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Two Scientists Walk Into a Bar

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From research on cancer vaccines to why we feel pain, Genentech scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool with host Jane Grogan, Principal Scientist of Cancer Immunology at Genentech, for “Two Scientists Walk Into A Bar.”

From research on cancer vaccines to why we feel pain, Genentech scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool with host Jane Grogan, Principal Scientist of Cancer Immunology at Genentech, for “Two Scientists Walk Into A Bar.”
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United States

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From research on cancer vaccines to why we feel pain, Genentech scientists are tackling some of the biggest challenges in human biology. Want to find out what they’re working on? Pull up a stool with host Jane Grogan, Principal Scientist of Cancer Immunology at Genentech, for “Two Scientists Walk Into A Bar.”

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@genentech

Language:

English


Episodes

S3E04: A Look Into the Eye

8/9/2019
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Our eyes are our windows to the world, but what happens when those windows start to fade or disappear? To understand how the eye works, scientists are combining developments in imaging and genetics to see into the eye and better understand why a disease occurs or whether a treatment is working. Hear from our host Jane Grogan and Menno van Lookeren Campagne, Principal Scientist, Immunology, and get a glimpse into how researchers are combining genetics, imaging and natural history data to...

Duration:00:33:01

S3E03: Cancer: When Cells Go Rogue

3/12/2019
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It’s easy to think of cancer as an invader to the body. But in reality, it’s simply the result of a few proofreading errors in DNA replication that occur over time when cells divide. In Episode 3, Jane Grogan chats with Fred de Sauvage, Vice President and Staff Scientist, Molecular Oncology, about how just a handful of mutations can make normal cells go rogue, and how the field is finding new ways to stop the growth of cancer in its tracks.

Duration:00:33:16

S3E02: Fire in the Gut: IBD Explained

2/6/2019
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Last episode, Jane and colleagues unraveled the intricacies of the human microbiome. This week, Jane chats with Mary Keir, Senior Scientist, Biomarker Discovery OMNI, to learn what happens during inflammatory bowel disease (IBD), what causes it, and how targeting dysfunction in our immune system, the gut epithelial barrier and our microbiome could reduce inflammation in the gut.

Duration:00:35:15

S3E01: Unraveling the Microbiome

1/4/2019
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Our bodies are full of bacteria - pounds of them actually. We’re kicking off Season 3 with a closer look at the human microbiome and what happens when the synergistic relationship between our cells and our bacteria goes awry. Jane Grogan talks about the latest discoveries in microbiome research with Allyson Byrd, Associate Scientist, Cancer Immunology, Bioinformatics.

Duration:00:31:25

Season Three Teaser

1/2/2019
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Two Scientists Walk Into a Bar is back for a third season with host Jane Grogan chatting with scientists who are leading the charge to understand complex diseases. This season will tackle a range of new topics, including a deep dive into the human microbiome, the latest in multiple sclerosis, asthma and aging, and how Big Data is redefining personalized healthcare. Subscribe today so you don’t miss an episode!

Duration:00:03:08

S2E08: Why You Should Study Immunology

4/11/2018
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So far this season we’ve talked about the immune system a lot – how immune cells communicate, traffic along connective tissue, and invasive tumors. But what actually is the immune system? What’s it made of? How does it work? To close out our second season, Jane speaks with Andy Chan, Senior Vice President of Research Biology, to unravel the mysteries behind the immune system.

Duration:00:44:52

S2E07: The Therapeutic Window

3/19/2018
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Pharmacology is the study of how a medicine works in the body, which is a critical step in understanding what medicines people should be given, and at what dose and schedule. As we learn more about the complex genomics that make each person unique, the role of pharmacologists is becoming increasingly important for personalizing safe and effective treatments. Jane speaks to Sara Kenkare-Mitra, Senior Vice President, Development Sciences, to get a glimpse into the future of this field.

Duration:00:28:21

S2E06: The Polarizing World of Neurons

2/26/2018
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Neurons, the cells that make up our brain, are some of the most unique cells in our bodies. The complex nature of how they communicate leads to everything we say, think, or do. That complexity makes it hard to correct neural communication when something goes wrong, as in neurodegenerative diseases. What can we do to fix that? Jane talks to Casper Hoogenraad, Senior Director and Staff Scientist in Neuroscience, to find out more.

Duration:00:29:04

S2E05: Why Cells Die

1/31/2018
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The lifecycle of a cell mirrors our own lives – cells live and die as we do. It would be easy to think of cell death, or apoptosis, as a negative action, but the death of a cell is actually critical to many of the important biological functions that keep our bodies running. Learn more about the mysteries behind cell death from Vishva Dixit, M.D., Vice President, Physiological Chemistry.

