This Week in Virology

TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode head NIHhead FDAhead CDCCervical cancer declining Local dengue casetransmissible and virulentcurrent situationGlobalConserved immune evasionJolene Weekly Picks Brianne – Pale Blue Pod Kathy – PhysicsGirl recent Instagram post, ScienceAdvisor signup free daily sci news distillation, Semi-conducting hydrogels, Bot that can pick up things with a soft touch, “Pigeonbot II”, a drone called LisRaptor, zapping forever chemicals like PFAS with light and here Rich – Vendee Globe Jolene – Center for the Improvement of Mentored Research Experiences Vincent – These two ancient human relatives crossed paths 1.5 million years ago Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1 or 2 trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center’s long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode cliff notesrespiratorysecondary infectionsearlyNetdeathsnational and regional11 pathogensvariant trackergenomes1 and 2 trimestersB1 cellvaccinationSpecific IgG4NVX-CoV2373 and BNT162b2 Phase III trialWhere EUA center CDC QuarantineNIH Infectious Disease Society guidelinescheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation30-day Readmissionevidence basedhotlinefibromyalgia-likeintranasal chlorpheniraminecirculatingLetters read pdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member’s ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode not suitable for HHSWrite your SenatorsSupportASV 2025asylum seekers RSV hospitalization Ethics failingsRSV transmissionGlycan reactive IgMJolene Weekly Picks Brianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game, and an article about its origin Vincent – In the Quantum World, Even Points of View Are Uncertain Listener Pick Ryan – A Dangerous Moment Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving! Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode cliff notesrespiratoryNetrespiratoryH5N1transmissionFrom 2022:First childraw milkdeathsnational and regional11 pathogensvariant trackergenomeshousehold boostersProvisionalnursing (seat beltsWhere EUA center CDC QuarantineNIH Infectious Disease Society guidelinescheckersafety30-day mortalityMontelukast immunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation Remdesivirevidence basedmanifestations pandemicRutgers Scientific harassmentDoxing Harassment factlessera of harm:indoor interplay between transmissibility and immune status hotlineLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research. Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel Guests: Stephanie Gras and Jenna Guthmiller Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Goldilocks zoneBroadly neutralizing T cell epitopesemerging H5N1 virusesJolene Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode E. coli RFK Jr.Salk poliocontrolled vaccineSafety and efficacyAnotherSERIOUSLY!RFK JrRacaniello and OffitMAN CAN’T YOU GET ANYTHING RIGHT?Racaniello and OffitTrump-Kennedy Make American Healthy Again?United States HEALTHY!Measlesmerry-go-aroundoutbreak 10.3 million measles infectionsantiviralchildrenclift notesmpox vaccineNYCactivitydeathsnational and regional11 pathogensvariant trackergenomesuse Indoor Settings interplay between transmissibility and immune status (longer intervalWhere EUA center CDC QuarantineNIH Infectious Disease Society guidelinesAntiviral Therapy for COVID-19 and Influenza Drug–DrugcheckereffectivenessReduction in Healthcare Utilizationsafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulationevidence basedClinical TrialsRECOVERychildrenOsler’s WebSex differencesprologueAnimal modelsTherapiesdevelopment, symptomThe Long COVID ISSUELetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord ServerMicrobeTV Fundraiser Novel H5N1cVDVP2 circulationwith proteases B cell receptor enhancement Jolene Weekly Picks Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video Vincent – ‘We need to be ready for a new world’: scientists globally react to Trump election win Listener Picks Jack – Coronavirus vaccine update Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax’s combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode flu flewBritish Columbia Highly PathogenicMarburg First kid’sclift notesnovel reassortmentsrecent infection50,000 mpoxactivitydeathsnational and regional11 pathogensvariant trackergenomes Science trust Vaccine mistrust levelsCOVID-fluWhere EUA center CDC QuarantineNIH Infectious Disease Society guidelinescheckereffectivenessReduction in Healthcare Utilizationsafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone AnticoagulationSecondaryevidence basedtrace-levelLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord ServerMicrobeTV Fundraiser Diane GriffinTWiV 453in US pigsinfluenza virus infection Trained innate immunityJolene Weekly Picks Angela – See a giant ‘ghost particle’ detector and more — October’s best science images Brianne – October 27 APoD: Bat nebula Dickson – Nikon Small World Contest 2024 winners Kathy – AAAS 150th anniversary