duration:01:05:26

193: Persisters

1/31/2019
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The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Please take theTWiM listener surveyBacteria alter behavior inmouse autism models(Neuron)Mice behaving badly (TWiM 131)Salmonella persistersundermine host...

Duration:01:00:44

192: A Qtip for phages

1/18/2019
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The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny. Please take theTWiM listener surveyVote for NJ State MicrobeHuge fungus is 2500 years old(Proc Roy Soc B) Humongous fungus(Wikipedia)Host-produced autoinducercontrols phage(Cell) These bacteria are bugged(virology blog) Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher,...

Duration:01:06:21

191: By the pulp of their teeth

12/21/2018
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The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode Oldest human plaguefrom 4,900...

Duration:01:01:35

190: Exosomes in your nose and in your gut

12/6/2018
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The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM. Links for this episode eliminate airway pathogensBacteria,...

Duration:01:18:49

189: Salmonella BonJovi

11/16/2018
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The TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses. Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter, and Michele Swanson Take our listener survey. Thanks! asm.org/twimpoll Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of...

Duration:01:11:04

188: Turducken antibiotics

10/31/2018
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The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome. Hosts: Vincent Racaniello and Michael Schmidt Links for this episode kill gram-negatives commentaryDNA and RNA Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a patron of TWiM.

Duration:01:20:44

187: Rounding up the bees

10/19/2018
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The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees. Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Links for this episode: Phages Cooperate to Overcome CRISPR-Cas...

Duration:01:06:28

186: Crypto-metamorphosis

10/5/2018
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The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson. Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app. Become a Patron of TWiM! Links for this episode after FlorenceCryptic niche switching Metamorphosisthen no eating (NY Times)tumor rejection Image creditLADD...

Duration:01:13:23

185: There’s no moa Moa

9/21/2018
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The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds. Subscribe to TWiM (free) on iTunes, Google Podcasts, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Become a Patron of TWiM! Episode Links: Hand sanitizerhand sanitizer toleranthandwash alcoholsCoprolitesSignificant Worry Over Infectious...

Duration:01:08:21

184: CRISPR-Cas immune systems

9/6/2018
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Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University. Host: Vincent Racaniello Guest: Sam Sternberg Become a Patron of TWiM! Links for this episode Sternberg Laboratorysubstrate selectionDNA interrogation DNA target cleavageA Crack in Creationrewrite the human genome?Sam Sternberg Music used on TWiM is composed and performed by...

Duration:01:26:07

183: Two symbioses

8/23/2018
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The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas. Become a patron of TWiM. Links for this episode: Parasitoid bacteriumof protist (bioRxiv)Fungal symbiont recruitmentin cicadas (PNAS)Fly by virus (TWiEVO 33) The Atlantic “How to Tame a Zombie Fungus” by Ed YongImage creditLetters read on TWiM 183 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions...

Duration:00:57:03