Duration:00:33:43

S2E04: Viruses, Bacteria and How to Beat Them

1/3/2018
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Despite the best efforts of the human immune system, viruses and bacteria are constantly evolving to find new ways to breach our bodies’ natural defenses. Over the years, scientists have stepped in to develop novel ways to help the immune system in fighting infectious diseases. It’s a complicated field, which is why in this episode Jane is bringing in two scientists – Man Wah Tan, Senior Director and Principal Scientist, and Jorge Tavel, Group Medical Director, from the infectious disease...

Duration:00:39:07

S2E03: What’s in a Pill?

11/16/2017
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Chemistry is all around us – from the air we breathe, to the food we eat, to the medicine we take when we’re sick. And for the researchers working to figure out how to make those medicines, chemistry can be an art as well as a science. Learn more as Jane talks to Wendy Young, Vice President, Discovery Chemistry.

Duration:00:23:16

S2E02: Proteins: Seeing is Believing

10/25/2017
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The world of proteins is a minuscule and elegant ballet. Recent advances in imaging techniques have given us unprecedented views into this microscopic world, which could help us design better targeted therapies for a wide range of diseases. Learn more from Sarah Hymowitz, Vice President, Protein Sciences at Genentech, about why she has fallen in love with all things protein.

Duration:00:27:33

S2E01: Connective Tissue: The Hidden Metropolis

9/27/2017
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If your body was a city, then connective tissue would be the infrastructure tying everything together. It’s a hidden universe that helps many types of cells talk to each other and helps us fight diseases like rheumatoid arthritis or cancer. That’s why Shannon Turley has dedicated her research to uncovering the complexities of connective tissue, from her days as a graduate student shuttling ice boxes of live cells on the train to Principal Scientist of Cancer Immunology at Genentech. Hear...

Duration:00:27:11

Season Two Teaser

9/12/2017
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Jane Grogan and her producer Wellington Bowler are back for a second season of Two Scientists Walk Into a Bar. After a summer hiatus, Jane is eager to take on a new season of topics, including the 101 on proteins, infectious disease, how tumor microenvironments work and cell death. Subscribe today so you don’t miss an episode!

Duration:00:03:10

S1E08: Designing Early Stage Clinical Trials

3/27/2017
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Designing a clinical trial is fascinatingly complex. There are dozens of variables that could influence the ability of any given trial to be successful. Navigating this complexity is truly a science unto itself. In our latest episode, Merdad Parsey, Senior Vice President of Early Clinical Development, explains how the science of clinical trial design has evolved, and where it’s headed.

Duration:00:27:43

S1E07: Biomarkers and Big Data

2/27/2017
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Each person’s cancer is unique, so trying to match the right treatment to the right person is one of cancer biology’s biggest remaining challenges. In our latest episode, Priti Hegde, Director of Oncology Biomarker Development at Genentech, talks about how big data and advanced technology are guiding the future of personalized cancer immunotherapies.

Duration:00:21:17

S1E06: Continuing the Fight Against Breast Cancer

1/11/2017
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Some types of breast cancer can become “addicted” to estrogen signaling, so treatments that target the estrogen receptor were once thought to be a magic bullet against this disease. But breast cancer is sneaky, and some mutations can allow it to sidestep these types of targeted therapies. In our latest episode, Lori Friedman, Senior Director of Translational Oncology at Genentech, talks about the ways scientists are trying to stay one step ahead of breast cancer.

Duration:00:16:55

S1E05: The Search for Super Antibiotics

12/14/2016
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Bacteria are remarkably fast shape-shifters. As soon as we develop new antibiotics against them, they mutate, leading to drug-resistant strains the world has never seen before. This could mean that one day we end up weaponless against an army of drug-resistant superbugs. But a new generation of “super antibiotics” could hold the key to overcoming this problem. Learn how as we sit down with Rick Brown, Vice President of Immunology and Infectious Diseases at Genentech, in our latest podcast.

Duration:00:21:52

S1E04: The Degenerating Brain

11/30/2016
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In 1848 an explosion launched an iron rod through Phineas Gage’s brain. He miraculously survived, but wasn’t the same person, giving scientists the first clues into how neurodegeneration can affect what it means to be human. In our latest episode, we sit down with Geoff Kerchner to learn about the latest ways scientists are trying to halt the neurodegeneration seen in diseases like Alzheimer’s, Parkinson’s and ALS. As both a practicing neurologist and research scientist, Geoff gives us an...

Duration:00:19:01

S1E03: How Your Cells Talk to Each Other (Hint: Not by Cell Phones)

11/16/2016
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Communication is the key to good relationships. That’s true not only for people, but for our cells as well. If cellular communication goes wrong, your brain may stop processing information, or your organs might form tumors. So how do cells talk to each other? This week Jane Grogan sits down with Shiva Malek, whose work focuses on “eavesdropping” on the chatter between cells to understand what they’re saying and what goes wrong in a diseased state like cancer. We’re sure the cells don’t mind.

Duration:00:20:23