video, celebrating scientists and Pew’s 2024 annual Trust in Science survey findings Rich – Cats Basically Are a Liquid After All, Study Confirms Alan – HHMI’s Beautiful Biology site Vincent – EcoHealth Alliance Fights Back Listener Picks Hunter – Don’t stop me now: Queen’s Brian May on saving badgers — and the scientific method Anne – Reasons to be cheerful Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode pathogensBritianstop Marburg virusfact sheetcliff notesRSVactivitydeathsnational and regional11 pathogensvariant trackergenomes additionalpemivibart Where EUA center CDC QuarantineNIH Infectious Disease Society guidelinescheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation Secondaryevidence-based Autoimmune and autoinflammatoryLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation. Hosts: Vincent Racaniello and Rich Condit Guests: Mala Maini and John Tavis Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Serverhepatitis B virus infectionhttps://www.hepb.org/Jolene Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about “walking pneumonia”, the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if antiviral therapy prevents long COVID and viral sequalae in healthy young marines. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Mycoplasma pneumoniae Polio North GazaUK importschildrenstop Marburg virusfact sheetconfirmedcliff notesnirsevimab RSVactivitydeathsnational and regional11 pathogensUKvariant trackergenomescontributes limitedI repeat Facial Palsy New preventive IDSA GuidelinesWhere EUA center CDC QuarantineNIH Infectious Disease Society guidelinesfollowingcheckerpreventssafetyimmunocompromisedSustained Recoveryrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation young marinesLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Servertype 2 polioviruspolioeradication.orgremoved from flu vaccine Nobel PrizesAAV-vectoredgene drive in miceJolene Weekly Picks Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent with a crowbar Vincent – The expanding world of neuroscience Listener Pick Jason – Solar eclipse on Mars and Polaris Program and their Harmony of Resilience Ryan – New York’s childhood vaccine coverage remains high Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode 1000 deaths Global trendpublic healthvariant confirmed63rd casestop Marburg virusfact sheetABRYSVONETpneumococcal PREVNAR 20CAPVEXIVE21-valentKey updatesdeathsnational and regional11 pathogensacrossvariant trackergenomesindoors NVX-CoV2327 vs BNT162b2 Second dose New preventive IDSA GuidelinesWhere EUA CDC QuarantineNIH Infectious Disease Society guidelinesfollowingcheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone AnticoagulationDr. Daniel Griffinaccount(ME/CFS)Letters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden. Host: Vincent Racaniello Guests: Niklas Björkström and Joakim Dillner Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord ServerEndometrial Immune defenseeliminationelimination strategiesJolene Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65 following the 3 dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Undiagnosedvaccine approvalglobalstop Marburg virusfact sheetwhooping coughdeathsnational and regional11 pathogensvariant trackergenomeseffectiveness and waning of immunity New preventive IDSA GuidelinesWhere EUA performance CDC QuarantineNIH Infectious Disease Society guidelinescheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortages dexamethasone Anticoagulationsurvival outcomesReadmissioncirculating viral antigens DUCI Long COVIDLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Marburg virus diseasetests negativeCryo-EM discovery Mosaic sarbecovirus nanoparticleLetters readJolene Weekly Picks Brianne – ASM Lesson Plans Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize Listener Pick Laura – Science of Public Communication (original article) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode second roundRSV vaccineArexvy Mpoxstop Marburg virusfact sheetCDC summary 700 dosesMarburg outbreak responsedeathsnational and regional11 pathogensvariant trackergenomes PICOBOOunvaccinated New preventive IDSA GuidelinesWhere EUA CDC QuarantineNIH Infectious Disease Society guidelinestrackeroutpatientcheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation coronary artery diseasedoubles QTL mappingLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Revieworiginal article EEE deathTWiV 1145farmed fur animalswildlife and virusesLetters readJolene Weekly Picks Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Marburg viruscommuteswhooping cough/pertussismaternal antibodiesrecommendations Ziresovireffective anti-RSVAfrican mpoxdeathsnational and regional11 pathogensvariant trackergenomes Doffing your PPEdoes not IDSA GuidelinesWhere EUA CDC QuarantineNIH Infectious Disease Society guidelinescheckersafetyimmunocompromisedrespiratory virusinfected/exposedshortagesdexamethasone Anticoagulation long COVIDcognitive deficitsLetters readpdfJolene Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv