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The Downstream Column Podcast

Science Podcasts

The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development, and manufacture of biologic therapeutics. Key industry coverage areas include: purification, formulation, fill/finish and QA/QC for cell and gene therapies, vaccines, biologics, and emerging therapeutic modalities.

The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development, and manufacture of biologic therapeutics. Key industry coverage areas include: purification, formulation, fill/finish and QA/QC for cell and gene therapies, vaccines, biologics, and emerging therapeutic modalities.

Location:

United States

Description:

The Downstream Column (DsC) is an online publication targeting members of the biologics industry. Our intent is to provide a community to share expertise and best practices as well as discuss topics of interest. The Downstream Column covers areas important to the research, discovery, development, and manufacture of biologic therapeutics. Key industry coverage areas include: purification, formulation, fill/finish and QA/QC for cell and gene therapies, vaccines, biologics, and emerging therapeutic modalities.

Language:

English

Contact:

9704818489


Episodes

Evolving Beyond the Status Quo with Next Generation Buffer Prep Solutions

8/17/2021
In this podcast, we spoke with Chris Rombach, Vice President of Sales and Marketing at Asahi Kasei Bioprocess America about buffer prep and delivery systems. We discussed current pain points and how next generation buffer prep solutions can greatly improve upon the status quo, including increasing the use of automation and remote operation, while reducing the overall footprint, labor and cost associated with more traditional approaches.

Duration:00:14:01

Integrated Freezing Solutions to Minimize Risk and Preserve Product Quality

4/27/2021
Claire Jarmey-Swan, Global Product Manager, Pall Corporation talks about the evolution freeze thaw technologies and how these new methods can streamline the process, minimize loss and maintain the highest product quality.

Duration:00:10:11

Start With The End In Mind. How to facilitate transfer from non-GMP to GMP Manufacturing

6/28/2018
Avril Vermunt, bioprocess hardware specialist at GE healthcare talks about transferring a process from non-GMP to GMP manufacturing, particularly how resource-intensive it is for process development and manufacturing groups. Avril has several years of experience working in the technology transfer group at a large pharmaceutical company. We discussed with her best practices and how being proactive and one step ahead can make the process more seamless.

Duration:00:14:12

Modeling Downstream Disruptive Technologies to Improve Downstream Bioprocessing.

6/7/2018
Dr. Yuyi Shen, Principal Scientist, Grifols, talks about the benefits of modeling downstream disruptive technologies to improve downstream bioprocessing and evaluating the financial impact of implementing these technologies.

Duration:00:08:16

Cell Harvesting – Selecting a technology compatible with cell density and feed turbidity

4/10/2018
Silke Bergheim-Pietza, Global Product Manager Depth Filtration, Pall. discusses challenges faced in the cell harvesting step, in particular, selecting the best cell harvesting method based on the cell density and feed turbidity of the process and meeting the demand of increasing cell densities. Download the cell harvesting technology selection guide and use the guide to compare the latest single-use harvesting technologies.

Duration:00:11:41

Continuous Biomanufacturing Implementation Now and in The Future

3/6/2018
Dr. Peter Levison, Senior Marketing Director – Downstream Processing, Pall Biotech talks about the evolution and benefits of continuous biomanufacturing, what implementation looks like today and what still needs to be realized for full industry adoption.

Duration:00:12:13

Addressing Challenges in Downstream Biomanufacturing with a Platform Purification Approach

1/31/2018
Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, talks about the biggest challenges in Downstream biomanufacturing including overcoming bottlenecks, changing antibody structures and bioburden control. Jonathan shared how a purification platform can address some of these issues and discusses purification challenges that still need to be resolved.

Duration:00:16:21

Protein A Chromatography – A look at where we have been and where we are going

12/12/2017
Jonathan Royce, Business Leader, Chromatography Resins, GE Healthcare Life Sciences, talks about the evolution of Protein A including the latest developments in Protein A chromatography resins. We also discussed what the future holds for this purification mainstay and how it can continue to address the changing needs of biopharma.

Duration:00:25:38

Resolving Large Scale Buffer Management Challenges

11/29/2017
Joakim Lundvist, Modality Manager, BioProcess™ Hardware, GE Healthcare talks about large-scale buffer management challenges. Buffer preparation is known to be one of the most resource-intensive activities in biomanufacturing as large volumes of buffers and process liquids are often required. So how can this be done in a more efficient way? How can more capacity be added to buffer preparation without adding major capital investment? Are there ways to reduce the manufacturing footprint and...

Duration:00:11:59

Job Outlook for the Biomanufacturing Industry a Recruiter’s Perspective

4/5/2017
Hillary Kaplan, Director, Bioprocess CMC Development & Operations, Klein Hersh talks about the job outlook for the biomanufacturing industry from a recruiter’s perspective.

Duration:00:13:40

Cell Culture Media Optimization – It’s about more than just high protein titer

7/19/2016
Dr. Adam Elhofy, Ph.D., CSO, Essential Pharmaceuticals, talks about cell culture media optimization. We discussed the evolution of cell culture media optimization, current goals, and the latest strategies and tools being used.

Automated Stem Cell Based High Throughput Drug Screening for ALS and Parkinson’s

6/14/2016
Dr. Jan Bruder talks about his work at the Max Planck Institute for Molecular Biology in Münster Germany and his group’s use of automated high throughput drug screening program for ALS and Parkinson’s Disease.