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This Week In Virology

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Episodes

TWiV 524: Slicing and dicing with Raul

12/12/2018
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Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul AndinoTWiV 33: Live in Phillyrestricts insect immunityJolene Weekly Science...

Duration:01:16:11

TWiV 523: Virology in Zürich

12/9/2018
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At the University of Zürich, Vincent speaks with virologists Cornel Fraeful, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. Hosts: Vincent Racaniello Guests: Cornel Fraeful, Urs Greber, and Silke Stertz Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode co-infectionsMoviesinfluenza virus entryPlaque 2.0Video of this episodeJolene Intro music is by Ronald Jenkees. Send...

Duration:01:17:27

TWiV 522: Readers of the lost ORF

12/2/2018
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The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Genome-edited CRISPR pregnancy Naturally occurringDrosophila missed itLetters...

Duration:01:47:15

TWiV 521: Spitting in the Allee

11/25/2018
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Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programsMollivirus sibericum promotes early...

Duration:01:54:11

TWiV 520: This old mouse

11/18/2018
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The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode PhD and postdoctoral programsMSc program Virology ComicsOutbreak universal...

Duration:01:55:47

TWiV 519: Fishing for viruses in senile

11/11/2018
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The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Virology Comics antiviral for ADTWiV 505 HSV1 in ADTaiwan cohort studyHSV1 antibodies amyloid-beta...

Duration:01:35:55

TWiV 518: Hershey's viruses

11/4/2018
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Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses. Host: Vincent Racaniello Guests: Nicholas Buchkovich and Leslie Parent Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode membrane binding domainNuclear experiencenucleolusretrovirus assemblyBiP levelsregulates Lamodulating syntaxin 5Non-envelopment role for...

Duration:01:26:21

TWiV 517: Just in time for Halloween

10/28/2018
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Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode San DiegoHoustonTWiV 364TWiV 183Bombali virus Asymptomatic mumps virus Image creditLetters...

Duration:01:19:00

TWiV 516: HUSH little virus, don't you transcribe

10/21/2018
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Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Leonid Yorkovetskiy and Jeremy Luban Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode San DiegoHoustoncounter HUSH counter HUSH HUSH complex sound...

Duration:02:00:45

TWiV 515: When virus is in retrograde

10/14/2018
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The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this...

Duration:01:38:49

TWiV 514: Staying below the ADAR

10/7/2018
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The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode programapplication materialspenalized by CNRSpdfpdfpdfPeace PrizeMitochondrial dsRNALetters readJolene...

Duration:01:48:27

TWiV 513: Double-stranded in Belgium

9/30/2018
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From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus. Host: Vincent Racaniello Guest: Harry Greenberg Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 13th dsRNA Virus SymposiumHepatitisInterferon treatmentMycoplasmamutantsNorwalk virus infectionRotavirus rescueCold-adaptedcorrelates of...

Duration:01:02:03

TWiV 512: Flexuous SUMO wrestlers

9/23/2018
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Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Brianne Barker, and Anne Simon Click arrow to play Download TWiV 512 (62 MB .mp3, 103 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Gordon ConferencePotyvirusPlum pox...

Duration:01:42:47

TWiV 511: Accessory found guilty in DC

9/16/2018
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Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Ned Landau Become a patron of TWiV! Links for this episode Gordon ConferenceTWiV #1restricts HIV-1 replicationdiverse retrovirusesindependent of uncoatingTransduction of myeloid cellsLetters readJolene Weekly Science...

Duration:01:48:53

TWiV 510: Retroviruses at Cold Spring Harbor

9/9/2018
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Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts: Vincent Racaniello and Dickson Despommier Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata Become a patron of TWiV! Links for this episode Retrovirus Meeting 2018TWiV 320HIV-1 reservoirHIV-1 latencyCG dinucleotide suppressionJolene Intro music is by...

Duration:01:04:11

TWiV 509: 41,103 bases under the sea

9/2/2018
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The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Gordon ConferenceBeijerinck Prize Bioterrorism and Biocrimes History of Biological Warfare Those Who Can Do, Can't TeachPlanarianAplysia Image creditLetters read Weekly Science Picks Brianne- Climate...

Duration:01:46:25

TWiV 508: Bioweapon

8/26/2018
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Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons LabsMedical Aspects of Biological WarfareThe Soviet Biological Weapons ProgramBiological Threats in...

Duration:02:07:37

TWiV 507: The fusion of form and function

8/19/2018
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The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode Viruses & Cells Gordon ConferenceOutbreakOutbreakEbola virus outbreakEbola virus outbreaksnomenclaturedistribution...

Duration:01:58:31

TWiV Special: David Tuller is PACEman

8/17/2018
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David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode ArticleAustralian tripown goalLightning processParliamentconflict of interestLancet 3.0still champions GETImage Credit Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Duration:01:08:35

TWiV 506: A Cafeteria full of jelly rolls

8/12/2018
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The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Become a patron of TWiV! Links for this episode Viruses & Cells Gordon Conferencestrains distinctImmunizationsCafeteria roenbergensis viruslaboratoryCroV moviesScaled...

Duration:01:37:27